MERS-CoV spike vaccine-induced N-terminal domain-specific antibodies are more protective than receptor binding domain-specific antibodies by Olubukola M. Abiona, Nianshuang Wang, Sarah R. Leist, Alexandra Schäfer, Adam S. Cockrell, Lingshu Wang, Sandhya Bangaru, Laura Stevens, Rachel L. Graham, Jacob F. Kocher, Yaroslav Tsybovsky, Masaru Kanekiyo, Azad Kumar, Kaitlyn M. Morabito, Osnat Rosen, Wei Shi, Anne Werner, Yi Zhang, Cynthia Ziwawo, Christian K.O. Dzuvor, Charis Palandjian, Connor Eastman, Hannah R. Matthews, Jeswin Joseph, James D. Chappell, Wing-Pui Kong, John R. Mascola, Andrew B. Ward, Mark R. Denison, Ralph Baric, Jason S. McLellan, Barney S. Graham, Kizzmekia S. Corbett-Helaire

“…Intriguingly, the immunogen MERS S-2P_ΔRBD, MERS S-2P with the RBDs removed, protects comparably to S1 and S-2P immunogens against MERS-CoV challenge. Moreover, passive transfer studies of polyclonal IgG from MERS S-2P immunized mice depleted of subdomain-specific antibodies demonstrated that non-RBD antibodies protected more than non-NTD antibodies. …”
Get full text

Evaluation of gestational nonpersistent pesticide exposure with newborn size and gestational length in rural Ghana using a novel time-varying extension of multiple informant models by Wylie BJ, Kaali S, Duttweiler L, Ae-Ngibise KA, Mujtaba M, Tawiah C, Gibson E, Calafat AM, Ospina M, Jack DJ, Agyei O, Lee AG, Roberts DJ, Boamah-Kaali EA, Factor-Litvak P, Modest AM, Hauser R, Coull BA, Asante KP

Get full text

Reflections and expectations of an endocrinologist and diabetologist on the launch of a new, board-certified Endocrinology, Diabetes and Metabolism specialist system pioneered by t... by Toshihiko Yanase

Get full text

Hepatovirus infections in juvenile seals from the North Sea by Monica Mirolo, Bianca Kühl, Melvin Daniel Roji, Ana Rubio-García, Valéria Andrade Lima, Christina Puff, Byron Martina, Andreas Beineke, Peter Wohlsein, Wolfgang Baumgärtner, Martin Ludlow, Albert Osterhaus

“…Abstract The discovery of several novel hepatovirus species in marine and terrestrial mammals has expanded the recognised members of the genus Hepatovirus and has provided better understanding on the evolutionary origins of human hepatovirus A (HAV). …”
Get full text

Associations of Maternal Complaints to Levator Ani Muscle Trauma within 9 Months after Vaginal Birth: A Prospective Observational Cohort Study by N. Kimmich, J. Birri, A. Richter, R. Zimmermann, M. Kreft

“…At P3, 72.9% of women with a LAM trauma in P1 and/or P2 were assessed with 21.6% being intact and 39.2% having a PAV and CAV, respectively. Obstetrical and baseline characteristics differed slightly between the groups. …”
Get full text

Clinical Characteristics of 31 Patients with Chest Pain Variant Asthma by Mao W, Gao Y, Sun W, Li J, Wang J, Wang Z, Zhang L, Huang K

“…Only 7 patients (22.6%) had normal inspiratory CT scans.Conclusion: CPVA is relatively rare in clinical practice. …”
Get full text

Effect of Co-Administration of Midazolam and Dexmedetomidine on Haemodynamics and Stress Response in Elderly Patients with Non-Small Cell Lung Cancer by Yanjun Zhao, Dongjiao An, Liang Bi

“…Patients treated with dexmedetomidine plus midazolam presented with a more stable hemodynamic status than those treated with dexmedetomidine only, as evidenced by the significantly lower variability of mean arterial pressure (MAP), oxygen saturation (SpO2), and heart rate (HR). …”
Get full text

A tannic acid-based intumescent flame retardant for improving flame retardancy of epoxy composites by Xiaosui Chen, Yaoting Ma, Shuzheng Liu, Aiqing Zhang, Wei Liu, Shengchao Huang

“…Additionally, its peak heat release rate (PHRR), total heat release (THR) and average mass loss rate (av-MLR) decreased by 23.2%, 15.5% and 30.2% respectively. …”
Get full text

