Phenylacetylglutamine produced from injury lung alveolar epithelial cells promotes the function of BMSCs by regulating NONRATT006276.2/Mapt pathway by Tianyun Yang, Juan Peng, Rongrong Ren, Lin Song

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Next-Generation Computational Approaches for Biological Network Analysis by Hamza Ali Mari, Maham Taqi, Abrar Ahmed Rattar, Ahsan Jamal Memon, Muhammad Talha Nasir, Arleen Yousuf

“…We cover sequence-based approaches, such as homology, domain, and motif-based methods, as well as structure-based methods like structural alignment, comparison, and interface-based prediction. …”
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Oral Angiotensin-(1-7) formulation after established elastase-induced emphysema suppresses inflammation and restores lung architecture by Giselle Santos Magalhaes, Giselle Santos Magalhaes, Alicia Villacampa, Alicia Villacampa, Maria Gloria Rodrigues-Machado, Maria Jose Campagnole-Santos, Robson Augusto Souza Santos, Carlos F. Sánchez-Ferrer, Carlos F. Sánchez-Ferrer, Concepción Peiró, Concepción Peiró

“…It is characterized by chronic inflammation, cellular senescence, and irreversible lung tissue damage, with no curative treatments currently available. …”
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High-throughput platform for label-free sorting of 3D spheroids using deep learning by Claudia Sampaio da Silva, Claudia Sampaio da Silva, Julia Alicia Boos, Jonas Goldowsky, Manon Blache, Noa Schmid, Tim Heinemann, Christoph Netsch, Francesca Luongo, Stéphanie Boder-Pasche, Gilles Weder, Alba Pueyo Moliner, Roos-Anne Samsom, Ary Marsee, Kerstin Schneeberger, Ali Mirsaidi, Bart Spee, Thomas Valentin, Andreas Hierlemann, Vincent Revol

“…The integration of bioprinting technologies with biological 3D models, such as multi-cellular spheroids, has enabled the fabrication of tissue constructs that better mimic complex structures and in vivo functionality of organs. …”
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Analysis of plant gene family heat shock protein 100 (HSP100) and its orthologs in Eukarya reveals sites of divergent evolution and insights into endosymbiotic origins of chloropla... by G. Gallas

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PKA regulation of neuronal function requires the dissociation of catalytic subunits from regulatory subunits by Weihong Xiong, Maozhen Qin, Haining Zhong

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Telecommunication of communication and control systems on unmanned aerial vehicles platforms by A. V. Poltavsky

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REALIZATION OF THE PHENOTYPIC EFFECT OF CHROMOSOMAL ABERRATIONS IN HUMANS by K. N. Grinberg, V. I. Kukharenko

“…It is conceivable that chromosomal aberrations strengthen the evolutionarily conditioned variability towards the delay of maturation of cellular and tissue structures, which is the key link in the pathogenesis associated with chromosomal imbalance.…”
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ON PROSPECTS OF DEVELOPMENT OF TELECOMMUNICATION SYSTEMS AND SERVICES BASED ON VIRTUAL REALITY TECHNOLOGY by A. S. Zuev, R. G. Bolbakov

“…In the nearest future, the possibility of creating a new segment in the international telecommunication services market that is oriented toward providing communication services to the mass consumer and the entertainment industry, new tools for goods promotion and education content delivery, as well as toward solving experimental problems in managing state structures and social economical systems, is being justified. …”
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Potential of a CO2-Responsive supramolecular drug-carrier system as a safer and more effective treatment for cancer by Enyew Alemayehu Bayle, Fasih Bintang Ilhami, Jem-Kun Chen, Chih-Chia Cheng

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Cerium Oxide Nanoparticles Achieve Long‐Lasting Senescence Inhibition in an Aging Mouse Model of Sarcopenia via Reactive Oxygen Species Scavenging and CILP2 Downregulation by Wei‐Chih Lien, Yu‐Ling Yu, Ya‐Jyun Liang, Chia‐Yih Wang, Yang‐Chen Lin, Huei‐Cih Chang, Feng‐Huei Lin, Hui‐Min David Wang

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Advanced strategies for screening and identifying RNA-targeted small molecules: Bridging therapeutic potential and innovation by Zukela Ruzi, Daxiong Han, Kailibinuer Aierken

