Association between DNA methylation levels of thioredoxin-interacting protein (TXNIP) and changes in glycemic traits: a longitudinal population-based study by Keisuke Maeda, Ryosuke Fujii, Hiroya Yamada, Eiji Munetsuna, Mirai Yamazaki, Yoshitaka Ando, Genki Mizuno, Hiroaki Ishikawa, Koji Ohashi, Yoshiki Tsuboi, Yuji Hattori, Yuya Ishihara, Nobuyuki Hamajima, Shuji Hashimoto, Koji Suzuki

“…At four years, the TXNIP DNA hypomethylation group had a higher percentage of changes in fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) compared to those in the hypermethylation group. …”
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Beyond the fever: shotgun metagenomic sequencing of stool unveils pathogenic players in HIV-infected children with non-malarial febrile illness by Patricia Nabisubi, Stephen Kanyerezi, Grace Kebirungi, Ivan Sserwadda, Mike Nsubuga, Grace Kisitu, Patricia Ntege Nahirya, Bonny Mulindwa, George P. Akabwai, Sylvia Nantongo, Adeodata Kekitiinwa, Edgar Kigozi, Nsubuga Moses Luutu, Fred Ashaba Katabazi, Leymon Kalema, Andrew Katabalwa, Daudi Jjingo, Gerald Mboowa

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Genetic and biochemical analysis of severe hypertriglyceridemia complicated with acute pancreatitis or with low post-heparin lipoprotein lipase mass by Takashi Suzuki, Makoto Kurano, Akari Isono, Takuya Uchino, Yohei Sayama, Honami Tomomitsu, Daiki Mayumi, Ruriko Shibayama, Toru Sekiguchi, Naoki Edo, Kiyoko Uno-Eder, Kenji Uno, Koji Morita, Toshio Ishikawa, Kazuhisa Tsukamoto

“…Moreover, phosphatidylcholine, lysophosphatidylinositol, and sphingomyelin levels tended to be higher in patients who experienced AP than those who did not, suggesting that these phospholipids may contribute to the onset of AP. …”
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Based on bioinformatics, SESN2 negatively regulates ferroptosis induced by ischemia reperfusion via the System Xc−/GPX4 pathway by Jiejie Hu, Lijun Qin, Guoqiang Zhu, Jingjing Ren, Hongxia Wang, Jing Jin, Haixue Zheng, Dan Li, Zhaoming Ge

“…IntroductionCerebral ischemia–reperfusion (IR) causes severe secondary brain injury. Previous studies have demonstrated that ferroptosis is involved in IR-induced brain injury. …”
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Preoperative hemoglobin A1c is associated with postoperative bleeding after vitrectomy for vitreous hemorrhage in patients with diabetic retinopathy by Saori Motoda, Masanori Kanai, Susumu Sakimoto, Harutoshi Ozawa, Chisaki Ishibashi, Shingo Fujita, Yoshiya Hosokawa, Megu Y. Baden, Yukari Fujita, Takekazu Kimura, Ayumi Tokunaga, Takao Nammo, Kenji Fukui, Junji Kozawa, Hirokazu Sakaguchi, Kohji Nishida, Iichiro Shimomura

“…A high HbA1c level just before vitrectomy tended to be associated with the bleeding (odds ratio = 1.27, p = 0.05), while preoperative HbA1c changes were not associated with rebleeding. The results of this study suggest that a high preoperative HbA1c level just before vitrectomy, not a decrease in HbA1c levels, in addition to the duration of the operation may increase the risk of postoperative bleeding after vitrectomy in diabetic retinopathy patients.…”
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稀土对林麝采食量、血液指标和粪便微生物的影响 by 罗雄, 吴杰, 陈凤, 蒋桂梅

“…（3）添加稀土后林麝血清尿素（UREA）和总胆固醇（TCH）含量较对照组低（<italic>p</italic>&lt;0.05），其他血液指标差异不显著（<italic>p</italic>&gt;0.05）。（4）试验组和对照组粪便微生物的Chao1指数、Simpson指数、Shannon指数和基于ANOSIM分析的Beta多样性没有显著差异（<italic>p</italic>&gt;0.05）。…”
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A compreensão do poder profissional docente a partir das representações sociais by Aparecida Tenório S. da Costa

