Development and preclinical testing of a naloxone prodrug depot for extended protection against opioid overdose by Hala Aldawod, Arjun D. Patel, Rasha Emara, Dengpan Liang, Joshua S. Ho, Toufiq Ul Amin, Md Tariqul Haque Tuhin, Abdulmalek Balgoname, Avishan Kiani, Jumana M. Ajlouny, Melanie A. Felmlee, Miki S. Park, Bhaskara R. Jasti, William K. Chan, James A. Uchizono, Mamoun M. Alhamadsheh

“…The opioid antidote naloxone has a short action ( ~ 1 hour), requiring repeated doses. …”
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The economic burden of breast cancer in western Iran: a cross-sectional cost-of-illness study by Banafsheh Darvishi Teli, Meysam Behzadifar, Mania Beiranvand, Aziz Rezapour, Seyed Jafar Ehsanzadeh, Samad Azari, Ahad Bakhtiari, Payam Haghighatfard, Mariano Martini, Maryam Saran, Masoud Behzadifar

“…Early detection and prevention programs can facilitate earlier diagnosis and reduce treatment costs. …”
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Therapy-induced senescent cancer cells contribute to cancer progression by promoting ribophorin 1-dependent PD-L1 upregulation by Hyun Jung Hwang, Donghee Kang, Jisoo Shin, Jonghun Jung, Soyeon Ko, Kyung Hee Jung, Soon-Sun Hong, Ji Eun Park, Myung Jin Oh, Hyun Joo An, Wen-Hao Yang, Young-Gyu Ko, Jong-Ho Cha, Jae-Seon Lee

“…Abstract Conventional chemotherapy- and radiotherapy-induced cancer senescence, which is characterized by poor proliferation, drug resistance, and senescence-associated secretory phenotype, has gained attention as contributing to cancer relapse and the development of an immunosuppressive tumor microenvironment. …”
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Genetic characteristics and pathogenesis of clade 2.3.4.4b H5N1 high pathogenicity avian influenza virus isolated from poultry in South Korea, 2022–2023 by Ra Mi Cha, Min-Ji Park, Yoon-Gi Baek, Yu-Na Lee, Yunyueng Jang, Yong-Myung Kang, Gyeong-Beom Heo, Se-Hee An, Kwang-Nyeong Lee, Jae-Kyeom Kim, Hye-Ryoung Kim, Youn-Jeong Lee, Eun-Kyoung Lee

“…Notably, in the 22G7-inoculated group, viral shedding via the cloacal route was longer, and viral replication in the cecal tonsil was higher than that in the 22G1-inoculated group, which may have contributed to the dominancy of the 22G7 genotype. …”
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Linking obesity-associated genotype to child language development: the role of early-life neurology-related proteomics and brain myelinationResearch in context by Jian Huang, Jinyi Che, Michelle Z.L. Kee, Ai Peng Tan, Evelyn C. Law, Patricia Pelufo Silveira, Irina Pokhvisneva, Sachin Patel, Keith M. Godfrey, Lourdes Mary Daniel, Kok Hian Tan, Yap Seng Chong, Shiao-Yng Chan, Johan G. Eriksson, Dennis Wang, Jonathan Yinhao Huang

“…Our findings suggested a shared genetic basis between obesity and language development rather than a causal effect of obesity on language development. …”
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Evaluation of the protective efficacy of OlysetPlus ceiling nets for reduction of malaria incidence in children in Homa Bay County, Kenya: a cluster-randomised controlled study pro... by Daisuke Yoneoka, Jesse Gitaka, James Kongere, Wataru Kagaya, Akira Kaneko, Yura K Ko, Chim W Chan, Mariko Kanamori, Bernard N Kanoi, Gordon Odhiambo Okomo, Protus Omondi, Kelvin B Musyoka, Takatsugu Okai, Victor Opiyo, Jared Oginga, Samuel Mungai, Kibor K Keitany, Elijah Songok, Noboru Minakawa

“…One novel vector control candidate is the pyrethroid-PBO ceiling nets (OlysetPlus ceiling nets) which can overcome the problems of variations in net use behaviours and metabolic resistance to insecticide in vectors. …”
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miR-449a/miR-340 reprogram cell identity and metabolism in fusion-negative rhabdomyosarcoma by Enrico Pozzo, Laura Yedigaryan, Nefele Giarratana, Chao-chi Wang, Gabriel Miró Garrido, Ewoud Degreef, Vittoria Marini, Gianmarco Rinaldi, Bernard K. van der Veer, Gabriele Sassi, Guy Eelen, Mélanie Planque, Alessandro Fanzani, Kian Peng Koh, Peter Carmeliet, Jason T. Yustein, Sarah-Maria Fendt, Anne Uyttebroeck, Maurilio Sampaolesi

