Research Progress on the Functional Regulation Mechanisms of ZKSCAN3 by Jianxiong Xu, Xinzhe Li, Jingjing Xia, Wenfang Li, Zhengding Su

“…The zinc finger protein with KRAB and SCAN domains 3 (ZKSCAN3) has emerged as a critical regulator of diverse cellular processes, including autophagy, cell cycle progression, and tumorigenesis. …”
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Zinc-based fixative as a novel approach for histological preservation: A comparative study with formalin-based fixatives by Omar Younis Altaey, Ali Ahmed Hasan, Adnan Ali Hasso

“…The histological evaluation, included staining affinity, cellular outline, cytoplasmic and nuclear attributes, and overall tissue structure, was conducted by a panel of academic experts and rated using a scale of poor (1), fair (2), good (3), very good (4), and excellent (5) grades. …”
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Mechanisms of Protection of the Lung by V. V. Moroz, L. M. Tuchina, G. G. Poroshenko

“…There is mechanical protection of the lung from foreign exposures, which consists in the structural functional and morphological features governing the aerodynamic system, kinetic mechanisms (respiratory apparatus movement, bronchial motility, current surface alveolar layer movement), and blood and lymph flows. …”
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Benzbromarone interferes with the interaction between Hsp90 and Aha1 by interacting with both of them by Yan Zhong, Li Shi, Zhuo Xu, Jing Gao, Qingyu Ma, Tianqi Gao, Junying Tang, Muya Xiong, Yechun Xu, Huixiong Dai, Hu Zhou, Naixia Zhang, Chen Zhou

“…Interestingly, as shown by the cryo-EM structures of Hsp90:Aha1 system, it is the same pocket that is involved in the in vitro interaction between Aha1-CTD and Hsp90-MD. …”
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Bioactivity descriptors for uncharacterized chemical compounds by Martino Bertoni, Miquel Duran-Frigola, Pau Badia-i-Mompel, Eduardo Pauls, Modesto Orozco-Ruiz, Oriol Guitart-Pla, Víctor Alcalde, Víctor M. Diaz, Antoni Berenguer-Llergo, Isabelle Brun-Heath, Núria Villegas, Antonio García de Herreros, Patrick Aloy

“…Abstract Chemical descriptors encode the physicochemical and structural properties of small molecules, and they are at the core of chemoinformatics. …”
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Core–Shell PLGA Nanoparticles: In Vitro Evaluation of System Integrity by Tatyana Kovshova, Julia Malinovskaya, Julia Kotova, Marina Gorshkova, Lyudmila Vanchugova, Nadezhda Osipova, Pavel Melnikov, Veronika Vadekhina, Alexey Nikitin, Yulia Ermolenko, Svetlana Gelperina

“…The nanoparticles had negative zeta potentials and sizes ranging from 100 to 250 nm (measured using DLS) depending on the shell structure and preparation technique. The core–shell structure was confirmed using TEM and fluorescence spectroscopy, with the appearance of FRET phenomena due to the donor–acceptor properties of the labels. …”
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Effects of non-contact electric fields on the kidneys and livers of tumour-bearing rats [version 6; peer review: 1 approved, 2 approved with reservations, 1 not approved] by Luthfi Nurhidayat, Ahmad Ghitha Fadhlurrahman, Firman Alamsyah, Warsito Purwo Taruno, Nisrina Firdausi, Subekti Evi Dwi Nugraheni, Rarastoeti Pratiwi

“…Therefore, this study aimed to investigate the effects of non-contact electric field exposure on kidney and liver structures. Methods Female rats were randomly divided into one control group and three treatment groups with six replications each. …”
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Roles of lactylation in lipid metabolism and related diseases by Bing Zhao, Zhuoqing Lan, Caixia Li, Hao Wang

“…Abstract Lipids are indispensable molecules that play key roles in cell physiology by acting as structural elements, energy reservoirs, and participants in signal transduction. …”
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Biomechanical Properties of Bone and Biomechanics of Age - Related Fractures - Review by Rezzan Günaydın, Altınay Göksel Karatepe

“…From a biomechanical viewpoint, fractures are due to a structural failure of the bone. This failure occurs when the forces applied to the bone exceed its load – bearing capacity. …”
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The Final Step in Molybdenum Cofactor Biosynthesis—A Historical View by Ralf R. Mendel, Kevin D. Oliphant

