Mitochondrial function: A new direction for the targeted treatment of cardiovascular diseases with Chinese herbal medicine by Lin Yang, Liang Wang, Baofeng Yang, Yue Zhang

“…Nevertheless, contemporary investigations into mitochondrial biology have unveiled their intricate structural and functional characteristics, as well as their complex roles within cellular systems, which present obstacles to the clinical implementation of mitochondria-focused cardiovascular therapies. …”
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Quantifying treatment response to a macrophage-targeted therapy in combination with immune checkpoint inhibitors after exposure to conventional chemotherapy by Shelby N. Bess, Gaven K. Smart, Timothy J. Muldoon

“…In addition to using the spheroid model, conventional 2D co-culture monolayers were used to quantify ICD hallmarks and changes in macrophage functional behavior while correlating immune responses after exposure to the combinatory regimen of immune checkpoint inhibitors and an ICD inducer.ResultsResults indicate that the combination of two immune checkpoint inhibitors in addition to a chemotherapy agent reduced spheroid growth (~46%) and reduced M2 macrophage expression and cellular proliferation while modulating cellular metabolism, ICD hallmarks, and phagocytic function.ConclusionsOverall, this study not only quantified microregional metabolic and structural changes in a simulated spheroid model but also quantified changes in ICD hallmarks and macrophage functional behavior. …”
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Landscape of nuclear transport receptor cargo specificity by Marie‐Therese Mackmull, Bernd Klaus, Ivonne Heinze, Manopriya Chokkalingam, Andreas Beyer, Robert B Russell, Alessandro Ori, Martin Beck

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ebv-sisRNA-3 contributes to the formation of G4-associated R-loop upstream of EBV lytic replication origin in latently infected cells by Bo Wang, Grace Tin Yun Chung, Yi Shuai, Man Wu, Danyang Ji, Raymond Wai Ming Lung, Yuk Yu Chan, Ming Ting Liu, Ee Ling Kong, Shin Yee Hui, Hei Man Leung, Qian Wu, Melissa Sue Ann Chan, Xin Wang, Guang Zhu, Kevin Y. Yip, Chun Kit Kwok, Kwok Wai Lo, Chi Man Tsang

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How influenza A virus NS1 impedes transcription of the host cell’s messenger RNAs by Daniel Marc

“…How influenza virus non-structural protein NS1 inhibits the activity of nuclear speckles, these liquid-liquid phase separation complexes that control the transcription and post-transcriptional regulation of cellular genes.…”
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Control of T-cell immunity by fatty acid metabolism by Jaemin Kim, Yoosun Lee, Yeonseok Chung

“…Fatty acids impact T cells by modulating signaling pathways, inducing metabolic changes, altering cellular structures, and regulating gene expression epigenetically. …”
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Mitochondrial Quality Control: Decommissioning Power Plants in Neurodegenerative Diseases by Rukmini Mukherjee, Oishee Chakrabarti

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Breaking down biofilms across critical priority fungal pathogens: proteomics and computational innovation for mechanistic insights and new target discovery by Oscar Romero, Jennifer Geddes-McAlister

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Myosin Light Chains in the Progression of Cancer by Savannah L. Kozole, Karen A. Beningo

“…The myosin light chains (MLCs) of non-muscle myosin II are known to regulate cellular architecture and generate cellular forces; they also have an increasingly emerging role in the progression of cancer. …”
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ATRX dysfunction induces replication defects in primary mouse cells. by David Clynes, Clare Jelinska, Barbara Xella, Helena Ayyub, Stephen Taylor, Matthew Mitson, Csanád Z Bachrati, Douglas R Higgs, Richard J Gibbons

“…It is as yet unknown whether there is a central underlying mechanism associated with ATRX dysfunction which can explain the numerous cellular phenomena observed. There is, however, growing evidence for its role in the replication of various repetitive DNA templates which are thought to have a propensity to form secondary structures. …”
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The rapidly evolving view of lysosomal storage diseases by Giancarlo Parenti, Diego L Medina, Andrea Ballabio

“…Most commonly affected are lysosomal hydrolases, which are involved in the breakdown and recycling of a variety of complex molecules and cellular structures. The understanding of lysosomal biology has progressively improved over time. …”
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Mycobacterium smegmatis Ribosome Purification, Co-sedimentation, and Subunit Association Assay by Aneek Banerjee, Sandip Dey, Krishnamoorthi Srinivasan, Ankit Dhur, Priya Baid, Jayati Sengupta

“…The ribosome, a complex macromolecular machine, plays a vital role in cellular translation. To investigate its structure and conduct in vitro experiments, isolating the ribosomes from cells is the first step. …”
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Combining dynamin 2 myopathy and neuropathy mutations rescues both phenotypes by Marie Goret, Evelina Edelweiss, Jérémy Jehl, David Reiss, Patricio Aguirre-Pineda, Sylvie Friant, Jocelyn Laporte

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The application of high-degree freedom titanium alloy implant based on TPMS in the repair of metacarpal bone defects by Mingrui Liu, Tao Lin, Jiaying Li, Junkai Hu, Lin Xu, Lincong Luo, Wenhua Huang

“…Using 3D structural optimization, a personalized biomimetic bone defect implant model (G model) based on Gyroid solid network structures was designed, with Ti-6Al-4V alloy as the material for 3D printing. …”
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Role of shielding gas in tailoring microstructure and anisotropy in wire arc additive manufactured Inconel 686 by S. Ajithkumar, B. Arulmurugan, M. Manikandan, M. Sathishkumar

“…Microstructural analysis revealed variations in dendritic structures, with pure He producing the finest cellular and equiaxed structures. …”
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Drug-induced cytotoxicity prediction in muscle cells, an application of the Cell Painting assay. by Roman Lambert, Eva Serrano Candelas, Pablo Aparicio, Aisling Murphy, Rafael Gozalbes, Howard Oliver Fearnhead

“…In this study, a myoblast cell line is used to characterize cellular responses to a panel of 30 known myotoxicants. …”
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Developing a new cleavable crosslinker reagent for in-cell crosslinking by Fränze Müller, Bogdan R. Brutiu, Iakovos Saridakis, Thomas Leischner, Micha J. Birklbauer, Manuel Matzinger, Mathias Madalinski, Thomas Lendl, Saad Shaaban, Viktoria Dorfer, Nuno Maulide, Karl Mechtler

“…Crosslinkers which are amenable to post-linking backbone cleavage simplify peptide identification, aid in 3D structure determination and enable system-wide studies of protein-protein interactions (PPIs) in cellular environments. …”
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Systematic analysis of cotranscriptional RNA folding using transcription elongation complex display by Skyler L. Kelly, Eric J. Strobel

“…Abstract RNA can fold into structures that mediate diverse cellular functions. …”
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Microbial Metabolite Effects on Vasculogenic Mimicry in Metastatic Cancers by Mohammad Kamalabadi Farahani, Aisa Bahar, Hamed Tahmasebi, Valentyn Oksenych, Mojdeh Jahantigh

“…Aggressive cancer cells can form new, functional blood vessel-like structures independently of endothelial cells, known as vasculogenic mimicry (VM), instead of the usual tumor blood vessel formation process. …”
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Exploring organoid and assembloid technologies: a focus on retina and brain by Sara Ouaidat, Alessandro Bellapianta, Franziska Ammer-Pickhardt, Tara Taghipour, Matthias Bolz, Ahmad Salti

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