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OUTPOST: A comprehensive analysis software for whole‐metagenome shotgun sequencing incorporating group stratification by Yihang Zhou, Jihong Zheng, Wenqi Song, Xinyi Yan, Li Du, Zhonglin Ma, Yanbin Fu, Zhaohui Ouyang, Yuchen Xiao, Zhuoqun Liu, Feng Tian, Jason Wing Hon Wong, Jen Hao David Shih, Shikang Liang, Honglei Tian, Liu Liu, Ke Wei, Chao Zhang, Jiangtao Li, Xiaozhu Wang

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Telomere Length Is Associated With Adverse Atrial Remodeling in Patients With Atrial Fibrillation by Kabita Pradhan, Balram Neupane, Paul Niehues, Martin Kirschner, Fabian Beier, Chao‐Chung Kuo, Erika Anneliese Hilbold, Christian Bär, Oana‐Maria Thoma, Maximilian Waldner, Margherita Vieri, Tim H. Brümmendorf, Vithurithra Tharmapalan, Wolfgang Wagner, Michael Kleines, Mahdi Emrani, Matthias Daniel Zink, Andreas Napp, Nikolaus Marx, Michael Gramlich

“…The prevalence of AF increases dramatically with age and can be up to 18% in patients older than 80 years. …”
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Primary results from the Japanese Heart Failure and Sudden Cardiac Death Prevention Trial (HINODE) by Kazutaka Aonuma, Kenji Ando, Kengo Kusano, Toru Asai, Koichi Inoue, Yukihiro Inamura, Takanori Ikeda, Takeshi Mitsuhashi, Toyoaki Murohara, Nobuhiro Nishii, Akihiko Nogami, Wataru Shimizu, Caroline Beaudoint, Torri Simon, Torsten Kayser, Hussin Azlan, Ngarmukos Tachapong, Joseph Yat‐Sun Chan, Valentina Kutyifa, Yasushi Sakata, For the HINODE Investigators

“…The pacing cohort revealed that patients implanted with pacemakers had higher mortality (26.0%) than those with CRT‐Pacing (8.4%, P = 0.05). …”
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Simultaneous Multiband Photometry of the Early Optical Afterglow of GRB 240825A with Mephisto by Yehao Cheng, Yu Pan, Yuan-Pei Yang, Jinghua Zhang, Guowang Du, Yuan Fang, Brajesh Kumar, Helong Guo, Xinzhong Er, Xinlei Chen, Chenxu Liu, Tao Wang, Zhenfei Qin, Yicheng Jin, Xingzhu Zou, Xuhui Han, Pinpin Zhang, Liping Xin, Chao Wu, Jianhui Lian, Xiangkun Liu, Xiaowei Liu

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Osteoarticular Infection in Three Young Thoroughbred Horses Caused by a Novel Gram Negative Cocco-Bacillus by Bernard J. Hudson, Catherine Chicken, Anna Blishen, Kristen H. Todhunter, Angela P. Begg, Leonie Chan, Thomas Karagiannis, Benjamin Raymond, Daniel Bogema, Angus R. Adkins, Christopher B. O’Sullivan, Brendon A. O’Rourke, Piklu Roy Chowdhury, Steven P. Djordjevic, Ian G. Charles, Andrew Edgar, Katerina Mitsakos

“…Analysis by 16S rRNA PCR enabled construction of a phylogenetic tree that placed the isolates closer to Simonsiella and Alysiella species, rather than Kingella species. Average nucleotide identity (ANI) comparison between the new isolate and Kingella kingae and Alysiella crassa however revealed low probability that the new isolate belonged to either of these species. …”
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Genomic insights into population dynamics and adaptive strategies of the endangered dipterocarp, Hopea chinensis by Wei-Min Xiang, Yu-Ting Jiang, Jie Zou, Yan Deng, Kai Jiang, Kai-Jian Zhang, Xin-Yu Zhou, Kai-Xi Quan, Zi-Wen Han, Wei-Chao Liu, Liang Tang, Yuan-Yuan Li, Simon T. Segar, Yuan-Ye Zhang, Xing-Hua Hu, Rong Wang, Xiao-Yong Chen

