Mechanism of small heat shock protein client sequestration and induced polydispersity by Adam P. Miller, Steve L. Reichow

“…Here, we present high-resolution cryo-EM structures of Methanocaldococcus jannaschii sHSP (mjHSP16.5) in apo and multiple client-bound states. …”
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Advances in Ophthalmic Organ-on-a-Chip Models: Bridging Translational Gaps in Disease Modeling and Drug Screening by Renhao Lu

“…Methods: A narrative review of recent advancements in organ-on-a-chip technology was conducted, focusing on models simulating ocular structures like the retina and cornea and their applications in studying diseases such as dry eye disease (DED), age-related macular degeneration (AMD), and glaucoma. …”
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A kinase-independent function of PAK is crucial for pathogen-mediated actin remodelling. by Anthony Davidson, Joe Tyler, Peter Hume, Vikash Singh, Vassilis Koronakis

“…The p21-activated kinase (PAK) family regulate a multitude of cellular processes, including actin cytoskeleton remodelling. …”
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The short story of the miraculous daily resurrection of life in us by Vukoman Jokanović

“…The complexity and complexity of the human body, countless intertwined feedback loops that regulate internal processes in the body and enable its survival, can best be interpreted at the micro and nano level, ie at the level of the cell and its subcellular structures. This opens up huge potentials for understanding and influencing living systems, but also unlimited challenges for science. …”
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Prospects of emerging 3D bioprinting technologies: major technology components, technology developers, and end users—Part I by Prasanta K. Ghosh

“…Bioprinting technology aims to create 3D structures with living cells to mimic real tissue and organ functions. …”
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Prolonged Pseudohypoxia Targets Ambra1 mRNA to P-Bodies for Translational Repression. by Somayeh Pourpirali, Cristina Valacca, Paola Merlo, Salvatore Rizza, Silvia D'Amico, Francesco Cecconi

“…This condition results in the activation of autophagy, a cyto-protective response involving the formation of double-membraned structures, the autophagosomes, in the cytoplasm. In this study, we investigated the cellular mechanisms regulating the autophagy gene Ambra1, after exposure to a hypoxia mimetic, cobalt chloride (CoCl2). …”
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Genome-wide screen of three herpesviruses for protein subcellular localization and alteration of PML nuclear bodies. by Jayme Salsman, Nicole Zimmerman, Tricia Chen, Megan Domagala, Lori Frappier

“…Twenty-four of the 93 proteins with nuclear localization formed subnuclear structures. Twelve of these localized to the nucleolus, and five at least partially localized with promyelocytic leukemia (PML) bodies, which are known to suppress viral lytic infection. …”
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A tripartite synapse model in Drosophila. by Rie Danjo, Fumiko Kawasaki, Richard W Ordway

“…Here we report a Drosophila tripartite synapse model which exhibits morphological and functional properties similar to those of mammalian synapses, including glial regulation of extracellular glutamate, synaptically-induced glial calcium transients and glial coupling of synapses with tracheal structures mediating gas exchange. In combination with classical and cell-type specific genetic approaches in Drosophila, this model is expected to provide new insights into the molecular and cellular mechanisms of tripartite synapse function.…”
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Advances in understanding the role of pentraxin-3 in lung infections by Li Ma, Dongmei Li, Yiyang Wen, Dongmei Shi, Dongmei Shi

“…Pentraxin-3 (PTX3) is a soluble pattern recognition molecule (PRM) characterized by a C-terminal pentraxin structural domain and a unique N-terminal structural domain. …”
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DPPC Membrane Under Lateral Compression and Stretching to Extreme Limits: Phase Transitions and Rupture by Subhalaxmi Das, Nikos Ch. Karayiannis, Supriya Roy

