Diagnosis and Treatment of Low Anterior Resection Syndrome by Masaaki Miyo, Emi Akizuki, Koichi Okuya, Ai Noda, Masayuki Ishii, Ryo Miura, Momoko Ichihara, Maho Toyota, Kohei Okamoto, Tatsuya Ito, Yuji Akiyama, Ichiro Takemasa

“…Based on comparisons with other evaluation instruments, the use of the LARS score is strongly recommended internationally for LARS screening in patients following rectal resection. Recent findings have indicated that multiple pathophysiological changes, including reservoir function and evacuation of the neorectum, anal sphincter function, negative impact of a diverting stoma, autonomic denervation, and radiotherapy, are involved in the etiology of LARS. …”
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Helicobacter pylori CagA+ strains modulate colorectal pathology by regulating intestinal flora by Shasha Cui, Xinqiang Liu, Fengxia Han, Lu Zhang, Jingjing Bu, Sainan Wu, Jiafen Wang

Subjects: “…CagA+…”
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A novel frameshift variant of GATA3 (p.Ala17ProfsTer178) responsible for HDR syndrome in a Japanese family by Yutaka Hasegawa, Toshie Segawa, Ai Chida, Eriko Yoshida, Hirofumi Kinno, Hiraku Chiba, Tomoyasu Oda, Yoshihiko Takahashi, Koji Nata, Yasushi Ishigaki

“…We present the case of a 38-year-old Japanese man with HDR syndrome who exhibited hypoparathyroidism, sensorineural deafness, renal dysfunction, severe symptomatic hypocalcemia with Chvostek’s and Trousseau’s signs, and QT prolongation on electrocardiography. He had a family history of deafness and hypocalcemia. …”
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Spermatic RXFP2 expression levels and seminal INSL3 concentrations among beef bull ejaculates with different levels of sperm morphological normality by Hewage Dilhan Anuradha WIMALARATHNE, Kenta ARASHI, Fumiyuki IWAKI, Mitsuhiro SAKASE, DURITAHALA, Hiroshi HARAYAMA, Noritoshi KAWATE

“…The levels of RXFP2 in the acrosomal principal segment, postacrosomal region, and neck in the Low group were significantly lower than those in the High and Mid groups, and those in the equatorial segment tended to be lower than those in the High group. …”
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Preoperative neck ultrasound combined with pathological data can significantly impact the outcome of medullary thyroid carcinoma by Maurilio Deandrea, Tommaso Piticchio, Alberto Mormile, Francesca Retta, Giovanni Canale, Alessandra Caracciolo, Lorenzo Daniele, Pierpaolo Trimboli

“…The diagnosis of medullary thyroid carcinoma (MTC) is challenging since the accuracy of ultrasound (US) and fine-needle aspiration cytology are suboptimal. As a result, MTC has a generally poor prognosis. The aim of this study was to analyze whether perioperative data can modify the risk of relapse in these patients. …”
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Unleashing the potential of chatbots in mental health: bibliometric analysis by Qing Han, Chenyang Zhao

“…The United States have made significant contributions to the development and expansion of publications, accounting for 27.97% of the total research output with 2452 citation counts. …”
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Radiographic Features of Spinal Meningioma and Schwannoma: A Novel Specific Feature―Ginkgo Leaf Sign by Yu Toda, Masashi Miyazaki, Takaomi Kobayashi, Yoshiaki Egashira, Deokcheol Lee, Hideaki Hamanaka, Shigeo Ueda, Hiromu Yoshizato, Masatsugu Tsukamoto, Tomohito Yoshihara, Hirohito Hirata, Hiroaki Konishi, Tatsuya Tanaka, Koji Otani, Masaaki Mawatari, Tadatsugu Morimoto