Efficacy of different preoperative antiseptics in preventing a risk of surgical site infections: a systematic review and meta‑analysis of randomized controlled trials by Lutao Yang, Shunxin Liao, Qing Cao, Sanjay Rastogi

“…This meta-analysis found that 2%–2.5% CHA is the most effective preoperative antiseptic for preventing SSIs, with significant reduction in their incidence and significant antimicrobial activity. …”
Get full text

Impacts of Connected and Autonomous Vehicles with Level 2 Automation on Traffic Efficiency and Energy Consumption by Haokun Song, Fuquan Zhao, Guangyu Zhu, Zongwei Liu

“…It is found that L2 CAVs can save the average travel time and reduce average energy consumption for a single vehicle in most scenes. …”
Get full text

Relating ecological diversity to genetic discontinuity across bacterial species by Hemanoel Passarelli-Araujo, Thiago M. Venancio, William P. Hanage

Subjects: Get full text

Progettare e valutare con il supporto dell’intelligenza artificiale: elementi per un approccio critico all’uso dei chatbot by Massimo Marcuccio, Maria Elena Tassinari, Vanessa Lo Turco

“…The findings reveal that chatbots, such as ChatGPT, can significantly reduce the workload of teachers and future training designers, improve access to educational resources, and provide timely feedback. …”
Get full text

Randomized studies in China show that studying and promoting civic honesty needs to consider local norms by Iris W. Hung, Yuho Yiu, Sihan Wu, Dan Liu, Liman Wang, Xiao Han

“…Results show that the psychological mechanism underlying lost-wallet reporting behavior in China is somewhat different from what has been suggested in the literature. Chinese participants indicated they are significantly more likely to put WeChat than email as contact information on their lost items, corroborating a local norm in China that email is infrequently used by ordinary Chinese citizens. …”
Get full text

Isoxazole-based molecules restore NK cell immune surveillance in hepatocarcinogenesis by targeting TM4SF5 and SLAMF7 linkage by Ji Eon Kim, Hyun Su Kim, Wonsik Kim, Eun Hae Lee, Soyeon Kim, Taewoo Kim, Eun-Ae Shin, Kyung-hee Pyo, Haesong Lee, Seo Hee Jin, Jae-Ho Lee, Soo-Min Byeon, Dong Joo Kim, Jinwook Jeong, Jeongwon Lee, Minjae Ohn, Hyojung Lee, Su Jong Yu, Dongyun Shin, Semi Kim, Jun Yeob Yoo, Seung-Chul Lee, Young-Ger Suh, Jung Weon Lee

“…Transmembrane 4 L six family member 5 (TM4SF5) is known to promote HCC, but it remains unclear how cancerous hepatocytes avoid immune surveillance and whether avoidance can be blocked. We investigated how TM4SF5-mediated hepatic tumorigenesis avoids surveillance by natural killer (NK) cells, which are prevalent in the liver, and whether the avoidance can be blocked by anti-TM4SF5 agents. …”
Get full text

Qualitative Assessment of Soil Carbon in a Rehabilitated Forest Using Fourier Transform Infrared Spectroscopy by Huck-Ywih Ch'ng, Osumanu Haruna Ahmed, Nik Muhamad Ab. Majid

“…The relatively high E4/E6 values of humic acids (HAs) in the rehabilitated forest indicate prominence of aliphatic components, suggesting that the HAs were of low molecular weight. …”
Get full text

Vaccinating Adult Patients with Cirrhosis: Trends over a Decade in the United States by Abhijeet Waghray, Nisheet Waghray, Hicham Khallafi, K. V. Narayanan Menon

“…This study assessed vaccination rates for pneumococcus, HAV, and HBV in patients with cirrhosis. Results. …”
Get full text

Cyberattack Monitoring Architectures for Resilient Operation of Connected and Automated Vehicles by Zulqarnain H. Khattak, Brian L. Smith, Michael D. Fontaine

“…The deployment of connected and automated vehicles (CAVs) may enhance operations and safety with little human feedback. …”
Get full text

The Influence of Coffee Husk Ash as a Filler on the Performance of Bituminous Concrete Mix by Amare Tilahun Tessema, Getachew Asefa Alene, Natnael Melsew Wolelaw

“…From the test results, it is seen that specimens made with coffee husk ash and basaltic stone dust are found to have satisfactory Marshall properties, and moisture susceptibility shows that mixes using CHA filler provide better resistance to moisture effects than mixtures using BSD filler. …”
Get full text