Analysis of Biomolecular Changes in HeLa Cervical Cancer Cell Line Induced by Interaction with [Pd(dach)Cl₂] by Vanja Ralić, Maja D. Nešić, Tanja Dučić, Milutin Stepić, Lela Korićanac, Katarina Davalieva, Marijana Petković

“…The impact of dichloro(1,2-diaminocyclohexane)palladium(II), [Pd(dach)Cl₂], was studied by synchrotron radiation-based Fourier transform infrared (SR FTIR) spectroscopy, a powerful tool for studying alterations in cellular components’ biochemical composition and biomolecular secondary structure on a single-cell level. …”
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Research Progress on Aflatoxin Inhibitors and Their Mechanisms of Action by Shaowen WU, Weijie ZHOU, Siyuan YANG, Shijuan YAN

“…Further analysis reveals that inhibitors function through five major mechanisms: (1) Disrupting cell membrane structural integrity and mitochondrial respiratory chain function in A. flavus, destroying fundamental cellular physiological structures. (2) Regulating the expression of key genes in the aflatoxin biosynthesis gene cluster and inhibiting activities of key enzymes such as polyketide synthase and monooxygenases, directly blocking aflatoxin biosynthetic pathway. (3) Modulating intracellular reactive oxygen species levels and antioxidant enzyme systems to maintain redox balance. (4) Inhibiting fungal development and differentiation processes, including key stages such as sclerotia formation, asexual reproduction, and spore germination. (5) Promoting detoxification of produced aflatoxins through physical adsorption, biodegradation, and chemical transformation. …”
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Effect of Microwave or Ultrasound Irradiation in the Extraction from Feather Keratin by Isis S. Rodríguez-Clavel, Silvia P. Paredes-Carrera, Sergio O. Flores-Valle, Eri J. Paz-García, Jesús C. Sánchez-Ochoa, Rosa M. Pérez-Gutiérrez

“…Therefore, the feather keratin biopolymer, when modified by microwaves and ultrasound in the recrystallization stage, is a fibrous protein that has good mechanical, structural, morphological, and thermal properties with potential applications such as development of biocompatible materials with cellular interaction and in catalysis as catalytic and enzymatic support to mention just a few.…”
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Activation of the bacterial defense-associated sirtuin system by Kaixiang Zhu, Kun Shang, Linyue Wang, Xia Yu, Lei Hua, Weihe Zhang, Bo Qin, Jia Wang, Xiaopan Gao, Hongtao Zhu, Sheng Cui

“…Herein, we report cryo-EM structures of a free-state Bacillus subtilis DSR2 tetramer and a fragment of the tetramer, a phage SPR tail tube, and two DSR2-TTP complexes. …”
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HBimmCue: A Versatile Fluorescent Probe for Multi‐Scale Imaging of Lipid Polarity and Membrane Order in Inner Mitochondrial Membrane by Shu Gao, Jing Sun, Yiwei Hou, Xichuan Ge, Ming Shi, Hongxi Zheng, Yan Zhang, Meiqi Li, Baoxiang Gao, Peng Xi

“…Here, HBimmCue is introduced as a fluorescent probe localized to inner mitochondrial membrane (IMM) that reports lipid polarity and membrane order changes, which correlate with cellular respiration levels. Using HBimmCue and fluorescence lifetime imaging microscopy (FLIM), IMM lipid heterogeneity is uncovered across scales, from nanoscale structures within individual mitochondria to mouse pre‐implantation embryos. …”
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Bronchial granulocytes in the development of epithelial destruction and oxidative lipid modification in patients with bronchial asthma with cold and osmotic airway hyperresponsiven... by A. B. Pirogov, A. G. Prikhodko, Ju. M. Perelman

“…Objective: to study the role of the structural and functional status of granulocytes in the development of epithelial destruction and oxidative lipid modification in the bronchi of asthma patients with airway hyperresponsiveness to cold and hyperosmolar stimuli. …”
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Borg3 controls septin polymerization for primary cilia formation by Janik N. Schampera, Friederike Lehmann, Ana Valeria Meléndez, Carsten Schwan

“…Summary: Septin GTPases form hexa- or octameric rods that polymerize into higher order structures and integrate into the cytoskeleton, playing crucial roles in cellular functions. …”
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Method development for correlating lipid molecular information with anatomy in C. elegans by Sara Mandic, Bryn Flinders, Michiel Vandenbosch, Akane Ohta, Atsushi Kuhara, Ron M. A. Heeren, Masazumi Fujiwara

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Metabolic perturbation of epigenome by inhibiting -adenosylhomocysteine hydrolase elicits senescence through DNA damage response in hepatoma cells by Guozhen Wu, Ning Wang, Ying Luo, Yanyan Zhang, Peng Wang, Zhengyan Zhu, Yingtang Gao, Zhi Du, Bin Yang

“…Given a crosstalk between methionine cycle and histone methylation, we hypothesize that pharmacologically disrupting methylation potential, defined as the ratio of cellular S -adenosylmethionine to S -adenosylhomocysteine, could affect the chromatin structures in cancer cells and thus enhance their sensitivity to DNA damage response signaling. …”
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Redox Regulation of cAMP-Dependent Protein Kinase and Its Role in Health and Disease by Ese S. Ekhator, Marco Fazzari, Robert H. Newman

