DepRescribing inapprOpriate Proton Pump InhibiTors (DROPIT): study protocol of a cluster-randomised controlled trial in Swiss primary care by Stefan Neuner-Jehle, Katharina Tabea Jungo, Sven Streit, Sven Trelle, Nicolas Rodondi, Carole Elodie Aubert, Kristie Rebecca Weir, Enriqueta Vallejo-Yagüe, Samantha Chan, Marie Roumet, Pascal Juillerat, Sofia Carolina Zambrano Ramos, Jennifer Inauen, Angela Edith Schulthess-Lisibach, Renata Vidonscky Lüthold, Clémentine Tombez, Martina Zangger, Flurina Jenal, Yvonne Mattmann, Christof Bieri, Michaela Barbier

“…Deprescribing strategies have emerged to safely reduce or substitute inappropriate PPIs and optimise patient care in an evidence-based manner. …”
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Efficacy and safety of combined low‐dose rituximab regimen for chronic inflammatory demyelinating polyradiculoneuropathy by Ying Du, Qi Yan, Chuan Li, Wenping Zhu, Chao Zhao, Yunfeng Hao, Lin Li, Dan Yao, Xuan Zhou, Ying Li, Yuting Dang, Rong Zhang, Lin Han, Yuanyuan Wang, Tao Hou, Juan Li, Hailin Li, Panpan Jiang, Pei Wang, Fenying Chen, Tingge Zhu, Juntong Liu, Shuyu Liu, Lan Gao, Yingjun Zhao, Wei Zhang

“…Interpretation Our simplified regimen of combined low‐dose rituximab has been firstly demonstrated for the better efficacy and safety than conventional therapy in CIDP treatment.…”
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Coke zero for the zero: A randomized controlled trial examining coke zero consumption on night call inpatient course and mortality by Yu Heng Kwan, Haoming Tang, Lihua Qi, Angela Frances Hui Wen Yap, Linxuan Yan, Yi Xin Li, Andrea Zhe Ern Lee, Antoinette Shui Wen Fong, Yarn Kit Chan, Feng Yi Low, Charmaine Wai Yan Sum, Benjamin Jun Jie Seng, Sungwon Yoon, Truls Østbye, Sheryl Shien Wen Gan, Haur Yueh Lee, Warren Fong

“…Conclusions No convincing evidence was present to support the consumption of Coca-Cola Zero Sugar versus the regular Coca-Cola had significant differences in the number of inpatient admissions and mortality in night call duties.…”
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Correction to: Functional and quality of life outcomes after partial glossectomy: a multi-institutional longitudinal study of the head and neck research network by Agnieszka Dzioba, Daniel Aalto, Georgina Papadopoulos-Nydam, Hadi Seikaly, Jana Rieger, Johan Wolfaardt, Martin Osswald, Jeffrey R. Harris, Daniel A. O’Connell, Cathy Lazarus, Mark Urken, Ilya Likhterov, Raymond L. Chai, Erika Rauscher, Daniel Buchbinder, Devin Okay, Risto-Pekka Happonen, Ilpo Kinnunen, Heikki Irjala, Tero Soukka, Juhani Laine, Head and Neck Research Network

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Human ACE2 transgenic pigs are susceptible to SARS-CoV-2 and develop COVID-19-like disease by Long Fung Chau, Simon Lillico, Tanja Opriessnig, Rosemary Blake, Luc Tardy, Chen-Hsuin Lee, Scott Maxwell, Claire Warren, Elizabeth Thornton, Catherine L. Mclaughlin, Gerry McLachlan, Christine Tait-Burkard, Sarah Fletcher, Stephen Anderson, Sharon Brown, Louise Gibbard, Thomas Tzelos, Dawn MacMillan-Christensen, J. Kenneth Baillie, David A. Dorward, David J. Griffiths, Finn Grey

