Gut microbiota differences linked to weight gain and ART in people living with HIV are enterotype specific and minor compared to the large differences linked to sexual behavior by Jan Kehrmann, Alireza Dostmohammadi, Anna-Lena Stumpf, Lara Best, Leah Consten, Hannah Sievert, Felix Maischack, Stefanie Sammet, Sarah Albayrak-Rena, Ann-Kathrin Doerr, Katharina Bohlen, Otgonzul von Velsen, Otgonzul von Velsen, Ivana Kraiselburd, Christina B. Karsten, Farnoush Farahpour, Farnoush Farahpour, Folker Meyer, Stefan Esser, Jan Buer

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Salivary microbiota and IgA responses are different in pre-diabetic individuals compared to normoglycemic controls by Nahoko Kato-Kogoe, Kouji Tsuda, Asako Kudo, Shoichi Sakaguchi, Michi Omori, Eri Komori, Mayu Ohmichi, Wataru Hamada, Shota Nakamura, Takashi Nakano, Junko Tamaki, Takaaki Ueno

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Helile formula from “Tai ping sheng hui fang”: anti-Helicobacter pylori activity, gut microbiota modulation, and inflammatory response regulation by Ling Ou, Meiyun Chen, Chang Peng, Haobo Chen, Yajie Hao, Qingchang Chen, Zhong Feng, Zhong Feng, Meicun Yao, Meicun Yao, Xianhe Kong, Xianhe Kong, Xianhe Kong

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Electrophysiological comparison of left versus right stellate ganglia neurons by Arie O. Verkerk, Carol Ann Remme, Molly O'Reilly

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Isoform switch of T-cell factor7L2 during mouse heart development by Bo Ye, Lu Xiao, Yuyong Xu, Haodong Xu, Faqian Li

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Sirtuin 4 accelerates heart failure development by enhancing reactive oxygen species-mediated profibrotic transcriptional signaling by Nikole J. Byrne, Christoph Koentges, Elisabeth Khan, Katharina Pfeil, Robert Sandulescu, Sayan Bakshi, Carolin Költgen, Ivan Vosko, Johannes Gollmer, Thomas Rathner, Günter Roth, Michael M. Hoffmann, Katja E. Odening, Hauke Horstmann, Luke A. Potter, Christoph Bode, Dennis Wolf, Harald Sourij, Senka Ljubojevic-Holzer, Markus Wallner, Peter P. Rainer, Simon Sedej, Daniel Scherr, Dirk von Lewinski, Adam R. Wende, Andreas Zirlik, Heiko Bugger

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Performance horses as a model for exercise-associated cardiac arrhythmias and sudden cardiac death by Amanda Avison, Peter W. Physick-Sheard, W. Glen Pyle

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Current status and challenges of multi-omics research using animal models of atherosclerosis by Tijana Mitić, Adriana Georgescu, Nicoleta Alexandru-Moise, Michael J. Davies, Cecile Vindis, Susana Novella, Eva Gerdts, Georgios Kararigas, Stephanie Bezzina Wettinger, Melissa M. Formosa, Brenda R. Kwak, Filippo Molica, Nuria Amigo, Andrea Caporali, Fernando de la Cuesta, Ignacio Fernando Hall, Angeliki Chroni, Fabio Martelli, Johannes A. Schmid, Paolo Magni, Dimitris Kardassis

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Characterization of human living myocardial slices culture-induced adaptations: a translational perspective by Jort S.A. van der Geest, Ernest Diez Benavente, Willem B. van Ham, Pieter A. Doevendans, Linda W. van Laake, Teun P. de Boer, Vasco Sampaio-Pinto, Joost P.G. Sluijter

“…Heart failure involves complex pathophysiological processes, best studied in multicellular human cardiac tissues that reflect the native cellular composition and microenvironment. However, maintaining primary cells and tissues in culture for extended periods remains challenging. …”
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SGLT2 inhibitor upregulates myocardial genes for oxidative phosphorylation and fatty acid metabolism in Gαq-mice by Jordan M. Chambers, Dominique Croteau, David R. Pimentel, Adam C. Gower, Marcello Panagia, Tomas Baka, Fuzhong Qin, Ivan Luptak, Wilson S. Colucci

