The Potential to Leverage Real-World Data for Pediatric Clinical Trials: A Proof-of-Concept Study by Jens Declerck, Joanne Lee, Anando Sen, Avril Palmeri, Rianne Oostenbrink, Viviana Giannuzzi, Simon Woodworth, Salma Malik, Fenna Mahler, Beate Aurich, Rebecca Leary, Dipak Kalra, Volker Straub

“…These issues are compounded by small, age-stratified populations and fragmented clinical data. …”
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Unraveling the mitochondrial genome of Quercus litseoides: a step towards conservation of an endangered species by Ruo-Han Shen, Ruo-Han Shen, Yu Li, Liang-Hai Yang, Si-Si Zheng, Xu Yan, Gregor Kozlowski, Gregor Kozlowski, Gregor Kozlowski, Xi-Ling Dai, Yi-Gang Song

“…The genome encoded 38 protein-coding genes, 23 transfer RNA genes, and three ribosomal RNA genes. …”
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Faecal microbiota transplantation protects against radiation‐induced toxicity by Ming Cui, Huiwen Xiao, Yuan Li, Lixin Zhou, Shuyi Zhao, Dan Luo, Qisheng Zheng, Jiali Dong, Yu Zhao, Xin Zhang, Junling Zhang, Lu Lu, Haichao Wang, Saijun Fan

“…FMT preserved the intestinal bacterial composition and retained mRNA and long non‐coding RNA expression profiles of host small intestines in a sex‐specific fashion. …”
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Effect of gene CRTC2 on the differentiation of subcutaneous precursor adipocytes in goats by Xuening Li, Tingting Hu, Ruiwen Li, Yanyan Li, Yaqiu Lin, Yong Wang, Wei Liu, Youli Wang

“…Results The results showed that the cloned goat CRTC2 gene was 2363 bp long (coding sequence [CDS] 2082 bp), encoding 693 amino acids. …”
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Sperm‐Derived CircRNA‐1572 Regulates Embryogenesis and Zygotic Genome Activation by Targeting CCNB2 via Bta‐miR‐2478‐L‐2 by Yanfang Wu, Yaochang Wei, Yuelin Li, Yiming Dou, YongQiang Yang, Hanghang Liu, Xiaoyan Wang, Zheng Wang, Jianmin Su, Yong Zhang, Yongsheng Wang

“…Abstract Sperm non‐coding RNAs, including micro RNAs, transfer RNA‐derived small RNAs, and long non‐coding RNAs, are pivotal in cellular cytoskeletal remodeling, early embryonic development, and offspring phenotypes. …”
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Cloning, expression, and polymorphism of the ECI1 gene in various pig breeds by Yun-feng LU, Ji-bao CHEN, Bo ZHANG, Qing-gang LI, Zhi-xiu WANG, Hao ZHANG, Ke-liang WU

“…Single-nucleotide polymorphisms (SNPs) of ECI1 were screened by PCR-sequencing and genotypes of those SNPs were tested by PCR-restriction fragment length polymorphism (PCR-RFLP) in Diannan small-ear pigs (DSP, n=40), Tibetan pigs (TP, n=60) and Yorkshire pigs (YP, n=30). …”
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Leveraging the dynamic adaptation process to address LGBTQ+ health equity in New Mexico high schools by Cathleen Elizabeth Willging, Cathleen Elizabeth Willging, Daniel Shattuck, Daniel Shattuck, Mary M. Ramos, Mary M. Ramos, Bonnie O. Richard, Adrien Lawyer, Elizabeth Dickson, Gregory A. Aarons

“…Data sources included annual structured assessments of EIP implementation, individual and small-group qualitative interviews with school professionals, periodic debriefs and interviews with implementation coaches, and coach activity logs. …”
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Management outcome of intestinal obstruction and associated factors among surgically managed patients in Awi Zone public hospitals, Northwest Ethiopia by Animut Takele Telayneh, Adane Gebeyehu Tegegne, Samuel Derbie Habtegiorgis, Bekalu Endalew, Abiot Aschale, Tsige Gebre, Mulugeta Tesfa

“…Epi data version 4.2 was used for data entry, and SPSS version 25 was used for data cleaning, coding, and analysis. A p-value <0.05, 95 % CI, and AOR were used to identify statistically significant. …”
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The intersection between circulatory microRNAs and biomarkers of neurodegeneration by Amber Yaqub, Rima Mustafa, M. Arfan Ikram, Mohsen Ghanbari

“…Abstract Background MicroRNAs (miRNAs) are small non-coding RNAs with a vast array of biological functions, including the regulation of gene expression. …”
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Evaluation of the Clear Fear Smartphone App for Young People Experiencing Anxiety: Uncontrolled Pre– and Post–Follow-Up Study by Chiara Samele, Norman Urquia, Rachel Edwards, Katie Donnell, Nihara Krause

“…Qualitative data derived from open-ended questions were coded and entered into NVivo (version 10) for analysis. …”
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Supporting Muslim undergraduate medical students through medical school: lessons from a novel, student-led case-based learning intervention by Zain Mohammed, Zain Mohammed, Hafsah Ba, Linta Nasim, Emily Roisin Reid

