Incidence and Clinical Features of Urethral Injuries with Pelvic Fractures in Males: A 6-Year Retrospective Cohort Study at a Single Institution in South Korea by Hyun Woo Sun, Hohyun Kim, Chang Ho Jeon, Jae Hoon Jang, Gil Hwan Kim, Chan Ik Park, Sung Jin Park, Jae Hun Kim, Seok Ran Yeom

“…Purpose Severe pelvic fractures are associated with genitourinary injuries, but the relationship between pelvic trauma and concomitant urethral injuries has yet to be elucidated. This study evaluated the incidence, mechanism, site, and extent of urethral injuries in male patients with pelvic fractures. …”
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Packed bed optofluidic microreactors with Au decorated TiO2 nanoflowers for visible light photocatalytic water purification by Yujiao Zhu, Pui Hong Yeung, Tsz Wing Lo, Yao Chai, Yat Lam Wong, Ying Chen, Huaming Yang, Weixing Yu, Anatoly V. Zayats, Fengjia Xie, Xuming Zhang

“…Optofluidic microreactors can address these constraints, yet optimizing reactor configurations and photocatalyst designs remains challenging. …”
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Investigating service delivery and perinatal outcomes during the low prevalence first year of COVID-19 in a multiethnic Australian population: a cohort study by Vincent W Lee, N Wah Cheung, Dharmintra Pasupathy, Sarah J Melov, James Elhindi, Therese M McGee, Seng Chai Chua, Justin McNab, Thushari I Alahakoon

“…Further research is suggested to understand the drivers for these changes.…”
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Network pharmacology: a crucial approach in traditional Chinese medicine research by Yiyan Zhai, Liu Liu, Fanqin Zhang, Xiaodong Chen, Haojia Wang, Jiying Zhou, Keyan Chai, Jiangying Liu, Huiling Lei, Peiying Lu, Meiling Guo, Jincheng Guo, Jiarui Wu

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Tailoring IPM plans to fight a cloaked pest: helping smallholder farmers combat the sweetpotato weevil in sub-Saharan Africa by Chad A. Keyser, Frederick S. Walters, Haley Turner, Elka Armstrong, Jeff Davis, Brooke Bissinger, Brant Johnson, Agnes Alajo, Paul Musana, Joseph Odongo, Benard Yada, Milton A. Otema

“…However, yield per hectare is considerably lower in SSA than from other regions primarily due to sweetpotato weevils (SPW, Cylas spp., Coleoptera: Brentidae). …”
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The Use of Mebendazole in COVID-19 Patients: An Observational Retrospective Single Center Study by Mostafa W. Galal, Mahmoud Ahmed, Yanqiu Shao, Chao Xing, Wael Ali, Abd Elhamid Baly, Abdallah Elfiky, Khaled Amer, John Schoggins, Hesham A. Sadek, Zeinab N. Gobara

“…An in-silico screen identified mebendazole with potential antiviral activity that could be a repurposed drug against SARS-CoV-2. Mebendazole is a well-tolerated and cheap antihelminthic agent that is readily available worldwide and thus could be a therapeutic tool in the fight against COVID-19. …”
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Akkermansia muciniphila and its metabolite propionic acid maintains neuronal mitochondrial division and autophagy homeostasis during Alzheimer’s disease pathologic process via GPR4... by Zifan Wang, Cai Wang, Boyu Yuan, Li Liu, Haoming Zhang, Mingqiang Zhu, Hongxia Chai, Jie Peng, Yanhua Huang, Shuo Zhou, Juxiong Liu, Liyong Wu, Wei Wang

“…In addition, short-chain fatty acids (SCFA) produced by intestinal microbiota metabolism have been considered to be important factors affecting central nervous system (CNS) homeostasis. …”
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Contributions of Mamu-A*01 status and TRIM5 allele expression, but not CCL3L copy number variation, to the control of SIVmac251 replication in Indian-origin rhesus monkeys. by So-Yon Lim, Tiffany Chan, Rebecca S Gelman, James B Whitney, Kara L O'Brien, Dan H Barouch, David B Goldstein, Barton F Haynes, Norman L Letvin

