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1661
Phosphoinositide signaling at the cytoskeleton in the regulation of cell dynamics
Published 2025-04-01“…Abstract The cytoskeleton, composed of microfilaments, intermediate filaments, and microtubules, provides the structural basis for cellular functions such as motility and adhesion. …”
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1662
A review of sphingolipids from marine sources and their analytical method, metabolic process, and essential roles in human health
Published 2024-09-01“…SLs from marine organisms exhibit special structures and diverse physiological functions due to the extreme environment, which have attracted ever‐increasing attention recently. …”
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1663
Promising Research Results and Development in the Field of Microwave Technology
Published 2024-04-01“…The use of the developed methods made it possible to optimize the structures of devices, calibration and measurement algorithms. …”
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1664
Pathogenic missense protein variants affect different functional pathways and proteomic features than healthy population variants.
Published 2021-04-01“…It allows users to programmatically annotate missense variants with protein structural information and to calculate variant enrichment in different protein structural regions.…”
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1665
Unveiling the potential: Patient-derived organoids in cancer research and treatment
Published 2024-03-01“…These three-dimensional structures, cultivated from patient tumor samples, faithfully mimic the intricate cellular composition and architecture of the original tumors. …”
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1666
The Potential of Single-Chain Variable Fragment Antibody: Role in Future Therapeutic and Diagnostic Biologics
Published 2024-01-01“…The advancement of genetic engineering has revolutionized the field of immunology by allowing the utilization of intrinsic antibody structures. One of the biologics that are being produced by recombinant antibody technology is single-chain fragments variable (scFv). …”
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1667
Dynamic and electrophoretic light scattering measurements on microtubules at low concentrations.
Published 2024-01-01“…The accurate characterization of microtubules is essential for understanding their roles in various biological activities in eukaryotic cellular processes. In vitro, experimental data on these systems often need more details and information on sample preparation protocols and experimental techniques. …”
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1668
The Evolution of Sensory Placodes
Published 2006-01-01“…Combined with morphological and cellular fate data, these results also suggest that the sensory placodes of the ancestor of all chordates differentiated into a wide range of structures, most likely to fit the lifestyle and environment of each species.…”
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1670
Deubiquitinases as novel therapeutic targets for diseases
Published 2024-12-01“…Abstract Deubiquitinating enzymes (DUBs) regulate substrate ubiquitination by removing ubiquitin or cleaving within ubiquitin chains, thereby maintaining cellular homeostasis. Approximately 100 DUBs in humans counteract E3 ubiquitin ligases, finely balancing ubiquitination and deubiquitination processes to maintain cellular proteostasis and respond to various stimuli and stresses. …”
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1671
Cryo-electron tomography pipeline for plasma membranes
Published 2025-01-01“…Abstract Cryo-electron tomography (cryoET) provides sub-nanometer protein structure within the dense cellular environment. Existing sample preparation methods are insufficient at accessing the plasma membrane and its associated proteins. …”
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1672
Mechanotransductive N-cadherin binding induces differentiation in human neural stem cells
Published 2025-03-01“…The neural stem cell niche is a complex microenvironment that includes cellular factors, secreted factors, and physical factors that impact stem cell behavior and development. …”
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1673
Allosteric regulation of Senecavirus A 3Cpro proteolytic activity by an endogenous phospholipid.
Published 2023-05-01“…In addition to cleavage of viral polyprotein, the viral 3C protease (3Cpro) plays an important role in the regulation of several physiological processes involved in cellular antiviral responses by cleaving critical cellular proteins. …”
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1674
Comparative analysis of the LARP1 C-terminal DM15 region through Coelomate evolution.
Published 2024-01-01“…TOR (target of rapamycin), a ubiquitous protein kinase central to cellular homeostasis maintenance, fundamentally regulates ribosome biogenesis in part by its target La-related protein 1 (LARP1). …”
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1675
The role of the essential GTPase ObgE in regulating lipopolysaccharide synthesis in Escherichia coli
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1676
Dysregulated metabolism of the late herpes simplex virus 1 transcriptome through the vhs-VP22 axis uncouples virus cytopathic effect and virus production.
Published 2023-06-01“…Herpes simplex virus 1 (HSV1) expresses its genes in a classical cascade culminating in the production of large amounts of structural proteins to facilitate virus assembly. HSV1 lacking the virus protein VP22 (Δ22) exhibits late translational shutoff, a phenotype that has been attributed to the unrestrained activity of the virion host shutoff (vhs) protein, a virus-encoded endoribonuclease which induces mRNA degradation during infection. …”
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1677
Modelling the spatio-temporal cell dynamics reveals novel insights on cell differentiation and proliferation in the small intestinal crypt.
Published 2012-01-01“…We developed a slow structural relaxation model to describe cellular dynamics in the crypt of the mouse small intestine. …”
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Bioengineered tracheal graft with enhanced vascularization and mechanical stability for functional airway reconstruction
Published 2025-06-01“…Tracheal reconstruction remains a formidable clinical challenge due to the complex structural, biomechanical, and physiological requirements of the airway. …”
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1680
COMPARATIVE CHARACTERISTICS OF BIOMATERIALS FOR THE REPLACEMENT OF JAW BONE DEFECTS AND THEIR ROLE IN THE PREVENTION OF INFLAMMATORY COMPLICATIONS
Published 2025-06-01“…Current approaches aim to create conditions for functional bone tissue regeneration through the synergy of biomaterials, cellular technologies, and factor-based therapy. …”
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