Alphaflexiviridae in Focus: Genomic Signatures, Conserved Elements and Viral-Driven Cellular Remodeling by Jesús R. Úbeda, Miguel A. Aranda, Livia Donaire

“…In this review, we summarize the current knowledge on the genomic structure, conserved genes, and phylogenetic relationships within <i>Alphaflexiviridae</i>, with a particular focus on the replicase and coat protein genes as signature markers. …”
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Cellular Communication Network Protein 2 in the Right Ventricle of Pulmonary Arterial Hypertension by Carly E. Byrd, Jennifer E. Schramm, Jun Yang, Allan E. Barnes, Megan Griffiths, Anjira S. Ambade, Darin T. Rosen, Ilton M. Cubero Salazar, Catherine E. Simpson, Ryan J. Tedford, Steven Hsu, Dhananjay Vaidya, Todd M. Kolb, Michael W. Pauciulo, William C. Nichols, David D. Ivy, Eric D. Austin, Paul M. Hassoun, Rachel L. Damico, Allen D. Everett

“…ABSTRACT Cellular communication network 2 (CCN2) is a secreted matricellular protein associated with pulmonary arterial hypertension (PAH) but has not been studied relative to PAH severity, outcomes, or right ventricle (RV) structure and function in a large human cohort and preclinical animal model. …”
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Structure-based design of an antibacterial peptide from the Myotoxin II sequence, evaluating its effectiveness against Gram-negative bacteria and its safety by Tatiana Huertas, Diana Millán, Angela V. Fonseca-Benítez, James Guevara-Pulido

“…Additionally, the safety of peptide 20 was evaluated, revealing that none of the tested concentrations caused hemolytic activity or loss of cellular viability in L929 and Caco-2 cells. This indicates that rational, structure-based design is an effective strategy for developing safe peptides.…”
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A structurally conserved site in AUP1 binds the E2 enzyme UBE2G2 and is essential for ER-associated degradation. by Christopher E Smith, Yien Che Tsai, Yu-He Liang, Domarin Khago, Jennifer Mariano, Jess Li, Sergey G Tarasov, Emma Gergel, Borong Tsai, Matthew Villaneuva, Michelle E Clapp, Valentin Magidson, Raj Chari, R Andrew Byrd, Xinhua Ji, Allan M Weissman

“…The G2BRAUP1 shares significant structural conservation with the G2BR found in the E3 ubiquitin ligase gp78 and in vitro can similarly allosterically activate ubiquitination in conjunction with ERAD E3s. …”
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Microbiome gut community structure and functionality are associated with symptom severity in non-responsive celiac disease patients undergoing a gluten-free diet by Laura Judith Marcos-Zambrano, Blanca Lacruz-Pleguezuelos, Elena Aguilar-Aguilar, Helena Marcos-Pasero, Alberto Valdés, Viviana Loria-Kohen, Alejandro Cifuentes, Ana Ramirez de Molina, Alberto Diaz-Ruiz, Vera Pancaldi, Enrique Carrillo de Santa Pau

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Isolation of a novel manganese-oxidizing bacterium Lysinibacillus xylanilyticus M125: characterization, structural evolution, and Cd-adsorption activity of biogenic Mn oxides produ... by Xiaoju Li, Xinyi Yuan, Yuxia Wei, Lianqi He, Yuanyuan Li, Meiquan Qiu, Yang Liu, Nannan Dong, Chengjia Zhang, Xin Pang, Xin Pang, Xin Pang

“…BioMnOx exhibited various morphologies, including nanosheets, globular structures encased in sheaths, and extracellularly dispersed forms. …”
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Development of a formalism of movable cellular automaton method for numerical modeling of fracture of heterogeneous elastic-plastic materials by S. Psakhie, E. Shilko, A. Smolin, S. Astafurov, V. Ovcharenko

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Structural and functional impact of the p.R163C mutation in the conserved palindromic motif within the C-terminal domain of human αB-crystallin. by Aref Baharvand, Zamara Mariam, Mohammad Bagher Shahsavani, Leila Rezaei Somee, Issa Zarei, Massoud Amanlou, Giuseppe Deganutti, Ali Akbar Saboury, Ali Akbar Moosavi-Movahedi, Reza Yousefi

“…Collectively, these structural and functional modifications in the mutated protein may perturb cellular homeostasis and contribute to the onset of DCM.…”
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Earthworms regulate soil microbial and plant residues through decomposition by Jiahui Liao, Juanping Ni, Xiaoming Zou, Han Y.H. Chen, Manuel Delgado-Baquerizo, Yuanyuan Li, Tingting Ren, Ke Shi, Honghua Ruan

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Long-term hippocampal low-frequency stimulation alleviates focal seizures, memory deficits and synaptic pathology in epileptic mice by Piret Kleis, Enya Paschen, Andrea Djie-Maletz, Andreas Vlachos, Carola A. Haas, Ute Häussler

