Hallmarks of aging: middle-aging hypovascularity, tissue perfusion and nitric oxide perspective on healthspan by Teow J. Phua

“…Key evidence suggests a systemic connection between the endocrine system (specifically sex hormones), endogenous NO deficiency, and the vascular system, which serves as a network of microvascular structures crucial for tissue perfusion functions at cellular level. …”
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Soft graph clustering for single-cell RNA sequencing data by Ping Xu, Pengfei Wang, Zhiyuan Ning, Meng Xiao, Min Wu, Yuanchun Zhou

“…(ii) The presence of significant inter-cluster connections within hard graphs, which can confuse GNN methods that rely heavily on graph structures, potentially causing erroneous message propagation and biased clustering outcomes. …”
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Targeting SHP2 with Natural Products: Exploring Saponin-Based Allosteric Inhibitors and Their Therapeutic Potential by Dong-Oh Moon

“…Natural products, especially saponins with their unique structural diversity, have emerged as promising candidates for SHP2 inhibition. …”
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Hampered AMPK-ULK1 cascade in Alzheimer’s disease (AD) instigates mitochondria dysfunctions and AD-related alterations which are alleviated by metformin by Arnaud Mary, Samantha Barale, Fanny Eysert, Audrey Valverde, Sandra Lacas-Gervais, Charlotte Bauer, Sabiha Eddarkaoui, Luc Buée, Valérie Buée-Scherrer, Frédéric Checler, Mounia Chami

“…This study investigated the AMPK-ULK1 pathway activation state in AD and the impact of its modulation on mitochondria structure and function as well as on AD-related alterations. …”
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A new ALK inhibitor overcomes resistance to first‐ and second‐generation inhibitors in NSCLC by Yue Lu, Zhenzhen Fan, Su‐Jie Zhu, Xiaoxing Huang, Zhongji Zhuang, Yunzhan Li, Zhou Deng, Lei Gao, Xuehui Hong, Ting Zhang, Li Li, Xihuan Sun, Wei Huang, Jingfang Zhang, Yan Liu, Baoding Zhang, Jie Jiang, Fu Gui, Zheng Wang, Qiyuan Li, Siyang Song, Xin Huang, Qiao Wu, Lanfen Chen, Dawang Zhou, Jianming Zhang, Cai‐Hong Yun, Liang Chen, Xianming Deng

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Engineering a 3D platform for testis bioengineering: generation and proteomic profiling of decellularized fish testicular scaffolds by Ivana Felipe Rosa, Ivana Felipe Rosa, Ivana Felipe Rosa, Beatriz Marques Souza, Lucas Benites Doretto, Lucas Benites Doretto, Maira da Silva Rodrigues, Caroline Nascimento Barquilha, Matheus Naia Fioretto, Luiz Marcos Frediani Portela, José Carlos Souza Vieira, Luis Antonio Justulin, Pedro de Magalhães Padilha, Changwei Shao, Changwei Shao, Rafael Henrique Nóbrega

“…SDS treatment effectively eliminated cellular components while preserving key ECM proteins, including Collagen I, Fibronectin, and Laminin α1. …”
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Caveolae and caveolins role in health and disease by R. I. Voroblev, G. I. Shumakher, M. A. Khoreva, I. V. Osipova, Yu. V. Korenovsky

“…Later, caveolins were identified - the proteins acting as principal structural components of caveolae membrane. Since then, the important role of caveolins in a variety of cellular functions, including endocytosis processes, lipid homeostasis, signal transduction, and tumor suppression, has been demonstrated in numerous studies. …”
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Carrot and stick: how RNase R contributes to function and destruction of the translation machinery by Helge Paternoga, Lyudmila Dimitrova-Paternoga

“…Given RNA’s abundance and its role in all cellular processes, RNases – enzymes responsible for RNA degradation and processing – are central to RNA metabolism. …”
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Glycerophospholipids in ALS: insights into disease mechanisms and clinical implication by Thibaut Burg, Ludo Van Den Bosch

“…These lipids not only play a structural role in membranes, but also contribute to cellular metabolism, signaling pathways, and cell type-specific processes such as neuronal transmission and muscle contraction. …”
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Heterogeneity as a feature: unraveling chromatin’s role in nuclear mechanics by Wessel S. Rodenburg, Amy R. Strom, Jorine M. Eeftens