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Generation and evaluation of a novel PI3K-targeting gene therapy in the failing mouse heart and healthy sheep heart by Sebastian Bass-Stringer, Daniel G. Donner, Clive N. May, Aya Matsumoto, Emma I. Masterman, Aascha A. D'Elia, Yi Ching Chen, Helen Kiriazis, Jieting Luo, Roger Chooi, Clara Liu Chung Ming, Paul Gregorevic, Colleen J. Thomas, Bianca C. Bernardo, Kate L. Weeks, Julie R. McMullen

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Molecular basis for the phosphorylation of bacterial tyrosine kinase Wzc by Yun Yang, Mariana Batista, Bradley R. Clarke, Michelle R. Agyare-Tabbi, Haigang Song, Noah M. Kuehfuss, Audrey Le Bas, Carol V. Robinson, Chris Whitfield, Phillip J. Stansfeld, James H. Naismith, Jiwei Liu

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A Micro-Computed Tomography-Based Simplified Approach to Measure Body Composition, Osteoporosis, and Lung Fibrosis in Mice by Madeleine Landau, Binghao Zou, Ziqi Yang, Brian Rowan, Muralidharan Anbalagan

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Building bridges toward invasion: tumor promoter treatment induces a novel protein kinase C-dependent phenotype in MCF10A mammary cell acini. by Kristine S Klos, Janel K Warmka, Disa M Drachenberg, Liang Chang, G W Gant Luxton, Cheuk T Leung, Kathryn L Schwertfeger, Elizabeth V Wattenberg

“…MCF10A cells, which are immortalized but nontumorigenic, form hollow, spheroid structures in 3D culture referred to as acini. The development of normal acini requires the tight spatiotemporal regulation of cellular proliferation, polarization, apoptosis, and growth arrest. …”
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Oligomerization of the Clostridioides difficile transferase B component proceeds through a stepwise mechanism. by Robin M Mullard, Michael J Sheedlo

“…These structures provide insight into the mechanism underlying toxin assembly and highlight a role for structural plasticity during this process. …”
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The use of intuitive AF-based modelling for the understanding of activation and signalling through insulin-like receptors by Andrzej M. Brzozowski, Talha Shafi, Olga V. Moroz, Pierre De Meyts

“…They tend to occlude the transmembrane (TM) and intra-cellular parts of the receptors, which, together with their inherent dynamic characters, prohibits - so far - determination of their full, continuous structures. …”
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Molecular mechanisms of thiazide-like diuretics-mediated inhibition of the human Na-Cl cotransporter by Chien-Ling Lee, Jianxiu Zhang, Liang Feng

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DNA supercoiling-mediated G4/R-loop formation tunes transcription by controlling the access of RNA polymerase by Jihee Hwang, Chun-Ying Lee, Sumitabha Brahmachari, Shubham Tripathi, Tapas Paul, Huijin Lee, Alanna Craig, Taekjip Ha, Sua Myong

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Extrusion-Based Printing of Myoblast-Loaded Fibrin Microthreads to Induce Myogenesis by Hanson S. Lee, Bryanna L. Samolyk, George D. Pins

“…Various biofabrication strategies have been developed to create engineered skeletal muscle constructs that mimic native matrix and cellular microenvironments to enhance muscle regeneration; however, there remains a need to create scalable engineered tissues that provide mechanical stability as well as structural and spatiotemporal signaling cues to promote cell-mediated regeneration of contractile skeletal muscle. …”
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Expanding the Functions of KHSRP Protein: Insights into DNA G‐Quadruplex Binding by Pasquale Russomanno, Pasquale Zizza, Linda Cerofolini, Federica D'Aria, Sara Iachettini, Serena Di Vito, Annamaria Biroccio, Jussara Amato, Marco Fragai, Bruno Pagano

“…G‐quadruplexes (G4s) are noncanonical nucleic acid structures involved in essential cellular activities, including gene expression, and are recognized as potential therapeutic targets in cancer. …”
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