Cryo-EM structures of apo-APC/C and APC/CCDH1:EMI1 complexes provide insights into APC/C regulation by Anna Höfler, Jun Yu, Jing Yang, Ziguo Zhang, Leifu Chang, Stephen H. McLaughlin, Geoffrey W. Grime, Elspeth F. Garman, Andreas Boland, David Barford

Get full text

An aspartyl protease-mediated cleavage regulates structure and function of a flavodoxin-like protein and aids oxidative stress survival. by Anamika Battu, Rajaram Purushotham, Partha Dey, S Surya Vamshi, Rupinder Kaur

Get full text

Selenium Nanoparticles (SeNPs) Inhibit the Growth and Proliferation of Reproductive Structures in <i>Phytophthora capsici</i> by Altering Cell Membrane Stability by Andrés de Jesús López-Gervacio, Joaquín Alejandro Qui-Zapata, Iliana Barrera-Martínez, Mayra Itzcalotzin Montero-Cortés, Soledad García-Morales

“…The aim of this study was to evaluate the inhibitory activity of SeNPs on mycelial growth and the development of reproductive structures in <i>Phytophthora capsici</i> in vitro. …”
Get full text

Chemical decellularization of porcine liver by two-stage treatment with surfactants and osmoregulators enhances preservation of liver extracellular matrix structure by A. D. Belova, E. A. Nemets, D. D. Filin, A. S. Ponomareva, L. A. Kirsanova, Yu. B. Basok, V. I. Sevastianov

“…Objective: to develop and investigate a tissue-specific matrix obtained using a modified chemical porcine liver decellularization regime in order to effectively increase preservation of extracellular matrix (ECM) structure, reduce decellularization time and improve purification of the ECM from cellular elements. …”
Get full text

Sperm storage in males of the Neotropical rattlesnake Crotalus durissus (Squamata: Viperidae): Structure and seasonal variation of the distal ductus deferens by Leonardo Carvalho, Gleide Fernandes de Avelar, Flávia Cappuccio de Resende

Get full text

Invadosomes as “shape-shifters” of cellular maturation: insights from megakaryocytes by Frédérique Gaits-Iacovoni

Get full text

Identification of New Potential Cyclooxygenase-2 Inhibitors Using Structure-Based Virtual Screening, Molecular Dynamics and Pharmacokinetic Modelling by Imene Derardja, Redouane Rebai, Mohamed Esseddik Toumi, Farouk Fethi Kebaili, Abdennacer Boudah

Get full text

Multiscale investigation of collagen structure in human skin and gel matrices using polarization resolved second harmonic generation microscopy by Mengyao Zhou, Madalena Pinto Gomes, Anouk Elgersma, H. Ibrahim Korkmaz, Bouke K. H. L. Boekema, Marie Louise Groot

“…These findings underscore the potential of PSHG microscopy for label-free, quantitative assessment of collagen structure across multiple scales, with THG offering complementary cellular insights. …”
Get full text

Stochastic Graph-Based Models of Tumor Growth and Cellular Interactions by José Alberto Rodrigues

“…Additionally, we construct a dynamic network to represent cellular interactions, allowing for an analysis of structural changes over time. …”
Get full text

In-cell NMR characterization of the secondary structure populations of a disordered conformation of α-synuclein within E. coli cells. by Christopher A Waudby, Carlo Camilloni, Anthony W P Fitzpatrick, Lisa D Cabrita, Christopher M Dobson, Michele Vendruscolo, John Christodoulou

“…To improve the accuracy in the measurement of backbone chemical shifts within crowded in-cell NMR spectra, we have developed a deconvolution method to reduce inhomogeneous line broadening within cellular samples. The resulting chemical shift values were then used to evaluate the distribution of secondary structure populations which, in the absence of stable tertiary contacts, are a most effective way to describe the conformational fluctuations of disordered proteins. …”
Get full text

The structure-selective endonucleases GEN1 and MUS81 mediate complementary functions in safeguarding the genome of proliferating B lymphocytes by Keith Conrad Fernandez, Laura Feeney, Ryan M Smolkin, Wei-Feng Yen, Allysia J Matthews, William Alread, John HJ Petrini, Jayanta Chaudhuri

