Patterns of pharmacological treatment in patients with atrial fibrillation: an analysis from the prospective GLORIA-AF Registry Phase III by Bernadette Corica, Giulio Francesco Romiti, Giuseppe Boriani, Brian Olshansky, Tze-Fan Chao, Menno V. Huisman, Marco Proietti, Gregory Y. H. Lip, on behalf of the GLORIA-AF Investigators

“…Methods Based on data from the prospective global GLORIA-AF Registry Phase III (recruiting patients with AF and CHA2DS2-VASc score ≥ 1), we performed a latent class analysis to identify treatment patterns based on 14 drug classes including cardiovascular (CV) and non-CV drugs. …”
Get full text

Retrospective comparative survival analysis of ablation plus systemic therapy versus systemic therapy alone for breast cancer liver metastases, stratified by extrahepatic metastase... by Xuxiazi Zou, Hong-Liang Zou, Xuan Luo, Xu-Wei Chen, Wei-Ling Huang, Chao Zhang, Ge Ren, Jin-Hua Huang, Xue Han, Yi-Quan Jiang

Get full text

Canadian Thoracic Society Guidelines for Occupational Asthma by Susan M Tarlo, Louis-Philippe Boulet, André Cartier, Donald Cockcroft, Johanne Côtè, Frederick E Hargreave, Linn Holness, Gary Liss, Jean-Luc Malo, Moira Chan-Yeung

Get full text

Structural insights on anti-biofilm mechanism of heated slightly acidic electrolyzed water technology against multi-resistant Staphylococcus aureus biofilm on food contact surface by Pianpian Yan, Ramachandran Chelliah, Kyoung Hee Jo, Xiuqin Chen, Akanksha Tyagi, Hyeon Yeong Jo, Fazle Elahi, Nam Chan Woo, Min Seung Wook, Deog Hwan Oh

“…Slightly acidic electrolyzed water (SAEW) has proven to be an efficient and novel sanitizer in food and agriculture field. …”
Get full text

Current Status of Trace Metal Pollution in Soils Affected by Industrial Activities by Ehsanul Kabir, Sharmila Ray, Ki-Hyun Kim, Hye-On Yoon, Eui-Chan Jeon, Yoon Shin Kim, Yong-Sung Cho, Seong-Taek Yun, Richard J. C. Brown

Get full text

SELP+ TEC:CD8+ T cell crosstalk associates with improved radiotherapy efficacy in cervical cancer by Qingyu Huang, Wenhui Yang, Fuhao Wang, Rui Huang, Qian Wang, Xiaohui Li, Tianyu Lei, Shengqin Yue, Wenxue Zou, Qi An, Jinbo Yue, Qinyong Hu, Chao Liu

“…Abstract P-selectin (SELP) expression in tumor cells has been implicated in promoting tumor progression and treatment resistance across various cancers. …”
Get full text

Improving Autonomous Vehicle Cognitive Robustness in Extreme Weather With Deep Learning and Thermal Camera Fusion by Mehmood Nawaz, Sheheryar Khan, Muhammad Daud, Muhammad Asim, Ghazanfar Ali Anwar, Ali Raza Shahid, Ho Pui Aaron HO, Tom Chan, Daniel Pak Kong, Wu Yuan

“…In autonomous vehicles (AV), sensor fusion methods have proven to be effective in merging data from multiple sensors and enhancing their perception capabilities. …”
Get full text

Recent progress in triboelectric platforms: engineering materials to industrial applications from the perspective of manufacturing by Yoonsang Ra, Minjun Song, Donghan Lee, Sunmin Jang, Yu-seop Kim, Joonmin Chae, Sumin Cho, Dongik Kam, Donghyun Lee, Gibeom Lee, Younghoon Lee, Dongwhi Choi

“…As a result, different manufacturing processes can be implemented as needed. Because the practical process can have a synergetic effect on the fundamental development, resulting in the growth of both, the development of the triboelectric platform from the standpoint of manufacturing engineering can be further advanced. …”
Get full text