“…To address this, we have developed transgenic pigs expressing human ACE2 that are susceptible to SARS-CoV-2 infection. …”
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Exploring cognitive and neuroimaging profiles of dementia subtypes of individuals with dementia in the Democratic Republic of Congo by Jean Ikanga, Jean Ikanga, Saranya Sundaram Patel, Saranya Sundaram Patel, Megan Schwinne, Caterina Obenauf, Caterina Obenauf, Emmanuel Epenge, Guy Gikelekele, Nathan Tshengele, Immaculee Kavugho, Samuel Mampunza, Lelo Mananga, Charlotte E. Teunissen, Julio C. Rojas, Brandon Chan, Argentina Lario Lago, Joel H. Kramer, Adam L. Boxer, Andreas Jeromin, Emile Omba, Alvaro Alonso, Alden L. Gross

“…Individuals were stratified into one of four dementia subtypes—AD only, non-AD vascular, non-AD other, or mixed – based on combinations of abnormalities in these markers.ResultsAmong the 45 individuals with dementia, mixed dementia had the highest prevalence (42.4%), followed by AD-only (24.4%), non-AD other dementia (22.2%), and non-AD vascular dementia subtypes (11.1%). …”
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Identification and Potential Clinical Utility of Common Genetic Variants in Gestational Diabetes among Chinese Pregnant Women by Claudia Ha-ting Tam, Ying Wang, Chi Chiu Wang, Lai Yuk Yuen, Cadmon King-poo Lim, Junhong Leng, Ling Wu, Alex Chi-wai Ng, Yong Hou, Kit Ying Tsoi, Hui Wang, Risa Ozaki, Albert Martin Li, Qingqing Wang, Juliana Chung-ngor Chan, Yan Chou Ye, Wing Hung Tam, Xilin Yang, Ronald Ching-wan Ma

“…Integrating genetic information can facilitate identification of pregnant women at a higher risk of developing GDM or later diabetes.…”
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Multi-institutional evaluation comparing guidance from International Ki67 Working Group vs National Health Commission of China on immunohistochemistry-based Ki67 assessment alongsi... by Yin Wang, Jiarui Zou, Qinghua Cao, Guihong Dai, Panhong Fan, Xue Gong, Jinyan Jiang, Yanqing Kong, Chao Liu, Chunhui Liu, Chenjia Lu, Meiren Li, Zhiqiang Lang, Yang Lin, Yan Peng, Haiyan Shi, Yuhuan Wang, Jiu Wang, Bichen Xie, Bing Yang, Guohua Yu, Cuiping Zhang, Hengming Zhang, Luting Zhou, Zilan Zhang, Zhenli Zhu, Junmei Hao

“…When IHC and QDB results were cross-referenced, more specimens were grouped as high-risk by QDB than IHC, and NHCCa9 led to the highest percentage of disagreement between the two methods.ConclusionThe IKWG recommendation was harder to achieve categorized agreement among pathologists than the NHCC recommendation, yet it led to the best agreement with the QDB to define the low-risk group. …”
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Steroids In caRdiac Surgery (SIRS) trial: acute kidney injury substudy protocol of an international randomised controlled trial by Michael Walsh, Salim Yusuf, Chirag Parikh, Jessica Vincent, P J Devereaux, Francois Lamontagne, Matthew T V Chan, Richard Whitlock, Meaghan Cuerden, Amit X Garg, Andre Lamy, Daniel I Sessler, Kevin Teoh, Ainslie Hildebrand, Yunxia Zuo, Pallav Shah, Seyed Hesameddin Abbasi, Mackenzie Quantz, Jean-Pierre Yared, Nicolas Noiseux, Georgios Tagarakis, Antoine Rochon, Janice Pogue, Abbas Salehiomran

“…Introduction Steroids In caRdiac Surgery trial (SIRS) is a large international randomised controlled trial of methylprednisolone or placebo in patients undergoing cardiac surgery with the use of a cardiopulmonary bypass pump. …”
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A legume-enriched diet improves metabolic health in prediabetes mediated through gut microbiome: a randomized controlled trial by Xiaorong Wu, Alvin Surya Tjahyo, Vera Sergeyevna Brok Volchanskaya, Long Hui Wong, Xianning Lai, Yi Ning Yong, Farhana Osman, Shia Lyn Tay, Priya Govindharajulu, Shalini Ponnalagu, Rachel Tso, Hwee Sze Teo, Kaijie Khoo, Huan Fan, Chew Chan Goh, Clara Poh Lian Yap, Melvin Khee-Shing Leow, Christiani Jeyakumar Henry, Sumanto Haldar, Kevin Junliang Lim