“…RNA molecules, including messenger RNAs (mRNAs) and non-coding RNAs (ncRNAs), play fundamental roles in gene regulation, protein synthesis, and cellular stress responses. However, their dynamic nature and structural complexity have historically posed challenges in developing small molecules with high affinity and selectivity. …”
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Conformational Space Profiling Enhances Generic Molecular Representation for AI‐Powered Ligand‐Based Drug Discovery by Lin Wang, Shihang Wang, Hao Yang, Shiwei Li, Xinyu Wang, Yongqi Zhou, Siyuan Tian, Lu Liu, Fang Bai

“…In this study, a new model named GeminiMol is proposed to incorporate conformational space profiles into molecular representation learning, which extracts the feature of capturing the complicated interplay between the molecular structure and the conformational space. Although GeminiMol is pre‐trained on a relatively small‐scale molecular dataset (39290 molecules), it shows balanced and superior performance not only on 67 molecular properties predictions but also on 73 cellular activity predictions and 171 zero‐shot tasks (including virtual screening and target identification). …”
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Modeling the Impact of Public Transportation and Mitigation Strategies in COVID-19 Spread in Mexico City by Fernando Reyes-Gomez, Emmanuel Torres-Marin, Maria Elena Larraga, Luis Alvarez-Icaza, Roman A. Mora-Gutierrez

“…This paper presents a novel approach using a discrete, probabilistic, and age-structured model that integrates the concept of compartmental models in epidemiology with cellular automata networks to investigate the role of public transportation and mitigation strategies in COVID-19 transmission in Mexico City districts. …”
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Different Mitotic Arrest Targets of Chemoprevention Curcumin Analog 1.1 (CCA-1.1) and Pentagamavunone-1 (PGV-1) in Leukemic K-562 Cells by Riris Istighfari Jenie, Dhania Novitasari, Dyaningtyas Dewi Pamungkas Putri, Ratna Asmah Susidarti, Ikuko Nakamae, Noriko Yoneda-Kato, Jun-ya Kato, Edy Meiyanto

“…However, due to its structure, PGV-1 is unstable and easily decomposed by light or high pH, causing decreased cytotoxic effect. …”
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Thermo-Mechanical Performance of Sustainable Lightweight Sandwich Panels Utilizing Ultra-High-Performance Fiber-Reinforced Concrete by Mariam Farouk Ghazy, Metwally abd allah Abd Elaty, Mohamed Abd Elkhalek Sakr, Eslam Mohamed Arafa

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Identification of non-charged 7.44 analogs interacting with the NHR2 domain of RUNX1-ETO with improved antiproliferative effect in RUNX-ETO positive cells by Mohanraj Gopalswamy, David Bickel, Niklas Dienstbier, Jia-Wey Tu, Melina Vogt, Stephan Schott-Verdugo, Sanil Bhatia, Manuel Etzkorn, Holger Gohlke

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Hartnup disease-causing SLC6A19 mutations lead to B0AT1 aberrant trafficking and ACE2 mis-localisation implicating the endoplasmic reticulum protein quality control by Nesreen F. Alkhofash, Bassam R. Ali, Bassam R. Ali

“…These variants were distributed across multiple B0AT1 structural domains. Importantly, several of these ER-retained variants, particularly R178Q and S303L, significantly disrupted ACE2 intracellular trafficking and its localization to the plasma membrane, indicating a direct effect on ACE2 subcellular targeting.DiscussionThe findings reveal that Hartnup disease-causing mutations can lead to ER retention of B0AT1, which in turn has a variable effect on ACE2 trafficking. …”
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Pioneering contribution of Professor Bruce Ames to early development in biochemical aspects of oxidatively generated damage to DNA by Jean Cadet, J. Richard Wagner

“…In a complementary way, the application of modified versions of the comet assay and alkaline elution techniques that target general classes of DNA lesions provides a more global account of damage although it gives less structural information about DNA damage formed under chronic exposure to mild oxidizing conditions.…”
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Evaluation of PAMAM Dendrimer-Stabilized Gold Nanoparticles: Two-Stage Procedure Synthesis and Toxicity Assessment in MCF-7 Breast Cancer Cells by Agnieszka Maria Kołodziejczyk, Magdalena Grala, Łukasz Kołodziejczyk

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