Metabolomics approach reveals key plasma biomarkers in multiple myeloma for diagnosis, staging, and prognosis by Xiaoxue Wang, Longhao Cheng, Aijun Liu, Lihong Liu, Lili Gong, Guolin Shen

“…Abstract Background Multiple myeloma (MM) is the most aggressive and prevalent primary malignant tumor within the blood system, and can be classified into grades RISS-I, II, and III. …”
Get full text

Snap diagnosis of fulminant type 1 diabetes by the normalized glucose/HbA1c ratio by Jun-Ichiro Mori, Takahiro Miyakoshi, Hanae Yuzuriha, Teruki Kondo, Eita Nishimori, Motoji Naka, Ai Sato, Mitsuhisa Komatsu, Koh Yamashita, Toru Aizawa

“…Normalizing the ratio significantly raised its accuracy: area under the curve for receiver operating curve, AUROC (95%CI), 0.927 (0.858–0.964) and 0.851 (0.763–0.910), respectively, with and without the normalization (p < 0.01). …”
Get full text

Initial validation of the clinical significance of the NETest in Japanese gastroenteropancreatic neuroendocrine tumor patients by Hao Zhang, Takahiro Tsuchikawa, Satoshi Takeuchi, Kenji Hirata, Kimitaka Tanaka, Aya Matsui, Yoshitsugu Nakanishi, Toshimichi Asano, Takehiro Noji, Toru Nakamura, Shintaro Takeuchi, Masataka Wada, Satoshi Hirano

“…Among three patients who underwent R0 resection and four treated with peptide receptor radionuclide therapy, the changes in NETest scores closely correlated with disease progression. …”
Get full text

Evaluating the usefulness of plasma chromogranin A measurement in cyclic ACTH-dependent Cushing’s syndrome by Keisuke Kakizawa, Miho Yamashita, Yuto Kawauchi, Akira Ikeya, Kenji Ohba, Akio Matsushita

“…The clinical presentation of cyclic Cushing’s syndrome can be ambiguous and its diagnosis is often challenging. …”
Get full text

Producing Effective and Clean Coke for Household Combustion Activities to Reduce Gaseous Pollutant Emissions by Shoujun Liu, Ju Shangguan, Song Yang, Wenguang Du, Xudong Yan, Kaixia Zhang

“…The results show that high-temperature co-pyrolysis could remove the volatile compounds that are major precursors for the formation of gaseous pollutants from the raw coal. During the coking process, the sulfur can be removed by being fixed in the form of CaS in presence of a Ca-based complex, which could be beneficial for the CaSO4 during the coke combustion. …”
Get full text

Transcript Changes of Placental Tissue in Gestational Diabetes Mellitus Based on Transcriptome Sequencing by Sun Y, Wang Y, Liu C, Yang J, Li Q, Zhao F

“…Yun Sun,1,* Yi Wang,1,* Chao Liu,2 Jie Yang,3 Qinwen Li,1 Fei Zhao1 1Department of Obstetrics, The Affiliated Taian City Central Hospital of Qingdao University, Taian, People’s Republic of China; 2Department of Obstetrics, Taian Maternal and Child Care Health Hospital, Taian, People’s Republic of China; 3Department of Gynaecology and Obstetrics, Liangshan County People’s Hospital, Jining, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qinwen Li; Fei Zhao, Department of Obstetrics, Taian Central Hospital (Taian Central Hospital affiliated to Qingdao University, Mount Taishan Medical Center), No. 29, Longtan Road, Mount Taishan District, Taian, Shandong, 271000, People’s Republic of China, Tel +86-13505482692, Email lqw81@126.com; 13505482692@163.comPurpose: This study aims to identify key genes that may be involved in the pathogenesis of gestational diabetes mellitus and to preliminarily elucidate the underlying mechanisms.Methods: High-throughput transcriptome sequencing was employed to identify Differentially expressed genes (DEGs) in placental tissue samples of GDM and normal pregnant women. …”
Get full text

Perturbations in gut microbiota composition in patients with autoimmune neurological diseases: a systematic review and meta-analysis by Xiaolin Deng, Xiaolin Deng, Xue Gong, Xue Gong, Dong Zhou, Zhen Hong, Zhen Hong

“…Regarding α-diversity, except for Chao1, which showed a consistent small decrease (SMD = −0.26, 95% CI = −0.45 to −0.07, p < 0.01), other indices demonstrated no significant changes. …”
Get full text

“Scarlet Cloak and the Forest Adventure”: a preliminary study of the impact of AI on commonly used writing tools by Barbara Bordalejo, Davide Pafumi, Frank Onuh, A. K. M. Iftekhar Khalid, Morgan Slayde Pearce, Daniel Paul O’Donnell

“…Initially prompted by noticing how tools like Grammarly were being flagged by AI detection software, it examines how these popular tools such as Grammarly, EditPad, Writefull, and AI models such as ChatGPT and Microsoft Bing Copilot affect human-generated texts and how accurately current AI-detection systems, including Turnitin and GPTZero, can assess texts for use of these tools. …”
Get full text

A Multivent System for Non-Invasive Ventilation: Solving the Problem of Ventilator Shortage During the COVID-19 Pandemic by Shuai Ren, Xiaohan Wang, Liming Hao, Tao Wang, Zujin Luo

“…Therefore, a novel multivent system for non-invasive ventilation has been proposed in this study. The close loop system consists of the proportional valve and the flow-pressure sensor can regulate the airway pressure and flow for each patient. …”
Get full text

