Pt/IrO x enables selective electrochemical C-H chlorination at high current by Bo Wu, Ruihu Lu, Chao Wu, Tenghui Yuan, Bin Liu, Xi Wang, Chenyi Fang, Ziyu Mi, Surani Bin Dolmanan, Weng Weei Tjiu, Mingsheng Zhang, Bingqing Wang, Zainul Aabdin, Sui Zhang, Yi Hou, Bote Zhao, Shibo Xi, Wan Ru Leow, Ziyun Wang, Yanwei Lum

“…We further demonstrate that our system can directly utilize concentrated seawater derived from a solar evaporation reverse osmosis process, achieving a FE of 93.8% towards chlorocyclohexane at a current of 1 A. …”
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Methodological insights into intervention and outcomes in randomised controlled trials of herbal medicine for obesity: a scoping review by Janice Sue Wen Chan, Mei Siu Lau, Siti Hajar Muhamad Rosli, Siti Khadijah Mustapha Kamal, Wan Nurul Nadia Wan Seman, Nurul Hidayah Ali, Terence Yew Chin Tan, Ida Farah Ahmad, Puspawathy Krishnan, Marisa Khatijah Borhan, Ami Fazlin Syed Mohamed, Xin Yi Lim

“…Sources of evidence: Only published journal articles were included. Charting methods: Articles were extracted from MEDLINE, CENTRAL and EMBASE using predetermined keywords. …”
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Decomposing the Poor-Non-Poor Gap in the Prevalence of Undiagnosed and Untreated Hypertension Among Bangladeshi Population by Mosiur Rahman, Mahfuza Khatun, Asrafun Naher Pinkey, Syed Emdadul Haque, Farhana Akhter Liza, Md. Nuruzzaman Haque, Prosannajid Sarkar, Tapan Kumar Roy, G. M. Rabiul Islam, Md. Rashed Alam, Mahmudul Hasan, Izzeldin Fadl Adam, Nguyen Huu Chau Duc, Saber Al-Sobaihi, Abid Hasan

“…People in the poor SES groups had a 0.88 times (95% confidence interval [CI] 0.77–0.99) lower likelihood of having hypertension compared to those in the non-poor SES group. …”
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Identifying Multiomic Signatures of X‐Linked Retinoschisis‐Derived Retinal Organoids and Mice Harboring Patient‐Specific Mutation Using Spatiotemporal Single‐Cell Transcriptomics... by Yueh Chien, You‐Ren Wu, Chih‐Ying Chen, Yi‐Ping Yang, Lo‐Jei Ching, Bo‐Xuan Wang, Wei‐Chao Chang, I‐Hsun Chiang, Pong Su, Shih‐Yu Chen, Wen‐Chang Lin, I‐Chieh Wang, Tai‐Chi Lin, Shih‐Jen Chen, Shih‐Hwa Chiou

“…Furthermore, therapeutic targeting of the chronic ER stress/eIF2α pathway activation synergistically enhances the efficacy of AAV‐mediated RS1 gene delivery, ultimately improving bipolar cell integrity, postsynaptic transmission, disorganized retinal architecture, and electrophysiological responses. …”
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Multiomic analysis reveals cellular, transcriptomic and epigenetic changes in intestinal pouches of ulcerative colitis patients by Yu Zhao, Ran Zhou, Bingqing Xie, Cambrian Y. Liu, Martin Kalski, Candace M. Cham, Zhiwei Jiang, Jason Koval, Christopher R. Weber, David T. Rubin, Mitch Sogin, Sean Crosson, Mengjie Chen, Jun Huang, Aretha Fiebig, Sushila Dalal, Eugene B. Chang, Anindita Basu, Sebastian Pott

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Smart phone-based transcutaneous electrical acupoint stimulation as adjunctive therapy for hypertension (STAT-H trial): protocol for a cluster randomised controlled trial by Yu Wang, Xiao Wang, Ying Lin, Chao-Qun Yan, Guang-Xia Shi, Cun-Zhi Liu, Jing-Wen Yang, Jian-Feng Tu, Shi-Yan Yan, Xin-Tong Su, Li-Qiong Wang, Si-Bo Kang, Bao-Hong Mi, He-Wen Li, Xue-Zhou Wang

“…Tertiary outcomes will include change in body mass index, change in waist circumference, physical activity and medication adherence. …”
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Single-cell Profiling of Intrahepatic Immune Cells Reveals an Expansion of Tissue-resident Cytotoxic CD4+ T Lymphocyte Subset Associated With Pathogenesis of Alcoholic-associated L... by Chao Gao, Shiguan Wang, Xiaoyu Xie, Pierluigi Ramadori, Xinying Li, Xiaoyu Liu, Xue Ding, Jinyuan Liang, Bowen Xu, Yawei Feng, Xueying Tan, Haoran Wang, Yan Zhang, Haiyan Zhang, Tingguo Zhang, Ping Mi, Shiyang Li, Cuijuan Zhang, Detian Yuan, Mathias Heikenwalder, Peng Zhang

