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    Effectiveness and Safety of Immunotherapy for Hepatocellular Carcinoma in Clinical Practice: A Brazilian Multicenter Study by Leonardo Gomes da Fonseca, Cecília Souza Freire, Rodrigo Antonio Vieira Guedes, Marcos Castro Lyra, Maria Ignez Freitas Melro Braguiroli, Mariana Bruno Siqueira, Maria De Lourdes Lopes de Oliveira, Alexandre de Mendonça Palladino, Henry Luiz Najman, Rodrigo Tancredi, Duilio Reis Da Rocha Filho, Markus Cavalcante Gifoni, Guilherme Luiz Stelko Pereira, Marcela Crosara Alves Teixeira, Lucila Soares Da Silva Rocha, Raimundo Paraná, Paulo Marcelo Hoff

    Published 2025-07-01
    “…Albumin-bilirubin grade 2 to 3, metabolic dysfunction–associated steatotic liver disease, and esophagogastric varices were independently associated with reduced OS.CONCLUSIONIn a real-world setting, immunotherapy-based treatments demonstrated effectiveness and safety profiles consistent with clinical trials, although survival was influenced by liver function, etiology, and baseline variceal status. …”
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    Quantitative and structural features of the SMN1 and SMN2 genes in patients with spinal muscular atrophy 5q by A. I. Vlasenko, V. D. Nazarov, S. V. Lapin, A. V. Mazing, E. A. Surkova, T. V. Blinova, T. M. Alekseeva

    Published 2024-12-01
    “…The clinical picture of the disease is heterogeneous and varies depending on the age of onset and the ability to perform motor functions. Several genetic and molecular modifiers have been identified that are thought to influence the severity of SMA. …”
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    Preoperative pectoralis muscle index predicts distant metastasis-free survival in non-small cell lung cancer patients: a retrospective study by Zhihui Shi, Lin Wu, Dengke Jiang, Ruiling Yang, Rui Liao, Lizhu Liu, Ruimin You, Yanli Li, Xingxiang Dong, Dafu Zhang, Jing Wang, Xuewen Zhang, Xiaobo Chen, Zhenhui Li

    Published 2025-08-01
    “…Abstract Background Thoracic muscles contribute to respiration, is a crucial indicator for assessing functional recovery following lung resection. However, there is a lack of research on the long-term prognostic value of pectoralis muscle. …”
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    Self-organizing expert communities in educational projects by Gennadiy P. Vinogradov, Vladimir N. Kuznetsov

    Published 2018-03-01
    “…The proposed approach allows considering the process of extracting new ideas and knowledge when forming a specialist’s knowledge model as an active system with heterogeneous agents with a counter way of sharing information and active influence of the center in the form of queries to obtain reflexive estimates. …”
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