“…CCL3 is a ligand for the HIV-1 co-receptor CCR5. There have recently been conflicting reports in the literature concerning whether CCL3-like gene (CCL3L) copy number variation (CNV) is associated with resistance to HIV-1 acquisition and with both viral load and disease progression following infection with HIV-1. …”
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The Three-Dimensional Culture System with Matrigel and Neurotrophic Factors Preserves the Structure and Function of Spiral Ganglion Neuron In Vitro by Gaoying Sun, Wenwen Liu, Zhaomin Fan, Daogong Zhang, Yuechen Han, Lei Xu, Jieyu Qi, Shasha Zhang, Bradley T. Gao, Xiaohui Bai, Jianfeng Li, Renjie Chai, Haibo Wang

“…Three-dimensional (3D) cultures have been demonstrated to have many biomedical applications, but the effect of 3D culture in maintaining the SGNs structure and function in explant culture remains uninvestigated. …”
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Artificially Cultivated Ophiocordyceps sinensis Alleviates Diabetic Nephropathy and Its Podocyte Injury via Inhibiting P2X7R Expression and NLRP3 Inflammasome Activation by Chao Wang, Xiao-xia Hou, Hong-liang Rui, Li-jing Li, Jing Zhao, Min Yang, Li-jun Sun, Hong-rui Dong, Hong Cheng, Yi-Pu Chen

“…ACOS also significantly antagonized all the above changes. Conclusion. Our research work suggests that P2X7R and NLRP3 inflammasome are involved in the pathogenesis of DN, and ACOS can effectively inhibit the high expression of P2X7R and the activation of NLRP3 inflammasome, which may contribute to the therapeutic effects of Ophiocordyceps sinensis.…”
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Alarmins and their pivotal role in the pathogenesis of spontaneous abortion: insights for therapeutic intervention by Qiqi Zhang, Dandan Yang, Xingxing Han, Yu Ren, Yongqi Fan, Chao Zhang, Lei Sun, Tingting Ye, Qiushuang Wang, Youhao Ban, Yunxia Cao, Huijuan Zou, Zhiguo Zhang

“…Spontaneous abortion (SA) is a common pregnancy-related disease, and its pathogenesis has been puzzling clinicians, so it needs to be further studied. …”
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Integrated single-cell and bulk transcriptome analysis of R-loop score-based signature with regard to immune microenvironment, lipid metabolism and prognosis in HCC by Long Chen, Houzhi Yang, Xianfu Wei, Xianfu Wei, Jianchao Liu, Xiuxin Han, Chao Zhang, Yongheng Liu, Yan Zhang, Yao Xu, Yiqin Li, Guowen Wang, Jinyan Feng

“…This study aimed to construct an R-loop scoring signature centered on prognosis and lipid metabolism, thereby enhancing our understanding of HCC progression and identifying potential therapeutic targets.MethodsIn this study, we utilized the single-cell RNA-sequencing (scRNA-seq) data from HCC patients (GSE149614 and CRA002308) to construct an R-loop scoring model based on the identified R-loop regulator genes (RLRGs) related to HBV infection through WGCNA analysis. …”
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Enhancing chemotherapy response prediction via matched colorectal tumor-organoid gene expression analysis and network-based biomarker selection by Wei Zhang, Chao Wu, Hanchen Huang, Paulina Bleu, Wini Zambare, Janet Alvarez, Lily Wang, Philip B. Paty, Paul B. Romesser, J. Joshua Smith, X. Steven Chen

