14-3-3 binding maintains the Parkinson’s associated kinase LRRK2 in an inactive state by Juliana A. Martinez Fiesco, Alexandra Beilina, Astrid Alvarez de la Cruz, Ning Li, Riley D. Metcalfe, Mark R. Cookson, Ping Zhang

“…Abstract Leucine-rich repeat kinase 2 (LRRK2) is an essential regulator in cellular signaling and a major contributor to Parkinson’s disease (PD) pathogenesis. 14-3-3 proteins are critical modulators of LRRK2 activity, yet the structural basis of their interaction has remained unclear. …”
Get full text

Proteomic landscape of Alzheimer’s disease: emerging technologies, advances and insights (2021 – 2025) by Jay M. Yarbro, Him K. Shrestha, Zhen Wang, Xue Zhang, Masihuz Zaman, Mengqi Chu, Xusheng Wang, Gang Yu, Junmin Peng

Get full text

The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology by Ana Martinez Hernandez, Hendrik Urbanke, Alan L Gillman, Joon Lee, Sergey Ryazanov, Hope Y Agbemenyah, Eva Benito, Gaurav Jain, Lalit Kaurani, Gayane Grigorian, Andrei Leonov, Nasrollah Rezaei‐Ghaleh, Petra Wilken, Fernando Teran Arce, Jens Wagner, Martin Fuhrmann, Mario Caruana, Angelique Camilleri, Neville Vassallo, Markus Zweckstetter, Roland Benz, Armin Giese, Anja Schneider, Martin Korte, Ratnesh Lal, Christian Griesinger, Gregor Eichele, Andre Fischer

Get full text

The PAZ pocket and dimerization drive CpAgo’s guide-independent and DNA-guided dual catalysis by Yuchan Liu, Jiasu Zhang, Ji Liu, Shengchun Zhang, Linfeng An, Wenbing Xie, Kaiming Zhang, Shanshan Li

Get full text

Numerical Solution to the Problem of Thermal Conductivity in a Porous Plate with a Topology of Triply Periodic Minimal Surfaces by K. V. Gubareva, A. V. Eremin

“…To achieve the stated objectives, mathematical modeling was performed, including the solution to the boundary value problem taking into account the identified correlations. A cellular structure made of PETG plastic and having pores consisting of identical repeating elements was considered. …”
Get full text

Integrative glycomic analysis reveals the crucial role of protein glycosylation in fungal pathogenesis. by Heeji Moon, Eun Jung Thak, Yejin Choi, Sieun Kim, Jiyeun Park, Nahyun Lee, Soobin Shin, Hosung Jeon, Jessica Winarto, Soyoung Choi, Ji Young Shin, Jung-Eun Kim, Dae-Geun Song, Hun Kim, Gyung Ja Choi, Hyun Ah Kang, Hokyoung Son

“…Through cell wall component profiling and HPLC analysis, we characterized the overall N- and O-glycan structures in F. graminearum and found that deletion of ALG3 and ALG12 led to truncated core N-glycan structures. …”
Get full text

The role of the molecular pathway of transforming growth factor β in the progression of myocardial fibrosis by A. S. Sinyaeva, S. A. Shcherbakova

“…The progression of myocardial fibrosis is based on mechanisms that are associated with both cellular and molecular pathways. The main cellular element is an activated fibroblast, which produces a large amount of extracellular matrix. …”
Get full text

The Arg/N-degron pathway mediates the secretion of apoptotic exosomes under oxidative stress in cancer cell by Su Bin Kim, Ji Su Lee, Chan Hoon Jung, Eun Hye Cho, Ho Seok Seo, Gee Eun Lee, Hye Yeon Kim, Su Jin Lee, Min Ju Lee, Hans Jin-young Oh, Ah Jung Heo, Do Hyun Han, Yong Tae Kwon, Chang Hoon Ji

Get full text

Regulation and mechanisms of action of RNA helicases by Nina Lang, Pravin Kumar Ankush Jagtap, Janosch Hennig

“…However, for selective targeting of a specific RNA helicase, it is crucial to develop a detailed understanding about its dynamics and regulation on a molecular and structural level. Deciphering unique features of specific RNA helicases is of fundamental importance not only for future drug development but also to deepen our understanding of RNA helicase regulation and function in cellular processes. …”
Get full text

Photobiomodulation in ocular therapy: current status and future perspectives by Hasan Chichan, Iftkhar Hamzah Aldujaly, Konstantinos Michalakis, Levent Kanal

“…Red light has the potential to penetrate cellular structures such as mitochondria and facilitate cellular processes. …”
Get full text

Retracted: Computer Medical Image Segmentation Based on Neural Network by Xiaopeng Wang, Lei Gu, Zhongyi Wang

“…It also introduces pipeline and dual cache structures to optimize memory access, and analyzes the limited resources through the Roofline model. …”
Get full text