The significance of the immunohistochemical method in diagnosing atypical endometrial polyps as manifestations of localized hyperplasia by O.V. Poslavska, D.A. Khaskhachykh, I.S. Shponka, V.O. Potapov

“…Immunohistochemical studies confirmed the high sensitivity of markers in identifying pathological chan­ges, particularly in diagnostically challenging cases. …”
Get full text

Postnatal cytomegalovirus infection and its effect on hearing and neurodevelopmental outcomes among infants aged 3-10 months: A cohort study in Eastern Uganda. by Noela Regina Akwi Okalany, David Mukunya, Peter Olupot-Olupot, Martin Chebet, Francis Okello, Andrew D Weeks, Fred Bisso, Thorkild Tylleskär, Kathy Burgoine, Ingunn Marie Stadskleiv Engebretsen

“…CMV status was determined by PCR screening of saliva samples, with positive results confirmed using urine samples (Chai Open qPCR, Santa Clara, CA). …”
Get full text

LIMIAR AERÓBIO E ANAERÓBIO NA CORRIDA AQUÁTICA: COMPARAÇAO COM OS VALORES OBTIDOS NA CORRIDA EM PISTA by Benedito Sérgio Denadai, Roberta Rosas, Mara Lucy Dompietro Ruiz Denadai

“…Ao final de cada tira foi anotada a FC; 2) 3 series de corrida estacionária dentro da água, com a auxilio de um flutuador (Aquajogger – Sports Science Int'l) presa ao tronco, sem tocar a pé no chão. Cada serie teve a duração de 5 min. e foram realizadas, respectivamente com uma FC de 120, 140 e 160 bpm. …”
Get full text

A Clinicopathological Study of 24 Cases of DFSP by Miyako Kachi, Atsumori Hamahata, Kohei Oashi, Hisato Konoeda, Miho Kirita, Masashi Ishikawa, Hirotaka Koyanagi, Hiroyuki Sakurai

Subjects: Get full text

Antioxidant Capacity and Total Phenolic Content in Fruit Tissues from Accessions of Capsicum chinense Jacq. (Habanero Pepper) at Different Stages of Ripening by Lizbeth A. Castro-Concha, Jemina Tuyub-Che, Angel Moo-Mukul, Felipe A. Vazquez-Flota, Maria L. Miranda-Ham

“…In the past few years, there has been a renewed interest in studying a wide variety of food products that show beneficial effects on human health. …”
Get full text

Interleukin-17 prevents oxidative stress from damaging osteoblast formation by inhibiting autophagic degradation of metallothionein-2 by Xueyan Ling, Cuixia Wang, Qin Feng, Tao Zhang

Get full text

Semen extender triggers a mild physiological inflammatory response in the uterus without disrupting sperm-uterine immune crosstalk in vitro in cattle by Malinda HULUGALLA, Alireza MANSOURI, Elham WAEHAMA, Ihshan AKTHAR, Akio MIYAMOTO

“…Artificial insemination (AI) in cattle involves introducing frozen-thawed sperm, a minimal amount of seminal plasma, and a significant volume of semen extender (SE) into the uterus. …”
Get full text

Pembrolizumab with external radiation therapy effectively controlled TMB-high unresectable recurrent parathyroid cancer: a case report with review of literature by Hiroshi Katoh, Tomoya Mitsuma, Riku Okamoto, Kanako Naito, Takaaki Tokito, Mariko Kikuchi, Takafumi Sangai

“…Accordingly, management of hypercalcemia by calcimimetics and bisphosphonates has been main treatment for unresectable PC. Here, we report a case of unresectable tumor mutational burden (TMB)-high recurrent PC that has been effectively controlled by pembrolizumab (PEM) with RT. …”
Get full text

Impact of Biomass Burning on Air Quality in Temuco City, Chile by Felipe Reyes, Sofía Ahumada, Francisca Rojas, Pedro Oyola, Yeanice Vásquez, Claudio Aguilera, Andres Henriquez, Ernesto Gramsch, Choong-Min Kang, Sanna Saarikoski, Kimmo Teinilä, Minna Aurela, Hilkka Timonen

“…These events matched with higher temperatures at high altitude than at the surface characterizing the typical profile of a vertical inversion that prevents the dilution of air pollutants.…”
Get full text

Sleeve gastrectomy improves cardiac function and glucose-lipid metabolism disorder in obese rats induced by a high-fat and high-sugar diet by Xiaojuan Li, Luming Qiao, Wei Wang, Ying Shi, Lei Yuan, Zhiwei Zhai

“…Furthermore, enhanced pathological changes, including inflammatory cell infiltration and loss of cytoplasm striations, enhanced oil red O staining, increased TUNEL-positive cells, upregulated Bax and cleaved-caspase-3, and downregulated Bcl-2, were observed in obese rats, which were notably alleviated by SG. …”
Get full text

A incorporação das TICs no trabalho de assistentes sociais: alterações, dilemas e desafios by Mabel Mascarenhas Torres, Claudiana Tavares da Silva Sgorlon

“…Na mesma medida, a utilização das TICs, favorece a ampliação da capilaridade dos atendimentos, contribuindo para o acesso e a democratização das informações sobre os direitos humanos e sociais e a prestação de serviços vinculadas às políticas sociais. Palavras-chave: Trabalho profissional; TICs; Condições de trabalho; jornada de trabalho; mídias sociais. …”
Get full text