Mechanosensitive nuclear checkpoint: nuclear envelope as a sensor of chromosomal instability and driver of cell fate by Chenyang Ji, Junwei Chen, Fuxiang Wei

“…The nuclear envelope (NE) is a dynamic, mechanosensitive structure that functions as a protective barrier for the genome and serves as a checkpoint responding to external stimuli. …”
Get full text

MORPHOLOGICAL CONDITION OF THE MUCOUS DURING THE PERIOD OF PHYSIOLOGICAL CHANGE OF THE CANINES OF THE UPPER JAW by M. Cholovskyi

“…The study of the features of the morphological structure of the gums during the change of temporary canines suggests that signs of inflammation prevail in the mucous membrane, which are more pronounced in the vestibular areas. …”
Get full text

Characteristics of the microvascular bed of rats’ testis exposed to electromagnetic field and using immunomodulator. by Ye. N. Sharapova

“…There were neither spasms of arteries, which formed cellular structure in the testicular tissue, no edematous signs. …”
Get full text

HEAD AND NECK SQUAMOUS CELL CARCINOMA DEPENDING ON THE MORPHOLOGICAL CHARACTERISTICS OF THE PRIMARY TUMOR by V. A. Bychkov, L. N. Bondar, E. L. Choynzonov, V. M. Perelmuter

“…Objective: to analyze the association of 5 types of cellular structures of squamous cell carcinoma with major clinical and morphological tumor characteristics. …”
Get full text

Effects of Volatile Substances from Trichoderma erinaceum M6-5 on the Cell Membrane and Wall of Alternaria alternata, a Postharvest Pathogen of Korla Fragrant Pear by HUANG Wei, WANG Ning, SONG Bo, LIU Fengjuan, ZHANG Miaomiao,, WANG Suling, WU Longyuan, ZHANG Lijuan, WANG Wei

“…For the control group, the mycelium growth was normal, the spore structure was complete, the cross-section structure was clear, the cytoplasm was uniform, and the cell wall and membrane structures were normal. …”
Get full text

Scaffold-hopping for molecular glues targeting the 14-3-3/ERα complex by Markella Konstantinidou, Marios Zingiridis, Marloes A. M. Pennings, Michael Fragkiadakis, Johanna M. Virta, Jezrael L. Revalde, Emira J. Visser, Christian Ottmann, Luc Brunsveld, Constantinos G. Neochoritis, Michelle R. Arkin

“…Rational structure-guided optimization is facilitated by multiple crystal structures of ternary complexes with the glues, 14-3-3 and phospho-peptides mimicking the highly disordered C-terminus of ERα. …”
Get full text

Chemical Biology of G-quadruplex and i-motif DNA: use of topologically constrained DNA by Dejeu, Jérôme, Defrancq, Eric

“…We have developed chemical tools named TASQ (Template-Assembled Synthetic Quadruplex) to address the following scientific goals: (i) identify unambiguous (i.e., affine and specific) G4- and i-DNA-interacting ligands, (ii) identify proteins interacting with those structures and determine their cellular relevance and (iii) select specific antibodies for G4 and i-DNA. …”
Get full text

Membraneless organelles in health and disease: exploring the molecular basis, physiological roles and pathological implications by Yangxin Li, Yuzhe Liu, Xi-Yong Yu, Yan Xu, Xiangbin Pan, Yi Sun, Yanli Wang, Yao-Hua Song, Zhenya Shen

“…Abstract Once considered unconventional cellular structures, membraneless organelles (MLOs), cellular substructures involved in biological processes or pathways under physiological conditions, have emerged as central players in cellular dynamics and function. …”
Get full text

Exploring Solar Granulation: from IMaX/SUNRISE to DKIST by Reza Mansouri, Rafal Angryk, Kevin Reardon

“… Granules are small cellular structures that populate the solar photosphere and are formed by the dynamic behavior of convection cells. …”
Get full text

The Role of Sox17 Gene Expression in Early Definition of Anterior Pole of the Rabbit Embryo at Early Pre-Gastrulation Stages by Baghdad Science Journal

“…These structures are defined morphologically and are called in mouse (AVE), in rabbit (AMC) and in the pig (AHB). …”
Get full text

Biomimetic design and integrated biofabrication of an in-vitro three-dimensional multi-scale multilayer cortical model by Ling Wang, Luge Bai, Sen Wang, Jiajia Zhou, Yingjie Liu, Chenrui Zhang, Siqi Yao, Jiankang He, Chaozong Liu, Dichen Li

