Cytotoxicity of citral against melanoma cells: The involvement of oxidative stress generation and cell growth protein reduction by Larissa Juliani Sanches, Poliana Camila Marinello, Carolina Panis, Tatiane Renata Fagundes, José Andrés Morgado-Díaz, Julio Cesar Madureira de-Freitas-Junior, Rubens Cecchini, Alessandra Lourenço Cecchini, Rodrigo Cabral Luiz

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Evolution and functional cross‐talk of protein post‐translational modifications by Pedro Beltrao, Peer Bork, Nevan J. Krogan, Vera van Noort

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Advancements and Perspectives in the Bioprosthetic Heart Valve: A Comprehensive Review on Biomaterial Processing and Emerging Polymeric Materials by Hanluo Li, Shenghua Li, Yalan Lei, Ming Sun, Chunlin Wu, Xueli Wang, Shiwen Xiong, Qing Wang, Sini Kang, Song Chen, Xiaoke Shang

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Marker-independent vibrational spectroscopy imaging recognizes the hypoxia effect in the human brain endothelium by Aleksandra Pragnąca, Anna Antolak, Zuzanna J. Krysiak, Monika Leśniak, Agata Borkowska, Robert Zdanowski, Kamilla Malek

“…Moreover, this approach allows for analyzing changes within specific cellular compartments, including nuclei, providing a comprehensive understanding of how hypoxia affects cellular functions and metabolism. …”
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Trans-synaptic molecular context of NMDA receptor nanodomains by Michael C. Anderson, Poorna A. Dharmasri, Martina Damenti, Sarah R. Metzbower, Rozita Laghaei, Thomas A. Blanpied, Aaron D. Levy

“…Abstract Tight coordination of spatial relationships between protein complexes is required for cellular function. In neuronal synapses, proteins responsible for neurotransmission form subsynaptic nanoclusters whose trans-cellular alignment modulates synaptic signal propagation. …”
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Direct and indirect pathways linking the Lon protease to motility behaviors in the pathogen Pseudomonas aeruginosa. by Aswathy Kallazhi, Anamika Rahman, Ute Römling, Kristina Jonas

“…The ATP-dependent cytoplasmic protease Lon has critical functions in protein quality control and cellular regulation in organisms across the three domains of life. …”
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M-Sec promotes the accumulation of intracellular HTLV-1 Gag puncta and the incorporation of Env into viral particles. by Masateru Hiyoshi, Youssef M Eltalkhawy, Randa A Abdelnaser, Akira Ono, Kazuaki Monde, Yosuke Maeda, Reem M Mahmoud, Naofumi Takahashi, Yasuyoshi Hatayama, Akihide Ryo, Satoshi Nozuma, Hiroshi Takashima, Ryuji Kubota, Shinya Suzu

“…We have demonstrated that the cellular protein M-Sec promotes the transmission of human T-cell leukemia virus type 1 (HTLV-1) in vitro and in vivo. …”
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Pathology-Dependent Effects Linked to Small Heat Shock Proteins Expression: An Update by A.-P. Arrigo

“…Moreover, small Hsps are actively released by cells and can act as immunogenic molecules that have dual effects depending on the pathology. The cellular consequences linked to their expression levels and relationships with other Hsps as well as therapeutic strategies are discussed in view of their dynamic structural organization required to interact with specific client polypeptides.…”
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Utilising single‐cell sequencing in clinical nutraceutical research: Recent progress and perspectives by Xiaoqiang Wang, Yin S. Chan, David Sadava, Shiuan Chen

“…Traditional bulk profiling methods for tissues and tumours do not adequately capture cellular heterogeneity or specific cellular responses to treatments. …”
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Anatomy Education and Training Methods in Oral Surgery and Dental Implantology: A Narrative Review by Carlo Barausse, Pietro Felice, Roberto Pistilli, Gerardo Pellegrino, Lorenzo Bonifazi, Subhi Tayeb, Irene Neri, Foteini-Dionysia Koufi, Antonietta Fazio, Maria Vittoria Marvi, Lucia Manzoli, Stefano Ratti

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Characterization of drug‐induced transcriptional modules: towards drug repositioning and functional understanding by Murat Iskar, Georg Zeller, Peter Blattmann, Monica Campillos, Michael Kuhn, Katarzyna H Kaminska, Heiko Runz, Anne‐Claude Gavin, Rainer Pepperkok, Vera van Noort, Peer Bork

