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Metformin exerted tumoricidal effects on colon cancer tumoroids via the regulation of autophagy pathway
Published 2025-02-01“…Therefore, the development and fabrication of various 3D culture systems can in part mimic intricate cell-to-cell interaction within the real tumor mass. …”
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Long-term survival and clinical implications of allogeneic stem cell transplantation in relapse/refractory lymphoma: A 20-year Singapore experience
Published 2025-01-01“… Introduction: Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is a curative option for relapse/refractory (R/R) lymphomas that have failed autologous transplantation or for high-risk lymphomas in the upfront setting. …”
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5745
Epigenetic Regulation of Mesenchymal Stem Cells: A Focus on Osteogenic and Adipogenic Differentiation
Published 2011-01-01“…Somatic or adult stem cells have a finite self-renewal capacity and are lineage-restricted. …”
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5746
CD4 T cell dynamics shape the immune response to combination oncolytic herpes virus and BRAF inhibitor therapy for melanoma
Published 2022-03-01“…Dual therapy results in changes in T cell dynamics within tumors, with relatively maintained antigen signaling in Treg compared with conv CD4+. …”
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5747
International Society of Sports Nutrition Position Stand: Long-Chain Omega-3 Polyunsaturated Fatty Acids
Published 2025-12-01“…The following conclusions represent the official position of the ISSN: Athletes may be at a higher risk for ω-3 PUFA insufficiency.Diets rich in ω-3 PUFA, including supplements, are effective strategies for increasing ω-3 PUFA levels.ω-3 PUFA supplementation, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), has been shown to enhance endurance capacity and cardiovascular function during aerobic-type exercise.ω-3 PUFA supplementation may not confer a muscle hypertrophic benefit in young adults.ω-3 PUFA supplementation in combination with resistance training may improve strength in a dose- and duration-dependent manner.ω-3 PUFA supplementation may decrease subjective measures of muscle soreness following intense exercise.ω-3 PUFA supplementation can positively affect various immune cell responses in athletic populations.Prophylactic ω-3 PUFA supplementation may offer neuroprotective benefits in athletes exposed to repeated head impacts.ω-3 PUFA supplementation is associated with improved sleep quality.ω-3 PUFA are classified as prebiotics; however, studies on the gut microbiome and gut health in athletes are currently lacking.…”
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Spatial tumor immune heterogeneity facilitates subtype co-existence and therapy response in pancreatic cancer
Published 2025-01-01“…Here, by combining preclinical models, multi-center clinical, transcriptomic, proteomic, and patient bioimaging data, we identify an interplay between neoplastic intrinsic AP1 transcription factor dichotomy and extrinsic macrophages driving subtype co-existence and an immunosuppressive microenvironment. ATAC-, ChIP-, and RNA-seq analyses reveal that JUNB/AP1- and HDAC-mediated epigenetic programs repress pro-inflammatory signatures in tumor cells, antagonizing cJUN/AP1 signaling, favoring a therapy-responsive classical neoplastic state. …”
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A Subclass of Gamma-Ray Burst Originating from Compact Binary Merger
Published 2025-01-01“…Type I gamma-ray bursts (GRBs) are believed to originate from compact binary mergers usually with a duration of main emission less than 2 s. However, recent observations of GRB 211211A and GRB 230307A indicate that some merger-origin GRBs could last much longer. …”
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Fabrication and Characterization of Chitosan-Polyethylene Glycol (Ch-Peg) Based Hydrogels and Evaluation of Their Potency in Rat Skin Wound Model
Published 2021-01-01“…When compared to other composite hydrogels, wounds treated with X : Ge : Peg : Ch : G, X : Ge : B : Peg : G, and X : Ge : B : Peg : Ch:G recovered faster after 28 days. …”
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Mobilization of Stem Cells Using G-CSF for Acute Ischemic Stroke: A Randomized Controlled, Pilot Study
Published 2011-01-01“…Although this study did not have power to examine efficacy, it provides preliminary evidence of potential safety, feasibility, and tolerability of G-CSF therapy. …”
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Impact of Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors on Lipoprotein(a)
Published 2025-02-01“…Background: Lipoprotein(a) [Lp(a)] has been independently associated with increased cardiovascular risk. …”
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Operational research as a mechanism to improve treatment outcomes for drug-resistant TB in the WHO European Region
Published 2024-03-01“…In the hope of encouraging others to adopt this model, we have described the principles of the initiative, its strengths and weaknesses and next steps.…”
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Distribution of Candida Species Isolated from People Living with Human Immunodeficiency Virus With Oropharyngeal and Oral Candidiasis in Africa in the Era Of Universal Test and Tre...
Published 2024“…Background The introduction of antiretroviral therapy (ART) and the implementation of the human immunodeficiency virus (HIV) universal test and treat (UTT) policy have led to a decline in the incidence of opportunistic infections. …”
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100 essential questions for the future of agriculture
Published 2023-03-01“…We focus on 10 primary themes: transforming agri‐food systems, enhancing resilience of agriculture to climate change, mitigating climate change through agriculture, exploring resources and technologies for breeding, advancing cultivation methods, sustaining healthy agroecosystems, enabling smart and controlled‐environment agriculture for food security, promoting health and nutrition‐driven agriculture, exploring economic opportunities and addressing social challenges, and integrating one health and modern agriculture. …”
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Resolving the generation mechanisms and electrodynamical effects of Medium Scale Traveling Ionospheric Disturbances (MSTIDs)
Published 2025-02-01“…Observational limitations can impede characterization and identification of MSTID generation mechanisms. …”
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