“…This study proposes a multi-scale design of a brain-like model with a biomimetic cortical structure, which includes the macroscopic structural features of six layers of different cellular components, as well as micrometer-scale continuous fiber structures running through all layers vertically. …”
Get full text

Preparation and characterization of Ti‒1Al‒8V‒5Fe alloy powders by LI Zeng-feng, TAN Ping, SHEN Lei, ZHAO Shao-yang, WANG Li-qing, LI Ai-jun, YIN Jing-ou

“…The powders with the particle size larger than 124 μm show the cellular dendrite structure with the small amount of rough and uneven micro pores on the surface of powders. …”
Get full text

Computational prediction of deleterious nonsynonymous SNPs in the CTNS gene: implications for cystinosis by Leila Adda Neggaz, Amira Chahinez Dahmani, Ibtissem Derriche, Nawel Adda Neggaz, Abdallah Boudjema

“…These mutations disrupt cystine efflux, leading to its accumulation in lysosomes and subsequent cellular damage. While more than 140 mutations have been identified, the functional and structural impacts of many nonsynonymous single nucleotide polymorphisms (nsSNPs) remain poorly understood. …”
Get full text

Cryo-electron tomography pipeline for plasma membranes by Willy W. Sun, Dennis J. Michalak, Kem A. Sochacki, Prasanthi Kunamaneni, Marco A. Alfonzo-Méndez, Andreas M. Arnold, Marie-Paule Strub, Jenny E. Hinshaw, Justin W. Taraska

“…Abstract Cryo-electron tomography (cryoET) provides sub-nanometer protein structure within the dense cellular environment. Existing sample preparation methods are insufficient at accessing the plasma membrane and its associated proteins. …”
Get full text

Coordinated synthesis of aromatic amino acid derived pigments in yeast via global transcriptional engineering by Huimin Xue, Mingshan Li, Yuhui Cui, Dongkui Tian, Duo Liu, Hanjie Wang

“…Conclusions Our strategy supplies an effective way to optimize the coordinated synthesis of two structurally divergent pigments downstream of the common aromatic amino acid pathway.…”
Get full text

The use of intuitive AF-based modelling for the understanding of activation and signalling through insulin-like receptors by Andrzej M. Brzozowski, Talha Shafi, Olga V. Moroz, Pierre De Meyts

“…They tend to occlude the transmembrane (TM) and intra-cellular parts of the receptors, which, together with their inherent dynamic characters, prohibits - so far - determination of their full, continuous structures. …”
Get full text

The Competitive Loss of Cerebellar Granule and Purkinje Cells Driven by X-Linked Mosaicism in a Female Mouse Model of CASK-Related Disorders by Takuma Mori, Mengyun Zhou, Ken Kunugitani, Taichi Akatsuka, Yukina Yoshida, Emi Kouyama-Suzuki, Shin Kobayashi, Yoshinori Shirai, Katsuhiko Tabuchi

Get full text

Identification of RING E3 pseudoligases in the TRIM protein family by Jane Dudley-Fraser, Diego Esposito, Katherine A. McPhie, Coltrane Morley-Williams, Tania Auchynnikava, Katrin Rittinger

“…Here, we present parallel in cellulo, in vitro, and in silico structure-function analyses of the ubiquitin E3 ligase activity and RING domain structural characteristics of the whole TRIM protein family. …”
Get full text

Integrative glycomic analysis reveals the crucial role of protein glycosylation in fungal pathogenesis. by Heeji Moon, Eun Jung Thak, Yejin Choi, Sieun Kim, Jiyeun Park, Nahyun Lee, Soobin Shin, Hosung Jeon, Jessica Winarto, Soyoung Choi, Ji Young Shin, Jung-Eun Kim, Dae-Geun Song, Hun Kim, Gyung Ja Choi, Hyun Ah Kang, Hokyoung Son

“…Through cell wall component profiling and HPLC analysis, we characterized the overall N- and O-glycan structures in F. graminearum and found that deletion of ALG3 and ALG12 led to truncated core N-glycan structures. …”
Get full text

Exosomes derived from ALR-modified adipose mesenchymal stem cells mediate hepatoprotective effects on hepatic ischemia–reperfusion injury by promoting regeneration and protecting m... by YaJun Ma, Tao Liu, Pujun Li, Lei Cao, Xiangyu Lu, HongBin Wang

“…Their unique lipid bilayer structure gives them the advantages of protecting the contents from degradation, easy cellular uptake, and good passive targeting. …”
Get full text