“…Mechanical forces are a ubiquitous feature of the cellular environment. These forces propagate to the nucleus, where the mechanical response is critical for cellular function and survival. …”
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Bioinformatic Prediction of Novel microRNAs Encoded in Krüppel-like Factor 4 Gene by Mina Zahiri, Maryam Hassanlou, Amir-Reza Javanmard, Nooshin Bijari

“…This study significantly contributes to our understanding of the complex function of KLF4 and reveals additional layers of regulatory complexity that affect gene function and cellular dynamics. Advanced bioinformatics methods, including SSCprofiler website, were used to predict stem-loop structures in KLF4 gene, and MatureBayes website was used to predict the mature sequence of microRNAs, which indicate potential miRNA candidates. …”
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HEAD AND NECK SQUAMOUS CELL CARCINOMA DEPENDING ON THE MORPHOLOGICAL CHARACTERISTICS OF THE PRIMARY TUMOR by V. A. Bychkov, L. N. Bondar, E. L. Choynzonov, V. M. Perelmuter

“…Objective: to analyze the association of 5 types of cellular structures of squamous cell carcinoma with major clinical and morphological tumor characteristics. …”
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Chemical Biology of G-quadruplex and i-motif DNA: use of topologically constrained DNA by Dejeu, Jérôme, Defrancq, Eric

“…We have developed chemical tools named TASQ (Template-Assembled Synthetic Quadruplex) to address the following scientific goals: (i) identify unambiguous (i.e., affine and specific) G4- and i-DNA-interacting ligands, (ii) identify proteins interacting with those structures and determine their cellular relevance and (iii) select specific antibodies for G4 and i-DNA. …”
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The conserved noncoding RNA ModT coordinates growth and virulence in Clostridioides difficile. by Tina Lenče, Johannes Sulzer, Kilian Andress, Anne-Sophie Gribling-Burrer, Vanessa Lamm-Schmidt, Lars Barquist, Redmond P Smyth, Franziska Faber

“…They often exhibit complex tertiary structures that are a key determinant of their biochemical function. …”
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Exploring Solar Granulation: from IMaX/SUNRISE to DKIST by Reza Mansouri, Rafal Angryk, Kevin Reardon

“… Granules are small cellular structures that populate the solar photosphere and are formed by the dynamic behavior of convection cells. …”
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The Role of Sox17 Gene Expression in Early Definition of Anterior Pole of the Rabbit Embryo at Early Pre-Gastrulation Stages by Baghdad Science Journal

“…These structures are defined morphologically and are called in mouse (AVE), in rabbit (AMC) and in the pig (AHB). …”
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Cryo‐Electron Tomography of Toxoplasma gondii Indicates That the Conoid Fiber May Be Derived from Microtubules by Zhixun Li, Wenjing Du, Jiong Yang, De‐Hua Lai, Zhao‐Rong Lun, Qiang Guo

“…The fine structure and cellular distribution of the cytoskeleton are resolved and analyzed at nanometer resolution. …”
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Diagnosis of the Multiepitope Protein rMELEISH3 for Canine Visceral Leishmaniasis by Rita Alaide Leandro Rodrigues, Mariana Teixeira de Faria, Isadora Braga Gandra, Juliana Martins Machado, Ana Alice Maia Gonçalves, Daniel Ferreira Lair, Diana Souza de Oliveira, Lucilene Aparecida Resende, Maykelin Fuentes Zaldívar, Ronaldo Alves Pinto Nagem, Rodolfo Cordeiro Giunchetti, Alexsandro Sobreira Galdino, Eduardo Sergio da Silva

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Coordinated synthesis of aromatic amino acid derived pigments in yeast via global transcriptional engineering by Huimin Xue, Mingshan Li, Yuhui Cui, Dongkui Tian, Duo Liu, Hanjie Wang

“…Conclusions Our strategy supplies an effective way to optimize the coordinated synthesis of two structurally divergent pigments downstream of the common aromatic amino acid pathway.…”
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Automated identification of pathways from quantitative genetic interaction data by Alexis Battle, Martin C Jonikas, Peter Walter, Jonathan S Weissman, Daphne Koller

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