“…Para a categorização e análise das representações sociais foram utilizadas três convenções: ilusão (para o grupo de professores que não creem no poder profissional docente); alvo (para os docentes do ensino superior, formadores de professores, que acreditam no poder da profissão, mas acham que esse poder é meta a ser conquistada), e evidência (professores cujos argumentos buscam provar a existência do poder da sua profissão). …”
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Augmented Reality-Assisted Pancreaticoduodenectomy with Superior Mesenteric Vein Resection and Reconstruction by Rui Tang, Wei Yang, Yucheng Hou, Lihan Yu, Guangdong Wu, Xuan Tong, Jun Yan, Qian Lu

“…Augmented reality (AR) technology can be used to assist in determining the extent of SMV involvement by superimposing virtual 3-dimensional (3D) images of the pancreas and regional vasculature on the surgical field. …”
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Abnormal ac4C modification in metabolic dysfunction associated steatotic liver cells by Xiqian Zhang, Yaxian Zheng, Jing Yang, Yan Yang, Qin He, Min Xu, Fangyi Long, Yujie Yang

“…Bioinformatics analysis showed that DEGs were significantly enriched in long-chain fatty acid biosynthetic process. Notably, 118 genes exhibited significant changes in both ac4C modification and expression levels in MASLD model cells. …”
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Exploring the impact of genetic factors and fatty acid quality on visceral and overall Fat levels in overweight and obese women: a genetic risk score study by Niloufar Rasaei, Atefeh Tavakoli, Saba Mohammadpour, Mehdi Karimi, Alireza Khadem, Azam Mohamadi, Seyedeh Fatemeh Fatemi, Fatemeh Gholami, Khadijeh Mirzaei

“…Genetic risk scores (GRS) can predict obesity risk based on genetic factors. …”
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WATCHMAN versus LACbes® device for percutaneous left atrial appendage closure: a single-center, propensity-matched study by Song Zhang, Sihuai Xiong, Sha Zhang, Keyu Chen, Hua Wang, Ke Li, Xudong Xu, Xianxian Zhao, Ni Zhu, Xinmiao Huang, Yongwen Qin, Zhifu Guo, Yuan Bai

“…Abstract Background Different left atrial appendage closure (LAAC) devices have been introduced into the clinical setting. A new dual-seal mechanism LACbes® occluder with isogenous barbs for LAAC has been designed to facilitate easier delivery and improve safety. …”
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HLA DR Genome Editing with TALENs in Human iPSCs Produced Immune-Tolerant Dendritic Cells by Yoo-Wook Kwon, Hyo-Suk Ahn, Jin-Woo Lee, Han-Mo Yang, Hyun-Jai Cho, Seok Joong Kim, Shin-Hyae Lee, Heung-Mo Yang, Hyun-Duk Jang, Sung Joo Kim, Hyo-Soo Kim

“…Although human induced pluripotent stem cells (iPSCs) can serve as a universal cell source for regenerative medicine, the use of iPSCs in clinical applications is limited by prohibitive costs and prolonged generation time. …”
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Effects of exercise training on the nigrostriatal glutamatergic pathway and receptor interactions in Parkinson’s disease: a systematic review by Shahid Ishaq, Iqbal Ali Shah, Shin-Da Lee, Shin-Da Lee, Bor-Tsang Wu

“…In addition, the exercise training downregulated the N-methyl-D-aspartate (NMDA) receptors, Arc, Cav1.3, CaMKII, and p-CaMKII in the nigrostriatal pathway in PD animal models.ConclusionExercise training exerted a neuroprotective effect on the glutamatergic pathway in Parkinson’s disease (PD) animal models by limiting excess glutamate in the synaptic cleft. …”
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The reliability and quality of short videos as health information of guidance for lymphedema: a cross-sectional study by Xuchuan Zhou, Gejia Ma, Xuefeng Su, Xinyi Li, Xinyi Li, Wenfei Wang, Linxi Xia, Linxi Xia, Chen Yang, Chen Yang, Bin Liu

“…Videos by medical professionals are generally more accurate and of higher quality than those by non-professionals. However, patient-uploaded videos often get more engagement due to their relatability. …”
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A comparative study of hospitalization costs of TKA inpatients before and after National Volume-based Procurement in Guangdong, China: an interrupted time-series analysis by Anqi Li, Gongduan Li, Dong Han, Manru Fu, Jinghui Chang, Jinghui Chang

