Utility of multimodal imaging in the clinical diagnosis of inherited retinal degenerations by Brian J. H. Lee, Christopher Z. Y. Sun, Charles J. T. Ong, Kanika Jain, Tien-En Tan, Choi Mun Chan, Ranjana S. Mathur, Rachael W. C. Tang, Yasmin Bylstra, Sylvia P. R. Kam, Weng Khong Lim, Beau J. Fenner

“…Inherited retinal degeneration (IRD) is a heterogeneous group of genetic disorders of variable onset and severity, with vision loss being a common endpoint in most cases. More than 50 distinct IRD phenotypes and over 280 causative genes have been described. …”
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Human adaptation and diversification in the Microsporum canis complex by Xin Zhou, Sarah A. Ahmed, Chao Tang, Maria Eduarda Grisolia, José Francisco Ghignatti Warth, Kristen Webster, Andrea Peano, Silke Uhrlass, Claudia Cafarchia, Marie Pierre Hayette, Rosalie Sacheli, Tadeja Matos, Yingqian Kang, G. Sybren de Hoog, Peiying Feng

“…Growth rates and lipase, keratinolysis and urea hydrolytic capacities of zoophilic M. canis isolates were all higher than those of anthropophilic strains; DNase activity of M. ferrugineum exceeded that of M. canis. …”
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Fetal Cartilage Progenitor Cells in the Repair of Osteochondral Defects by Bruno C. Menarim, DVM, PhD, Chan Hee Mok, PhD, Kirsten E. Scoggin, PhD, Alexis Gornik, DVM, Emma N. Adam, DVM, PhD, Shavahn C. Loux, PhD, James N. MacLeod, VMD, PhD

“…In salamanders, interzone (IZN) tissue can regenerate large joint lesions. The mammalian homolog to this tissue exists during fetal development and exhibits remarkable chondrogenesis in vitro. …”
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Development and validation of a prognostic prediction model for elderly gastric cancer patients based on oxidative stress biochemical markers by Xing-Qi Zhang, Ze-Ning Huang, Ju Wu, Chang-Yue Zheng, Xiao-Dong Liu, Ying-Qi Huang, Qi-Yue Chen, Ping Li, Jian-Wei Xie, Chao-Hui Zheng, Jian-Xian Lin, Yan-Bing Zhou, Chang-Ming Huang

“…Predictive models for five-year overall survival (OS) were constructed using random forest (RF), decision tree (DT), and support vector machine (SVM) methods, and validated using area under the curve (AUC) and calibration plots. The SHapley Additive exPlanations (SHAP) method was used for model interpretation. …”
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Understanding the formation of a low-pressure pedestal in the presence of a strong internal transport barrier in DIII-D high βp plasmas by X.R. Zhang, X. Jian, Y.R. Zhu, Y.P. Zou, Z.Y. Li, Y.J. Zhou, L.Z. Liu, S. Zheng, Z.X. Wang, W. Chen, S.Y. Ding, A.M. Garofalo, V.S. Chan, G.Q. Li

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The Addition of ROTEM Parameter Did Not Significantly Improve the Massive Transfusion Prediction in Severe Trauma Patients by Dongyup Baik, Seok-Ran Yeom, Sung-Wook Park, Youngmo Cho, Wook Tae Yang, Hoon Kwon, Jae Il Lee, Jun-Kyeung Ko, Hyuk Jin Choi, Up Huh, Tae Sik Goh, Chan-Hee Song, Lee Hwangbo, Il Jae Wang

“…Rotational thrombelastometry (ROTEM) has been used to evaluate the coagulation state, predict transfusion, and optimize hemostatic management in trauma patients. …”
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Rational Design of Biocompatible Ir(III) Photosensitizer to Overcome Drug‐Resistant Cancer via Oxidative Autophagy Inhibition by Mingyu Park, Jung Seung Nam, Taehyun Kim, Gwangsu Yoon, Seoyoon Kim, Chaiheon Lee, Chae Gyu Lee, Sungjin Park, Kochan S. Bejoymohandas, Jihyeon Yang, Yoon Hee Kwon, Yoo Jin Lee, Jeong Kon Seo, Duyoung Min, Taiho Park, Tae‐Hyuk Kwon