Get full text

Sensitivity of yeast to lithium chloride connects the activity of YTA6 and YPR096C to translation of structured mRNAs. by Maryam Hajikarimlou, Houman Moteshareie, Katayoun Omidi, Mohsen Hooshyar, Sarah Shaikho, Tom Kazmirchuk, Daniel Burnside, Sarah Takallou, Narges Zare, Sasi Kumar Jagadeesan, Nathalie Puchacz, Mohan Babu, Myron Smith, Martin Holcik, Bahram Samanfar, Ashkan Golshani, Ashkan Golshani

“…Lithium Chloride (LiCl) toxicity, mode of action and cellular responses have been the subject of active investigations over the past decades. …”
Get full text

Nimesulide derivatives reduced cell proliferation against breast and ovarian cancer: synthesis, characterization, biological assessment, and crystal structure by Laila Abdulmohsen Jarragh Alhadad

“…Heat shock protein 27 (HSP27) and tubulin proteins are important cellular proteins for normal cell division and growth, which are elevated in cancer cells. …”
Get full text

ROS/pH Dual-Responsive Hydrogel Dressings Loaded with Amphiphilic Structured Nano Micelles for the Repair of Infected Wounds by Wang J, Lin Y, Fan H, Cui J, Wang Y, Wang Z

“…A full-thickness skin defect rat model with bacterial infection was established to investigate the ability of GC/OCS-CL@Cur to enhance wound repair in vivo.Results: The unique cross-linked structure of GC/OCS-CL@Cur significantly improves the mechanical properties of hydrogels. …”
Get full text

The unique structure of the highly conserved PPLP region in HIV-1 Vif is critical for the formation of APOBEC3 recognition interfaces by Yasumasa Iwatani, Kazuhiro Matsuoka, Hirotaka Ode, Mai Kubota, Yoshihiro Nakata, Yuka Setoyama, Kanako Kojima, Mayumi Imahashi, Yoshiyuki Yokomaku

“…ABSTRACT The human cellular cytidine deaminases APOBEC3s (A3s) inhibit virion infectivity factor (Vif)-deficient HIV-1 replication. …”
Get full text

A novel algorithm identifies stress-induced alterations in mitochondrial connectivity and inner membrane structure from confocal images. by Mathieu Ouellet, Gérald Guillebaud, Valerie Gervais, David Lupien St-Pierre, Marc Germain

Get full text

Biophysical analysis of the effect of chemical modification by 4-oxononenal on the structure, stability, and function of binding immunoglobulin protein (BiP). by Dinen D Shah, Surinder M Singh, Monika Dzieciatkowska, Krishna M G Mallela

“…These results indicate that 4-ONE modification can significantly affect the structure-function of key proteins such as BiP involved in cellular pathways, and provide a molecular basis for how chemical modifications can result in the failure of quality control mechanisms inside the cell.…”
Get full text

Decoding MexB efflux pump genes: structural, molecular, and phylogenetic analysis of multidrug-resistant and extensively drug-resistant Pseudomonas aeruginosa by Muhammad Bilal Habib, Naseer Ali Shah, Afreenish Amir, Huda Ahmed Alghamdi, Muhammad Haseeb Tariq, Kiran Nisa, Mariam Ammoun

Get full text

Crystal structure of Fis1 and Bap31 provides information on protein-protein interactions at mitochondria-associated ER membranes by Minh Duc Nguyen, Yonghyeok Kim, Seung-Hyun Bae, Soeun Kim, Hyun Ku Yeo, Nam-Chul Ha, Ginam Cho, Sunghyun Moon, Kwang-Hwi Cho, Hyonchol Jang, Seoung Min Bong, Byung Il Lee

“…Here, we present crystal structures of the cytosolic domain of human Fis1 in two distinct conformations, along with a co-crystal structure of Fis1 bound to the C-terminal region of the Bap31_vDED domain. …”
Get full text

CDK5-mediated hyperphosphorylation of Tau217 impairs neuronal synaptic structure and exacerbates cognitive impairment in Alzheimer’s disease by Kangyue Fu, Nan Lin, Yiwen Xu, En Huang, Raoli He, Zhixin Wu, Dianbo Qu, Xiaochun Chen, Tianwen Huang

Get full text