Supramolecular prodrug inspiried by the Rhizoma Coptidis-Fructus Mume herbal pair alleviated inflammatory diseases by inhibiting pyroptosis by Wenhui Qian, Bei Zhang, Ming Gao, Yuting Wang, Jiachen Shen, Dongbing Liang, Chao Wang, Wei Wei, Xing Pan, Qiuying Yan, Dongdong Sun, Dong Zhu, Haibo Cheng

“…Huanglian-Wumei decoction (HLWMD) is a classic prescription used for treating inflammatory diseases, but the necessity of their combination and the exact underlying anti-inflammatory mechanism have not yet been elucidated. Inspired by the supramolecular self-assembly strategy and natural drug compatibility theory, we successfully obtained berberine (BBR)-chlorogenic acid (CGA) supramolecular (BCS), which is an herbal pair from HLWMD. …”
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Oncometabolite D-2HG drives tumor metastasis and protumoral macrophage polarization by targeting FTO/m6A/ANGPTL4/integrin axis in triple-negative breast cancer by Siyue Zhang, Ning Zhang, Tong Wan, Yinqiao He, Jie Hao, Yiwei Liu, Yidong Liu, Bing Chen, Wenjing Zhao, Lijuan Wang, Dan Luo, Chao Gao, Qifeng Yang

“…Abstract Background D-2-hydroxyglutarate (D-2HG), an oncometabolite derived from the tricarboxylic acid cycle. Previous studies have reported the diverse effects of D-2HG in pathophysiological processes, yet its role in breast cancer remains largely unexplored. …”
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Delta-Like-1 Changes the Immunomodulatory Property of OP9 Cells by Lei Zhang, Rui-Jie Dang, Yan-Mei Yang, Dian-Chao Cui, Ping Li, Yan-Li Ni, Tong Hao, Changyong Wang, Xiao-Xia Jiang, Nan-Zhu Fang

“…However, the immunomodulatory capacity of OP9 or OP9DL1 on mature B and T cell proliferation has not been elucidated. Here, we show that OP9 and OP9DL1 have similar proliferation capacities and immunophenotypes except DL1 expression. …”
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An Optimized Anti-adherence and Anti-biofilm Assay: Case Study of Zinc Oxide Nanoparticles versus MRSA Biofilm by Hefa Mangzira Kemung, Loh Teng-Hern Tan, Kooi Yeong Khaw, Yong Sze Ong, Chim Kei Chan, Darren Yi Sern Low, Siah Ying Tang, Bey-Hing Goh

“…In recent years, zinc oxide nanoparticles (ZnO-NPs) has emerged as a prospective candidate for new anti-biofilm agents. …”
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Perioperative Animal Care for Xenotransplantation from Genetically Edited Pigs to Monkeys by ZHU Chan, ZHANG Dongliang, ZHAO Deli, SHI Xueqin, QIAN Lei, ZHANG Xuan, JIN Yan, DUAN Wei, QI Ruocheng, LIU Chaohua, YANG Xuekang, HAN Juntao, PAN Dengke

“…Conclusion Proper care and wound protection during xenotransplantation from genetically edited pigs to monkeys not only promote wound healing, but also alleviate pain and harm to animals. This has significant implications for advancing experimental research in pig-monkey xenotransplantation and enhancing animal welfare.…”
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Interleukin-12p35 Deficiency Reverses the Th1/Th2 Imbalance, Aggravates the Th17/Treg Imbalance, and Ameliorates Atherosclerosis in ApoE-/- Mice by Ying Huang, Haiying Hu, Ling Liu, Jing Ye, Zhen Wang, Bin Que, Wenjing Liu, Ying Shi, Tao Zeng, Lei Shi, Qingwei Ji, Chao Chang, Yingzhong Lin

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Generation and characterization of three induced pluripotent stem cell lines for modeling coronary artery vasospasm by Ines Ross Tacco, Joseph Olshausen, Tse Yuan Chan, Naima Turbes, Ming-Yow Hung, Chi-Tai Yeh, Patricia K. Nguyen, Karim Sallam, Nazish Sayed, Ian Y. Chen

“…Coronary artery vasospasm (CAV) is characterized by transient constriction of epicardial coronary arteries leading to angina. …”
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Mesenchymal stromal cell-derived extracellular vesicles as nanotherapeutics for concanavalin a-induced hepatitis: modulating the gut‒liver axis by Fan Yang, Beibei Ni, Xiaoqi Liang, Yizhan He, Chao Yuan, Jiajie Chu, Yiju Huang, Hongyu Zhong, Li Yang, Jianxi Lu, Yan Xu, Qi Zhang, Wenjie Chen

“…Abstract Background As cell-free nanotherapeutics, extracellular vesicles derived from mesenchymal stem cells (MSC-EVs) have shown potential therapeutic action against liver diseases. …”
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Mesenchymal stem cells from perinatal tissues promote diabetic wound healing via PI3K/AKT activation by Jiawei Huang, Qingwen Deng, Lai Ling Tsang, Guozhu Chang, Jinghui Guo, Ye Chun Ruan, Chi Chiu Wang, Gang Li, Hon Fai Chan, Xiaohu Zhang, Xiaohua Jiang

“…Mesenchymal stem cell (MSC) therapies have emerged as a promising alternative, given their potential to modulate various pathways involved in wound healing. …”
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Simplified Assessment of Antiretroviral Adherence and Prediction of Virological Efficacy in HIV-Infected Patients in Cambodia by Olivier Segeral, Yoann Madec, Boroath Ban, Vara Ouk, Chan Roeurn Hak, Clotilde Le Tiec, Eric Nerrienet, Cécile Goujard, Anne Marie Taburet, Jean Francois Delfraissy, Arnaud Fontanet