“…After implementation (from May 1, 2022 to December 26, 2023), the total expenses (β3=−106.95, p&lt;0.05), consumables costs (β3= − 65.05, p&lt;0.05), diagnostic fees (β3= − 22.44, p &lt; 0.05), treatment fees (β3= − 28.01, p &lt; 0.05), total Chinese medicine costs (β3= − 9.98, p &lt; 0.05), and blood and blood products costs (β3= − 5.88, p&lt;0.05) continued to decrease.ConclusionThe volume-based procurement policy in Guangdong, China has shown initial effectiveness. After it was implemented, total expenses, consumables costs, and self-financed expenses decreased. …”
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Parents' perception of the promotion of physical activity as part of the Purzelbaum project in Swiss daycare centers by Bianca Celine Schmidli, Claudio R. Nigg

“…On a Likert scale, parents rated the extent to which they felt that PA is part of the daycare center's daily routine, the importance of PA, and the extent to which children have the opportunity to be physically active. In addition, they were asked to what extent parents are informed by the daycare centers about the topic of PA and whether the daycare centers offer parent-child activities involving PA. …”
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Coinfection and clinical impact of enterotoxigenic Escherichia coli harboring diverse toxin variants and colonization factors: 2017-2022 by Mohammad Ashraful Amin, Marjahan Akhtar, Zahid Hasan Khan, Md Taufiqul Islam, Md. Golam Firoj, Yasmin Ara Begum, Sadia Isfat Ara Rahman, Mokibul Hassan Afrad, Taufiqur Rahman Bhuiyan, Fahima Chowdhury, A.S.G. Faruque, Edward T Ryan, Firdausi Qadri, Ashraful Islam Khan

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American Society for Gastrointestinal Endoscopy guideline on gastrostomy feeding tubes: methodology and review of evidence by Divyanshoo Rai Kohli, MD, Natalie Cosgrove, MD, Wasif M. Abidi, MD, PhD, Jorge D. Machicado, MD, MPH, Madhav Desai, MD, MPH, Nauzer Forbes, MD, MSc, Neil B. Marya, MD, Nikhil R. Thiruvengadam, MD, Nirav C. Thosani, MD, MHA, Omeed Alipour, MD, Saowanee Ngamruengphong, MD, Sherif E. Elhanafi, MD, Sunil G. Sheth, MD, Wenly Ruan, MD, John C. Fang, MD, Stephen A. McClave, MD, Rodrick C. Zvavanjanja, MD, MSc, FRCR(UK), FSIR, DABR(DR/VIR), Dhruvil K. Radadiya, MBBS, Amir Y. Kamel, PharmD, BCNSP, Bashar J. Qumseya, MD, MPH

“…The ASGE suggests that a PEG can be performed without the need to withhold antiplatelet medications. …”
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Associations between muscle quality and whole-body vibration exercise-induced changes in plasma hypoxanthine following an oral glucose load in healthy male subjects by Tomoyuki Hara, Yuya Fujishima, Hitoshi Nishizawa, Yusuke Kawachi, Takashi Nakamura, Seigo Akari, Yoshiyuki Ono, Hirotaka Watanabe, Taka-aki Sakaue, Yoshinari Obata, Hirofumi Nagao, Shiro Fukuda, Takashi Kanamoto, Mitsuyoshi Takahara, Naoto Katakami, Ken Nakata, Iichiro Shimomura

“…Blood levels of hypoxanthine (HX) have been suggested as potential biomarkers associated with intramuscular metabolic dynamics in response to exercise. …”
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Characterizing tumor biology and immune microenvironment in high-grade serous ovarian cancer via single-cell RNA sequencing: insights for targeted and personalized immunotherapy st... by Fu Zhao, Fu Zhao, Xiaojing Jiang, Yumeng Li, Tianjiao Huang, Zhikai Xiahou, Wenyang Nie, Qian Li

“…Despite standard treatments, including cytoreductive surgery and platinum-based chemotherapy, significant improvements in survival have been limited. Understanding the molecular mechanisms, immune landscape, and drug sensitivity of HGSOC is crucial for developing more effective and personalized therapies. …”
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