“…Using Case-Based Learning (CBL) as a pedagogical framework, a novel student-led teaching intervention was created and delivered to small groups of faculty and students, with the aim of enhancing awareness, promoting inclusivity, and supporting educators of these issues.MethodsThis CBL intervention was designed and led by Muslim medical student facilitators with subject expertise and previous experience in implementing curricular interventions. …”
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Circulating microRNAs as biomarkers for ischemic heart disease: a systematic review and gene set enrichment analysis by Yasmine Alcibahy, Radwan Darwish, Ghena Abu-Sharia, Quinten Maes, Omar Elgamassy

“…IntroductionIschemic heart disease (IHD) remains a major global health burden, highlighting the urgent need for early, non-invasive diagnostic biomarkers. MicroRNAs (miRNAs), small non-coding RNA molecules that regulate gene expression, have emerged as promising candidates due to their stability in circulation and involvement in cardiovascular processes. …”
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On the choice of finite element for applications in geodynamics – Part 2: A comparison of simplex and hypercube elements by C. Thieulot, W. Bangerth

“…For the numerical solution of the Stokes equations, geodynamics codes over the past decades have used essentially every finite element that has ever been proposed for the solution of this equation, on both triangular/tetrahedral (“simplex”) and quadrilaterals/hexahedral (“hypercube”) meshes. …”
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The Ways of Using Social Media for Health Promotion Among Adolescents: Qualitative Interview and Focus Group Study by Elizabeth Zimmermann, Samuel Tomczyk

“…Data were analyzed using content analysis with a combined deductive-inductive coding approach in MAXQDA software, achieving high intercoder reliability (Cohen κ=0.93). …”
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Comparative chloroplast genomics of wild-type Panicum miliaceum cv. ATL1 and its M4 mutant line: insights for molecular breeding applications by Ayushi Kumar, Ravikesavan Rajasekaran, Iyanar Krishnamoorthy, Senthil Alagarswamy, K. Chandrakumar, Sowmya Pulapet, Kesavan Markkandan, Selvaraju Kanagarajan, Manikanda Boopathi Narayanan

“…While they shared identical total lengths (139 837 bp), small single-copy (SSC: 12 795 bp), large single-copy (LSC: 84 522 bp), and inverted repeat (IR: 20 560 bp) regions, these metrics diverged from the reference genome, which displayed a total length of 139 826 bp, with distinct SSC (12 574 bp), LSC (81 682 bp), and IR (22 785 bp) regions. …”
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Profiling Plant circRNAs Provides Insights into the Expression of Plant Genes Involved in Viral Infection by Ghyda Murad Hashim, Travis Haight, Xinyang Chen, Athanasios Zovoilis, Srividhya Venkataraman

“…Interestingly, the non-coding exogenous scLTSV specifically induced several circRNAs, some of which contain open reading frames (ORFs) capable of encoding proteins. …”
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Novel type II toxin-antitoxin systems with VapD-like proteins by Konstantin Gilep, Dmitry Bikmetov, Aleksandr Popov, Anastasiia Rusanova, Shunsuke Tagami, Svetlana Dubiley, Konstantin Severinov

“…They consist of neighboring genes encoding two small proteins: a toxin that inhibits a critical cellular process and an antitoxin that binds to and neutralizes the toxin. …”
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Effects of high CO2 treatment on green-ripening and peel senescence in banana and plantain fruits by Mu-bo SONG, Lu-ping TANG, Xue-lian ZHANG, Mei BAI, Xue-qun PANG, Zhao-qi ZHANG

“…Compared to the effect on plantains, 20% CO2 treatment delayed the decline in the chlorophyll florescence (Fv/Fm) values and in the mRNA levels of a gene coding small subunit of Rubisco (SSU), and postponed the disruption of the ultrastructure of chloroplast in the peel tissue of bananas, indicating that the senescence of the green cells in the exocarp layer was delayed by 20% CO2, to more extent in bananas than in plantains. …”
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High-Density Lipoproteins from Coronary Artery Disease and Aortic Valve Stenosis Patients Differentially Regulate Gene Expression in a Model of Cardiac Adipocytes by María Luna-Luna, Araceli Páez, Felipe Massó, Rebeca López-Marure, Jorge Moisés Zozaya-García, Ariana Vargas-Castillo, Daniel Gómez-Pineda, Armando R. Tovar, Jonathan J. Magaña, José Manuel Fragoso, Margarita Gutiérrez-Saldaña, Zuriel Téllez-Osorio, Óscar Pérez-Méndez

“…Previous reports have described a statistical association between high-density lipoproteins (HDL) subclasses and the expression of genes coding for pro-calcifying proteins in the epicardial adipose tissue of patients with coronary artery disease (CAD) and aortic valvular stenosis (AVS). …”
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Population genetics reveal potential threats from low maternal genetic diversity in wild Asian elephants in China by Minhui Shi, Yinping Tian, Yongjing Tang, Haimeng Li, Jishan Wang, Yue Ma, Xin Liu, Ahimsa Campos-Arceiz, Fei Chen, Tianming Lan

“…These elephants occur in small, fragmented populations and face significant threats from habitat loss and fragmentation. …”
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