Rbm3 deficiency leads to transcriptome-wide splicing alterations by Steffen Erkelenz, Marta Grzonka, Antonios Papadakis, Heiner Schaal, Jan H. J. Hoeijmakers, Ákos Gyenis

“…Rbm3 (RNA-binding motif protein 3) is a stress responsive gene, which maintains cellular homeostasis and promotes survival upon various harmful cellular stimuli. …”
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Characterizing Host microRNA: Virus Interactions of <i>Orthoavulavirus javaense</i> by Megan C. Mears, Abhijeet Bakre

“…The analysis of the secondary structures flanking these vSMs and vSSs showed structural features common to miRNA precursors. …”
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The environmental adaptation of acidophilic archaea: promotion of horizontal gene transfer by genomic islands by Jingxuan Qiu, Huiling Tao, Hongyu Li, Xinyi Liu, Rui Liu, Muhammed Naveed Nawaz, Xingjie Wang, Liyuan Ma

“…However, the distribution, structure, and function of GI within the genomes of archaea remain poorly understood. …”
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An mRNA-display derived cyclic peptide scaffold reveals the substrate binding interactions of an N-terminal cysteine oxidase by Yannasittha Jiramongkol, Karishma Patel, Jason Johansen-Leete, Joshua W. C. Maxwell, Yiqun Chang, Jonathan J. Du, Toby Passioura, Kristina M. Cook, Richard J. Payne, Mark D. White

“…Abstract N-terminal cysteine oxidases (NCOs) act as enzymatic oxygen (O2) sensors, coordinating cellular changes to hypoxia in animals and plants. …”
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How does a small molecule bind at a cryptic binding site? by Yibing Shan, Venkatesh P Mysore, Abba E Leffler, Eric T Kim, Shiori Sagawa, David E Shaw

“…Protein-protein interactions (PPIs) are ubiquitous biomolecular processes that are central to virtually all aspects of cellular function. Identifying small molecules that modulate specific disease-related PPIs is a strategy with enormous promise for drug discovery. …”
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Stroke increases neural stem cells and angiogenesis in the neurogenic niche of the adult mouse. by Rui Lan Zhang, Michael Chopp, Cynthia Roberts, Xianshuang Liu, Min Wei, Siamak P Nejad-Davarani, Xinli Wang, Zheng Gang Zhang

“…The unique cellular and vascular architecture of the adult ventricular-subventricular zone (V/SVZ) neurogenic niche plays an important role in regulating neural stem cell function. …”
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Loose binding of the DF axis with the A3B3 complex stimulates the initial activity of Enterococcus hirae V1-ATPase. by Md Jahangir Alam, Satoshi Arai, Shinya Saijo, Kano Suzuki, Kenji Mizutani, Yoshiko Ishizuka-Katsura, Noboru Ohsawa, Takaho Terada, Mikako Shirouzu, Shigeyuki Yokoyama, So Iwata, Yoshimi Kakinuma, Ichiro Yamato, Takeshi Murata

“…We have previously reported crystal structures of Enterococcushirae V-ATPase A3B3 and A3B3DF (V1) complexes; the result suggested that the DF axis induces structural changes in the A3B3 complex through extensive protein-protein interactions. …”
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CRISPR-Cas9 Gene Therapy: Non-Viral Delivery and Stimuli-Responsive Nanoformulations by Hyunwoo Lee, Won-Yeop Rho, Yoon-Hee Kim, Hyejin Chang, Bong-Hyun Jun

“…We describe how recent reports emphasize that nonviral vectors, including lipid-based nanoparticles, extracellular vesicles, polymeric nanoparticles, gold nanoparticles, and mesoporous silica nanoparticles, can offer diverse advantages to enhance stability, cellular uptake, and biocompatibility, based on their structures and physio-chemical stability. …”
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Application of biomedical cell products in the treatment of congenital epidermolysis bullosa by Arfenya E. Karamova, Kseniya M. Aulova, Vadim V. Chikin, Аlexey A. Kubanov

“…Congenital epidermolysis bullosa is a phenotypically and genetically heterogeneous group of genodermatoses, which are characterized by decreasing of skin’s structural protein production up to complete absence or violation of the structure as a result of mutation. …”
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Polyphosphate discriminates protein conformational ensembles more efficiently than DNA promoting diverse assembly and maturation behaviors by Saloni Goyal, Divya Rajendran, Anup Kumar Mani, Athi N Naganathan

