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741
Modeling the different conformations of the human mitochondrial ADP/ATP carrier using AlphaFold and molecular dynamics simulations of the protein-ligand complexes
Published 2025-01-01“…It serves as a master regulator of the cellular ADP/ATP ratio and is involved in various pathologies, including cancer. …”
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Anti-obesity functions of fucoidan conducted by bioinformatics and validation findings targeting of autophagy
Published 2025-03-01“…Autophagy, one of cell death mechanisms that lysosomes degrade endogenous cellular organelles and cytoplasm, is reported to regulate the development of obesity. …”
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Revisiting the Structural and Magnetic Properties of SmCo<sub>5</sub>/Sm<sub>2</sub>Co<sub>17</sub> Interface from First-Principles Investigations
Published 2024-11-01“…The formation and evolution of SmCo<sub>5</sub>/Sm<sub>2</sub>Co<sub>17</sub> (1:5<sub>H</sub>/2:17<sub>R/H</sub>) cellular structures play an essential role in understanding the coercivity of Sm-Co magnets. …”
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Effects of cellular membranes and the precore protein on hepatitis B virus core particle assembly and DNA replication
Published 2025-04-01“…When the precore protein was expressed by itself, it could also form particulate structures in association with cellular RNAs in the nucleus. …”
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The NS1 protein of the parvovirus MVM Aids in the localization of the viral genome to cellular sites of DNA damage.
Published 2020-10-01“…The autonomous parvovirus Minute Virus of Mice (MVM) localizes to cellular DNA damage sites to establish and sustain viral replication centers, which can be visualized by focal deposition of the essential MVM non-structural phosphoprotein NS1. …”
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The Role of Connections Between Cellular and Tissue Mechanical Elements and the Importance of Applied Energy in Mechanotransduction in Cancerous Tissue
Published 2025-03-01“…In the presence of cellular mutations and impaired mechanisms of energy transmission to the attached cells and tissues, excess energy is available to upregulate some of the mechanotransduction pathways that maintain cell and tissue structure and function. …”
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Fc glycan sialylation of biotherapeutic monoclonal antibodies has limited impact on antibody‐dependent cellular cytotoxicity
Published 2021-11-01“…However, many of the effects of highly heterogeneous Fc glycan structures have yet to be fully characterized. Different glycosylation patterns can affect Fc‐dependent activities, such as the ability of mAbs to bind Fcγ receptors on the effector cell surface, which is critical to immune effector functions, such as antibody‐dependent cellular cytotoxicity (ADCC). …”
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iGPCR-drug: a web server for predicting interaction between GPCRs and drugs in cellular networking.
Published 2013-01-01“…Although some computational methods were developed in this regard based on the knowledge of the 3D (dimensional) structure of protein, unfortunately their usage is quite limited because the 3D structures for most GPCRs are still unknown. …”
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A repurposed AMP binding domain reveals mitochondrial protein AMPylation as a regulator of cellular metabolism
Published 2025-08-01“…Cryo-EM reconstruction of an AMPylated protein bound to hinT provides a structural basis for AMP selectivity. Using structure guided mutagenesis, we optimize enrichment to identify novel substrates of the evolutionarily conserved AMPylase, Selenoprotein O. …”
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Cellular and Molecular Mechanisms Underlying Transcranial Magnetic Stimulation: Experimental Data for Evaluating Changes in Nervous Tissue
Published 2025-01-01“…Although TMS efficacy was demonstrated in the treatment of several neurological and mental disorders, changes in nervous tissue at the cellular and molecular levels with different duration and intensity of stimulation have been relatively understudied by cellular neurobiology methods. …”
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Cellular and molecular mechanisms of pathological tau phosphorylation in traumatic brain injury: implications for chronic traumatic encephalopathy
Published 2025-05-01“…Abstract Tau protein plays a critical role in the physiological functioning of the central nervous system by providing structural integrity to the cytoskeletal architecture of neurons and glia through microtubule assembly and stabilization. …”
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Chemical synthesis and analytical profiling of NTSH: a versatile probe for hydrogen sulfide sensing and cellular imaging
Published 2024-01-01“…The development of novel probes featuring diverse structural motifs, with promising applications in H _2 S detection and cellular imaging remains a central focus of scientific research. …”
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Gelatin-Based Hydrogels for Peripheral Nerve Regeneration: A Multifunctional Vehicle for Cellular, Molecular, and Pharmacological Therapy
Published 2025-06-01“…In this context, gelatin-based hydrogels have emerged as a promising class of biomaterials due to their excellent biocompatibility, biodegradability, and structural similarity to the native extracellular matrix. …”
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A decellularized flowable placental connective tissue matrix supports cellular functions of human tenocytes in vitro
Published 2022-01-01“…Abstract Purpose Injectable connective tissue matrices (CTMs) may promote tendon healing, given their minimally invasive properties, structural and biochemical extracellular matrix components, and capacity to fill irregular spaces. …”
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Increased perivascular fibrosis and pro-fibrotic cellular transition in intramyocardial blood vessels in myocardial infarction patients
Published 2024-12-01“…Background and objectives: Structural and functional changes in the intramyocardial microcirculation increase the risk of myocardial infarction (MI). …”
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