Biomarkers predicting postoperative adverse outcomes in children with congenital heart disease: a systematic review and meta-analysis by Shifan Zhou, Shifan Zhou, Lu Liu, Xiaochuang Jin, Daniel Dorikun, Songfeng Ma

“…Publication bias was detected in some studies.ConclusionSerum lactate, NT-Pro BNP, and serum albumin are reliable biomarkers for predicting adverse outcomes in children with CHD after surgery.Systematic Review RegistrationPROSPERO [CRD42024512753].…”
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Booster Vaccination against Yellow Fever in Gambian children-(BoVY) -a Phase 3 clinical trial to establish safety and immunogenicity of repeated YF vaccination in healthy Gambian c... by David Jeffries, Caitlin Pley, Beate Kampmann, Mam Nabou Leigh, Julia Strandmark, Ed Clarke, Peter Ndow, Ebrima Kanteh, Amadou Faal, Elishia Roberts

“…The children will receive booster doses at 15 months, 4 years, or 8.5 years. …”
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Expression of Matrix Metalloproteinases and Their Tissue Inhibitors in Peripheral Blood Leukocytes and Plasma of Children with Nonalcoholic Fatty Liver Disease by Joanna B. Trojanek, Jacek Michałkiewicz, Renata Grzywa-Czuba, Wojciech Jańczyk, Lidia Gackowska, Izabela Kubiszewska, Anna Helmin-Basa, Aldona Wierzbicka-Rucińska, Mieczysław Szalecki, Piotr Socha

“…The MMP-9, TIMP-2 expression levels, plasma amounts of MMP-9, TIMP-1, and the MMP-9/TIMP-1 ratio were increased in children with NAFLD. Concentrations of AST, ALT, GGT, and leptin were elevated in serum patients with NAFLD, while concentration of other inflammatory or liver injury markers was unchanged. …”
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Thyroid Function in Chronically Transfused Children with Beta Thalassemia Major: A Cross-Sectional Hospital Based Study by Suraj Haridas Upadya, M. S. Rukmini, Sowmya Sundararajan, B. Shantharam Baliga, Nutan Kamath

“…Methodology. BTM children, 3 years old and above, on regular blood transfusions with serum ferritin > 1500 mcg/l were included in the study. …”
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Seroprevalence of Hepatitis C, Hepatitis B, Cytomegalovirus, and Human Immunodeficiency Viruses in Multitransfused Thalassemic Children in Upper Egypt by Ramadan A. Mahmoud, Abdel-Azeem M. El-Mazary, Ashraf Khodeary

“…Frequent blood transfusions in thalassemia major children expose them to the risk of transfusion-transmitted infections (TTIs). …”
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The role of vitamin D in slipped capital femoral epiphysis in children and adolescents: a retrospective case-control study by Peng Ning, Shuting Lin, Huiyu Geng, Tianjing Liu

“…The control group consisted of healthy children matched by gender, age, weight, height, body mass index (BMI), and date of blood tests at a 1:2 ratio from the pediatric developmental clinic. …”
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Neonatal BCG vaccination and child survival in TB-exposed and TB-unexposed children: a prospective cohort study by Peter Aaby, Per Kallestrup, Christine Stabell Benn, Sanne M Thysen, Ane Fisker, Victor Francisco Gomes, Frauke Rudolf, Christian Wejse, Adam Roth

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Vitamin B12, folate, and homocysteine levels in children and adolescents with obesity: a systematic review and meta-analysis by Juan R. Ulloque-Badaracco, Esteban A. Alarcon-Braga, Enrique A. Hernandez-Bustamante, Enrique A. Hernandez-Bustamante, Beatrix M. Von-Koeller-Jones, Miguel Huayta-Cortez, Esduardo Saavedra-Custodio, Percy Herrera-Añazco, Vicente A. Benites-Zapata

“…There were no significant differences between children/adolescents with and without obesity with respect to serum vitamin B12 levels (SMD: −0.24; 95% CI: −0.53 to 0.06; p > 0.05, I2 = 74.93%) and folate levels (SMD: −0.12; 95% CI: −0.29 to 0.06; p > 0.05, I2 = 19.6%). …”
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Economic burden of acute kidney injury in children and adults: a protocol for a systematic review and meta-analysis by Sean M Bagshaw, Catherine Morgan, Rashid Alobaidi, Emma Heydari Ulrich, Aspen Lillywhite, Michael Paulden, Michael Zappitelli

“…Inclusion criteria will be randomised controlled trials (RCTs) and observational studies (cohort or case–control) from all countries of hospitalised adults and children. The exposure will be AKI based on definitions using serum creatinine and/or urine output criteria, relative to patients without AKI. …”
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Prevalence of vitamin D deficiency in children with cerebral palsy and autism spectrum disorder: a comparative pilot study by Ruzha Pancheva, Albena Toneva, Yana Bocheva, Miglena Georgieva, Krassimira Koleva, Ivan Yankov

“…Aim: This study aims to explore the prevalence of vitamin D deficiency (VDD) among children with cerebral palsy (CP) and autism spectrum disorder (ASD) in Bulgaria, while analyzing associated demographic, nutritional, and biochemical factors. …”
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Naturally Occurring Hepatitis B Virus B-Cell and T-Cell Epitope Mutants in Hepatitis B Vaccinated Children by Yu-Min Lin, Guey-Mei Jow, Shu-Chi Mu, Bing-Fang Chen

