Structural characterization reveals substrate recognition by the taurine transporter TauT by Hao Xu, Qinru Bai, Han Wang, Jun Zhao, Aiping Guo, Renjie Li, Qihao Chen, Yiqing Wei, Na Li, Zhuo Huang, Yan Zhao

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Structural insights into terminal arabinosylation of mycobacterial cell wall arabinan by Yaqi Liu, Chelsea M. Brown, Satchal Erramilli, Yi-Chia Su, Shih-Yun Guu, Po-Sen Tseng, Yu-Jen Wang, Nam Ha Duong, Piotr Tokarz, Brian Kloss, Cheng-Ruei Han, Hung-Yu Chen, José Rodrigues, Kay-Hooi Khoo, Margarida Archer, Anthony A. Kossiakoff, Todd L. Lowary, Phillip J. Stansfeld, Rie Nygaard, Filippo Mancia

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Capturing protein communities by structural proteomics in a thermophilic eukaryote by Panagiotis L Kastritis, Francis J O'Reilly, Thomas Bock, Yuanyue Li, Matt Z Rogon, Katarzyna Buczak, Natalie Romanov, Matthew J Betts, Khanh Huy Bui, Wim J Hagen, Marco L Hennrich, Marie‐Therese Mackmull, Juri Rappsilber, Robert B Russell, Peer Bork, Martin Beck, Anne‐Claude Gavin

“…Using a structural proteomics approach, we simultaneously characterized the abundance, interactions, and structure of a third of the C. thermophilum proteome within these extracts. …”
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The Effects of Viral Structural Proteins on Acidic Phospholipids in Host Membranes by Ricardo de Souza Cardoso, Akira Ono

“…In particular, the knowledge regarding the relationship between viral structural proteins and acidic phospholipids has been steadily increasing in recent years. …”
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Structural and mechanistic studies of measles virus illuminate paramyxovirus entry. by Richard K Plemper, Melinda A Brindley, Ronald M Iorio

“…Recently reported crystal structures of the MeV attachment protein in complex with its cellular receptors CD46 or SLAM and newly developed functional assays have now illuminated some of the fundamental principles that govern cell entry by this archetype member of the paramyxovirus family. …”
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Structural plasticity of the FOXO-DBD:p53-TAD interaction by Klara Kohoutova, Pavel Srb, Veronika Obsilova, Vaclav Veverka, Tomas Obsil

“…Overall, our findings not only provide the structural insights into interactions between FOXO4 and p53 but also highlight their potential as targets for developing senolytic compounds.…”
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Structural properties of PAS domains from the KCNH potassium channels. by Ricardo Adaixo, Carol A Harley, Artur F Castro-Rodrigues, João H Morais-Cabral

“…To better understand their role we characterized the structural properties of several channel PAS domains. …”
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Functional and structural organization of medial entorhinal cortex layer VI by Märt Rannap, Shinya Ohara, Janis Winterstein, Fabian C. Roth, Andreas Draguhn, Alexei V. Egorov

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Impacts of structural properties of myosin II filaments on force generation by Shihang Ding, Pei-En Chou, Shinji Deguchi, Taeyoon Kim

“…Myosin II plays the most important role in cellular force generation. Myosin II molecules self-assemble into filaments with different structures depending on myosin II isoforms and other conditions such as pH and ionic concentration. …”
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Structural insights into Beclin 1 interactions with it's regulators for autophagy modulation by Debapriyo Sarmadhikari, Shailendra Asthana

“…Since the network can only be traced through structural data, such insights are essential. However, identifying the critical structural and conformational determinants facilitating signalling cascades remains a major challenge for protein-protein interactions (PPIs) based therapeutic interventions. …”
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Structural basis of SIRT7 nucleosome engagement and substrate specificity by Carlos Moreno-Yruela, Babatunde E. Ekundayo, Polina N. Foteva, Dongchun Ni, Esther Calvino-Sanles, Henning Stahlberg, Beat Fierz

