Bifurcation analysis of multistability and hysteresis in a model of HIV infection by I. V. Mironov, M. Yu. Khristichenk, Yu. M. Nechepurenko, D. S. Grebennikov, G. A. Bocharov

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High Glucose with Insulin Induces Cell Cycle Progression and Activation of Oncogenic Signaling of Bladder Epithelial Cells Cotreated with Metformin and Pioglitazone by Daejin Kim, Byul-Nim Ahn, YeongSeok Kim, Dae Young Hur, Jae Wook Yang, Ga Bin Park, Jung Eun Jang, Eun Ju Lee, Min Jeong Kwon, Tae Nyun Kim, Mi Kyung Kim, Jeong Hyun Park, Byoung Doo Rhee, Soon Hee Lee

“…Levels of tumor suppressor proteins p53 and cav-1 were downregulated while those of the oncogenic protein as c-Myc were upregulated under high glucose and insulin supplementation in HBlEpC cotreated with pioglitazone and metformin. …”
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Second-line treatment patterns and outcomes in advanced HCC after progression on atezolizumab/bevacizumab by Meng Wu, Claudia A.M. Fulgenzi, Antonio D’Alessio, Alessio Cortellini, Ciro Celsa, Giulia F. Manfredi, Bernardo Stefanini, Y. Linda Wu, Yi-Hsiang Huang, Anwaar Saeed, Angelo Pirozzi, Tiziana Pressiani, Lorenza Rimassa, Martin Schoenlein, Kornelius Schulze, Johann von Felden, Yehia Mohamed, Ahmed O. Kaseb, Arndt Vogel, Natascha Roehlen, Marianna Silletta, Naoshi Nishida, Masatoshi Kudo, Caterina Vivaldi, Lorenz Balcar, Bernhard Scheiner, Matthias Pinter, Amit G. Singal, Joshua Glover, Susanna Ulahannan, Fredrich Foerster, Arndt Weinmann, Peter R. Galle, Neehar D. Parikh, Wei-Fan Hsu, Alessandro Parisi, Hong Jae Chon, David J. Pinato, Celina Ang

“…In the second-line setting, patients treated with TKIs had a numerically shorter mPPS compared to those treated with IO (8.4 vs. 14.9 months; HR 1.37, p = 0.256). …”
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Comprehensive evaluation of spring barley mutants according to their yield components by A. A. Belozerova, D. A. Bazyuk, N. A. Bome

“…The need to increase the genetic diversity of barley (Hordeum vulgare L.) is determined by its value and cultivation scope, which is especially important in the context of the changing climate.Material and methods. The study was carried out in 2021 and 2022 at the experimental site of the Lake Kuchak biostation located in Nizhnetavdinsky District, Tyumen Province (57°20ʼ57.3”N, 66°03ʼ21.8”E). …”
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Special issue: Proceedings of the 15th ISIC - The Information Behaviour Conference, Aalborg, Denmark, August 26-29, 2024

“…‘It never seems to stop’ Six high school students’ experiences of information overload Mira Grønning Aadland, Jannica Heinström Exploring scholarly perceptions of preprint servers Shir Aviv-Reuven, Jenny Bronstein, Ariel Rosenfeld Enhancing conceptualisations of information behaviour contexts through insights from research on e-dictionaries and e-lexicography Theo JD Bothma, Ina Fourie Trends in data literacy, 2018-2023: a review of the literature Leanne Bowler, Charlie Shaw Analysis of collaborative innovation behaviour and its influencing factors in scientific research crowdsourcing platforms: based on the fsQCA method Jiajun Cao, Yuefen Wang, Xin Xie, Yuanzhi Lv, Peng Chen Information relations for social change: exploring the information behaviour of academics undertaking impact work Joann Cattlin, Lisa M. …”
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Expression of SMADs in orthotopic human endometrium, ovarian endometriosis, and endometriotic lesions in a murine model by Yuri Kadota, Takeshi Kato, Kana Kasai, Takako Kawakita, Misaki Murayama, Akari Shinya, Hikari Sasada, Sachiko Katayama, Mari Nii, Shota Yamamoto, Hiroki Noguchi, Kou Tamura, Hidenori Aoki, Miyu Taniguchi, Tomotaka Nakagawa, Takashi Kaji, Masato Nishimura, Riyo Kinouchi, Kanako Yoshida, Takeshi Iwasa