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Toxicity of Low-dose Graphene Oxide Nanoparticles in an in-vivo Wild Type of Caenorhabditis elegans Model by Ming-Hsien Tsai, How-Ran Chao, Jheng-Jie Jiang, Yu-Hsieh Su, Mariene-syne P. Cortez, Lemmuel L. Tayo, I-Cheng Lu, Hao Hsieh, Chih-Chung Lin, Sheng-Lun Lin, Wan Nurdiyana Wan Mansor, Ching-Kai Su, Sen-Ting Huang, Wen-Li Hsu

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Heterogeneity of Intermediate Care Organization Within a Single Healthcare System by Aaron S. Case, MD, MHS, Chad H. Hochberg, MD, MHS, Binu Koirala, PhD, MGS, BSN, RN, Eleni Flanagan, DNP, MBA, Souvik Chatterjee, MD, William N. Checkley, MD, PhD, Ayse P. Gurses, PhD, MS, MPH, David N. Hager, MD, PhD

“…Six IC settings (50%) were embedded within acute care wards, four (33%) were stand-alone units, and two (17%) were embedded within an ICU. All had a nurse-to-patient ratio of 1:3, provided continuous cardiac telemetry, continuous pulse oximetry, high-flow nasal oxygen, and bedside intermittent hemodialysis. …”
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A lineage 1 branch porcine reproductive and respiratory syndrome virus live vaccine candidate provides broad cross-protection against HP-like PRRSV in piglets by Chao Li, Jinhao Li, Bangjun Gong, Hu Xu, Zhenyang Guo, Lirun Xiang, Siyu Zhang, Qi Sun, Jing Zhao, Menglin Zhang, Yan-Dong Tang, Chaoliang Leng, Jianan Wu, Qian Wang, Jinmei Peng, Guohui Zhou, Huairan Liu, Tongqing An, Xuehui Cai, Zhi-Jun Tian, Hongliang Zhang

“…Our previous research confirmed that a PRRSV lineage 1 branch attenuated live vaccine (SD-R) provides cross-protection against HP-PRRSV, NADC30-like PRRSV and NADC34-like PRRSV. HP-PRRSV has undergone significant genetic variation following nearly two decades of evolution and has transformed into a subtype referred to as HP-like PRRSV, which also exhibits high pathogenicity. …”
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N-Cadherin promotes cardiac regeneration by potentiating pro-mitotic β-Catenin signaling in cardiomyocytes by Yi-Wei Tsai, Yi-Shuan Tseng, Yu-Shuo Wu, Wei-Lun Song, Min-Yi You, Yun-Chia Hsu, Wen-Pin Chen, Wei-Han Huang, Jia-Ci Chng, Chai-Ling Lim, Ke-Hsuan Wei, Shih-Lei Ben Lai, Wen-Chih Lee, Kai-Chien Yang

“…Post-injury cardiomyocyte (CM) loss can lead to myocardial dysfunction and failure. …”
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Impaired creatinine-based estimated glomerular filtration rate in Thai individuals switching to dolutegravir: illustrating the role of cystatin C testing to aid clinical decision making by Carlo Sacdalan, Curtis Austin, Aswathy Varma, Suteeraporn Pinyakorn, Eugène Kroon, Donn J. Colby, Phillip Chan, Orlanda Goh, Krittaporn Pornpaisakul, Jintana Intasan, Tassanee Luekasemsuk, Merlin L. Robb, Nitiya Chomchey, Nittaya Phanuphak, Jintanat Ananworanich, Sandhya Vasan, Denise Hsu, the SEARCH 010/RV254 study group

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Angiographic Complete versus Clinical Selective Incomplete Percutaneous Revascularization in Heart Failure Patients with Multivessel Coronary Disease by Chieh-Yu Chang, Chun-Chi Chen, I-Chang Hsieh, Ming-Jer Hsieh, Cheng-Hung Lee, Dong-Yi Chen, Ming-Lung Tsai, Ming-Yun Ho, Jih-Kai Yeh, Yu-Chang Huang, Yu-Ying Lu, Chao-Yung Wang, Shang-Hung Chang, Ming-Shien Wen

“…However, patients who failed CR had a significantly greater incidence of 5-year MACEs than those in the other two groups (failed CR: 46.4% vs. selective IR: 27.7% vs. successful CR: 27.8%, p<0.001). …”
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7-Day Nonbismuth-Containing Concomitant Therapy Achieves a High Eradication Rate for Helicobacter pylori in Taiwan by Sung-Shuo Kao, Wen-Chi Chen, Ping-I Hsu, Kwok-Hung Lai, Hsien-Chung Yu, Hui-Hwa Cheng, Nan-Jing Peng, Chiun-Ku Lin, Hoi-Hung Chan, Wei-Lun Tsai, Huay-Min Wang, Tzung-Jiun Tsai, Kung-Hung Lin, Feng-Woei Tsay