“…While its activation by the second messenger 3′,5′-cyclic adenosine triphosphate (cAMP) is well characterized, recent research highlights additional regulatory mechanisms, particularly oxidative post-translational modifications, that influence PKA’s structure, activity, and substrate specificity. Both the regulatory and catalytic subunits of PKA are susceptible to redox modifications, which have been shown to play important roles in the regulation of key cellular functions, including cardiac contractility, lipid metabolism, and the immune response. …”
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Architecture of the biofilm-associated archaic Chaperone-Usher pilus CupE from Pseudomonas aeruginosa. by Jan Böhning, Adrian W Dobbelstein, Nina Sulkowski, Kira Eilers, Andriko von Kügelgen, Abul K Tarafder, Sew-Yeu Peak-Chew, Mark Skehel, Vikram Alva, Alain Filloux, Tanmay A M Bharat

“…Taken together, our study provides insights into the architecture of archaic CUP pili, providing a structural basis for understanding their role in promoting cellular adhesion and biofilm formation in P. aeruginosa.…”
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Physiological aspects of myocardial function improving during mechanical circulatory support by D. V. Shumakov, D. I. Zybin, M. A. Popov

“…The aim of this research is to study a significant improvement in the structure and function of the myocardium during the mechanical support of blood circulation.…”
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Targeting of interleukin-10 receptor by a potential human interleukin-10 peptide efficiently blocks interleukin-10 pathway-dependent cell proliferation by Chun-Chun Chang, Cheng-Der Liu, Sheng-Feng Pan, Wei-Han Huang, Chih-Wen Peng, Hao-Jen Hsu

“…Objective: Human interleukin-10 (IL-10) is a dimeric and pleiotropic cytokine that plays a crucial role in cellular immunoregulatory responses. As IL-10 binds to its receptors, IL-10Ra and IL-10Rb, it will suppress or induce the downstream cellular immune responses to protect from diseases. …”
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Closing the multichannel gap through computational reconstruction of interaction in super-resolution microscopy by Ben Cardoen, Hanene Ben Yedder, Ivan Robert Nabi, Ghassan Hamarneh

“…Summary: Cellular function is defined by pathways that, in turn, are determined by distance-mediated interactions between and within subcellular organelles, protein complexes, and macromolecular structures. …”
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Percutaneous cryoablation in soft tissue tumor management: an educational review by Sylvain Bodard, Ruben Geevarghese, Leo Razakamanantsoa, Julien Frandon, Elena N. Petre, Clement Marcelin, François H. Cornelis

“…PCA functions by freezing tissue, which induces ice crystal formation and cell death without damaging collagen structures. Technical considerations include the selection and handling of cryoprobes and cryogenic agents, procedural duration, and choice of image guidance for precision. …”
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Possibilities of using tear fluid for electron microscopic diagnostics of eye diseases by A. E. Grigor’Eva, A. V. Eremina, A. V. Tupitsyna, O. M. Stanishevskaya, V. V. Chernykh, V. V. Vlasov, E. I. Ryabchikova

“…All the examined samples contained cells, cellular fragments and debris, mucous granules and lipid structures. …”
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Insights into the length and breadth of methodologies harnessed to study human telomeres by Tiernan Coulter, Claire Hill, Amy Jayne McKnight

“…Abstract Telomeres are protective structures at the end of eukaryotic chromosomes that are strongly implicated in ageing and ill health. …”
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Tailoring smart hydrogels through manipulation of heterogeneous subdomains by Haoqing Yang, Tengxiao Liu, Lihua Jin, Yu Huang, Xiangfeng Duan, Hongtao Sun

“…Abstract The mechanical interactions among integrated cellular structures in soft tissues dictate the mechanical behaviors and morphogenetic deformations observed in living organisms. …”
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Conventional and High-Speed Intravital Multiphoton Laser Scanning Microscopy of Microvasculature, Lymphatics, and Leukocyte-Endothelial Interactions by Timothy P. Padera, Brian R. Stoll, Peter T.C. So, Rakesh K. Jain

“…Intravital epifluorescence microscopy has provided powerful insight into gene expression, tissue pH, tissue pO 2 , angiogenesis, blood vessel permeability, leukocyte-endothelial (L-E) interaction, molecular diffusion, convection and binding, and barriers to the delivery of molecular and cellular medicine. Multiphoton laser scanning microscopy (MPLSM) has recently been applied in vivo to overcome three drawbacks associated with traditional epifluorescence microscopy: (i) limited depth of imaging due to scattering of excitation and emission light; (ii) projection of three-dimensional structures onto a two-dimensional plane; and (iii) phototoxicity. …”
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Cytological development, calcium dynamic and metabolite profile of stress-induced tobacco (Nicotiana tabacum L.) microspore under calcium chloride treatment by C. T. Rahmawati, D. K. Wahyuni, H. Purnobasuki, N. K. K. Ikram, S. Subramaniam, S. P. O. Werbrouck, Hamidah

“…Altering the external calcium levels in the medium has been documented to impact the success rate of microspore embryogenesis initiation. However, the cellular effects on the formation of embryogenic tobacco microspore and its cellular changes during stress treatment remain elusive. …”
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