“…Activin A promotes the development of endometriotic lesions in a murine model of endometriosis, and the immunohistochemical localization of phosphorylated suppressor of mothers against decapentaplegic homolog 2/3 (pSMAD2/3) complex in endometriotic lesions has been reported. Activin may therefore be involved in the development and proliferation of endometriotic cells via the SMAD signaling pathway. …”
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Integrating 16S rDNA and metabolomics to uncover the therapeutic mechanism of electroacupuncture in type 2 diabetic rats by Zhang Yue, Wang Xiang, Deng Duping, Gong Yuanyuan, Chen Xuanyi, Li Juan, Li Juan, Hong Xiaojuan

“…The abundance of operational taxonomic units (OTUs) in the EA group increased than the model group (p < 0.05), and EA upregulated the Shannon, Chao1, and Ace indices (p < 0.05). …”
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Global, regional, and national burden of esophageal cancer: a systematic analysis of the Global Burden of Disease Study 2021 by Weiqiu Jin, Kaichen Huang, Ziyin Ding, Mengwei Zhang, Chongwu Li, Zheng Yuan, Ke Ma, Xiaodan Ye

“…However, owing to the population size, China, India, the United States, Japan, and Brazil had the heaviest absolute EC burdens. More pronounced alleviations of ASRs were observed in locations with high SDI levels, indicated by their lower AAPC values compared to those of low-SDI locations, while Sub-Saharan Africa regions had increasing EC ASRs, especially in Chad (114.76% in ASDR, for example), Sao Tome and Principe (97.93%), Togo (92.53%), Northern Mariana Islands (84.32%), Liberia (82.33%), etc. …”
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Survey on the Status and Training Demands of Capabilities for Diagnosing and Treating Common Diseases of Primary Care General Practitioners in Hunan Province by LI Lingqi, GAO Yinyan, ZHANG Yuqin, SUN Dingkui, WU Xinyin, ZHANG Weiru

“…Furthermore, 71.8% (242/337) of participants reported being unfamiliar with referral practices. 73.0% (246/337) of participants indicated limited knowledge of evidence-based practice, and 85.8% (247/288) of participants have limited use of evidence-based practice. Additionally, 77.2% (260/337) of participants lacked sufficient knowledge of clinical practice guidelines; 90.8% (306/337) of participants rarely consulted guidelines when facing decision-making difficulties, mainly because they felt guidelines could not address complex cases[50.0% (153/306) ], were unclear on how to search for guidelines[43.1% (132/306) ]and the resources available for retrieving guidelines[34.3% (105 /306) ]; participants mainly obtain the guidelines through the WeChat official account[72.5% (237/327) ] and databases such as the China National Knowledge Infrastructure [50.2% (164/327) ]. 97.0% (327/337) of participants expressed a demand for training to improve their capabilities, suggesting that training should be tailored to the specific needs of primary care institutions[60.8% (205/337) ]; the preferred approaches are advanced training in higher-level hospitals[71.3% (233/327) ]and primary care institutions with high diagnostic and treatment capabilities[56.3% (184/327) ]; the preferred training programs are on standardized treatment of common diseases[78.0% (263/337) ]and multiple coexisting diseases[69.4% (234/337) ]. …”
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Metabolic changes before and after weaning in Dezhou donkey foals in relation to gut microbiota by Qiwen Yang, Qiwen Yang, Haibing Liu, Halima Jafari, Bing Liu, Zhaofei Wang, Jiangtian Su, Fuwen Wang, Ge Yang, Minhao Sun, Jie Cheng, Boying Dong, Min Li, Mingjian Gen, Jie Yu

“…We found that with the growth and weaning progress of donkey foals, the intestinal microbiota of donkey foals underwent obvious changes, and the diversity of fecal bacteria increased (Chao1 and Shannon indexes). …”
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Application of gastrointestinal decompression method in determining tip position of the triple-lumen nasointestinal tube in critically ill patients (胃肠减压法在危重症患者三腔鼻肠管位置判断中的应用)... by WANG Zhimin (王志民), LI Xuejing (李雪晶), QIAO Shouang (乔首昂)

“…Conclusion Gastrointestinal decompression method can quickly and accurately determine the tip position of the nasointestinal tube, which is of great help for clinical work. …”
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Diversity in the medical research ecosystem: a descriptive scientometric analysis of over 49 000 studies and 150 000 authors published in high-impact medical journals between 2007... by Leo Anthony Celi, Jonathan Shaffer, Marie-Laure Charpignon, Liam G McCoy, Luis Filipe Nakayama, Jack Gallifant, Urvish Jain, Joao Matos, Pia Gabrielle I Alfonso, Marisa Cobanaj, Amelia Morel Fiske, Alexander J Gates, Frances Dominique V Ho, Mohammad Kashkooli, Naira Link