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Prediction and identification of sequences coding for orphan enzymes using genomic and metagenomic neighbours by Takuji Yamada, Alison S Waller, Jeroen Raes, Aleksej Zelezniak, Nadia Perchat, Alain Perret, Marcel Salanoubat, Kiran R Patil, Jean Weissenbach, Peer Bork

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Bioinformatic exploration reveals features of tenpIN family of type III toxin-antitoxin systems in bacteria and viruses by Kavyashree Nadig, Sankaran Sandhya, Mahavir Singh

“…Using sequence alignments and structure prediction tools, we identified unique signatures in the TenpN toxins and tenpI RNA antitoxins that may play crucial roles for their structure and function. …”
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Evaluating ultrastructural preservation quality in banked brain tissue by Macy Garrood, Alicia Keberle, Allison Sowa, William Janssen, Emma Thorn, Claudia De Sanctis, Kurt Farrell, John Crary, Andrew McKenzie

“… The ultrastructural analysis of postmortem brain tissue can provide important insights into cellular architecture and disease-related changes. …”
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Characterisation of a cyclic peptide that binds to the RAS binding domain of phosphoinositide 3-kinase p110α by Mohamed Ismail, Stephen R. Martin, Roger George, Francesca Houghton, Geoff Kelly, Raphaël A. G. Chaleil, Panayiotis Anastasiou, Xinyue Wang, Nicola O’Reilly, Stefania Federico, Dhira Joshi, Hemavathi Nagaraj, Rachel Cooley, Ning Sze Hui, Miriam Molina-Arcas, David C. Hancock, Ali Tavassoli, Julian Downward

“…We show that cyclo-CRVLIR binds selectively to the p110α-RBD but not to KRAS or the structurally-related RAF-RBD. Further, using biophysical, biochemical and cellular assays, we show that cyclo-CRVLIR effectively blocks the p110α/KRAS interaction in a dose dependent manner and reduces phospho-AKT levels in several oncogenic KRAS cell lines.…”
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Selective Requirement for Maintenance of Synaptic Contacts onto Motoneurons by Target-Derived trkB Receptors by Xiya Zhu, Patricia J. Ward, Arthur W. English

“…Selective knockout of the trkB gene resulted in a marked reduction in contacts made by VGLUT2- and GAD67-immunoreactive structures in both sexes and a significant reduction in contacts containing only glycine in male mice. …”
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Pulsed field ablation in medicine: irreversible electroporation and electropermeabilization theory and applications by Jacobs Edward J, Rubinsky Boris, Davalos Rafael V

“…PEFs induce cell death through permeabilization of the cellular membrane, leading to loss of homeostasis. …”
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The role of mitochondria in aging, cell death, and tumor immunity by Qiang Wang, Yixiao Yuan, Jing Liu, Chunhong Li, Xiulin Jiang

“…Mitochondria are essential double-membrane organelles with intricate structures and diverse functions within cells. Under normal physiological conditions, mitochondria regulate cellular metabolism and maintain energy homeostasis via the electron transport chain, mediate stem cell fate, and modulate reactive oxygen species production, playing a pivotal role in energy supply and lifespan extension. …”
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Pathogenesis of Acute Respiratory Distress Syndrome by A. M. Golubev, V. V. Moroz, D. V. Sundukov

“…In turn the alteration of cellular and extracellular structures is followed by the increased permeability of hemomicrocirculatory bed vessels, leading to the development of non-cardiogenic (interstitial, alveolar) pulmonary edema that is a central component in the pathogenesis of ARDS. …”
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Effects of ocular hypothermia: potential perspectives in vitreoretinal surgery by Emanuele Crincoli, Matteo Mario Carlà, Alfonso Savastano, Mariacristina Savastano, Raphael Kilian, Clara Rizzo, Tomaso Caporossi, Stanislao Rizzo

“…Results Temperature changes induce several regulatory responses within the eye, including modifications of intraocular pressure (IOP), local blood flow, cytokine secretion and cellular metabolism. Cooling of retinal structures has been demonstrated to induce beneficial effects including increased survival of RPE and retinal neurons. …”
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