Spatial transcriptomics reveals unique metabolic profile and key oncogenic regulators of cervical squamous cell carcinoma by Limin Zhou, Jiejie Liu, Peipei Yao, Xing Liu, Fei Chen, Yu Chen, Li Zhou, Chao Shen, You Zhou, Xin Du, Junbo Hu

“…Abstract Background As a prevalent and deadly malignant tumor, the treatment outcomes for late-stage patients with cervical squamous cell carcinoma (CSCC) are often suboptimal. Previous studies have shown that tumor progression is closely related with tumor metabolism and microenvironment reshaping, with disruptions in energy metabolism playing a critical role in this process. …”
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Repeatability and reproducibility of a new spectral-domain optical coherence tomography biometer and agreement with swept-source optical coherence tomography based biometer by Xin Li, Chak Seng Lei, Rui Ning, Luze Liu, Aodong Chen, Xinning Yang, Giacomo Savini, Domenico Schiano-Lomoriello, Xingtao Zhou, Jinhai Huang

“…Except J45 and PD, the ICCs were all higher than 0.928. The reproducibility Sw and TRT values of Colombo IOL were also low, and ICCs were not lower than 0.900. …”
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IL-1β and Allergy: Focusing on Its Role in Allergic Rhinitis by Han-Rui Wang, Shi-Zhuang Wei, Xiao-Yu Song, Yao Wang, Wen-Bin Zhang, Chao Ren, Ya-Kui Mou, Xi-Cheng Song

“…It has been proposed that IL-1β may be a potential biomarker of AR. …”
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Clinical efficacy of Tuina therapy combined with traditional Chinese exercises in the treatment of symptomatic lumbar disc herniation: a multicentre randomised controlled trial pro... by Zhihong Fan, Shenghong Jia, Xin Zhou, Chao Li, Jiahao Shao, Xiaofeng Liu, Yitao Liao, Yenan Xu, Dandan He, Shixiang Wu, Xian Zhang

“…proj=209956, identifier ChiCTR2300077361.…”
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Foliar application of nano biochar solution elevates tomato productivity by counteracting the effect of salt stress insights into morphological physiological and biochemical indice... by Javeria Shahzadi, Zaib-un-Nisa, Naila Ali, Muhammad Iftikhar, Anis Ali Shah, M. Yasin Ashraf, Chen Chao, Shifa Shaffique, Mansour K. Gatasheh

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Anti-Inflammatory Effect of Columbianetin on Lipopolysaccharide-Stimulated Human Peripheral Blood Mononuclear Cells by Junying Lu, Keyong Fang, Shiji Wang, Lingxin Xiong, Chao Zhang, Zhongmin Liu, Xuewa Guan, Ruipeng Zheng, Guoqiang Wang, Jingtong Zheng, Fang Wang

“…Although the anti-inflammatory effect of CBT has been reported, its anti-inflammatory mechanism was poorly studied. …”
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Corrigendum to “p85α Inactivates MMP-2 and Suppresses Bladder Cancer Invasion by Inhibiting MMP-14 Transcription and TIMP-2 Degradation” [Neoplasia (2019) 21, 908–920] by Jingjing Wang, Ning Zhang, Minggang Peng, Xiaohui Hua, Chao Huang, Zhongxian Tian, Qipeng Xie, Junlan Zhu, Jingxia Li, Haishan Huang, Chuanshu Huang

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Bindarit attenuates neuroinflammation after subarachnoid hemorrhage by regulating the CCL2/CCR2/NF-κB pathway by Yanting Yao, Qiaowei Wu, Kaikun Yuan, Pei Wu, Chao Xu, Zhiyong Ji, Weishi Xu, Hongli Yu, Anyu Xu, Yanchen Liu, Huaizhang Shi

“…Bindarit, an inhibitor of chemokine CC motif ligand 2(CCL2), has been shown to demonstrate neuroprotective effects in various central nervous system diseases. …”
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Three-dimensional Middle Infrared Spectroscopy Study on Crystalline and Amorphous Structures and Thermostability of Corn, Wheat, and Pea Starch by KONG Xiao-mei, DU Lin-nan, JIANG Meng-wei, CHAI Jia-xin, CHANG Mei-ling, ZHANG Yong, CHANG Ming, XU Yuan-yuan

“…The structures of the three types of starch are sensitive to temperature changes, with the amorphous structure being the first to change and the crystalline structure being relatively stable. …”
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Ir-6: A Novel Iridium (III) Organometallic Derivative for Inhibition of Human Platelet Activation by Ren-Shi Shyu, Themmila Khamrang, Joen-Rong Sheu, Chih-Wei Hsia, Marappan Velusamy, Chih-Hsuan Hsia, Duen-Suey Chou, Chao-Chien Chang

“…Platelet activation has been reported to play a major role in arterial thrombosis, cancer metastasis, and progression. …”
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Model Optimization of Shale Gas Reservoir Volume Fracturing Dissolved Gas Simulation Adsorbed Gas by Hao Dong, Yi Zhang, Zongwu Li, Chao Jiang, Jiaze Li, Tao Wu, Liting Wang, Chuangjiang Wang, Hao Wang, Fujing Li, Qian Ru

“…Shale reservoirs have some natural fractures with a certain density and connectivity. …”
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Transcriptome Analysis of Interspecific Hybrid between Brassica napus and B. rapa Reveals Heterosis for Oil Rape Improvement by Jinfang Zhang, Guangrong Li, Haojie Li, Xiaobin Pu, Jun Jiang, Liang Chai, Benchuan Zheng, Cheng Cui, Zujun Yang, Yongqing Zhu, Liangcai Jiang