“…SIRT7 is an NAD+-dependent deacylase often deregulated in cancer, which deacetylates either H3 lysine 36 (H3K36) or H3K18 with high specificity within nucleosomes. Here, we report structures of nucleosome-bound SIRT7, and uncover the structural basis of its specificity towards H3K36 and K18 deacylation, combining a mechanism-based cross-linking strategy, cryo-EM, and enzymatic and cellular assays. …”
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Structural basis of TMPRSS11D specificity and autocleavage activation by Bryan J. Fraser, Ryan P. Wilson, Sára Ferková, Olzhas Ilyassov, Jackie Lac, Aiping Dong, Yen-Yen Li, Alma Seitova, Yanjun Li, Zahra Hejazi, Tristan M. G. Kenney, Linda Z. Penn, Aled Edwards, Richard Leduc, Pierre-Luc Boudreault, Gregg B. Morin, François Bénard, Cheryl H. Arrowsmith

“…We show these proteases spontaneously and efficiently cleave their own zymogen activation motifs, activating their broader protease activity on cellular substrates. We determine TMPRSS11D co-crystal structures with a native and an engineered activation motif, revealing insights into its autocleavage activation and distinct substrate binding cleft features. …”
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Structural basis for the human SENP5’s SUMO isoform discrimination by Lucía Sánchez-Alba, Li Ying, Matthew D. Maletic, Anna De Bolòs, Helena Borràs-Gas, Bing Liu, Nathalia Varejão, Virginia Amador, Monique P. C. Mulder, David Reverter

“…These results suggest that subtle structural differences within SUMO isoforms can significantly influence their deconjugation by SENP enzymes, opening new avenues for exploring the regulation of SUMOylation in various cellular processes and for developing therapeutic agents targeting SUMOylation pathways.…”
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Structural basis for Retriever-SNX17 assembly and endosomal sorting by Amika Singla, Daniel J. Boesch, Ho Yee Joyce Fung, Chigozie Ngoka, Avery S. Enriquez, Ran Song, Daniel A. Kramer, Yan Han, Esther Banarer, Andrew Lemoff, Puneet Juneja, Daniel D. Billadeau, Xiaochen Bai, Zhe Chen, Emre E. Turer, Ezra Burstein, Baoyu Chen

“…Here, we provide biochemical, structural, cellular, and proteomic analyses of the SNX17-Retriever interaction. …”
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Structure and mechanism of biosynthesis of Streptococcus mutans cell wall polysaccharide by Jeffrey S. Rush, Svetlana Zamakhaeva, Nicholas R. Murner, Pan Deng, Andrew J. Morris, Cameron W. Kenner, Ian Black, Christian Heiss, Parastoo Azadi, Konstantin V. Korotkov, Göran Widmalm, Natalia Korotkova

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Minimal metabolic pathway structure is consistent with associated biomolecular interactions by Aarash Bordbar, Harish Nagarajan, Nathan E Lewis, Haythem Latif, Ali Ebrahim, Stephen Federowicz, Jan Schellenberger, Bernhard O Palsson

“…Here, we introduce an unbiased, pathway structure for genome‐scale metabolic networks defined based on principles of parsimony that do not mimic canonical human‐defined textbook pathways. …”
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Spotlight on USP30: structure, function, disease and target inhibition by Jiapeng Du, Yiyang Gao, Guoqing Xue, Zhuoyue Zhao, Ying Yang, Peng Chu, Xingping Duan

“…This review comprehensively summarizes the current understanding of ubiquitin-specific protease 30 (USP30), covering its structural characteristics, functions in cellular processes, associations with diseases, diagnostic and therapeutic strategies, as well as controversies and future perspectives. …”
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Dishevelled localization and function are differentially regulated by structurally distinct sterols by Sonali Sengupta, Jazmine D.W. Yaeger, Maycie M. Schultz, Danielle G. May, Kyle J. Roux, Kevin R. Francis

“…While DVL binding to cholesterol is required for its membrane association, the specific structural requirements and cellular impacts of DVL-sterol association are unclear. …”
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Optimization of properties and structure of lightweight materials using digital methods by Igor V. Bessonov, Alexey D. Zhukov, Ekaterina Yu. Bobrova, Elina A. Gorbunova, Ilya S. Govryakov

“…The solution to problems aimed at improving the efficiency of construction is closely linked to the use of lightweight mineral materials, which include mineral fibres, foam glass, cold-curing cellular glass, cellular concrete, and foam gypsum. …”
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Manganese Superoxide Dismutase: Structure, Function, and Implications in Human Disease by Jovan Grujicic, Antiño R. Allen

“…Manganese superoxide dismutase (MnSOD) is a vital mitochondrial antioxidant enzyme that preserves cellular integrity by catalyzing the dismutation of superoxide radicals into hydrogen peroxide. …”
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