Theaflavin Ameliorates Cerebral Ischemia-Reperfusion Injury in Rats Through Its Anti-Inflammatory Effect and Modulation of STAT-1 by Fei Cai, Cai-Rong Li, Ji-Liang Wu, Jian-Guo Chen, Chao Liu, Qing Min, Wei Yu, Chang-Han Ouyang, Jin-He Chen

“…Phosphorylation of STAT-1, a protein which mediates intracellular signaling to the nucleus, was enhanced 2-fold over that of sham group and was inhibited by theaflavin. Our study demonstrated that theaflavin significantly protected neurons from cerebral ischemia-reperfusion injury by limiting leukocyte infiltration and expression of ICAM-1, and suppressing upregulation of inflammatory-related prooxidative enzymes (iNOS and COX-2) in ischemic brain via, at least in part, reducing the phosphorylation of STAT-1.…”
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The compound (E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer’s disease by Xueyan Liu, Wei Wu, Xuejuan Li, Chengyan Wang, Ke Chai, Fanru Yuan, Huijuan Zheng, Yuxing Yao, Chenlu Li, Zu-Cheng Ye, Daijun Zha

“…Previous studies have shown that the compound (E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one (D30), a pyromeconic acid derivative, possesses antioxidant and anti-inflammatory properties, inhibits amyloid-β aggregation, and alleviates scopolamine-induced cognitive impairment, similar to the phase III clinical drug resveratrol. …”
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Imaging study of adult coccygeal morphology using direct digital radiography technology in China by Yingsen Pan, Feipeng Qin, Yi Shen, Ndalyolusha Tileinge Hapulile, Haoyang Zhang, Xin Ye, Shuailin Li, Xiaoming Li, Chao Yang, Xiang Zhou, Xiaoming Ying

“…Abstract Extensive studies on the morphological characteristics of the coccyx, using CT or MRI techniques, have been conducted in some European and Asian countries. …”
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Association between cytokines and progression-free survival in ovarian cancer following CRS/HIPEC treatment by Chao-Yu Chen, Ting-Yao Wang, Jing-Lan Liu, Yu-Che Ou, Li-Wen Lee, Chien-Hui Hung, Chuan-Pin Lee, Jrhau Lung

“…Lower IL-13 change and higher GROα change were associated with better progression-free survival (PFS) (p = 0.002 and p = 0.025, respectively). …”
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Thrombolytic therapy for patients with acute ischemic stroke: systematic review and network meta-analysis of randomized trials by Li-Chao-Yue Sun, Wen-Shu Li, Wei Chen, Zhao Ren, Chun-Xing Li, Ze Jiang, Le Wang, De-Li Wang, Qing Xie

“…When considering a good functional outcome at 90 days, tenecteplase had an OR of 1.03 (95% CI: 0.81 to 1.3, P = 0.82), while reteplase had an OR of 1.15 (95% CI: 0.61 to 2.19, P = 0.66). …”
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Exploring the significance of medical humanities in shaping internship performance: insights from curriculum categories by Chao Ting Chen, Anna Y.Q. Huang, Po-Hsun Hou, Ji-Yang Lin, His-Han Chen, Shiau-Shian Huang, Stephen J. H. Yang

“…Multiple variables regression revealed that MH, after controlling for the scores of other subjects, has the highest odds ratio (OR: 1.29, p < 0.0001) on internship grades. …”
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Clinical Effects of Intra-Abdominal Pressure in Critically Ill Trauma Patients by Dong Yeon Ryu, Hohyun Kim, June Pill Seok, Chan Kyu Lee, Kwang-Hee Yeo, Seon-Uoo Choi, Jae-Hun Kim, Hyun Min Cho

“…The Sequential Organ Failure Assessment (SOFA) score was significantly higher in patients with IAP ≥20 mmHg than in those with IAP <20 mmHg (16 vs. 5, p=0.049). …”
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A Current Overview of Next-Generation Probiotics and Their Prospects in Health and Disease Management by Ke-Yan Loo, Joanne Yuen Heng Thong, Loh Teng-Hern Tan, Vengadesh Letchumanan, Kok-Gan Chan, Learn-Han Lee, Jodi Woan-Fei Law

“…However, emerging research has shifted focus to previously understudied probiotic strains, now known as next-generation probiotics (NGPs), with the aim of harnessing their unique potential to elicit targeted therapeutic effects in disease management. …”
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Recent Trends in the Development and Application of Nano-Antioxidants for Skin-Related Disease by Yi Xue, Tao Wang, Ji-Peng Liu, Qi Chen, Xiao-Long Dai, Min Su, Yu-Hang Cheng, Cheng-Chao Chu, Yun-Qing Ren

“…However, traditional drug therapies have limitations in treating these conditions, such as lack of lasting effect and insufficient skin permeability. …”
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Adhesive polyelectrolyte coating through UV-triggered polymerization on PLGA particles for enhanced drug delivery to inflammatory intestinal mucosa by Jie Zhang, Yi-jing Yin, Xing-wang Wang, Wei-qi Lu, Zhao-yang Chen, Chao-hui Yu, Ke-feng Ren, Cheng-fu Xu

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Natural language processing to identify suicidal ideation and anhedonia in major depressive disorder by L. Alexander Vance, Leslie Way, Deepali Kulkarni, Emily O. C. Palmer, Abhijit Ghosh, Melissa Unruh, Kelly M. Y. Chan, Amey Girdhari, Joydeep Sarkar