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Improving the Detection, Assessment, Management and Prevention of Delirium in Hospices (the DAMPen-D study): protocol for a co-design and feasibility study of a flexible and scalab... by Najma Siddiqi, Chao Huang, Maureen Twiddy, Miriam Johnson, Margaret Ogden, Kathryn Sartain, Imogen Featherstone, Jason Boland, Mark Pearson, Catriona Jackson, Gillian Jackson

“…Descriptive statistics, rapid thematic analysis and a realist logic of analysis will be used be used to analyse quantitative and qualitative data, as appropriate.Ethics and dissemination Ethical approval obtained: Hull York Medical School Ethics Committee (Ref 21/23), Health Research Authority Research Ethics Committee Wales REC7 (Ref 21/WA/0180) and Health Research Authority Confidentiality Advisory Group (Ref 21/CAG/0071). Written informed consent will be obtained from interview participants. …”
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Optimizing photoperiods for enhanced microalgae-based phycoremediation of food wastewater in Malaysia by Abdul Ghani Syamimi Afiqah, Chng Lee Muei, Yeap Swee Pin, Chan Derek Juinn Chieh, Geng Jing, Leong Sim Siong, Toh Pey Yi

“…While Chlorella vulgaris has shown promise in wastewater treatment, the optimal light/dark photoperiod regimes for maximizing biomass growth, nutrient removal efficiency, and COD reduction remain underexplored. …”
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Serum Soluble ST2 Correlated with Symptom Severity and Clinical Response of Sublingual Immunotherapy for House Dust Mite-Induced Allergic Rhinitis Patients by Kang Zhu, Cui Xia, Jingguo Chen, Chao Yu, Tianxi Gao, Jing Yan, Na Shao, Pin Zhu, Bin Sun, Xiaoyong Ren, Yanni Zhang

“…Receiver operating characteristic (ROC) curve showed promising accuracy for predicting clinical efficacy of SLIT in AR patients (area under the curve=0.839, P<0.001). …”
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Prevalence and distribution of hypertension and related risk factors in Jilin Province, China 2015: a cross-sectional study by Bin Liu, Wei Sun, Junduo Wu, Tianyi Li, Xianjing Song, Yangyu Zhang, Yingyu Liu, Longbo Li, Yunpeng Yu, Yihang Liu, Chao Qi

“…Moreover, the prevalence of hypertension increased with age in both sexes, and was higher in men than in women. The modifiable factors that were associated with hypertension were body mass index, smoking and alcohol drinking. …”
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Water Accounting and Productivity Analysis to Improve Water Savings of Nile River Basin, East Africa: From Accountability to Sustainability. by Hirwa, Hubert, Zhang, Qiuying, Li, Fadong, Qiao, Yunfeng, Measho, Simon, Muhirwa, Fabien, Xu, Ning, Tian, Chao, Cheng, Hefa, Chen, Gang, Ngwijabagabo, Hyacinthe

“…Climate change impacts on drylands pose more vexing risks to socio-ecological systems, resulting in food security issues, biodiversity loss, and livelihood shifts in Africa. …”
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Immune checkpoint inhibitor-induced severe epidermal necrolysis mediated by macrophage-derived CXCL10 and abated by TNF blockade by Chun-Bing Chen, Shuen-Iu Hung, John Wen-Cheng Chang, Chan-Keng Yang, David Hui-Kang Ma, Yu-Chuan Teng, Chun-Wei Lu, Wei-Ti Chen, Hsiao-Yin Yang, Cheng-Chang Tsai, Chih Liang Wang, Pin-Hsuan Chiang, Jennifer Wu, Ya-Wen Tsai, Lai-Ying Lu, Yang Yu-Wei Lin, Rosaline Chung-Yee Hui, Fu-Mei Hsieh, Chao-Kai Hsu, Chaw-Ning Lee, Yi-Ju Chen, Chih-Chiang Chen, Yilei Cui, Hung-Chih Hsu, Ya-Ching Chang, Chih-Jung Chang, Ho-Chen Lin, Chee Jen Chang, Yu-Jr Lin, Cheng-Lung Ku, Chuang-Wei Wang, Wen-Hung Chung

“…Abstract Immune checkpoint inhibitors (ICI) represent new anticancer agents and have been used worldwide. However, ICI can potentially induce life-threatening severe cutaneous adverse reaction (SCAR), such as Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), hindering continuous ICI therapy. …”
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Changes of Regulatory T Cells and of Proinflammatory and Immunosuppressive Cytokines in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis by Yong-chao Qiao, Jian Shen, Lan He, Xue-zhi Hong, Fang Tian, Yan-hong Pan, Ling Liang, Xiao-xi Zhang, Hai-lu Zhao

“…The aim of this study was to investigate the changes of regulatory T cells (Treg), interleukin-6 (IL-6), IL-10, transforming growth factor-β (TGF-β), and tumor necrosis factor-alpha (TNF-α) in patients with type 2 diabetes mellitus (T2DM). …”
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Pyruvate-Enriched Oral Rehydration Solution Improves Glucometabolic Disorders in the Kidneys of Diabetic db/db Mice by Xiao Meng Zhang, Hao Deng, Jin Dong Tong, Yi Zhen Wang, Xu Chao Ning, Xiu Hong Yang, Fang Qiang Zhou, Hui Min Jin

“…Both Pyr-ORS and 1% pyruvate showed comparable therapeutic effectiveness with controls of body weight and blood sugar, increases of blood insulin levels, and improvement of renal function and pathological changes. Aberrant key enzyme activities in glucometabolic pathways, AR, PK, and PDK/PDH, were also restored; indexes of oxidative stress and inflammation, NAD+/NADH ratio, and AGEs in the kidneys were mostly significantly preserved after pyruvate treatments. …”
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