Virus-modified paraspeckle-like condensates are hubs for viral RNA processing and their formation drives genomic instability by Katherine L. Harper, Elena M. Harrington, Connor Hayward, Chinedu A. Anene, Wiyada Wongwiwat, Robert E. White, Adrian Whitehouse

“…We demonstrate that Kaposi’s sarcoma-associated herpesvirus (KSHV) drives formation of structurally distinct paraspeckles with a dramatically increased size and altered protein composition that are required for productive lytic replication. …”
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A goldilocks computational protocol for inhibitor discovery targeting DNA damage responses including replication-repair functions by Davide Moiani, Davide Moiani, Davide Moiani, John A. Tainer, John A. Tainer, John A. Tainer

“…Here, we present a robust Goldilocks (GL) computational discovery protocol to efficiently innovate inhibitor tools and preclinical drug candidates for cellular and structural biologists without requiring extensive virtual screen (VS) and chemical synthesis expertise. …”
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Comparison of the Tendon Damage Caused by Four Different Anchor Systems Used in Transtendon Rotator Cuff Repair by Qing-Song Zhang, Sen Liu, Qiuyang Zhang, Yun Xue, Dongxia Ge, Michael J. O'Brien, Felix H. Savoie, Zongbing You

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THE BASIC HYPOTHESIS FOR MECHANOTRANSDUCTION IN SENSORY RECEPTORS by Ch. Chouchkov, Iv. Maslarski

“…There also exist difficulties regarding the correlation of the physiological with morphological data due to the fact that the receptor axolemma is surrounded by complex cellular structures whose isolation is hard to perform.…”
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Aging Phenotypes of Common Marmosets (Callithrix jacchus) by Corinna N. Ross, Kenneth Davis, Georgina Dobek, Suzette D. Tardif

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Assessment of membrane and metabolic parameters of erythrocytes exposed to selected bromophenols by Monika Jarosiewicz, Piotr Duchnowicz, Bożena Bukowska

“…This study provides new insights into the potential toxicological mechanisms of BPs and their impact on cellular integrity. Moreover, the number of bromine atoms in bromophenols plays a crucial role in inducing damage to specific cellular structures and, ultimately, in determining their toxicity.…”
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Phasor-FSTM: a new paradigm for multicolor super-resolution imaging of living cells based on fluorescence modulation and lifetime multiplexing by Luwei Wang, Yue Chen, Jiaqing Guo, Xiaoyu Weng, Wei Yan, Jun Song, Tong Ye, Junle Qu

“…Abstract Multicolor microscopy and super-resolution optical microscopy are two widely used techniques that greatly enhance the ability to distinguish and resolve structures in cellular imaging. These methods have individually transformed cellular imaging by allowing detailed visualization of cellular and subcellular structures, as well as organelle interactions. …”
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Autophagy, apoptosis, necroptosis, pyroptosis and netosis in pathogenesis of immune-inflammatory rheumatic diseases by M. Z. Saidov

“…There are organized forms of cellular infiltrate observed in immune-inflammatory rheumatic diseases, i.e., ectopic follicle-like lymphoid structures and delayed-type response granulomas, whereas diffuse cellular inflammatory infiltrates represent non-organized forms. …”
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Optimized AAV capsids for basal ganglia diseases show robust potency and distribution by D. E. Leib, Y. H. Chen, L. Tecedor, P. T. Ranum, M. S. Keiser, B. C. Lewandowski, E. M. Carrell, S. Arora, I. Huerta-Ocampo, D. Lai, C. M. Fluta, C. Cheng, X. Liu, B. L. Davidson

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Unveiling the intricacies of cardiac valve pathophysiology by Johannes H. Jedrzejczyk, Johannes H. Jedrzejczyk, Oline Hjertensgaard, Oline Hjertensgaard, Victor G. Puelles, Victor G. Puelles, Victor G. Puelles, J. Michael Hasenkam, J. Michael Hasenkam