“…For schwannomas, specific findings included a lobule shape (sensitivity 25%, specificity 95%), dumbbell shape (sensitivity 54%, specificity 100%), and cystic changes (sensitivity 54%, specificity 97%). Conclusions: GLS may be a specific radiological feature for meningiomas and can aid in diagnosis when combined with DTS. …”
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Single-cell RNA sequencing revealed PPARG promoted osteosarcoma progression: based on osteoclast proliferation by Lei Sun, Jinhao Zhang, Zhikai Xiahou, Zhenzhen Zhao, Yanchen Liang

“…In most primary and metastatic malignant tumors, bone destruction can promote cancer progression, which is closely related to osteoclast activation and the imbalance between osteoblasts and osteoclasts. …”
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Fluorescent identification of axons, dendrites and soma of neuronal retinal ganglion cells with a genetic marker as a tool for facilitating the study of neurodegeneration by Puttipong Sripinun, Wennan Lu, Sergei Nikonov, Suhani Patel, Sarah Hennessy, Tianyuan Yao, Qi N. Cui, Brent A. Bell, Claire H. Mitchell

“…There was no cross‐labeling of ChAT‐positive displaced amacrine cells in the GCL, although some signal emanated from the outer plexiform layer, consistent with horizontal cells. …”
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LMS MOODLE ЯК ЗАСІБ ОРГАНІЗАЦІЇ СЕРЕДОВИЩА ЗДОБУТТЯ ПЕДАГОГАМИ ПІСЛЯДИПЛОМНОЇ ОСВІТИ by Ірина Доманецька, Олена Федусенко, Олег Іларіонов, Ганна Красовська

“…Детально розглянуті питання побудови розгалужених структур курсів (елемент Lesson), організації проблемно-орієнтованого контенту з елементами групового опрацювання (Forum, Chat, Choice, Workshop, Wiki, MindMap), відстежування інтересів кожного слухача за вибором блоків навчальної інформації та зворотним зв'язком (елементи Lesson, Assignment, Feedback, Survay), оперативного моніторингу якості знань (елементи Lesson, Quize, Choice), організації навчального процесу за моделлю перевернутого класу. …”
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Management of thyroid tumors diagnosed cytologically as follicular neoplasms in a high-volume center: utility of a scoring system using serum thyroglobulin level, tumor size, ultra... by Yasuhiro Ito, Makoto Kawakami, Mitsuyoshi Hirokawa, Masashi Yamamoto, Minoru Kihara, Naoyoshi Onoda, Akihiro Miya, Akira Miyauchi, Takashi Akamizu

“…After assigning scores of 2 and 1 for cytological findings favoring malignancy and others, respectively, a receiver operating characteristic curve analysis indicated a score of 3 as the optimal cutoff for predicting malignant diagnosis; however, the area under the curve remained low, at 0.642. …”
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Mortality causes and health spending by gender and health conditions in octogenarians, nonagenarians and centenarians in Colombia by Oscar Espinosa, Valeria Bejarano, Isabella Franky, Sandeep Pagali, Michael Drummond, Oscar H. Franco

“…Deaths were higher due to ischemic heart disease, COVID-19, chronic obstructive pulmonary disease, cancer, and cerebrovascular diseases in the oldest old Colombian population with urban areas having higher mortality rates than rural areas (an average of 948 (min: 847, max: 1207) against 630 (min: 558, max: 789) per 10,000 people, respectively). …”
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Characteristic external genitalia in male neonates with 5α-reductase deficiency by Takeshi Munenaga, Yosuke Ichihashi, Satsuki Nakano, Hironori Shibata, Takeshi Sato, Hiroshi Asanuma, Keiko Homma, Tomonobu Hasegawa, Tomohiro Ishii

“…There have been no reports comparing neonatal external genitalia of 5α-reductase deficiency (5αRD) with those of other 46,XY differences of sex differentiation (DSD). …”
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Transient sex-related changes in the mice hypothalamo–pituitary–adrenal (HPA) axis during the acute phase of the inflammatory process by T. Daneva, E. Spinedi, R. Hadid, M.-C. Jacquier, M. Giacomini, R. C. Gaillard

