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IDO1 inhibits ferroptosis by regulating FTO-mediated m6A methylation and SLC7A11 mRNA stability during glioblastoma progression
Published 2025-01-01“…Abstract Indoleamine 2, 3-dioxygenase 1 (IDO1) has been recognized as an enzyme involved in tryptophan catabolism with immunosuppressive ability. …”
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Transketolase attenuates the chemotherapy sensitivity of glioma cells by modulating R-loop formation
Published 2025-01-01“…Mechanistically, chemotherapeutic drugs can facilitate the translocation of TKT protein from the cytosol into the nucleus, where TKT physically interacts with XRN2 to regulate the resolution and removal of R-loops. …”
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5445
Living plastics from plasticizer-assisted thermal molding of silk protein
Published 2025-01-01“…Living materials composed of embedded yet active organisms can leverage endogenous biotic resources to achieve functional materials that align with sustainability goals. …”
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5446
Prevalence and Risk Factors of Asymptomatic Colorectal Polyps in Taiwan
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Pre-immunotherapy alters stereotactic ablative radiotherapy-induced systemic T cell responses in early-stage NSCLC
Published 2025-02-01“…Of note, both SABR and icSABR largely changed TCR clonotypes, which were mainly large clones post-SABR but single clone post-icSABR, and predominantly from terminal effector CD8+ T cells and T helper cells, respectively. …”
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Anesthetic Isoflurane Posttreatment Attenuates Experimental Lung Injury by Inhibiting Inflammation and Apoptosis
Published 2013-01-01“…Moreover, ISO markedly prevented ZY-induced pulmonary cell apoptosis in mice, as reflected by the decrease in expression of procaspase-8, procaspase-3, cleaved caspase-8, and cleaved caspase-3, as well as in caspase-3 activity and Bcl-2-associated X/B-cell lymphoma 2 ratio. …”
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Investigating the Efficacy of the Web-Based Common Elements Toolbox (COMET) Single-Session Interventions in Improving UK University Student Well-Being: Randomized Controlled Trial
Published 2025-01-01“…ObjectiveCOMET (Common Elements Toolbox) is an online self-help SSI that includes behavioral activation, cognitive restructuring, gratitude, and self-compassion. COMET has previously been evaluated in India, Kenya, and the United States with promising results. …”
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Precision Medicine Assessment of the Radiographic Defect Angle of the Intrabony Defect in Periodontal Lesions by Deep Learning of Bitewing Radiographs
Published 2025-01-01“…In this approach, radiographic defect angles of the intrabony defect greater than 37 degrees are classified as severe, while those less than 37 degrees are considered mild. …”
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Lipid Levels and Lung Cancer Risk: Findings from the Taiwan National Data Systems from 2012 to 2018
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Accuracy of Imputation of Microsatellite Markers from BovineSNP50 and BovineHD BeadChip in Hanwoo Population of Korea
Published 2018-03-01“…Until now microsatellite (MS) have been a popular choice of markers for parentage verification. …”
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Biomechanics in the tumor microenvironment: from biological functions to potential clinical applications
Published 2025-01-01“…Abstract Immune checkpoint therapies have spearheaded drug innovation over the last decade, propelling cancer treatments toward a new era of precision therapies. …”
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Genomic characterization of Escherichia coli with a polyketide synthase (pks) island isolated from ulcerative colitis patients
Published 2025-01-01“…Abstract The E. coli strains harboring the polyketide synthase (pks) island encode the genotoxin colibactin, a secondary metabolite reported to have severe implications for human health and for the progression of colorectal cancer. …”
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Soluble Epoxide Hydrolase Inhibitor and 14,15-Epoxyeicosatrienoic Acid-Facilitated Long-Term Potentiation through cAMP and CaMKII in the Hippocampus
Published 2017-01-01“…TPPU- or 14,15-EET-facilitated FSK-mediated LTP can be potentiated by an A1 adenosine receptor antagonist and a phosphodiesterase inhibitor, but is prevented by a cAMP-dependent protein kinase (PKA) inhibitor. sEHI and 14,15-EET upregulated the activation of extracellular signal-regulated kinases (ERKs) and Ca2+/calmodulin- (CaM-) dependent protein kinase II (CaMKII). …”
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Burnout, anxiety and depression in healthcare workers during the early COVID-19 period in Singapore
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Global glucose metabolism rate as diagnostic marker for disorder of consciousness of patients: quantitative FDG-PET study
Published 2025-01-01“…Using the above diagnostic criterion, the diagnostic accuracy yielded an area under the curve (AUC) of 0.89 across the pooled cohort (95%CI 0.79–0.99). …”
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Africa's Lakes : atlas of our changing environment /
Published 2006Table of Contents: “…Case studies of Africa's changing lakes. Case studies: Lake Chad ; Lake Victoria ; Toshka Project -- Images of change : Africa's lakes: Africa's killer lakes ; Lake Alaotra ; Lake Al Wahda ; Lake Cahora Basa ; Challawa Gorge Reservoir ; Lake Chivero ; Lake Djoudj ; Lake Ichkeul ; Lesotho Highlands ; Lake Manantali ; Lake Nakuru ; Lake Sibaya ; Songor Lagoon ; Lake Tonga.…”
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