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Application of family whole-exome sequencing for prenatal diagnosis—an analysis of 357 cases by Yijun Ge, Huizhen Yuan, Yao Yu, Junfang Xiao, Danping Liu, Yongbao Peng, Ying Liu, Shuhui Huang, Bicheng Yang, Yongyi Zou, Yanqiu Liu

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Investigation of potential KRASG12D inhibitors: a comparative study between MRTX1133 and natural compounds via computational structural biology approaches by Safiye Merve Bostancioglu, Ahmet Acar

“…Targeting KRASG12D with natural compounds offers a unique therapeutic potential, leveraging the structural diversity and bioactivity of natural compounds. …”
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Long-read sequencing is required for precision diagnosis of incontinentia pigmenti by Monica H. Wojcik, Robin D. Clark, Abdallah F. Elias, Casie A. Genetti, Jill A. Madden, Dana Simpson, Linda Golkar, Miranda P.G. Zalusky, Angela L. Miller, Araceli Rodriguez, Joy Goffena, Camille A. Dash, Nikhita Damaraju, Sophia B. Gibson, Sophie H.R. Storz, Zachary B. Anderson, Jonas A. Gustafson, Isabelle Thiffault, Emily G. Farrow, Tomi Pastinen, Jasmine Lin, Jennifer T. Huang, Alan H. Beggs, Pankaj B. Agrawal, David T. Miller, Danny E. Miller

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Functional and Structural Consequences of Single-Nucleotide Polymorphisms in the NPM1 Gene Associated with Acute Myeloid Leukemia: Insights from a Comprehensive Bioinformatics Appr... by Tamosree Sikder, Mijan Mia, Nazmul Rahman Chowdhury, Md. Emdadul Islam

“…The secondary structure was predicted with PSIPRED. The 3-dimensional structure of the NPM1 protein was obtained from AlphaFold, visualization along with mutant models was generated using PyMOL, and all information about physiological properties was taken from the HOPE project. …”
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Comparative analysis of multifaceted properties of Agaricus bisporus and Ganoderma lucidum macro-fungi powder: Techno-functional and structural characterization, mineral uptake, an... by Vaishali Singh, Aarti Bains, Gulden Goksen, Vittorio Capozzi, Anarase Dattatray Arjun, Nemat Ali, Muzaffar Iqbal, Prince Chawla

“…For both mushrooms, spherical porous and fibrous interconnected structural morphology was observed, which led to distinguishing crystallinity and techno-functional properties. …”
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The Transformation Experiment of Frederick Griffith II: Inclusion of Cellular Heredity for the Creation of Novel Microorganisms by Günter A. Müller

“…However, this strategy seems to be limited to closely related bacterial species only, due to the need for a “fit” between donor and acceptor proteomes and structures. “Fitting” of cellular regulation of metabolite fluxes and turnover between donor and acceptor cells, i.e. cybernetic heredity, may be even more difficult to achieve. …”
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Selective laser melted uniform and functionally graded lattice structures diamond tools: Microstructure, compressive behavior and grinding performance of CuSn20-bonded diamond comp... by Yangli Xu, Haoqing Li, Guoqin Huang, Guangyao Han, Yu Sun, Congming Ke, Xiaodong Li, Xinyan Zheng, Xipeng Xu

“…SLMed porous CuSn20-bonded diamond tools were systematically investigated to elucidate the influence of Uniform Lattice Structures (ULS, UL-30 %–50 % porosity) and Functionally Graded Lattice Structures (FGLS, GL-P and GL-V) on compressive behaviour and grinding performance in this work. …”
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Structure- and machine learning-guided engineering demonstrate that a non-canonical disulfide in an anti-PD-1 rabbit antibody does not impede antibody developability by Wei-Ching Liang, Hongkang Xi, Dawei Sun, Luigi D’Ascenzo, Jonathan Zarzar, Nicole Stephens, Ryan Cook, Yinyin Li, Zhengmao Ye, Marissa Matsumoto, Jian Payandeh, Matthieu Masureel, Yan Wu

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Integrating immune library probing with structure-based computational design to develop potent neutralizing nanobodies against emerging SARS-CoV-2 variants by Lidia Cerdán, Katixa Silva, Daniel Rodríguez-Martín, Patricia Pérez, María A. Noriega, Ana Esteban Martín, Alfonso Gutiérrez-Adán, Yago Margolles, Juan A. Corbera, Miguel A. Martín-Acebes, Juan García-Arriaza, Juan Fernández-Recio, Luis A. Fernández, José M. Casasnovas

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Morphologic changes of retina cellular elements under long low intensity light exposure by S. V. Logvinov, Ye. Yu. Varakouta, A. V. Potapov, Ye. P. Mikhoulya, A. A. Zhdankina

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