miR-210 loss leads to widespread phenotypic and gene expression changes in human 293T cells by Xiaoxiao Zhang, Zhen Meng, Chengyong Yang, Chenghao Wang, Kexin Zhang, Anxin Shi, Jingjing Guo, Yong Feng, Yan Zeng

“…IntroductionHypoxia responses are critical for myriad physiological and pathological processes, such as development, tissue repair, would healing, and tumorigenesis. microRNAs (miRNAs) are a class of small non-coding RNAs that exert their functions by inhibiting the expression of their target genes, and miR-210 is the miRNA universally and most conspicuously upregulated by hypoxia in mammalian systems. …”
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Delivery of LOXL1-AS1-siRNAs using targeting peptide-engineered extracellular vesicles with focused ultrasound to suppress medulloblastoma metastasis by Anh Duy Do, Shing-Shung Chu, Le Hien Giang, Pei-Lin Huang, Yu-Ling Lin, Che-Chang Chang, Tai-Tong Wong, Shian-Ying Sung, Chia-Ling Hsieh

“…In this study, we report an RNA therapy model using targeted extracellular vesicles (EVs) to deliver therapeutic small-interfering (si)RNAs to MB. Results First, MB-targeted EVs (MB-tEVs) were generated via genetic modification of EV-producing cells to express E1-3, an MB-specific peptide. …”
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Effect of Amyloid Beta on Cholesterol Metabolism-Correlated microRNAs in Primary Cultured Astrocytes of C57BL/6J Mice: A Focus on CYP46A1 and APOE Genes by Bahar Jaberian Asl, Zahra Nazeri, Seyadeh Pardis Pezeshki, Alireza Kheirollah, Shirin Azizidoost, Maryam Adelipour, Maryam Cheraghzadeh

“…Apolipoprotein E (ApoE) and cholesterol 24-hydroxylase (CYP46A1) are keyproteins involved in the efflux and metabolism of excess cholesterol, and small non-coding RNAs (miRNAs), can helpto regulate the expression of the genes encoding these proteins. …”
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High-throughput end-to-end aphid honeydew excretion behavior recognition method based on rapid adaptive motion-feature fusion by Zhongqiang Song, Jiahao Shen, Qiaoyi Liu, Wanyue Zhang, Ziqian Ren, Kaiwen Yang, Xinle Li, Jialei Liu, Fengming Yan, Wenqiang Li, Yuqing Xing, Lili Wu

“…Compared with the model excluding the RK50 module, the mAP50 improved by 2.9%, and its performance in detecting small-target honeydew significantly surpassed mainstream algorithms. …”
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Comparative analysis of complete chloroplast genomes of Flemingia prostrata and Flemingia macrophylla, two commonly used medicinal plants in southern China by Fan Wei, Fan Wei, Yang Lin, Danfeng Tang, Danfeng Tang, Ying Liang, Shuangshuang Qin

“…Each genome consisted of a large single copy (LSC) region (83,594 and 83,701 bp, respectively), a small single copy (SSC) region (17,773 and 17,776 bp, respectively), and two inverted repeats (IR) regions (50,570 and 51,556 bp, respectively). …”
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Wood-Inhabiting Nematode, <i>Bursaphelenchus ussuriensis</i> sp. n. (Nematoda: Aphelenchoididae) from David Elm, with Molecular Phylogeny of the Genus Based on Partial Mitochondria... by Alexander Yu. Ryss, Sergio Álvarez-Ortega, Boris D. Efeykin, Ivan A. Kerchev, Kristina S. Polyanina, Anna I. Solovyeva, Sergei A. Subbotin

“…Sequences of twelve mitochondrial protein-coding genes of <i>B. cocophilus, B. fraudulentus, B. michalskii, B. ussurensis</i> sp. n., and <i>B. willibaldi</i> were obtained in this study. …”
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miR-16-5p, miR-21-5p, and miR-155-5p in circulating vesicles as psoriasis biomarkers by Carlos A. Guzmán-Martín, Rogelio F. Jiménez-Ortega, María Fernanda Ortega-Springall, Mario Peña-Peña, Ana Elena Guerrero-Ponce, María Elisa Vega-Memije, Luis M. Amezcua-Guerra, Fausto Sánchez-Muñoz, Rashidi Springall

“…Abstract Psoriasis is a chronic skin disorder marked by fast skin cell growth, leading to thick, red, scaly patches. MicroRNAs are small, non-coding RNA molecules that play a crucial role in post-transcriptional gene regulation. …”
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Characterization and comparative profiling of piRNAs in serum biopsies of pediatric Wilms tumor patients by Fatma S. Mohamed, Deena Jalal, Youssef M. Fadel, Samir F. El-Mashtoly, Wael Z. Khaled, Ahmed A. Sayed, Mohamed A. Ghazy

“…Abstract Piwi-interacting RNAs (piRNAs) are small non-coding RNAs involved in transposon silencing and linked to cancer progression. …”
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Pelvic organ prolapse after hysterectomy: A 10‐year national follow‐up study by Tea Kuittinen, Sari Tulokas, Päivi Rahkola‐Soisalo, Tea Brummer, Jyrki Jalkanen, Eija Tomas, Juha Mäkinen, Jari Sjöberg, Päivi Härkki, Maarit Mentula

“…The cohort was linked to the Finnish Care Register to catch any prolapse‐related diagnoses and operation codes following the hysterectomy. Different hysterectomy approaches were compared according to the risk for a prolapse, including abdominal, laparoscopic, laparoscopic‐assisted vaginal and vaginal. …”
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Inhibition of microRNA-21 via locked nucleic acid-anti-miR suppressed metastatic features of colorectal cancer cells through modulation of programmed cell death 4 by Reza Nedaeinia, Mohammadreza Sharifi, Amir Avan, Mohammad Kazemi, Abdolreza Nabinejad, Gordon A Ferns, Majid Ghayour-Mobarhan, Rasoul Salehi