“…However, elevated autophagy levels can promote drug resistance in cancer cells, enhancing their survival. …”
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Serum High-Density Lipoprotein Cholesterol Concentrations in Pancreatic Ductal Adenocarcinoma and Its Association With Histological Grade in a Chinese Population by Ying-Ying Cao PhD, Xiao-Jing Lv MD, Hui Li PhD, Li-Chao Qian PhD, Hai-Peng Si MD, Yuan Li PhD, Kai Guo PhD, Shuai Ren PhD, Zhong-Qiu Wang MD

“…Clinical data, blood biochemical results, imaging features, and pathological details of the patients were collected, such as age, gender, diabetes, hypertension, tumor grade, tumor size and location, high-density lipoprotein (HDL-c), low-density lipoprotein (LDL), total cholesterol (TC), triglycerides (TG), carbohydrate antigen 19-9 (CA19-9), and carcinoembryonic antigen (CEA). Results Patients with high-grade PDAC had significantly lower HDL-c levels compared to those with low-grade PDAC across both training and validation cohorts ( P < 0.05). …”
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A Novel Real-Time Threshold Algorithm for Closed-Loop Epilepsy Detection and Stimulation System by Liang-Hung Wang, Zhen-Nan Zhang, Chao-Xin Xie, Hao Jiang, Tao Yang, Qi-Peng Ran, Ming-Hui Fan, I-Chun Kuo, Zne-Jung Lee, Jian-Bo Chen, Tsung-Yi Chen, Shih-Lun Chen, Patricia Angela R. Abu

“…This research is conducted through innovative algorithms to reduce power consumption and the area of the circuit. It can maintain a high accuracy of more than 90% and perform seizure detection every 64 ms. …”
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NUAK1 acts as a novel regulator of PD-L1 via activating GSK-3β/β-catenin pathway in hepatocellular carcinoma by Chao-Yan Yao, Hang-Tian Tao, Jin-Jin He, Feng-Yi Zhu, Cui-Qing Xie, Yu-Na Cheng, Ji-Qin Li, Zhuang-Zhuang Liu, Chun-Yu Hou, Xue-Li Liu, Yong-Li Fan, Dong Fang, Xin-Rui Lv

“…Both gain and loss of functions have identified NUAK1 promoted PD-L1 expression at transcriptional level in HCC cells. …”
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Prevalence and influencing factors of the dyadic psychological stress among patients with lung cancer and their family caregivers: a cross-sectional study by Juan Li, Chan Li, Jie Zou, Fang-Qun Cheng, Li Peng, Li-Hong Deng, Pei-Pei Wu, Sai-Yu Gao, Zhi-Yao Xiong, Ying Zuo, Yan Luo, Xiao-Hua Rao, Bo Yuan, Ou-Ying Chen, Jing-Ping Zhang

“…Abstract Background A lung cancer diagnosis has a huge impact on the psychological well-being of both patients and family caregivers. …”
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YHSeqY3000 panel captures all founding lineages in the Chinese paternal genomic diversity database by Mengge Wang, Shuhan Duan, Qiuxia Sun, Kaijun Liu, Yan Liu, Zhiyong Wang, Xiangping Li, Lanhai Wei, Yunhui Liu, Shengjie Nie, Kun Zhou, 10K_CPGDP consortium, Yongxin Ma, Huijun Yuan, Bing Liu, Lan Hu, Chao Liu, Guanglin He

“…Abstract Background The advancements in second-/third-generation sequencing technologies, alongside computational innovations, have significantly enhanced our understanding of the genomic structure of Y-chromosomes and their unique phylogenetic characteristics. …”
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Room-temperature creation and conversion of individual skyrmion bags in magnetic multilayered disks by Quan Liu, Shouzhe Dong, Yutong Wang, Junhang Liu, Guofu Xu, Hua Bai, Hao Bai, Weideng Sun, Zhiying Cheng, Yunjie Yan, Guozhi Chai, Jing Ma, Jianwang Cai, Cheng Song, Wanjun Jiang, Jing Zhu, Cewen Nan, Houbing Huang, Yonggang Zhao

