Aging‐Driven Blood–Brain Barrier Dysfunction and Its Impact on CNS Cancer Susceptibility: A Comprehensive Narrative Review by Quang La, Aiman Baloch, David F. Lo

“…ABSTRACT Background Aging significantly affects the structural and functional integrity of the blood–brain barrier (BBB), increasing the susceptibility of the central nervous system (CNS) to both primary and metastatic cancers. …”
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Nanopesticides for managing primary and secondary stored product pests: Current status and future directions by Mohammed Lengichow Kadir, Asli Dageri, Tuğba Nur Aslan

“…Studies demonstrate that NPs of alumina, carbon, silica, silver, copper, zinc oxide, nickel oxide, titanium dioxide, nano zeolite, as well as chitosan and polymers exhibit significant insecticidal activity against a variety of pests, in some cases surpassing mortality rates caused by traditional insecticides at recommended dosages. Structural, biochemical and molecular studies reveal that NPs induce oxidative stress, disrupt cellular homeostasis, and cause structural damage in pests. …”
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Are current atomistic force fields accurate enough to study proteins in crowded environments? by Drazen Petrov, Bojan Zagrovic

“…The high concentration of macromolecules in the crowded cellular interior influences different thermodynamic and kinetic properties of proteins, including their structural stabilities, intermolecular binding affinities and enzymatic rates. …”
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Developing a Standard Tool for Measuring Health Literacy Related to Transfusion-Transmitted Infections by Leila Manzouri MD, Saman Masoudifar PhD, Narges Roustaei PhD, Fariba Rad PhD

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Chemical Constituents and Pharmacological Activities of Steroid Saponins Isolated from Rhizoma Paridis by Fen Liu, Luning Li, Xinchen Tian, Dengtian Zhang, Wenxue Sun, Shulong Jiang

“…In this review, we discussed the chemical structures of steroid saponins and their related biological activity and mechanisms in cellular and animal models, aiming to provide a reference for future comprehensive exploitation and development of saponins.…”
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Virtual library docking for cannabinoid-1 receptor agonists with reduced side effects by Tia A. Tummino, Christos Iliopoulos-Tsoutsouvas, Joao M. Braz, Evan S. O’Brien, Reed M. Stein, Veronica Craik, Ngan K. Tran, Suthakar Ganapathy, Fangyu Liu, Yuki Shiimura, Fei Tong, Thanh C. Ho, Dmytro S. Radchenko, Yurii S. Moroz, Sian Rodriguez Rosado, Karnika Bhardwaj, Jorge Benitez, Yongfeng Liu, Herthana Kandasamy, Claire Normand, Meriem Semache, Laurent Sabbagh, Isabella Glenn, John J. Irwin, Kaavya Krishna Kumar, Alexandros Makriyannis, Allan I. Basbaum, Brian K. Shoichet

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P09 | EFFECTS OF NUTLIN-3A ACTIVITY ON 2D AND 3D RETINOBLASTOMA MODELS

“…Two days after bioprinting, the 3D structures were treated with Nutlin-3a and assessed for viability using MTT 72 h after. …”
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In silico and in vitro analysis of boAP3d1 protein interaction with bovine leukaemia virus gp51. by Adriana Patricia Corredor, Janneth González, Luis Alfredo Baquero, Hernando Curtidor, Nury Nathalia Olaya-Galán, Manuel Alfonso Patarroyo, María Fernanda Gutiérrez

“…Although the bovine adaptor protein 3 complex subunit delta-1 (boAP3D1) has been proposed as the potential receptor, the specific ligand-receptor interaction has not yet been completely defined and boAP3D1 receptor and gp51 3D structures have not been determined. This study was thus aimed at a functional annotation of boAP3D1 cellular adaptor protein and BLV gp51 and, proposing a reliable model for gp51-AP3D1 interaction using bioinformatics tools. …”
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The role of autophagy in periodontal diseases: a bibliometric analysis from 2006 to 2023 by Bitong Zhang, Bitong Zhang, Yahui Wang, Yahui Wang, Yahui Wang, Haoxiang Chang, Haoxiang Chang, Chong Wang, Chong Wang, Hong Fan, Hong Fan, Xiuyun Ren, Xiuyun Ren