“…This review also highlights key milestones in the study of Mo-insertase, including mutant characterization, gene cloning, structural elucidation at the atomic level, functional domain assignment, and the spatial organization of the enzyme within cellular protein networks.…”
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Spontaneous splenic rupture in dengue fever with non-fatal outcome in an adult by Emmanuel Bhaskar, Swathy Moorthy

“…In due course he developed hypotension and underwent splenectomy. Non-structural protein 1 (NS1) dengue antigen was positive in the admission sample and IgM dengue antibodies were detected in the follow-up sample. …”
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Zero-shot performance analysis of large language models in sumrate maximization. by Ali Abir Shuvro, Md Shahriar Islam Bhuiyan, Faisal Hussain, Md Sakhawat Hossen

“…The experiment also concludes that some variants of the large language models currently in use are not suitable for numerical and structural data without fine-tuning their parameters.…”
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PLATELET-RICH PLASMA IN ANTI-AGING AND AESTHETIC MEDICINE by Yuliya Fedorchenko

“…Skin aging is a multifactorial process influenced by intrinsic and extrinsic factors, leading to structural and functional deterioration, including wrinkles, laxity, pigmentation, and barrier dysfunction. …”
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Biobased Organic Nanoparticles: A Promising Versatile Green Tool for Novel Antimicrobial Agents for Improved Safety by Edith Dube, Grace Emily Okuthe

“…This review comprehensively analyses their structural features, mechanisms of action, and dual roles in infection control and drug delivery. …”
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Functional Role of Hepatitis C Virus NS5A in the Regulation of Autophagy by Po-Yuan Ke, Chau-Ting Yeh

“…Autophagy acts as a catabolic pathway in which unnecessary materials are removed via the lysosome, thus maintaining cellular homeostasis. The HCV non-structural 5A (NS5A) protein is a phosphoprotein required for viral RNA replication, virion assembly, and the determination of interferon (IFN) sensitivity. …”
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Flaviviruses induce ER-specific remodelling of protein synthesis. by Ho Him Wong, Dorian Richard Kenneth Crudgington, Lewis Siu, Sumana Sanyal

“…Here we show that Zika virus bypasses the SRP receptor via extensive interactions between the viral non-structural proteins and the host translational machinery. …”
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Dehydrated Human Amnion–Chorion Membrane as a Bioactive Scaffold for Dental Pulp Tissue Regeneration by Sahng G. Kim

“…The dehydrated human amnion–chorion membranes (dHACMs) derived from the human placenta have emerged as a promising biomaterial for dental pulp regeneration owing to their unique biological and structural properties. The purpose of this review is to explore the potentials of dHACMs in dental pulp tissue engineering, focusing on their ability to promote cellular proliferation, differentiation, angiogenesis, and neurogenesis. dHACMs are rich in extracellular matrix proteins and growth factors such as TGF-β1, FGF2, and VEGF. …”
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Evolutionary plasticity and functional versatility of CRISPR systems. by Eugene V Koonin, Kira S Makarova

“…A major route of innovation in CRISPR evolution is the repurposing of diverged repeat variants encoded outside CRISPR arrays for various structural and regulatory functions. The evolutionary plasticity and functional versatility of CRISPR systems are striking manifestations of the ubiquitous interplay between defense and "normal" cellular functions.…”
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Polymer Design of Microwell Hydrogels Influences Epithelial–Mesenchymal Interactions During Human Bronchosphere Formation by Madeline K. Eiken, Justin E. Levine, Shinyeong Lee, Samantha Lukpat, Eleanor M. Plaster, Vikram Bala, Jason R. Spence, Claudia Loebel

“…The study shows that the cellular composition regulates the formation and structure of the bronchosphere which also depends on the type and adhesiveness of the hydrogel. …”
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Exosomes promise better bone regeneration by Shuaiwen Hu, Shaogeng Wang, Xiaomao Yang, Ping Li, Zhiguo Li, Bin Luo, Yujie Liang, Xiaohua Pan

“…Fractures primarily result from high-energy trauma, leading to structural discontinuity of bone tissue. Contemporary therapeutic approaches continue to face persistent challenges including nonunion, infection, and inflammatory complications that pose significant clinical management difficulties. …”
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