“…Abstract Healthy dietary patterns rich in legumes can improve metabolic health, although their additional benefits in conjunction with calorie restriction have not been well-established. …”
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East Asian Gene flow bridged by northern coastal populations over past 6000 years by Juncen Liu, Yichen Liu, Yongsheng Zhao, Chao Zhu, Tianyi Wang, Wen Zeng, Bo Sun, Fen Wang, Hui Han, Zhenguang Li, Xiaotian Feng, Peng Cao, Fengshi Luan, Feng Liu, Qingyan Dai, Junfeng Guo, Zimeng Wang, Chengmin Wei, Qiaowei Wei, Ruowei Yang, Weihong Hou, Wanjing Ping, Fan Bai, Bo Miao, Wenjun Wang, Melinda A. Yang, Qiaomei Fu

“…To examine how ShanDong populations changed over time and interacted with island and inland East Asian populations, we sequenced 85 individuals from 11 ancient sites in the ShanDong region dating to ~6000-1500 BP. …”
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Human respiratory organoids sustained reproducible propagation of human rhinovirus C and elucidation of virus-host interaction by Cun Li, Yifei Yu, Zhixin Wan, Man Chun Chiu, Jingjing Huang, Shuxin Zhang, Xiaoxin Zhu, Qiaoshuai Lan, Yanlin Deng, Ying Zhou, Wei Xue, Ming Yue, Jian-Piao Cai, Cyril Chik-Yan Yip, Kenneth Kak-Yuen Wong, Xiaojuan Liu, Yang Yu, Lin Huang, Hin Chu, Jasper Fuk-Woo Chan, Hans Clevers, Kwok Yung Yuen, Jie Zhou

“…Abstract The lack of a robust system to reproducibly propagate HRV-C, a family of viruses refractory to cultivation in standard cell lines, has substantially hindered our understanding of this common respiratory pathogen. …”
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Optical time-lapsed in situ mechanochemical studies on metal halide perovskite systems by Yonghao Xiao, David G. Bradley, Wei Xin Chan, Xinwen Hu, Lian Xiao, Zhenpeng Liu, Zi Yang Tan, Xin Zhao, Chenfei Li, Mansour Sadek, Vikash Kumar Ravi, Ying Hern Tam, Xiaotao Wang, Felipe García, Handong Sun, Seow Chin Low, Poh Boon Phua, Tze Chien Sum, Xiuwen Zhou, Yee-Fun Lim, John V. Hanna, Han Sen Soo

“…To overcome these challenges, solvent-free mechanochemical synthesis of perovskites can be conducted, although traditional opaque ball milling equipment hinder real-time monitoring of the reaction progress. …”
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V3+ extends the V3 framework to ensure user-centricity and scalability of sensor-based digital health technologies by Jessie P. Bakker, Roland Barge, Jacob Centra, Bryan Cobb, Chas Cota, Christine C. Guo, Bert Hartog, Nathalie Horowicz-Mehler, Elena S. Izmailova, Nikolay V. Manyakov, Samantha McClenahan, Stéphane Motola, Smit Patel, Oana Paun, Marian Schoone, Emre Sezgin, Thomas Switzer, Animesh Tandon, Willem van den Brink, Srinivasan Vairavan, Benjamin Vandendriessche, Bernard Vrijens, Jennifer C. Goldsack

“…Abstract We propose the addition of usability validation to the extended V3 framework, now “V3+”, and describe a pragmatic approach to ensuring that sensor-based digital health technologies can be used optimally at scale by diverse users. …”
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Adapting and deploying a digital program for training non-specialist providers on a brief psychological intervention for depression in rural Gujarat, India. by Aakrushi Brahmbhatt, Darshana Rathod, Udita Joshi, Azaz Khan, G Sai Teja, Shrey Desai, Ajay Chauhan, Shobha Shah, Deepti Bhatt, Sethuraman Venkatraman, Deepak Tugnawat, Satchit Balsari, Vikram Patel, Anant Bhan, John A Naslund