Improving tropical cyclone rapid intensification forecasts with satellite measurements of sea surface salinity and calibrated machine learning by Ryan Eusebi, Hui Su, Longtao Wu, Pingping Rong, Karthik Balaguru, Ruby Leung, Yong-Sang Choi, Pak Wai Chan, Jianping Gan, Mark DeMaria, Galina Chirokova

“…One under-researched factor that affects TC intensification is salinity, which is important for density stratification in certain ocean regions and can affect the surface enthalpy flux under a strengthening hurricane. …”
Get full text

Could the Injury Severity Score be a new indicator for surgical treatment in patients with traumatic splenic injury? by HyeJeong Jeong, SungWon Jung, Tae Gil Heo, Pyong Wha Choi, Jae Il Kim, Sung Min Jung, Heungman Jun, Yong Chan Shin, Eunhae Um

“…Results When analyzed with the chi-square test and t-test, splenectomy was associated with a systolic blood pressure lower than 90 mmHg, a Glasgow Coma Scale score lower than 13, active bleeding found on computed tomography, a splenic laceration grade greater than or equal to 4, and an ISS greater than 15 at presentation. …”
Get full text

Association of HLA Genotype and Fulminant Type 1 Diabetes in Koreans by Soo Heon Kwak, Yoon Ji Kim, Jeesoo Chae, Cue Hyunkyu Lee, Buhm Han, Jong-Il Kim, Hye Seung Jung, Young Min Cho, Kyong Soo Park

“…A histidine residue at HLA-DRβ1 position 13 was marginally associated with increased risk of fulminant T1DM (OR, 2.45; 95% CI ,1.01 to 5.94; p = 0.054). Although we had limited statistical power, we provide evidence that HLA haplotype and amino acid change can be a genetic risk factor of fulminant T1DM in Koreans. …”
Get full text

Molecular Imaging of Hypoxia-Inducible Factor 1α and von Hippel-Lindau Interaction in Mice by Clara Y.H. Choi, Denise A. Chan, Ramasamy Paulmurugan, Patrick D. Sutphin, Quynh-Thu Le, Albert C. Koong, Wayne Zundel, Sanjiv S. Gambhir, Amato J. Giaccia

“…Under normoxia, HIF-1α is hydroxylated on prolines 402 and 564 and is targeted for ubiquitin-mediated degradation by interacting with the von Hippel-Lindau protein complex (pVHL). We have developed a novel method of studying the interaction between HIF-1α and pVHL using the split firefly luciferase complementation-based bioluminescence system in which HIF-1α and pVHL are fused to amino-terminal and carboxy-terminal fragments of the luciferase, respectively. …”
Get full text

Comparing physician associates and foundation year two doctors-in-training undertaking emergency medicine consultations in England: a mixed-methods study of processes and outcomes by Simon de Lusignan, Mary Halter, Carly Wheeler, Laura Nice, Sally Brearley, James Ennis, Jonathan Gabe, Heather Gage, Phil Begg, Chao Wang, Jim Parle, Vari Drennan

“…Objectives To compare the contribution of physician associates to the processes and outcomes of emergency medicine consultations with that of foundation year two doctors-in-training.Design Mixed-methods study: retrospective chart review using 4 months’ anonymised clinical record data of all patients seen by physician associates or foundation year two doctors-in-training in 2016; review of a subsample of 40 records for clinical adequacy; semi-structured interviews with staff and patients; observations of physician associates.Setting Three emergency departments in England.Participants The records of 8816 patients attended by 6 physician associates and 40 foundation year two doctors-in-training; of these n=3197 had the primary outcome recorded (n=1129 physician associates, n=2068 doctor); 14 clinicians and managers and 6 patients or relatives for interview; 5 physician associates for observation.Primary and secondary outcome measures The primary outcome was unplanned re-attendance at the same emergency department within 7 days. …”
Get full text

Synthesis and Characterization of 5-Fluoroacil Loaded Calcium Carbonate Nanoparticles for Targeted Cancer Therapy by Kshidan Marim Abdullah Salem, Mohamed Ahmed Ibrahim, Kim Wei Chan, Md Zuki Abu Bakar, Noorjahan Banu Alitheen, Mohammed Alsubbi, Ahmad Faizal Abdull Razis, Norsharina Ismail