“…The aim of this study was to investigate the role of B-cell and T-cell epitope variations of HBsAg and polymerase in HBV infection in vaccinated children. One hundred sixty-three sera from vaccinated children were enrolled randomly. …”
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Disrupting effects of neonicotinoids and their interaction with metals on thyroid hormone, an evidence of children in a rural area, South China by Ling-Chuan Guo, Pan Zhu, Chunyan Gui, Jing Deng, Yanhong Gao, Chaoyang Long, Han Zhang, Zhanlu Lv, Shengbing Yu

“…To fill this knowledge gap, we conducted a cross-sectional study on children of a rural area in South China (n = 88), and analyzed urinary ten neonicotinoids (including metabolites), serum TH, thyroxine-binding globulin (TBG), and thyroid stimulating hormone (TSH) levels. …”
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Vitamin D Deficiency and Associated Factors in Children: A Multicenter Study of 21,811 Samples in Southern China by Chuican Huang, Sijia Liu, Chen Cheng, Shiyun Chen, Qing Luo, Yan Huang, Yanxian Yao, Xixia Ye, Haizhen Wang, Liangyi Luo, Junwei Xie, Hongai Li, Yumei Duan, Beibei Liu, Wenting Cao, Fangfang Zeng, Wei Xiang, Lichun Fan

“…ObjectiveTo investigate the prevalence of vitamin D deficiency (VDD) in children/adolescents in extreme southern China.MethodsThis multicenter, cross-sectional study included 21,811 children aged 0–18 years from 18 districts in Hainan Province, using a multistage stratified random sampling method from January 2021 to March 2022.ResultsSerum 25(OH)D levels decreased with age (p trend <0.001). …”
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Associations of dietary choline intake and kidney function with hyperuricemia in Chinese children and adolescents: a cross-sectional studyResearch in context by Chengping Li, Jing Li, Zhiquan Diao, Lianhong Chen, Siwen Yu, Lianlong Yu, Qianrang Zhu, Xiaomei Dong, Yiya Liu, Tao Liu, Dan Liu

“…Based on recommendation in Clinical Paediatric Nephrology (3rd ed), HUA is defined based on fasting serum uric acid levels, with cutoffs varying by age and sex. …”
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Management of Vitamin D Deficiency Among the Under-Five Children Residing in Coastal Areas of Karnataka: A Study Protocol by Mamatha Shivananda Pai, Reshma R Kotian, Suneel C Mundkur, Shobha U Kamath, Anjeline D'Souza, Bhavana B Bhat, Sangeetha M Acharya

“…The objective of this study is to assess the effectiveness of sun exposure and Vitamin D supplement and Vitamin D supplements alone on serum vitamin D levels among the under-fives. Methods: This protocol is a randomized controlled study planned to be carried out among the under-five children with vitamin D deficiency. …”
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Increased Frequency of Circulating Follicular Helper T Cells in Children with Hand, Foot, and Mouth Disease Caused by Enterovirus 71 Infection by Jianping Wu, David Cui, Xianzhi Yang, Jianzhou Lou, Jie Lin, Xianfei Ye, Zhimei Qin, Li Huang, Dejian Zhao, Zhaoxia Huo, Guoliang Xie, Shufa Zheng, Fei Yu, Liwei Lu, Yu Chen

“…Enterovirus 71 (EV71) is a major causative agent of hand, foot, and mouth disease (HFMD) in children. The role of T follicular helper (TFH) cells in EV71-infected children remains unclear in regulating humoral immunity. …”
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Clinical, immune and genetic risk factors of malaria-associated acute kidney injury in Zambian children: A study protocol. by Chisambo Mwaba, Sody Munsaka, David Mwakazanga, David Rutagwerae, Owen Ngalamika, Suzanna Mwanza, Mignon McCulloch, Evans Mpabalwani

“…<h4>Background</h4>Acute kidney injury (AKI) affects nearly half of children with severe malaria and increases the risk of adverse outcomes such as death and poor cognitive function. …”
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Patterns and Determinants of Change in Cortisol Levels and Thyroid Function as a Function of Cardiac Risk in Children Undergoing Cardiac Surgery by Khouloud Abdulrahman Al-Sofyani, Mohammed Shahab Uddin, Ebtehal Ahmed Qulisy, Osman Osama Al-Radi

“…Background. Children undergoing cardiac surgery with cardiopulmonary bypass (CPB) are exposed to the risk of hormonal imbalances resulting from acute stress, which may eventually result in high postoperative mortality and morbidity. …”
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Expression of LINC00847 in Peripheral Blood Mononuclear Cells of Children with Asthma and Its Prediction between Asthma Exacerbation and Remission by Jiaying Hu, Zhike Wang, Suzhen Han, Kai Chen

“…The expression levels of LINC00847 were quantified in PBMCs collected from 54 children with asthma exacerbation, 54 children with asthma remission, and 54 healthy children by real-time qPCR. …”
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Effect of rhGH treatment on lipidome and brown fat activity in prepuberal small for gestational age children: a pilot study by Lorena González, Carolina Gonzalez-Riano, Pablo Fernández-García, Rubén Cereijo, Aina Valls, Andrea Soria-Gondek, Nativitat Real, Belén Requena, Joan Bel-Comos, Patricia Corrales, David Jiménez-Pavón, Coral Barbas, Francesc Villarroya, David Sánchez-Infantes, Marta Murillo

“…While its effects on white adipose tissue are well-documented, this pilot study aimed to investigate its impact on the lipidome and the thermogenic and endocrine activities of brown adipose tissue (BAT) in SGA children following rhGH treatment. The study involved 11 SGA children divided into two groups: (a) SGA children who were not treated with rhGH (n = 4) and (b) SGA children who received rhGH treatment with Saizen® (n = 7). …”
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