“…This work was supported by National Institutes of Health (NIH) under the following grants: T32CA009501-31A1 and R37CA248289. This work was also supported by the MSK P30CA008748 grant.…”
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Predicting hepatocellular carcinoma outcomes and immune therapy response with ATP-dependent chromatin remodeling-related genes, highlighting MORF4L1 as a promising target by Chao Xu, Litao Liang, Guoqing Liu, Yanzhi Feng, Bin Xu, Deming Zhu, Wenbo Jia, Jinyi Wang, Wenhu Zhao, Xiangyu Ling, Yongping Zhou, Wenzhou Ding, Lianbao Kong

“…Experimental validation was conducted using quantitative real-time Polymerase Chain Reaction (qRT-PCR), Western blotting, and functional assays in HCC cell lines and xenograft models. …”
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Effect of Traditional Chinese Medicine Baduanjin exercise combined with remote ischemic conditioning on mild cognitive impairment after stroke (中医传统功法八段锦联合远隔缺血适应治疗脑卒中后轻度认知障碍的效果研究)... by XUE CHAO (薛超), LI Juan (李娟), FANG Qian (方茜), CHEN Lihua (陈丽华), HAO Mingqing (郝明青), CHEN Zuoxiu (陈作秀)

“…Results After 12-week intervention, the scores of Montreal Cognitive Assessment (MoCA), Modified Barthel Index (MBI) and Stroke-specific Quality of Life Scale (SS-QOL) were significantly better than those before the intervention in both groups (P＜0. 01), and scores of the intervention group were significantly higher than those of control group (P＜0. 01). …”
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Neuromorphic-enabled video-activated cell sorting by Weihua He, Junwen Zhu, Yongxiang Feng, Fei Liang, Kaichao You, Huichao Chai, Zhipeng Sui, Haiqing Hao, Guoqi Li, Jingjing Zhao, Lei Deng, Rong Zhao, Wenhui Wang

“…NEVACS adopts event camera, CPU, spiking neural networks deployed on a neuromorphic chip, and achieves sorting throughput of 1000 cells/s with relatively economic hybrid hardware solution (~$10 K for control) and simple-to-make-and-use microfluidic infrastructures. …”
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Acupotomy and Thread-embedding Acupuncture Combined with Korean Medicine Treatments for Adhesive Capsulitis of the Hip: A Case Report and Literature Review by Seungeun Lee, Jaeho Song, Jinkyung Park, Chan-Ju Im, Jung-Hyun Kim, Bonhyuk Goo, Yeon-Cheol Park, Yong-Hyeon Baek, Sang-Soo Nam, Byung-Kwan Seo

Neural Plastic Effects of Cognitive Training on Aging Brain by Natalie T. Y. Leung, Helena M. K. Tam, Leung W. Chu, Timothy C. Y. Kwok, Felix Chan, Linda C. W. Lam, Jean Woo, Tatia M. C. Lee

“…Increasing research has evidenced that our brain retains a capacity to change in response to experience until late adulthood. …”
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De Novo Sequencing and Characterization of the Transcriptome of Dwarf Polish Wheat (Triticum polonicum L.) by Yi Wang, Chao Wang, Xiaolu Wang, Fan Peng, Ruijiao Wang, Yulin Jiang, Jian Zeng, Xing Fan, Houyang Kang, Lina Sha, Haiqin Zhang, Xue Xiao, Yonghong Zhou

“…In this study, a transcriptome, including 76,014 unigenes, was assembled from dwarf polish wheat (DPW) roots, stems, and leaves using the software of Trinity. Among these unigenes, 61,748 (81.23%) unigenes were functionally annotated in public databases and classified into differentially functional types. …”
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Establishment of a Model of Microencapsulated SGC7901 Human Gastric Carcinoma Cells Cocultured with Tumor-Associated Macrophages by Jin-Ming Zhu, Xiu-Lian Quan, Shi-Chao Han, Xue-Jun Fan, He-Ming Li, Shan-Shan Liang, Xi Chen, Ruo-Yu Wang, Xue-Ning Ji

“…Our study confirms the successful establishment of the microencapsulated GC cells. TAMs can promote PCNA, VEGF, MMP-2, and MMP-9 expressions of the GC cells.…”
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