“…Notably, under compression, the membrane initially thickens, leading to a phase transition to an undulated state between 40 and 50 bar, as gauged by the sharp changes in the diverse structural metrics. Stretching induces systematic membrane thinning, with rupture becoming probable at −170 bar and certain at −200 bar. …”
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A common origin for the bacterial toxin-antitoxin systems parD and ccd, suggested by analyses of toxin/target and toxin/antitoxin interactions. by Andrew B Smith, Juan López-Villarejo, Elizabeth Diago-Navarro, Lesley A Mitchenall, Arjan Barendregt, Albert J Heck, Marc Lemonnier, Anthony Maxwell, Ramón Díaz-Orejas

“…Bacterial toxin-antitoxin (TA) systems encode two proteins, a potent inhibitor of cell proliferation (toxin) and its specific antidote (antitoxin). Structural data has revealed striking similarities between the two model TA toxins CcdB, a DNA gyrase inhibitor encoded by the ccd system of plasmid F, and Kid, a site-specific endoribonuclease encoded by the parD system of plasmid R1. …”
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Telocytes and Atrial Fibrillation: From Basic Research to Clinical Practice by V. I. Podzolkov, A. I. Tarzimanova, A. S. Frolova

“…The emergence of new research methods makes it possible to study the tissue, structural, cellular, and molecular causes of atrial fibrillation (AF). …”
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Insights into the strategy of micro-environmental adaptation: Transcriptomic analysis of two alvinocaridid shrimps at a hydrothermal vent. by Fang-Chao Zhu, Jin Sun, Guo-Yong Yan, Jiao-Mei Huang, Chong Chen, Li-Sheng He

“…Finally, genes related to structural proteins, immune proteins and protectants were overexpressed or positively selected. …”
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Fostering Inflammatory Bowel Disease: Sphingolipid Strategies to Join Forces by Loubna Abdel Hadi, Clara Di Vito, Laura Riboni

“…Complex sphingolipids are essential structural components of intestinal membranes, providing protection and integrity to the intestinal mucosa and regulating intestinal absorption processes. …”
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Biological Insights into Therapeutic Protein Modifications throughout Trafficking and Their Biopharmaceutical Applications by Xiaotian Zhong, Jill F. Wright

“…It also focuses on the underlying mechanisms and structural-functional relationship between modifications and therapeutic properties. …”
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Technology features of decellularization of human liver fragments as tissue-specific fine-grained matrix for cell-engineering liver construction by E. A. Nemets, L. A. Kirsanova, Ju. B. Basok, M. Ju. Schagidulin, E. A. Volkova, S. T. Metelsky, V. I. Sevastianov

“…It was elaborated the algorithm and technology of obtaining of decellularized liver tissue fragments from the human donor liver which saved the structural properties of native ECM of the liver and complete removal of cellular elements and detritus.…”
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Doxorubicin and NFL-TBS.40-63 peptide loaded gold nanoparticles as a multimodal therapy of glioblastoma by Myriam El Moutaoukil, Maria Grazia Lolli, Stefania D’Amone, Memona Khan, Roberta Grillo, Joel Eyer, Maddalena Grieco, Ornella Ursini, Jolanda Spadavecchia, Barbara Cortese

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Immune mapping of the peripheral part of the visual analyzer and optic nerve by V. G. Likhvantseva, K. A. Kuzmin, M. V. Solomatina, E. V. Korosteleva, A. Ben Regeb

“…Complete labelling of retina structures was performed. As a result, IHC profiles of retinal neurons, optic nerve axons, interneurons, and microglial cells were described. …”
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Comparative analysis of amino acid sequence level in plant GATA transcription factors by Mangi Kim

“…Through comparative sequence analysis, I identify conserved domains and structural features that enhance the understanding functional roles, evolutionary conservation, and lineage-specific adaptations of GATA TFs. …”
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TMPRSS2 in microbial interactions: Insights from HKU1 and TcsH. by Zhengyang Pan, Daoqun Li, Leiliang Zhang

“…HKU1 utilizes both sialoglycan and TMPRSS2 for cellular entry, where sialoglycan primes the spike protein for TMPRSS2 binding. …”
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