“…MicroRNAs are endogenous non-coding small RNA molecules that function as post-transcriptional regulators of gene expression. …”
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Impact of the PD-1/PD-L1 inhibitor SCL-1 on MDA-MB231 tumor growth in a humanized MHC-double knockout NOG mouse model by Tomoatsu Ikeya, Tadashi Ashizawa, Akari Kanematsu, Chie Maeda, Akira Iizuka, Kazue Yamashita, Haruo Miyata, Yasufumi Kikuchi, Kouji Maruyama, Mamoru Ito, Ken Yamaguchi, Yasuto Akiyama

“…Our group developed the small compound-based anti-PD-1/PD-L1 inhibitor SCL-1 and reported its potent anti-tumor effects on various syngeneic mouse tumors. …”
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Functional Polymorphisms in the Neuropeptide Y (NPY) Gene Associated with Egg Production in Thai Native, Black-Bone, and Commercial Laying Hens Using SNP Markers by Doungnapa Promket, Jennarong Kammongkun, Jiranan Insee, Wootichai Kenchaiwong, Khanitta Pengmeesri, Thassawan Somchan, Wuttigrai Boonkum

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Lower expression of miR-218 in human breast cancer is associated with lymph node metastases, higher grades, and poorer prognosis by Fereshteh Ahmadinejad, Seyed Javad Mowla, Mohammad-Amin Honardoost, Mostafa Gholami Arjenaki, Mohammad Moazeni-Bistgani, Soleyman Kheiri, Hossein Teimori

“…MicroRNAs are highly conserved small non-coding regulatory RNAs involved in post-transcriptional regulating of gene expression during different cellular mechanisms. …”
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Differential Mitochondrial Genome Expression of Four Skink Species Under High-Temperature Stress and Selection Pressure Analyses in Scincidae by Xuxiang Wu, Lemei Zhan, Kenneth B. Storey, Jiayong Zhang, Danna Yu

“…As ectotherms highly sensitive to environmental temperature fluctuations, skinks (a small lizard) are increasingly vulnerable to population instability due to global heatwaves. …”
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Inequities in Treatments and Outcomes Among Patients Hospitalized With Hypertrophic Cardiomyopathy in the United States by Daniel Y. Johnson, R. J. Waken, Daniel K. Fox, Gmerice Hammond, Karen E. Joynt Maddox, Sharon Cresci

“…Background Hypertrophic cardiomyopathy (HCM) is the most common heritable cardiac disease. In small studies, sociodemographic factors have been associated with disparities in septal reduction therapy, but little is known about the association of sociodemographic factors with HCM treatments and outcomes more broadly. …”
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Developing a mindfulness program for pre-clinical medical students in Indonesia: a mixed-methods study on suitability and appropriateness by Denish Gunawan, Lia Antico, William Nardi, Judson Brewer

“…Mindfulness-Based Interventions (MBI) have demonstrated small-to-moderate effectiveness in reducing stress and improving well-being, yet culturally adapted and developmentally appropriate programs for Indonesian medical students remain limited. …”
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Human genetics in rheumatoid arthritis guides a high-throughput drug screen of the CD40 signaling pathway. by Gang Li, Dorothée Diogo, Di Wu, Jim Spoonamore, Vlado Dancik, Lude Franke, Fina Kurreeman, Elizabeth J Rossin, Grant Duclos, Cathy Hartland, Xuezhong Zhou, Kejie Li, Jun Liu, Philip L De Jager, Katherine A Siminovitch, Alexandra Zhernakova, Soumya Raychaudhuri, John Bowes, Steve Eyre, Leonid Padyukov, Peter K Gregersen, Jane Worthington, Rheumatoid Arthritis Consortium International (RACI), Namrata Gupta, Paul A Clemons, Eli Stahl, Nicola Tolliday, Robert M Plenge

“…Our study demonstrates proof-of-concept that human genetics can be used to guide the development of phenotype-based, high-throughput small-molecule screens to identify potential novel therapies in complex traits such as RA.…”
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Micro-RNA expression data from common carp brain cells infected by Cyvirus cyprinidallo3 at permissive and non-permissive temperaturesSequence Read ArchiveNCBI by Olivier Rué, Nurul Novelia Fuandila, Saliha Hammoumi, Christine Gaspin, Jean-Christophe Avarre

“…MicroRNAs (miRNAs) are small non-coding RNAs capable of altering gene expression. …”
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Temporal and Seasonal Trends in Pediatric Eye Trauma in California by Bishay MN, Xu A, Nesemann JM, Keenan JD, Oatts JT

“…Over the 6-year period, the percentage of self-pay (uninsured) pediatric patients decreased over time, and public insurance (Medicaid/Title V) remained the most common payor.Conclusion: Ocular trauma represents a small fraction of ED visits for children in California. …”
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Endovascular thrombectomy versus intravenous tissue plasminogen activator for vertebrobasilar stroke treatment: insights from the national inpatient sample by Ram Saha, Gaurav Nepal, Dhanshree Solanki, Ahmed Shaheen, Mohammed Maan Al-Salihi, Shamser Singh Dalal, Anil Roy

“…In large hospitals, EVT was more commonly used than IV-tPA (8.1% vs. 7%, p &lt; 0.0001), while in small hospitals, IV-tPA usage was significantly higher (3.8% vs. 2%, p &lt; 0.0001). …”
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