“…Despite the perceived conservation priority of these species, we know little about how they became endangered and how they have adapted to marginal habitats. Here, we focused on the population genomics of Hopea chinensis, an endangered species narrowly distributed at the northern limit of dipterocarps, to (1) reveal its demographic history and infer factors contributing to endangered status; (2) evaluate the genetic consequences of its small remnant population; and (3) identify key genes associated with its adaptation. …”
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A CACTA-like transposon in the Anthocyanidin synthase 1 (Ans-1) gene is responsible for apricot fruit colour in the raspberry (Rubus idaeus) cultivar 'Varnes'. by Daniel James Sargent, Matteo Buti, Stefan Martens, Claudio Pugliesi, Kjersti Aaby, Dag Røen, Chandra Bhan Yadav, Felicidad Fernández Fernández, Muath Alsheikh, Jahn Davik, R Jordan Price

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Knowledge and Attitude about Basic Life Support and Emergency Medical Services amongst Healthcare Interns in University Hospitals: A Cross-Sectional Study by Shahabe A. Saquib, Hassan M. Al-Harthi, Anas A. Khoshhal, Adel A. Shaher, Abdulsalam B. Al-Shammari, AbdulAhad Khan, Tahani A. Al-Qahtani, Imran Khalid

“…There was no significant difference in the attitude of interns among the different faculties. 60 to 70% of interns had recommended to include BLS training in the university curriculum. …”
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Machine-learning versus traditional methods for prediction of all-cause mortality after transcatheter aortic valve implantation: a systematic review and meta-analysis by Clara K Chow, Aravinda Thiagalingam, Rohan Jayasinghe, Sarah Zaman, Stephen Bacchi, Justin Chan, Aashray Gupta, Shaun Evans, Pramesh Kovoor, Brandon Stretton, Jayme Bennetts, Ammar Zaka, Naim Mridha, Joshua Kovoor, Gopal Sivagangabalan, Cecil Mustafiz, Daud Mutahar, Shreyans Sinhal, James Gorcilov, Benjamin Muston, Fabio Ramponi, Dale J Murdoch

“…Background Accurate mortality prediction following transcatheter aortic valve implantation (TAVI) is essential for mitigating risk, shared decision-making and periprocedural planning. Surgical risk models have demonstrated modest discriminative value for patients undergoing TAVI and are typically poorly calibrated, with incremental improvements seen in TAVI-specific models. …”
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Compliance with face mask use during the COVID-19 pandemic: a community observational study in Singapore by Sean Wei Xiang Ong, Ying Wei Tang, Kyaw Zaw Linn, Xiao Wei Huan, Allie Lim, Chu Ying Poon, Danielle Hui Ru Tan, Nur Hafizah Binte Hamed, Sharifah Farhanah Binte Syed Husen, Clara Chong Hui Ong, Monica Chan, Shawn Vasoo, Yee-Sin Leo, Oon-Tek Ng, Kalisvar Marimuthu

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Correction: Genome editing of an African elite rice variety confers resistance against endemic and emerging Xanthomonas oryzae pv. oryzae strains by Van Schepler-Luu, Coline Sciallano, Melissa Stiebner, Chonghui Ji, Gabriel Boulard, Amadou Diallo, Florence Auguy, Si Nian Char, Yugander Arra, Kyrylo Schenstnyi, Marcel Buchholzer, Eliza PI Loo, Atugonza L Bilaro, David Lihepanyama, Mohammed Mkuya, Rosemary Murori, Ricardo Oliva, Sebastien Cunnac, Bing Yang, Boris Szurek, Wolf B Frommer

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Spatiotemporal Assessment of PM2.5 Exposure of a High-risk Occupational Group in a Southeast Asian Megacity by Jarl Tynan Collado, Jose Gabriel Abalos, Imee de los Reyes, Melliza T. Cruz, Gabrielle Frances Leung, Katrina Abenojar, Carlos Rosauro Manalo, Bernell Go, Christine L. Chan, Charlotte Kendra Gotangco Gonzales, James Bernard B. Simpas, Emma E. Porio, John Q. Wong, Shih-Chun Candice Lung, Maria Obiminda L. Cambaliza

“…Multiple linear regression (MLR) analysis revealed that the area by the shopping mall had the highest contribution (β = 52 µg m−3) to PUJ driver exposure. …”
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