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Distribution and Antifungal Susceptibility Profile of Oropharyngeal Candida Species Isolated from People Living with HIV in the Era of Universal Test and Treat Policy in Uganda. by Musinguzi, Benson, Turyamuhika, Laban, Mwesigwa, Alex, Nalumaga, Pauline Petra, Kabajulizi, Immaculate, Njovu, Israel Kiiza, Mwebesa, Edson, Luggya, Tonny, Ocheng, Francis, Kateete, David Patrick, Itabangi, Herbert, Mboowa, Gerald, Obondo, James Sande, Achan, Beatrice

“…Background: Despite the increased frequency of oropharyngeal candidiasis among people living with human immunodeficiency virus (HIV), its management is no longer effective due to empirical treatment and the emergence of antifungal resistance (AFR). …”
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β2 integrin regulates neutrophil trans endothelial migration following traumatic brain injury by Lei Li, Ruilong Peng, Cong Wang, Xin Chen, Dilmurat Gheyret, Siyu Guan, Bo Chen, Yafan Liu, Xilei Liu, Yiyao Cao, Cha Han, Jianhua Xiong, Fanjian Li, Taoyuan Lu, Haoran Jia, Kaiji Li, Jinchao Wang, Xu Zhang, Jianye Xu, Yajuan Wang, Xin Xu, Tuo Li, Jianning Zhang, Shu Zhang

“…Moreover, ITGB2 blockade has effectively limited the adherence, migration, and infiltration of neutrophils, and has impeded the formation of neutrophil extracellular traps (NETs) upon their activation. …”
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Ellagic Acid from <i>Geranium thunbergii</i> and Antimalarial Activity of Korean Medicinal Plants by Hojong Jun, Joon-Hee Han, Min Hong, Fadhila Fitriana, Jadidan Hada Syahada, Wang-Jong Lee, Ernest Mazigo, Johnsy Mary Louis, Van-Truong Nguyen, Seok Ho Cha, Wanjoo Chun, Won Sun Park, Se Jin Lee, Sunghun Na, Soo-Ung Lee, Eun-Taek Han, Tae-Hyung Kwon, Jin-Hee Han

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Understanding the long‐term impact of the COVID‐19 pandemic on non‐muscle‐invasive bladder cancer outcomes: 12‐Month follow‐up data from the international, prospective COVIDSurg Ca... by Cameron E. Alexander, Arjun Nathan, Alexander Light, Chuanyu Gao, Vinson Chan, Sinan Khadhouri, Kevin Gallagher, Kevin G. Byrnes, Michael Walters, Terry Hughes, Rita Perry, Kelvin Okoth, Laura Magill, Thomas Pinkney, Joseph B. John, John S. McGrath, Alexandra Colquhoun, Yuhao Zhang, James Blackmur, Eric Etchill, Stanley Tang, Damián García Escudero, Grant D. Stewart, Veeru Kasivisvanathan, COVIDSurg Collaborative

“…Within this included cohort, 229 patients had NMIBC and 12‐month follow‐up data available. …”
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Unconventional Anomalous Hall Effect Driven by Self‐Intercalation in Covalent 2D Magnet Cr2Te3 by Keke He, Mengying Bian, Samuel D. Seddon, Koushik Jagadish, Andrea Mucchietto, He Ren, Erik Kirstein, Reza Asadi, Jaeil Bai, Chao Yao, Sheng Pan, Jie‐Xiang Yu, Peter Milde, Chang Huai, Haolei Hui, Jiadong Zang, Renat Sabirianov, Xuemei M. Cheng, Guoxing Miao, Hui Xing, Yu‐Tsun Shao, Scott A. Crooker, Lukas Eng, Yanglong Hou, Jonathan P. Bird, Hao Zeng

“…This component competes with the contribution from bands that are less affected by the self‐intercalation, resulting in a sign change in AHE with temperature and the emergence of additional humps and dips. …”
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