“…1736142025"> Chemotherapy is often limited by its systemic toxicity and lack of specificity, necessitating the development of targeted drug delivery systems that can enhance therapeutic efficacy while minimizing adverse effects. …”
Get full text

Role of solute elements in Mg-Mg2Ni hydrogen storage alloys: A first-principles calculation study by Min-Seok Yoon, Jae Hur, Seo-Hui Park, Ui-Jong Lee, Guanglong Xu, Hyung-Ki Park, Byeong-Chan Suh, Young Min Kim, Won-Seok Ko

“…In particular, qualitatively valid information for predicting changes in plateau pressures in the pressure-composition-temperature (PCT) curve was provided by calculating changes in the energy of related hydrogenation reactions. …”
Get full text

Changes in flavor profile of sauce-flavor baijiu: Perceptual interactions between 1-propanol and aroma compounds by Han Zhao, Li-Juan Chai, Wei Zhang, Xiao-Juan Zhang, Zhen-Ming Lu, Song-Tao Wang, Cai-Hong Shen, Jin-Song Shi, Zheng-Hong Xu

“…However, the mechanism by which it affects the aroma of sauce-flavor Baijiu has not been fully investigated. In this study, an instrumental and perceptual analysis was employed to assess the impact of 1-propanol on the flavor and volatile compounds in sauce-flavor Baijiu. …”
Get full text

Variation in human gut microbiota impacts tamoxifen pharmacokinetics by Yasmine Alam, Sheron Hakopian, Lizett Ortiz de Ora, Ian Tamburini, Julio Avelar-Barragan, Sunhee Jung, Zane Long, Alina Chao, Katrine Whiteson, Cholsoon Jang, Elizabeth Bess

“…Such differential inter-individual response has a significant socioeconomic impact as one in eight women will develop breast cancer and nearly half a million people in the United States are treated with tamoxifen annually. …”
Get full text

Inflammatory Bowel Disease Patients Are Frequently Nonadherent to Scheduled Induction and Maintenance Infliximab Therapy: A Canadian Cohort Study by Christopher Ma, Chad J Evaschesen, Grenvil Gracias, Vivian W Huang, Darryl K Fedorak, Karen I Kroeker, Levinus A Dieleman, Brendan P Halloran, Richard N Fedorak

“…BACKGROUND: Adherence to maintenance medication regimens in inflammatory bowel disease patients has traditionally been poor. Although infliximab has demonstrated efficacy in inducing and maintaining disease remission, adherence to regularly scheduled infliximab infusions is required to maintain therapeutic trough drug levels and prevent the development of anti-infliximab antibodies.…”
Get full text

Magnetic Foreign Body Ingestion in Children: The Attractive Hazards by Anna Lin, Lawrence Chi Ngong Chan, Kam Lun Ellis Hon, Siu Yan Bess Tsui, Kristine Kit Yi Pang, Hon Ming Cheung, Alexander K. C. Leung

“…However, on occasion, they can also be a rare cause of morbidity and even mortality, such as in the case of multiple magnetic foreign body ingestion, which can cause injury via magnetic attraction through bowel walls. …”
Get full text

Mechanism of stable lithium plating and stripping in a metal-interlayer-inserted anode-less solid-state lithium metal battery by Dong-Su Ko, Sewon Kim, Sangjun Lee, Gabin Yoon, Daeho Kim, ChaeHo Shin, Dongmin Kim, Jaewoo Lee, Soohwan Sul, Dong-Jin Yun, Changhoon Jung

“…Abstract To reliably operate anode-less solid-state Li metal batteries, wherein precipitated Li acts as the anode, stabilizing the interface between the solid electrolyte and electrode is crucial. The interface can be controlled by a metal interlayer on the electrolyte to form a Li alloy buffer that facilitates stable Li plating/stripping, thereby mitigating the loss of physical contact and preventing short circuits. …”
Get full text