“…Polyphosphate induces large secondary-structure changes, with two of the mutants adopting polyproline II-like structures within droplets, while DNA has only minimal structural effects. …”
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Biochemical analysis of packing and assembling heptad repeat motifs in the coronavirus spike protein trimer by Jun Kobayashi, Kazuhiko Kanou, Hiyori Okura, Tahmina MST Akter, Shuetsu Fukushi, Shutoku Matsuyama

“…This biochemical study provides mechanistic insight into the previously unknown intermediate structure of the viral fusion protein.IMPORTANCEDuring infection by an enveloped virus, receptor binding triggers fusion between the cellular membrane and the virus envelope, enabling delivery of the viral genome to the cytoplasm. …”
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Scalability in SLA lattice through lattice orientation and hybrid frame and plate architectures by Mahan Ghosh, Nandika Anne D'Souza, Yunwei Xu, Mohan Sai Kiran Kumar Yadav Nartu, Vignesh Pagadalu, Sina Rastegarzadeh, Jida Huang

“…Cellular structure-inspired lattice truss frame designs made of struts, have been extensively studied. …”
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Mammalian cell-based production of glycans, glycopeptides and glycomodules by Thapakorn Jaroentomeechai, Richard Karlsson, Felix Goerdeler, Fallen Kai Yik Teoh, Magnus Nørregaard Grønset, Dylan de Wit, Yen-Hsi Chen, Sanae Furukawa, Venetia Psomiadou, Ramon Hurtado-Guerrero, Elena Ethel Vidal-Calvo, Ali Salanti, Thomas J. Boltje, Leendert J. van den Bos, Christian Wunder, Ludger Johannes, Katrine T. Schjoldager, Hiren J. Joshi, Rebecca L. Miller, Henrik Clausen, Sergey Y. Vakhrushev, Yoshiki Narimatsu

“…However, access to human glycans in formats and quantities that allow structural studies of molecular interactions and use of glycans in biomedical applications currently rely on chemical and chemoenzymatic syntheses associated with considerable labor, waste, and costs. …”
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Dataset of transcriptomic changes induced by naringenin treatment in MCF-7 breast cancer cellsGene Expression Omnibus by Van T. Hoang, Mackenzie L. Hawes, Jack R. Elliott, Steven Elliott, Binghao Zou, Stephen M. Boué, Brian G. Rowan, Bridgette M. Collins-Burow, Jorge A. Belgodere, Muralidharan Anbalagan, Elizabeth C. Martin, Matthew E. Burow

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Altered olfactory responses in Fmr1 KO mice by Jan Tuma, Amtul-Noor Rana, Teena Philip, Jeong Ben Park, Hye Young Lee

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Liquid-liquid phase separation of membrane-less condensates: from biogenesis to function by Huanyu Guan, Hui Wang, Xin Cai, Jiabo Wang, Zhixin Chai, Jikun Wang, Haibo Wang, Ming Zhang, Zhijuan Wu, Jiangjiang Zhu, Jincheng Zhong, Binglin Yue

“…Membrane-less condensates (MLCs) are highly concentrated non-membrane-bounded structures in mammalian cells, comprising heterogeneous mixtures of proteins and/or nucleic acids. …”
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A systematic screen for protein–lipid interactions in Saccharomyces cerevisiae by Oriol Gallego, Matthew J Betts, Jelena Gvozdenovic‐Jeremic, Kenji Maeda, Christian Matetzki, Carmen Aguilar‐Gurrieri, Pedro Beltran‐Alvarez, Stefan Bonn, Carlos Fernández‐Tornero, Lars Juhl Jensen, Michael Kuhn, Jamie Trott, Vladimir Rybin, Christoph W Müller, Peer Bork, Marko Kaksonen, Robert B Russell, Anne‐Claude Gavin

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Millimeter‐scale genetic gradients and community‐level molecular convergence in a hypersaline microbial mat by Victor Kunin, Jeroen Raes, J Kirk Harris, John R Spear, Jeffrey J Walker, Natalia Ivanova, Christian von Mering, Brad M Bebout, Norman R Pace, Peer Bork, Philip Hugenholtz

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Solving the Amyloid Paradox: Unveiling the Complex Pathogenicity of Amyloid Fibrils by Maksim I. Sulatsky, Olesya V. Stepanenko, Olga V. Stepanenko, Anna I. Sulatskaya

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Decoding phospho-regulation and flanking regions in autophagy-associated short linear motifs by Mattia Utichi, Oana N. Antonescu, Valentina Sora, Henri-Baptiste Marjault, Matteo Tiberti, Emiliano Maiani, Matteo Lambrughi, Elena Papaleo

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