“…However, researchers identifying as women and those affiliated with institutions in low- and middle-income countries (LMICs) have been largely under-represented in high-IF journals across multiple fields of medicine. …”
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Multimodal machine learning enables AI chatbot to diagnose ophthalmic diseases and provide high-quality medical responses by Ruiqi Ma, Qian Cheng, Jing Yao, Zhiyu Peng, Mingxu Yan, Jie Lu, Jingjing Liao, Lejin Tian, Wenjun Shu, Yunqiu Zhang, Jinghan Wang, Pengfei Jiang, Weiyi Xia, Xiaofeng Li, Lu Gan, Yue Zhao, Jiang Zhu, Bing Qin, Qin Jiang, Xiawei Wang, Xintong Lin, Haifeng Chen, Weifang Zhu, Dehui Xiang, Baoqing Nie, Jingtao Wang, Jie Guo, Kang Xue, Hongguang Cui, Jinwei Cheng, Xiangjia Zhu, Jiaxu Hong, Fei Shi, Rui Zhang, Xinjian Chen, Chen Zhao

“…This study developed and evaluated the ChatGPT-powered Intelligent Ophthalmic Multimodal Interactive Diagnostic System (IOMIDS) to enable patient self-diagnosis and self-triage. …”
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Differences in soil Cd immobilization and blockage of rice Cd uptake by biochar derived from crop residue and bone − A 2-year field experiment by Zhongjun Xue, Fengfeng Sui, Yanjie Qi, Siyu Pan, Ning Wang, Rongjun Bian, Stephen Joseph, Xuhui Zhang, Lianqing Li, Genxing Pan

“…Rapeseed straw biochar (REB), rice husk biochar (RHB), and bone char (BOC) were applied once at rates of 0 t ha−1 (CK) and 15 t ha−1, respectively. …”
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Associations between changes in the gut microbiota and liver cirrhosis: a systematic review and meta-analysis by Ye Liu, Ziwei Chen, Chang Li, Tianhan Sun, Xuanmei Luo, Boyue Jiang, Meilan Liu, Qing Wang, Tong Li, Jianfu Cao, Yayu Li, Yuan Chen, Lu Kuai, Fei Xiao, Hongtao Xu, Hongyuan Cui

“…The pooled estimates revealed a moderately significant reduction in gut microbiome richness in patients with liver cirrhosis compared with controls, including the Shannon, Chao1, observed species, ACE, and PD indices, but no significant difference was observed for the Simpson index. …”
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Factors Affecting the Prognosis after Primary Tumor Resection for Patients with Metastatic Colorectal Cancer with Synchronous Peritoneal Metastasis: A Multi-center, Prospective, Ob... by Satoru Kagami, Kimihiko Funahashi, Hirotoshi Kobayashi, Kenjiro Kotake, Masayasu Kawasaki, Yusuke Kinugasa, Hideki Ueno, Kotaro Maeda, Takeshi Suto, Michio Itabashi, Heita Ozawa, Fumikazu Koyama, Shingo Noura, Hideyuki Ishida, Masayuki Ohue, Tomomichi Kiyomatsu, Soichiro Ishihara, Keiji Koda, Hideo Baba, Kenji Kawada, Yojiro Hashiguchi, Takanori Goi, Yuji Toiyama, Naohiro Tomita, Eiji Sunami, Fumihiko Fujita, Jun Watanabe, Kenichi Hakamada, Goro Nakayama, Kenichi Sugihara, Yoichi Ajioka

“…R0 surgery became more difficult as the degree of dissemination increased, and the PTR group had a significantly better prognosis than the non-PTR group. …”
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Bulk and single-cell transcriptome revealed the metabolic heterogeneity in human glioma by Yong Xiao, Mengjie Zhao, Ran Wang, Liang Liu, Chong Xiang, Taiping Li, Chunfa Qian, Hong Xiao, Hongyi Liu, Yuanjie Zou, Xianglong Tang, Kun Yang

“…Group 1 samples were predominantly located in the peripheral region and had a high composition of neuron cells. Group 2, however, had increased infiltration of tumor-promoting immune cells, such as M2 macrophages, and was characterized by traits of invasion, hypoxia, and immunity. …”
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Medical Jousting: Going for the kill! by Dr.Fuad Ahmed Khan Niazi

“…Although, this unfortunate practice can be unintentional, sadly, it is more often than not, intentional. …”
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