“…BackgroundPeriodontal disease is a chronic inflammatory condition affecting the supporting structures of the teeth, involving complex interactions between systemic and local immune responses. …”
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Mitochondria at the crossroads: Quality control mechanisms in neuronal senescence and neurodegeneration by Yifei Zheng, Jiahui Yang, Xuanyao Li, Linjie Qi, Zhuo Zheng, Jiming Kong, Guohui Zhang, Ying Guo

“…Mitochondria play a central role in essential cellular processes, including energy metabolism, biosynthesis of metabolic substances, calcium ion storage, and regulation of cell death. …”
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Calcium Unified: Understanding How Calcium’s Atomic Properties Impact Human Health by Karen B. Kirkness, John Sharkey, Suzanne Scarlata

“…Calcium plays a major role in all cellular functions, and its regulation is important in all aspects of human health. …”
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Transferrin receptors by Qian Guo, Christopher Qian, Xinyu Wang, Zhong-Ming Qian

“…Abstract The transferrin receptor (TfR) is one of the key proteins involved in cellular iron uptake. TfR-mediated endocytosis of transferrin-bound iron is the major pathway for iron acquisition by most cells in the body. …”
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Molecular basis for the calcium-dependent activation of the ribonuclease EndoU by Florian Malard, Kristen Dias, Margaux Baudy, Stéphane Thore, Brune Vialet, Philippe Barthélémy, Sébastien Fribourg, Fedor V. Karginov, Sébastien Campagne

“…We determine the crystal structure of EndoU bound to calcium and find that calcium binding remote from the catalytic triad triggers water-mediated intramolecular signaling and structural changes, activating the enzyme through allostery. …”
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A Society-to-Cells approach to evaluating multilevel and interrelated drivers of breast cancer disparities in Black women by Maurade Gormley, Wayne R. Lawrence, Jesse J. Plascak, Electra D. Paskett, Coral Omene, Adana A. M. Llanos

“…Framed through a Society-to-Cells lens, this review presents a comprehensive framework for understanding how multilevel drivers—from structural forces to cellular responses—interact to perpetuate disparities. …”
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The Complex Interaction of Matrix Metalloproteinases in the Migration of Cancer Cells through Breast Tissue Stroma by Kerry J. Davies

“…In the normal breast, cellular structures change cyclically in response to ovarian hormones leading to regulated cell proliferation and apoptosis. …”
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Developmental characterization of the microRNA-specific C. elegans Argonautes alg-1 and alg-2. by Alejandro Vasquez-Rifo, Guillaume Jannot, Javier Armisen, Michel Labouesse, Syed Irfan Ahmad Bukhari, Evelyne L Rondeau, Eric A Miska, Martin J Simard

“…Embryos without zygotic alg-1/2 predominantly arrest during the morphogenetic process of elongation with defects in the epidermal-muscle attachment structures. Altogether our results highlight similarities and specificities of the alg-1/2 likely to be explained at different cellular and molecular levels.…”
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Molecular basis for new approaches to therapy of osteoarthritis (part I) by E. V. Chetina, G. A. Markova, A. M. Lila

“…The review presents new promising methods in the treatment of OA using stem cells and subcellular structures, based on modern knowledge of molecular and cellular mechanisms that are disrupted during development and disease progression.…”
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Ephaptic conduction molding memory engrams by A. Rabinovitch, R. Rabinovitch, D. Braunstein, E. Smolik, Y. Biton

“…Our model is based on the cellular automata approach, which can specifically distinguish between neurons operated on by the synaptic and those operated on by the ephaptic modes. …”
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Self‐organized partitioning of dynamically localized proteins in bacterial cell division by Barbara Di Ventura, Victor Sourjik

“…Abstract How cells manage to get equal distribution of their structures and molecules at cell division is a crucial issue in biology. …”
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Tertiary lymphoid organs in wild boar exposed to a low-virulent isolate of African swine fever virus by Néstor Porras, José M. Sánchez-Vizcaíno, Antonio Rodríguez-Bertos, Aleksandra Kosowska, José Á. Barasona

“…TLOs in LVI and LVI-HVI groups were located adjacent to the mucosa and presented a similar structure to MALT. Immunoexpresion of p72 observed in the inflammatory cells adjacent to TLOs/MALTs confirmed its development and reactivity generated by ASF attenuated isolates. …”
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