Diversity, expression, and structural modeling of sugar transporters in Anisakis simplex s. s. L3 and L4 larvae: an in vitro and in silico study by Iwona Polak, Robert Stryiński, Łukasz Paukszto, Jan Paweł Jastrzębski, Iwona Bogacka, Elżbieta Łopieńska-Biernat

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Tertiary lymphoid structures correlate with the therapeutic efficacy and prognosis of resectable esophageal squamous cell carcinoma undergoing neoadjuvant chemoradiotherapy plus im... by Ke Zhai, Ru Xie, Kun Ru, Miaoqing Zhao

“…BackgroundTertiary lymphoid structures (TLSs) are linked to prognosis in esophageal squamous cell carcinoma (ESCC), but whether the distribution, abundance, and maturity of TLSs affect therapeutic efficacy and prognosis in ESCC treated with neoadjuvant chemoradiotherapy plus immunotherapy (NRCI) remains unclear. …”
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Food Iminosugars and Related Synthetic Derivatives Shift Energy Metabolism and Induce Structural Changes in Colon Cancer Cell Lines by Thomas Montebugnoli, Charlotte Grootaert, Alessandra Bordoni, Andreja Rajković, Elien Alderweireldt, Jeltien Rombaut, Sofie L. De Maeseneire, John Van Camp, Maarten Lieven De Mol

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Host protein PRPS2 interact with the non-structural protein p17 of Avian Reovirus and promote viral replication by Hu Xiaomiao, Zhao Ruihong, Li Wei, Pan Xiaocheng, Dai Yin, Wu Huimin, Wu Yantao, Zhang Chengcheng

“…Avian reovirus (ARV) is highly prevalent in healthy poultry flocks and has been linked to viral arthritis/tendonitis, dwarf syndrome, chronic respiratory disease, and immunosuppression in avian species, resulting in significant economic losses within the poultry industry. The non-structural protein p17 encoded by ARV induces cellular autophagy and facilitates viral proliferation, playing a pivotal role in viral pathogenesis. …”
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PARG Mutation Uncovers Critical Structural Determinant for Poly(ADP-Ribose) Hydrolysis and Chromatin Regulation in Embryonic Stem Cells by Yaroslava Karpova, Sara Piatz, Guillaume Bordet, Alexei V. Tulin

“…Our results define a critical structural determinant of PARG catalytic function, underscore the distinct requirements for pADPr metabolism in cellular versus developmental contexts, and provide a genetically tractable model for studying the regulation of poly(ADP-ribose) dynamics and therapeutic responses to PARP inhibition in vivo.…”
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Avermectins Inhibit Replication of Parvovirus B19 by Disrupting the Interaction Between Importin α and Non-Structural Protein 1 by Gualtiero Alvisi, Elisabetta Manaresi, Silvia Pavan, David A. Jans, Kylie M. Wagstaff, Giorgio Gallinella

“…Human parvovirus B19 (B19V) is a major human pathogen in which the ssDNA genome is replicated within the nucleus of infected human erythroid progenitor cells (EPCs) through a process involving both cellular and viral proteins, including the non-structural protein (NS)1. …”
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Structural mechanisms of PIP2 activation and SEA0400 inhibition in human cardiac sodium-calcium exchanger NCX1 by Jing Xue, Weizhong Zeng, Scott John, Nicole Attiq, Michela Ottolia, Youxing Jiang

“…Thus, this study reveals the structural basis of PIP2 activation and SEA0400 inhibition of NCX1 and provides some mechanistic understandings of cellular regulation and pharmacology of NCX family proteins.…”
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In What Ways Do Synthetic Nucleotides and Natural Base Lesions Alter the Structural Stability of G-Quadruplex Nucleic Acids? by Janos Sagi

“…Synthetic analogs of natural nucleotides have long been utilized for structural studies of canonical and noncanonical nucleic acids, including the extensively investigated polymorphic G-quadruplexes (GQs). …”
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Clinical variants of the <i>Helicobacter pylori</i>-associated peptic ulcerin comparison to structural and functional changes in gastric mucosa by N. R. Shakurova, Ye. P. Roslyakova, A. I. Hvaschevsky, A. N. Poltoratsky, Ye. G. Afrikantova