Calmodulin: The switch button of calcium signaling by Chiu-Fen Yang, Wen-Chin Tsai

“…The conformation of each HD is sensitive to the levels of the intracellular Ca2+ concentrations while the flexible structure of the central domain enables its interactions with hundreds of cellular proteins. …”
Get full text

Electron Beam Additive Manufacturing of SS316L with a Stochastic Scan Strategy: Microstructure, Texture Evolution, and Mechanical Properties by K. N. Chaithanya Kumar, Shashank Sharma, Madhavan Radhakrishnan, Rohit Randhavan, Krishna Kamlesh Verma, Shelden Dowden, Zane Weldon Hughes, Rajarshi Banerjee, Narendra B. Dahotre

“…X-ray diffraction confirmed the presence of a pure austenitic phase in the fabricated material. Equiaxed cellular structures were observed in the center of the melt pool regions and elongated cellular structures observed at the melt pool overlap regions. …”
Get full text

Attachment and Proliferation of Osteoblasts on Lithium-Hydroxyapatite Composites by Ana Paula M. Shainberg, Patrícia Valério, Alessandra Zonari, Faik N. Oktar, Lutfiye S. Ozyegin, Manuel Pedro F. Graça, Maria F. Leite, Alfredo M. Goes

“…The osteoblast culture behavior was assessed in the presence of these LiHA compositions. The cellular interactions were analyzed by evaluating the viability and cellular proliferation, ALP production and collagen secretion. …”
Get full text

Cuticular collagens mediate cross-kingdom predator-prey interactions between trapping fungi and nematodes. by Han-Wen Chang, Hung-Che Lin, Ching-Ting Yang, Rebecca J Tay, Dao-Ming Chang, Yi-Chung Tung, Yen-Ping Hsueh

“…Adhesive interactions, mediated by specific molecular and structural mechanisms, are fundamental to host-pathogen and predator-prey relationships, driving evolutionary dynamics and ecological interactions. …”
Get full text

Widespread cotranslational formation of protein complexes. by Caia D S Duncan, Juan Mata

“…We obtained analogous results with proteins with different structures and cellular functions (kinesins, protein kinases, transcription factors, proteasome components, etc.). …”
Get full text

Nano-XRF of lung fibrotic tissue reveals unexplored Ca, Zn, S and Fe metabolism: a novel approach to chronic lung diseases by Bryan Falcones, Maik Kahnt, Ulf Johansson, Barbora Svobodová, Karin A. von Wachenfelt, Charlott Brunmark, Göran Dellgren, Linda Elowsson, Karina Thånell, Gunilla Westergren-Thorsson

“…Abstract Synchrotron-radiation nano-X-Ray Fluorescence (XRF) is a cutting-edge technique offering high-resolution insights into the elemental composition of biological tissues, shedding light on metabolic processes and element localization within cellular structures. In the context of Idiopathic Pulmonary Fibrosis (IPF), a debilitating lung condition associated with respiratory complications and reduced life expectancy, nano-XRF presents a promising avenue for understanding the disease’s intricate pathology. …”
Get full text

A hybrid YOLO-UNet3D framework for automated protein particle annotation in Cryo-ET images by Ziyang Liu, Chunhong Yuan, Zixin Zhang, Xiang Zhou, Xiangyu Li, Zhen Tian, Yuting Pei, Zuowen Jiang, Zhikui Tian

“…Abstract Accurate localization and identification of protein complexes in cryo-electron tomography (cryo-ET) volumes are essential for understanding cellular functions and disease mechanisms. However, automated annotation of these macromolecular assemblies remains challenging due to low signal-to-noise ratios, missing wedge artifacts, heterogeneous backgrounds, and structural diversity. …”
Get full text

IRF2BP2 binds to a conserved RxSVI motif of protein partners and regulates megakaryocytic differentiation by Guanchao Wang, Tiantian Lu, Lei Zhang, Jianping Ding

“…Abstract IRF2BP2 is a transcriptional coregulator that plays diverse regulatory roles in various cellular processes in either IRF2-dependent or IRF2-independent manner through interactions with protein partners via its RING domain; however, the underlying molecular mechanisms remain unclear. …”
Get full text

Production, purification and characterization of recombinant, full-length human claudin-1. by Nicklas Bonander, Mohammed Jamshad, Dominik Oberthür, Michelle Clare, James Barwell, Ke Hu, Michelle J Farquhar, Zania Stamataki, Helen J Harris, Karsten Dierks, Timothy R Dafforn, Christian Betzel, Jane A McKeating, Roslyn M Bill

“…The transmembrane domain proteins of the claudin superfamily are the major structural components of cellular tight junctions. One family member, claudin-1, also associates with tetraspanin CD81 as part of a receptor complex that is essential for hepatitis C virus (HCV) infection of the liver. …”
Get full text