Tracking fructose 1,6-bisphosphate dynamics in liver cancer cells using a fluorescent biosensor by Israel Pérez-Chávez, John N. Koberstein, Julia Malo Pueyo, Eduardo H. Gilglioni, Didier Vertommen, Nicolas Baeyens, Daria Ezeriņa, Esteban N. Gurzov, Joris Messens

Get full text

Therapeutic Potential of Exercise-Induced SPARC in Bone Health? by Abdelaziz Ghanemi, Mayumi Yoshioka, Jonny St-Amand

“…Secreted protein acidic and rich in cysteine (SPARC) is an exercise-induced glycoprotein known for its functions at different cellular and molecular levels. Among the properties it has, its calcium and collagen binding patterns along with other biochemical, metabolic, and structural effects represent a starting point towards developing therapeutic options based on SPARC properties for bones in pathological, preventive, and regenerative contexts. …”
Get full text

Post-translational modifications of ezrin: a crucial regulator for diseases by Yi-Chen Li, Hong-Kai Yuan, Lei-Miao Yin

“…With the help of PTMs, ezrin not only plays a structural role in connecting the cell membrane to F-actin, but also participates in transmitting cellular signals including those related to inflammatory responses. …”
Get full text

Treatment of chronic liver disease using cell‑engineered constructs: morphofunctional characteristics by M. Yu. Shagidulin, N. A. Onishchenko, A. V. Grechina, M. E. Krasheninnikov, A. O. Nikolskaya, E. A. Volkova, N. P. Mogeiko, N. A. Boiarinova, A. V. Lyundup, G. A. Piavchenko, L. I. Davydova, A. Yu. Arhipova, V. G. Bogush, S. V. Gautier

“…Implantation of CECs in the liver facilitates effective correction of CLD by activating regenerative processes in the damaged liver, which is due to long-term preservation of structural cellular homeostasis in the CECs.…”
Get full text

Aptamers Binding to c-Met Inhibiting Tumor Cell Migration. by Birgit Piater, Achim Doerner, Ralf Guenther, Harald Kolmar, Bjoern Hock

“…The human receptor tyrosine kinase c-Met plays an important role in the control of critical cellular processes. Since c-Met is frequently over expressed or deregulated in human malignancies, blocking its activation is of special interest for therapy. …”
Get full text

Quantitative evaluation of equation-based model in hypokalemic periodic paralysis condition with bistability by Buntha Wanchai, Theera-Umpon Nipon

“…We analyzed the structural model focusing on the intracellular potassium pool and connected cellular electrophysiology information to the macroscale. …”
Get full text

Serine/threonine/tyrosine kinase 1 drives pancreatic carcinogenesis via GSK3β sequestration-mediated Wnt/β-catenin pathway hyperactivation by Cefan Zhou, Xueying Dong, Shi Li, Yue Xi, Yuan Liu, Xuehong Qian, Ziyan Song, Li Zhou, Rui Zhang, Hao Lyu, Shuai Xiao, Dong Guo, Qi Zhang, Weiyong Liu, Yan Xiong, Zhentian Wang, Chaojun Yan, Zijian Zhang, Haichuan Zhu, Xing-Zhen Chen, Zhiyin Song, Jingfeng Tang

Get full text

Research advances in anti-cancer activities and mechanism of action of neocryptolepine and its derivatives by Yunhao Ma, Zhongkun Zhou, Lixue Tu, Juan Lu, Liqian Du, Yuqi Yue, Hua Zhang, Xin Ma, Xinhang Wang, Zhenzhen Si, Hongmei Zhu, Yingqian Liu, Peng Chen

“…This review summarizes the structures of 228 neocryptolepine derivatives, including 84 neocryptolepine derivatives synthesized by our laboratory, and analyzed the cytotoxic effects and mechanism of action at the cellular level. …”
Get full text

A genetic and microscopy toolkit for manipulating and monitoring regeneration in Macrostomum lignano by R. Nelson Hall, Hongquan Li, Chew Chai, Sidney Vermeulen, Robin R. Bigasin, Eun Sun Song, Souradeep R. Sarkar, Jesse Gibson, Manu Prakash, Andrew Z. Fire, Bo Wang

“…Using tissue-specific reporter expression, we examine how various structures regenerate. Enabled by a custom luminescence/fluorescence microscope, we overcome intense stress-induced autofluorescence to demonstrate genetic cellular ablation and reveal the limited regenerative capacity of neurons and their essential role during wound healing, contrasting muscle cells’ rapid regeneration after ablation. …”
Get full text

CLSY docking to Pol IV requires a conserved domain critical for small RNA biogenesis and transposon silencing by Luisa Felgines, Bart Rymen, Laura M. Martins, Guanghui Xu, Calvin Matteoli, Christophe Himber, Ming Zhou, Josh Eis, Ceyda Coruh, Marcel Böhrer, Lauriane Kuhn, Johana Chicher, Vijaya Pandey, Philippe Hammann, James Wohlschlegel, Florent Waltz, Julie A. Law, Todd Blevins