“…However, pathological stimuli can cause aberrant activation of the valvular interstitial cells, leading to valve calcification and stenosis.ConclusionThe intricate interplay of cellular components within cardiac valves is vital for maintaining normal valve function and structural integrity, but also contributes to valve pathology. …”
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Membraneless organelles in health and disease: exploring the molecular basis, physiological roles and pathological implications by Yangxin Li, Yuzhe Liu, Xi-Yong Yu, Yan Xu, Xiangbin Pan, Yi Sun, Yanli Wang, Yao-Hua Song, Zhenya Shen

“…Abstract Once considered unconventional cellular structures, membraneless organelles (MLOs), cellular substructures involved in biological processes or pathways under physiological conditions, have emerged as central players in cellular dynamics and function. …”
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Heparin, Heparin-like Molecules, and Heparin Mimetics in Breast Cancer: A Concise Review by Diego R. Gatica Portillo, Yishu Li, Navneet Goyal, Brian G. Rowan, Rami A. Al-Horani, Muralidharan Anbalagan

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NMR characterization of the near native and unfolded states of the PTB domain of Dok1: alternate conformations and residual clusters. by Sebanti Gupta, Surajit Bhattacharjya

“…<h4>Background</h4>Phosphotyrosine binding (PTB) domains are critically involved in cellular signaling and diseases. PTB domains are categorized into three distinct structural classes namely IRS-like, Shc-like and Dab-like. …”
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METODOLOGICAL ISSUES IN PROTEIN AND LIPIDIC EXPRESSIONS IN BRAIN TISSUE EXPOSED TO Co60 BASED ON DESI/MALDI-MSI by Matheus Figueiredo Soares Mingote

“…Lipids and proteins are biomolecules with diverse structures and functionalities that participate in important intracellular processes. …”
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Isolation of human mitotic protein phosphatase complexes: identification of a complex between protein phosphatase 1 and the RNA helicase Ddx21. by Veerle De Wever, David C Lloyd, Isha Nasa, Mhairi Nimick, Laura Trinkle-Mulcahy, Robert Gourlay, Nick Morrice, Greg B G Moorhead

“…Metazoan mitosis requires remodelling of sub-cellular structures to ensure proper division of cellular and genetic material. …”
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Microscopy image reconstruction with physics-informed denoising diffusion probabilistic model by Rui Li, Gabriel della Maggiora, Vardan Andriasyan, Anthony Petkidis, Artsemi Yushkevich, Nikita Deshpande, Mikhail Kudryashev, Artur Yakimovich

“…Abstract Light microscopy is a practical tool for advancing biomedical research and diagnostics, offering invaluable insights into the cellular and subcellular structures of living organisms. …”
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Interleukin-33 and Obesity-Related Inflammation and Cancer by Cameron Kowitt, Qiuyang Zhang

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Targeted detection of endogenous LINE-1 proteins and ORF2p interactions by Mathias I. Nielsen, Justina C. Wolters, Omar G. Rosas Bringas, Hua Jiang, Luciano H. Di Stefano, Mehrnoosh Oghbaie, Samira Hozeifi, Mats J. Nitert, Alienke van Pijkeren, Marieke Smit, Lars ter Morsche, Apostolos Mourtzinos, Vikram Deshpande, Martin S. Taylor, Brian T. Chait, John LaCava

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Targeting ERBB3 and AKT to overcome adaptive resistance in EML4-ALK-driven non-small cell lung cancer by Josephina Sampson, Hyun-min Ju, Nan Zhang, Sharon Yeoh, Jene Choi, Richard Bayliss

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Dimerization and substrate recognition of human taurine transporter by Yimin Zhang, Jiahui Chen, Nanhao Chen, Haolin Xiong, Zhengjiang Zhu, Dongxue Yang, Jingpeng Ge, Jie Yu

“…Here we determine structures of TauT in two states: the apo inward-facing open state and the occluded state bound with substrate taurine or γ-aminobutyric acid (GABA). …”
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