“…Abstract Skyrmion bags, with arbitrary topological charge Q, have recently attracted much interest, since such high-Q topological systems could open a way for topological magnetism research and are promising for spintronic applications with high flexibility for information encoding. …”
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Exploring the antifungal potential of Cannabis sativa-derived stilbenoids and cannabinoids against novel targets through in silico protein interaction profiling by Kevser Kübra Kırboğa, Aman Karim, Ecir Uğur Küçüksille, Mithun Rudrapal, Johra Khan, Raghu Ram Achar, Ekaterina Silina, Natalia Manturova, Victor Stupin

“…The proteins investigated included Glycosylphosphatidylinositol (GPI), Enolase, Mannitol-2-dehydrogenase, GMP synthase, Dihydroorotate dehydrogenase (DHODH), Heat shock protein 90 homolog (Hsp90), Chitin Synthase 2 (CaChs2), and Mannitol-1-phosphate 5-dehydrogenase (M1P5DH), all of which play crucial roles in fungal survival and pathogenicity. …”
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Open surgical repair of an abdominal aortic aneurysm during the second trimester of pregnancy by Ndeye Fatou Sow, MD, Abdoul Ahad Mbengue, MD, Jean Michel Davaine, MD, PhD, Morgane Lemierre, MD, Papa Adama Dieng, MD

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Comparison of Finasteride and Dutasteride on Risk of Prostate Cancer in Patients with Benign Prostatic Hyperplasia: A Pooled Analysis of 15 Real-world Databases by Dae Yul Yang, Won-Woo Seo, Rae Woong Park, Sang Youl Rhee, Jae Myung Cha, Yoon Soo Hah, Chang Won Jeong, Kyung-Jin Kim, Hyeon-Jong Yang, Do Kyung Kim, Ji Yong Ha

“…Conclusions: Using real-world databases, the present study demonstrated that dutasteride was not associated with a lower risk of prostate cancer than finasteride in patients with BPH.…”

Cryogenic III-V and Nb electronics integrated on silicon for large-scale quantum computing platforms by Jaeyong Jeong, Seong Kwang Kim, Yoon-Je Suh, Jisung Lee, Joonyoung Choi, Joon Pyo Kim, Bong Ho Kim, Juhyuk Park, Joonsup Shim, Nahyun Rheem, Chan Jik Lee, Younjung Jo, Dae-Myeong Geum, Seung-Young Park, Jongmin Kim, Sanghyeon Kim

“…Recent results in high-fidelity spin qubits manufactured with a Si CMOS technology, along with demonstrations that cryogenic CMOS-based control/readout electronics can be integrated into the same chip or die, opens up an opportunity to break out the challenges of qubit size, I/O, and integrability. …”
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Metabolomics analysis of anaphylactoid reactions induced by Xueshuantong injection in normal and immunocompromised mice by Xiaoqian Guo, Xiaoqian Guo, Chi Zhang, Chi Zhang, Yingyu Li, Yingyu Li, Yingyu Li, Wen Wen, Wen Wen, Wen Wen, Yinghui He, Feng Tang, Chunming Chen, Chao Hu, Linqi OuYang, Wenlong Liu, Wenlong Liu, Zhenhua Zhu, Hongyu Liu

“…Metabolomic analysis revealed significant metabolic changes in XSTI-treated mice. The metabolic pathways predicted from these different metabolites include biotin metabolism, histidine metabolism, glycerolipid metabolism, bile secretion, arachidonic acid metabolism, sphingolipid metabolism, niacin and nicotinamide metabolism, tryptophan metabolism, steroid biosynthesis, and arginine and proline metabolism.ConclusionResearch indicated that the sensitization of XSTI is dose-dependent, and mice with weakened immune functions exhibit lower sensitivity. …”
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