Get full text

A Scoping Review of Sarcoglycan Expression in Non-Muscle Organs: Beyond Muscles by Fabiana Nicita, Josè Freni, Antonio Centofanti, Angelo Favaloro, Davide Labellarte, Giuseppina Cutroneo, Michele Runci Anastasi, Giovanna Vermiglio

“…Similarly, SGs maintain cellular integrity and homeostasis in glands and adipose tissue. …”
Get full text

Phytochemical nanozymes reprogram redox for balanced antimicrobial and regenerative therapy in acute and chronic diabetic wounds by Yipeng Pang, Fructueux Modeste Amona, Xiaohan Chen, Yuxin You, Ziqi Sha, Zilu Liu, Jiamin Li, Yi Liu, Xingtang Fang, Xi Chen

Get full text

A high-resolution anatomical atlas of the transcriptome in the mouse embryo. by Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R Davidson, Pascal Dollé, Stylianos E Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Salvador Martinez, Richard A Baldock, Gregor Eichele, Andrea Ballabio

“…It is, therefore, crucial to determine on a genome-wide level, the spatio-temporal gene expression profiles at cellular resolution. This information is provided by colorimetric RNA in situ hybridization that can elucidate expression of genes in their native context and does so at cellular resolution. …”
Get full text

African swine fever virus infection of porcine peripheral blood monocyte-derived macrophages induces the formation of tunneling nanotube-connected large vesicle-like cell segments:... by Brecht Droesbeke, Nadège Balmelle, Hans J. Nauwynck, Herman Favoreel, Marylène Tignon

“…These findings suggest that ASFV induces cellular segmentation linked by TNT-like structures. …”
Get full text

Implantation of the collagen membrane with adsorbed multipotent stem cells in experiment by I. V. Маyborodin, S. V. Khomenyuk, Т. V. Мikheyeva, G. Yu. Yarin, V. I. Маyborodina, N. V. Оnopriyenko, I. А. Vilgelmi, А. I. Shevela

“…The main cause for the tissue vascularization enhancement around the implanted collagen with the MMSC adsorbed on the surface is their differentiation into cellular elements of vascular membranes. Starting from the second week all the MMSC undergo destruction and are phagocytized by macrophages, also in this term the structures from these MMSC disappear as a result of their differentiation, including the vessels.…”
Get full text

The Relationship Between Vitamin B12 and Telomere Length: A Systematic Review by Zeyneb Yıldırım, Emine Merve Ekici

“…Telomeres are natural nucleoprotein structures that cover the ends of chromosomes. The phenomenon of telomere shortening, which plays a crucial role in maintaining the stability of the genome, occurs gradually over time when cells undergo division due to the end replication issue. …”
Get full text

Hypermethylation at 45S rDNA promoter in cancers. by Trang Thi Quynh Tran, Trang Hien Do, Tung The Pham, Phương Thi Thu Luu, Oanh Minh Pham, Uyen Quynh Nguyen, Linh Dieu Vuong, Quang Ngoc Nguyen, Tuan Van Mai, Son Van Ho, Than Thi Nguyen, Lan Thi Thuong Vo

“…The ribosomal genes (rDNA genes) encode 47S rRNA which accounts for up to 80% of all cellular RNA. At any given time, no more than 50% of rDNA genes are actively transcribed, and the other half is silent by forming heterochromatin structures through DNA methylation. …”
Get full text

Midbrain encodes sound detection behavior without auditory cortex by Tai-Ying Lee, Yves Weissenberger, Andrew J King, Johannes C Dahmen

“…The auditory cortex is considered crucial for the integration of acoustic and contextual information and is thought to share the resulting representations with subcortical auditory structures via its vast descending projections. By imaging cellular activity in the corticorecipient shell of the inferior colliculus of mice engaged in a sound detection task, we show that the majority of neurons encode information beyond the physical attributes of the stimulus and that the animals’ behavior can be decoded from the activity of those neurons with a high degree of accuracy. …”
Get full text

Tunable network architecture in a hydrogel with extreme vibration damping properties by Graham J. Day, Qicheng Zhang, Chrystel D. L. Remillat, Gianni Comandini, Adam W. Perriman, Fabrizio Scarpa

Get full text

Predictability of environment-dependent formation of G-quadruplex DNAs in human mitochondria by Lutan Liu, Shuntaro Takahashi, Sarptarshi Ghosh, Tamaki Endoh, Naoto Yoshinaga, Keiji Numata, Naoki Sugimoto

“…Abstract Molecular crowding affects the stability of nucleic acids (DNA and RNA) and induces their non-canonical structures. As the level of molecular crowding varies spatio-temporally in cells, it would be beneficial to predict the behaviour of DNA and RNA structures depending on the local cellular environments. …”
Get full text