Genome biology of long non-coding RNAs in humans: A virtual karyotype by Alessandro Palma, Giulia Buonaiuto, Monica Ballarino, Pietro Laneve

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Estimating the effect of tissue- and blood-derived cell reference matrices on deconvolving bulk transcriptomic datasets by Siqi Sun, Shweta Yadav, Mulini Pingili, Dan Chang, Jing Wang

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ChiMSource improves the accuracy of studies on novel amino acid sequences by predicting alternative sources of mass spectrometry-derived peptides by Umut Çakır, Noujoud Gabed, Ali Yurtseven, Igor Kryvoruchko

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Characterizing the pan-cancer role of exosomal miRNAs in metastasis across cancers by Piyush Agrawal, Gulden Olgun, Arashdeep Singh, Vishaka Gopalan, Sridhar Hannenhalli

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From homogeneity to heterogeneity: Refining stochastic simulations of gene regulation by Seok Joo Chae, Seolah Shin, Kangmin Lee, Seunggyu Lee, Jae Kyoung Kim

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Dual threat: Susceptibility mechanisms and treatment strategies for COVID-19 and bacterial co-infections by Keda Chen, Ruiqi Weng, Jiaxuan Li, Hao Wu, Xiaotian Tie, Hongyu Li, Yuanyuan Zhang

“…This review offers an in-depth examination of the mechanisms underlying susceptibility and associated clinical features, and treatment strategies associated with bacterial co-infections in COVID-19 patients. A structured review of the literature revealed that the overall rate of bacterial co-infection among COVID-19 patients is relatively low (6.9 %). …”
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A molecular dynamics protocol for rapid prediction of EGFR overactivation and its application to the rare mutations S768I, S768N, D761N by Julian Behn, R.N.V. Krishna Deepak, Jiancheng Hu, Hao Fan

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BCMA: An integrative and versatile database for multi-scale and multi-omics molecular atlas of breast cancer by Wenbo Guo, Zikang Yin, Qinglin Mei, Lianshuo Li, Yonghui Gong, Xinqi Li, Wei Zhang, Wenjie Lei, Bingqiang Liu, Lin Hou, Mei Yang, Jin Gu

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Deciphering mitochondrial dysfunction in keratoconus: Insights into ACSL4 from machine learning-based bulk and single-cell transcriptome analyses and experimental validation by Yuchen Cai, Tianyi Zhou, Xueyao Cai, Wenjun Shi, Hao Sun, Yao Fu

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Inhibiting MARCH5/Mfn2 signaling as an alternative strategy to protect cardiomyocytes from hypoxia-induced mitochondrial dysfunction by Faten Habrat Zoabi, Mulate Zerihun, Roy Lizarovich, Chiara Dalla Torre, Liron Davis, Offir Ertracht, Michal Barsheshet, Shaul Atar, Deborah E. Shalev, Marta De Zotti, Hanoch Senderowitz, Nir Qvit

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Mechanistic in vitro–in vivo extrapolation (IVIVE) approach using a biomimetic in vitro system for the prediction of hepatic clearance by Seongwon Park, Sun-Sook Song, Woojin Jung, Hwi-yeol Yun, Soyoung Lee, Sun-Woong Kang, Jung-Woo Chae

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Leveraging multiple labeled datasets for the automated annotation of single-cell RNA and ATAC data by Joseba Sancho-Zamora, Akash Kanhirodan, Xabier Garrote, Juan Manuel Silva Rojas, Olivier Gevaert, Mikel Hernaez, Guillermo Serrano, Idoia Ochoa

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Phloretin-induced modulation in gut microbiome, mitigates colonic inflammation and alleviates colitis-associated colorectal cancer in mice by Smita Kapoor, Priyanka Mehta, Vikram Patial, Rajesh Pandey, Yogendra S. Padwad

“…The histopathological analysis revealed normal colonic structure by decreasing leukocyte infiltration, as well as, circumvention in the reduction of the numbers of goblet cell, crypt abscess and ulceration in phloretin and 5-ASA (5-aminosalicylic acid) treated animals, compared to the diseased group. …”
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In-silico proteomic analysis of the role of IL-4 and IL-10 in IVD degeneration: Protein-protein interaction networks for candidate prioritisation by Paola Bermudez-Lekerika, Francesco Gualdi, Christine L. Le Maitre, Janet Piñero, Baldomero Oliva, Benjamin Gantenbein

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CTGCT, Centre of Excellence for the Technologies of Gene and Cell Therapy: Collaborative translation of scientific discoveries into advanced treatments for neurological rare geneti... by Darja Marolt Presen, Duško Lainšček, Jane Kinghorn, Zsolt Sebestyen, Jurgen Kuball, Leila Amini, Petra Reinke, Anke Fuchs, Roman Jerala, Mojca Benčina

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Analysis of mutations in precision oncology using the automated, accurate, and user-friendly web tool PredictONCO by Rayyan Tariq Khan, Petra Pokorna, Jan Stourac, Simeon Borko, Adam Dobias, Joan Planas-Iglesias, Stanislav Mazurenko, Ihor Arefiev, Gaspar Pinto, Veronika Szotkowska, Jaroslav Sterba, Jiri Damborsky, Ondrej Slaby, David Bednar

“…The tool models the structure of the mutant protein in the first step. …”
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Practical guidelines for cell segmentation models under optical aberrations in microscopy by Boyuan Peng, Jiaju Chen, P. Bilha Githinji, Ijaz Gul, Qihui Ye, Minjiang Chen, Peiwu Qin, Xingru Huang, Chenggang Yan, Dongmei Yu, Jiansong Ji, Zhenglin Chen

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An Automated Method for the Quantification and Fractal Analysis of Immunostaining by Armin Gerger, Patrick Bergthaler, Josef Smolle

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Malaria Cytoskeletal Proteins Require Alveolin–Alveolin Interactions for Differential Localization by Ana Karla Cepeda Diaz, Peter S. Back, Sreelakshmi K. Sreenivasamurthy, Jeffrey D. Dvorin

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PRIMA-1MET Inhibits Growth of Mouse Tumors Carrying Mutant p53 by Nicole Zache, Jeremy M. R. Lambert, Klas G. Wiman, Vladimir J. N. Bykov

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