“…Whether shortening the duration of concomitant therapy can still keep a high eradication rate remains unclear. …”
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A suite of wildlife crossing structures facilitates mammal movement across tropical forest fragments in a city by Li Si Tay, Ruisheng Choo, Max D. Y. Khoo, Eunice Kong, Yi Xiang Chan, Wivian H. Y. Neo, Sebastian Ow, Yuet Hsin Toh, Han Ling, Malcolm C. K. Soh, Benjamin P. Y.‐H. Lee, Adrian H. B. Loo, Kenneth B. H. Er

“…Although many species used multiple crossing types, most species had a preferred crossing method. Between culverts and roads, factors that influenced crossing preferences included group size for wild boars and time of day and presence of fences for other mammals. …”
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A deep multiple instance learning framework improves microsatellite instability detection from tumor next generation sequencing by John Ziegler, Jaclyn F. Hechtman, Satshil Rana, Ryan N. Ptashkin, Gowtham Jayakumaran, Sumit Middha, Shweta S. Chavan, Chad Vanderbilt, Deborah DeLair, Jacklyn Casanova, Jinru Shia, Nicole DeGroat, Ryma Benayed, Marc Ladanyi, Michael F. Berger, Thomas J. Fuchs, A. Rose Brannon, Ahmet Zehir

“…Previous work has demonstrated that next-generation sequencing data can be used to identify samples with MSI-high phenotype. …”
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Prognostic utility of neutrophil gelatinase-associated lipocalin (NGAL) levels for cardiovascular events in patients with stable coronary artery disease treated with percutaneous c... by Ting-Yu Lin, Hsin-Bang Leu, Yen-Wen Wu, Wei-Kung Tseng, Tsung-Hsien Lin, Hung-I Yeh, Kuan-Cheng Chang, Ji-Hung Wang, Wei-Hsian Yin, Chau-Chung Wu, Chun-Yao Huang, Shing-Jong Lin, Chien-Yi Hsu, Jaw-Wen Chen

“…However, studies that have measured NGAL levels in patients with stable coronary artery disease (CAD) are limited. …”
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Long-Term Outcomes of Caustic Esophageal Stricture with Endoscopic Balloon Dilatation in Chinese Children by Lan-Lan Geng, Cui-Ping Liang, Pei-Yu Chen, Qiang Wu, Min Yang, Hui-Wen Li, Zhao-Hui Xu, Lu Ren, Hong-Li Wang, Shunxian Cheng, Wan-Fu Xu, Yang Chen, Chao Zhang, Li-Ying Liu, Ding-You Li, Si-Tang Gong

“…We retrospectively reviewed the data of all patients who had a diagnosis of CES and underwent EBD from August 1, 2005, to December 31, 2014. …”
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Peripheral neuropathy in the phase 3 ASPEN study of Bruton tyrosine kinase inhibitors for Waldenström macroglobulinemia by Benjamin M. Heyman, Stephen S. Opat, Björn E. Wahlin, Meletios-Athanasios C. Dimopoulos, Jorge J. Castillo, Alessandra Tedeschi, Constantine S. Tam, Christian Buske, Roger G. Owen, Véronique Leblond, Judith Trotman, Gisoo Barnes, Wai Y. Chan, Jingjing Schneider, Heather Allewelt, Aileen Cohen, Jeffrey V. Matous

“…Patients with PN symptom resolution had greater improvement in HRQOL. Physical functioning improved in patients with PN symptom resolution and was unchanged in patients without resolution. …”
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Combined pyrotinib and fulvestrant for hormone receptor‐positive and HER2‐positive metastatic breast cancer: A multicenter, single‐arm, phase II trial by Jianli Zhao, Yunfang Yu, Wei Ren, Linxiaoxiao Ding, Yongjian Chen, Peng Yuan, Jian Yue, Yaping Yang, Guorong Zou, Tao Chen, Jie Chai, Li Zhang, Wenjing Wu, Yinduo Zeng, Xiujuan Gui, Yangyang Cai, Simin Luo, Zhongyu Yuan, Kang Zhang, Herui Yao, Ying Wang

“…Abstract This multicenter, single‐arm, phase II clinical trial (NCT04034589) evaluated the efficacy and safety of pyrotinib combined with fulvestrant in patients with HR‐positive/HER2‐positive metastatic breast cancer who had experienced trastuzumab treatment failure. A total of 46 patients were enrolled, receiving pyrotinib orally once daily and fulvestrant intramuscularly on days 1 and 15 of cycle 1, followed by monthly doses on day 1. …”
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