“…The purpose of research was to compare cellular structure inflammatory in a gastric and a duodenal mucosa, its ratio with disregenerations at peptic ulcers of not complicated current and complicated with a bleeding, punching and its ratio with disregenerations at one peptic ulcers or plural peptic ulcers. …”
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The Superoxide Dismutase Family in Balloon Flower (<i>Platycodon grandiflorus</i>): Phylogenetic Relationships, Structural Characteristics, and Expression Patterns by Tae Kyung Hyun

“…Detailed bioinformatics analyses revealed variations in structural characteristics and physicochemical properties. …”
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Structural diversity and initial oligomerization of PrP106-126 studied by replica-exchange and conventional molecular dynamics simulations. by Lulu Ning, Jingjing Guo, Qifeng Bai, Nengzhi Jin, Huanxiang Liu, Xiaojun Yao

“…In this study, replica exchange molecular dynamics simulations were performed to investigate monomeric and dimeric states of PrP106-126 in implicit solvent. The structural diversity of PrP106-126 was observed and this peptide did not acquire stable structure. …”
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Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease. by Gergely Tóth, Shyra J Gardai, Wagner Zago, Carlos W Bertoncini, Nunilo Cremades, Susan L Roy, Mitali A Tambe, Jean-Christophe Rochet, Celine Galvagnion, Gaia Skibinski, Steven Finkbeiner, Michael Bova, Karin Regnstrom, San-San Chiou, Jennifer Johnston, Kari Callaway, John P Anderson, Michael F Jobling, Alexander K Buell, Ted A Yednock, Tuomas P J Knowles, Michele Vendruscolo, John Christodoulou, Christopher M Dobson, Dale Schenk, Lisa McConlogue

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Cutibacterium Acnes induces Alzheimer’s disease-like pathology in brains of wistar rats through structural changes associated with microtubules by Morteza Aliashrafi, Mohammad Nasehi, Seyed Davar Siadat, Mohammad-Hossein Mohammadi-Mahdiabadi-Hasani, Hakimeh Zali, Zahra Niknam

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Comprehensive immunoinformatics and bioinformatics strategies for designing a multi-epitope based vaccine targeting structural proteins of Nipah virus by Shivangi Sharma, Pragya D. Yadav, Sarah Cherian

“…Two vaccine constructs (NiV_1 &amp; 2) were designed using different adjuvants (Cholera toxin and Beta-defensin 3) and linkers and their predicted 3D structures were evaluated for interaction with Toll-Like Receptor TLR-3 using docking and molecular dynamics (MD) simulation studies. …”
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The role of glypicans in Wnt inhibitory factor-1 activity and the structural basis of Wif1's effects on Wnt and Hedgehog signaling. by Andrei Avanesov, Shawn M Honeyager, Jarema Malicki, Seth S Blair

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Structural and functional study of YER067W, a new protein involved in yeast metabolism control and drug resistance. by Tatiana Domitrovic, Guennadi Kozlov, João Claudio Gonçalves Freire, Claudio Akio Masuda, Marcius da Silva Almeida, Mónica Montero-Lomeli, Georgia Correa Atella, Edna Matta-Camacho, Kalle Gehring, Eleonora Kurtenbach

“…As the majority of these ORFs have no homologs with characterized sequence or protein structure, traditional sequence-based approaches cannot be applied to deduce their biological function. …”
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Comparative assessment of structural and tear film alterations in rabbit meibomian gland dysfunction models using chemical and electrocauterization techniques by Deeksha Prasad, Saumya Jakati, Kiran Kumar Bokara, Sayan Basu, Vivek Singh, Pragnya Rao Donthineni

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Development of a formalism of movable cellular automaton method for numerical modeling of fracture of heterogeneous elastic-plastic materials by S. Psakhie, E. Shilko, A. Smolin, S. Astafurov, V. Ovcharenko

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Repetitive magnetic stimulation with iTBS600 induces persistent structural and functional plasticity in mouse organotypic slice cultures by Han Lu, Shreyash Garg, Maximilian Lenz, Andreas Vlachos

“…Background:: Repetitive transcranial magnetic stimulation (rTMS) is well known for its ability to induce synaptic plasticity, yet its impact on structural and functional remodeling within stimulated networks remains unclear. …”
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Atrial electrical alterations with intact cardiac structure and contractile function in a mouse model of an HCM-linked ACTN2 variant by Maya Noureddine, Sophie Broadway-Stringer, Christopher O'Shea, Bethany A.I. Jones, Abbie Hayes, Chris Denning, Siobhan Loughna, Fiyaz Mohammed, Davor Pavlovic, Katja Gehmlich

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