“…Conclusions NLP techniques can leverage contextual information in EHRs to identify anhedonia and suicidal symptoms in patients with MDD. …”
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COVID-19 and pediatric out-of-hospital cardiac arrest using U.S. registry database by Christopher Schmitt, Gary Beasley, Karine Guerrier, Jennifer Kramer, Maryam Y. Naim, Heather Griffis, Bryan McNally, Paul S. Chan, Rabab Al-Araji, Joseph Rossano

“…Conclusions: Adolescent populations showed higher rates of OHCAs during the COVID pandemic, especially in areas with higher COVID incidence. Infants, however, had slightly decreased rates, which may be related to changes in other respiratory infections, and parental behavioral changes during the pandemic.…”
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Application of BOPPPS combined with dynamic scenarios simulation in ICU clinical nursing teaching (BOPPPS结合动态情景模拟在ICU护理教学中的应用) by CHEN Xi (陈曦), LI Baoyu (李宝妤), WANG Lingling (王玲玲), ZHANG Chao (张超), XIU Limin (修立敏)

“…The experimental group had higher evaluation on the teaching effect of BOPPPS combined with dynamic scenario simulation. …”
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Trans-Septal Myocardial Biopsy in Hypertrophic Cardiomyopathy Using the Liwen Procedure: An Introduction of a Novel Technique by Chao Han, Mengyao Zhou, Rui Hu, Bo Wang, Lei Zuo, Jing Li, Shengjun Ta, David H. Hsi, Jiani Liu, Lichun Wei, Liwen Liu

“…Conclusion. This study has shown that myocardial biopsy of the Liwen procedure is relatively safe and technically feasible with adequate tissue sampling, which may help pathological diagnosis and further research of HOCM of diverse etiologies. …”
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Case Study of Ground-Based Glaciogenic Seeding of Clouds over the Pyeongchang Region by Ha-Young Yang, Ki-Ho Chang, Sanghee Chae, Eunsil Jung, Seongkyu Seo, Jin-Yim Jeong, Jung-Ho Lee, Yonghun Ro, Baek-Jo Kim

“…In one case that did not show changes after seeding, it is analyzed that a sufficient cloud depth was not supplied to the seeding region due to the blocking effect of the Taebaek Mountains.…”
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Relationship between Serum Cytokeratin-18, Control Attenuation Parameter, NAFLD Fibrosis Score, and Liver Steatosis in Nonalcoholic Fatty Liver Disease by Sumitro Kosasih, Wong Zhi Qin, Rafiz Abdul Rani, Nazefah Abd Hamid, Ngiu Chai Soon, Shamsul Azhar Shah, Yazmin Yaakob, Raja Affendi Raja Ali

“…Using CAP, AUROC curves for detection of S≥2 and S≥3 were good (0.76, 0.77, respectively). …”
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Plasma fibronectin is a prognostic biomarker of disability in Parkinson’s disease: a prospective, multicenter cohort study by Shuzhen Zhu, Hualin Li, Zifeng Huang, Yiheng Zeng, Jianmin Huang, Guixia Li, Shujuan Yang, Hang Zhou, Zihan Chang, Zhenchao Xie, Rongfang Que, Xiaobo Wei, Minzi Li, Yanran Liang, Wenbiao Xian, Mengyan Li, Ying Pan, Fanheng Huang, Lin Shi, Chengwu Yang, Chao Deng, Lucia Batzu, Karolina Poplawska-Domaszewicz, Shuhan Chen, Ling-Ling Chan, K Ray Chaudhuri, Eng-King Tan, Qing Wang

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Engineered CRISPR-Cas9 for Streptomyces sp. genome editing to improve specialized metabolite production by Duck Gyun Kim, Boncheol Gu, Yujin Cha, Jeonghan Ha, Yongjae Lee, Gahyeon Kim, Byung-Kwan Cho, Min-Kyu Oh

“…Abstract The CRISPR-Cas9 system has frequently been used for genome editing in Streptomyces; however, cytotoxicity, caused by off-target cleavage, limits its application. …”
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Ten-year outcomes of repeat keratoplasty for optical indications by Victoria Grace Dimacali, Hon Shing Ong, Hon Shing Ong, Hon Shing Ong, Hon Shing Ong, Stephanie Shuang Lang, Hla Myint Htoon, Hla Myint Htoon, Howard Cajucom-Uy, Hui Chen Charmaine Chai, Hui Chen Charmaine Chai, Marcus Ang, Marcus Ang, Anshu Arundhati, Anshu Arundhati, Anshu Arundhati, Jodhbir S. Mehta, Jodhbir S. Mehta, Jodhbir S. Mehta

“…Graft rejection (38.4%) and late endothelial failure (15.8%) were the main causes of initial graft failure. PK/EK and EK/EK had better one-year postoperative best corrected visual acuity compared to PK/PK (p = 0.006 and p &lt; 0.001 respectively). …”
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Role of Cone Beam Computed Tomography in Rehabilitation of a Traumatised Deficient Maxillary Alveolar Ridge Using Symphyseal Block Graft Placement by Shipra Arora, Arundeep Kaur Lamba, Farrukh Faraz, Shruti Tandon, Abdul Ahad

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