“…Adherence to antiviral therapy is important for HIV-infected people living in low- and middle-income countries, because of poor access to alternative regimens. …”
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Applying Concepts of Curriculum Design and Cultural Adaptation: Collaborating on a Dual-Degree Occupational Therapy Program in Mainland China by Julie McLaughlin Gray, Ling Yu (Elena) Meng, Adley Chan, Cameron Chang, Yijun Liu, Liguo Qian, Hui Wang, Ninghua Wang, Yanyan Yang, Mouwang Zhou, Grace T. Baranek

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Uncovering the whole genome silencers of human cells via Ss-STARR-seq by Xiusheng Zhu, Lei Huang, Chao Wang, Guoli Li, Biao Deng, Dashuai Kong, Xiaoxiao Wang, Rongrong Chang, Yi Gu, Qiuhan Wen, Siyuan Kong, Yuwen Liu, Yubo Zhang

“…Additionally, the silencer did not have any significant histone markers at the genome-wide level. …”
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Association between Metformin and a Lower Risk of Age-Related Macular Degeneration in Patients with Type 2 Diabetes by Yu-Yen Chen, Ying-Cheng Shen, Yun-Ju Lai, Chun-Yuan Wang, Keng-Hung Lin, Shih-Chao Feng, Chiao-Ying Liang, Li-Chen Wei, Pesus Chou

“…After adjusting for confounders, the metformin group had a significantly lower risk of AMD (adjusted HR = 0.54; 95% confidence interval [CI], 0.50–0.58). …”
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Efficacy of PD-1 blockade plus chemotherapy in patients with oncogenic-driven non-small-cell lung cancer by Haowei Wang, Lei Cheng, Jian Chen, Peixin Chen, Zhuoran Tang, Qianyi Wang, Ying Ma, Chao Zhao, Xuefei Li, Tao Jiang, Fei Zhou, Xiaoxia Chen, Caicun Zhou

“…Abstract Background PD-1 blockade plus chemotherapy has become the first-line standard of care for patients with advanced non-small-cell lung cancer (NSCLC) without oncogenic drivers. …”
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Exploring the role of internal social media in fostering employee green behavior (EGB) by Peggy M.L. Ng, Tai Ming Wut, Jason K.Y. Chan, Mei Mei Lau, Cherry T.Y. Cheung, Man Lung Jonathan Kwok, Ellesmere T.K. Choy

“…Previous research has consistently highlighted the impact of internal communication strategies on employees’ pro-environmental behavior. …”
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Investigation on Circadian Regulation of Four-Primary LED Display Differed in People by GA by Wenhui Li, Junying Li, Yating Feng, Yi Lin, Haoyang Liu, Ruoping Lian, Qinzhen Lin, Jingyi Cui, Zixin Huang, Yaling Chai, Ziquan Guo, Lili Zheng, Zhong Chen

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Reconstruction and computational analysis of the microRNA regulation gene network in wheat drought response mechanisms by M. A. Kleshchev, A. V. Maltseva, E. A. Antropova, P. S. Demenkov, T. V. Ivanisenko, Y. L. Orlov, H. Chao, M. Chen, N. A. Kolchanov, V. A. Ivanisenko

“…These miRNAs regulate many network nodes and are promising candidates for experimental studies to enhance wheat resistance to water deficiency. The results obtained can find application in breeding for the development of new wheat varieties with increased resistance to water deficit, which is of substantial importance for agriculture in the context of climate change.…”
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Single-Nucleus RNA Sequencing Reveals Cellular Transcriptome Features at Different Growth Stages in Porcine Skeletal Muscle by Ziyu Chen, Xiaoqian Wu, Dongbin Zheng, Yuling Wang, Jie Chai, Tinghuan Zhang, Pingxian Wu, Minghong Wei, Ting Zhou, Keren Long, Mingzhou Li, Long Jin, Li Chen

“…Meat quality indicators, such as the proportion of muscle fibers and intramuscular fat (IMF) deposition, vary during the growth and development of pigs. Numerous studies have highlighted the heterogeneous nature of skeletal muscle, with phenotypic differences reflecting variations in cellular composition and transcriptional profiles. …”
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Impact of liver graft steatosis on long-term post-transplant hepatic steatosis and fibrosis via magnetic resonance quantification by Lung-Yi Mak, Lung-Yi Mak, James Fung, James Fung, James Fung, James Fung, Gladys Lo, Christine Shing-Yen Lo, Trevor Kwan-Hung Wu, Matthew Shing-Hin Chung, Tiffany Cho-Lam Wong, Tiffany Cho-Lam Wong, Wai-Kay Seto, Wai-Kay Seto, Albert Chi-Yan Chan, Albert Chi-Yan Chan, Man-Fung Yuen, Man-Fung Yuen

“…BackgroundThe rising prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) has led to an increased occurrence of steatotic liver grafts (SLG) in liver transplantation (LT). …”
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COVID-19 vaccination and cerebral small vessel disease progression—A prospective cohort study by Yiu Ming Bonaventure Ip, Sangqi Pang, Alan Yao, Lucas Lau, Anki Miu, Katarina Chiu, Ho Ko, Andrew Kwok, Helen Y Chan, Sharon Lee, Howard Chan, Trista Hung, Bonnie Lam, Vincent Hui, Haipeng Li, Lin Shi, Jill Abrigo, Xinyi Leng, Yannie Soo, Sze Ho Ma, Vincent CT Mok, Hugh S Markus, Chris Mok, David SC Hui, Thomas W Leung

“…Objectives: The association between SARS-CoV-2 spike protein and cerebrovascular diseases raised a concern of cerebrovascular safety of COVID-19 vaccines. …”
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