“…The results indicate that: (a) basal B but not ACTH plasma levels were significantly higher in female than in male mice; (b) LPS significantly increased both ACTH and B plasma levels over the baseline 2 h after injection, both hormone levels being higher in female than in male mice; (c) although plasma ACTH concentrations recovered the basal value at 72 h after LPS in animals of both sexes, plasma B levels returned to the baseline only at 120 h after treatment; (d) E plasma levels significantly increased 2 h after LPS and returned to the baseline at 72 h post-treatment, in both sexes; (e) at 2 h after LPS, testosterone plasma levels significantly decreased in male mice and increased in female mice, recovering the baseline level at 120 and 72 h after LPS, respectively; (f) AP ACTH content was similar in both sexes in basal condition and it was significantly diminished 72 h post-treatment without sex difference; whereas AP ACTH returned to basal content 120 h after LPS in males, it remained significantly decreased in females; (g) basal adrenal B content was higher in female than in male mice, and it significantly increased in both sexes 2 h post-LPS, maintaining this sex difference. …”
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The frequency of mutations in advanced thyroid cancer in Japan: a single-center study by Soji Toda, Hiroyuki Iwasaki, Yoichiro Okubo, Hiroyuki Hayashi, Mei Kadoya, Hiroyuki Takahashi, Tomoyuki Yokose, Yukihiko Hiroshima, Katsuhiko Masudo

“…One case each of ATC and PTC had a tumor mutation burden of ≥10. ATC cases had a significantly higher prevalence of TP53 alterations than the other cases (82.3% vs. 11.8%), whereas the frequencies of TERT promoter mutations were 88.2% in ATC cases and 64.7% in the other cases, albeit without a significant difference. …”
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A case of 49,XXXYY followed-up from infancy to adulthood with review of literature by Junko Kanno, Akinobu Miura, Sayaka Kawashima, Hirohito Shima, Dai Suzuki, Miki Kamimura, Ikuma Fujiwara, Masayuki Kamimura, Mitsugu Uematsu, Masataka Kudo, Atsuo Kikuchi

“…Among these cases, only three have been documented into adulthood. Moreover, no cases of 49,XXXYY have been reported in Japan. …”
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Relationship between Ca2+ and cAMP as second messengers in ACTH-induced cortisol production in bovine adrenal fasciculata cells by Masahiko Kutsukake, Naoko Kuwabara, Yoshikazu Miyate, Kenzo Kudo, Shoko Goto, Eiichi Taira, Eiichi Tachikawa

Subjects: “…ca2+…”
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Effects of laparoscopic sleeve gastrectomy on nonalcoholic fatty liver disease and TGF-β signaling pathway by Hideki Kumagai, Akira Sasaki, Akira Umemura, Keisuke Kakisaka, Takeshi Iwaya, Satoshi S Nishizuka

“…The aim of the present study was to evaluate changes in serum proteins before and after LSG by proteomic analysis and to investigate their association with NAFLD. …”
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The effect of acute sleep deprivation on cortisol level: a systematic review and meta-analysis by Yifei Chen, Wenhui Xu, Yiru Chen, Jiayu Gong, Yanyan Wu, Shutong Chen, Yuan He, Haitao Yu, Lin Xie

“…Acute sleep deprivation has aroused widespread concern and the relationship between acute sleep deprivation and cortisol levels is inconsistent. …”
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Emergence of Enteric Viruses in Production Chickens Is a Concern for Avian Health by Elena Mettifogo, Luis F. N. Nuñez, Jorge L. Chacón, Silvana H. Santander Parra, Claudete S. Astolfi-Ferreira, José A. Jerez, Richard C. Jones, Antonio J. Piantino Ferreira

“…Chicken astrovirus (CAstV), rotavirus, reovirus, chicken parvovirus (ChPV), fowl adenovirus of subgroup I (FAdV-1), and avian nephritis virus (ANV) were investigated using the conventional polymerase chain reaction (PCR) and the reverse transcription polymerase chain reaction (RT-PCR). …”
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