High-throughput SHAPE analysis reveals structures in HIV-1 genomic RNA strongly conserved across distinct biological states. by Kevin A Wilkinson, Robert J Gorelick, Suzy M Vasa, Nicolas Guex, Alan Rein, David H Mathews, Morgan C Giddings, Kevin M Weeks

“…High-throughput SHAPE reveals a comprehensive view of HIV-1 RNA genome structure, and further application of this technology will make possible newly informative analysis of any RNA in a cellular transcriptome.…”
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Secondary structures involving the poly(A) tail and other 3’ sequences are major determinants of mRNA isoform stability in yeast by Zarmik Moqtaderi, Joseph V. Geisberg, Kevin Struh

“…In many cases, the poly(A) tail is likely to participate in the formation of stability - enhancing secondary structures at mRNA 3’ ends. Our results point to an important role for mRNA structure at 3’ termini in governing transcript stability, likely by reducing the interaction of the mRNA with the degradation apparatus.…”
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Compressive performance of 3D-printed lightweight structures: Infill pattern optimization via Multiple-Criteria Decision Analysis method by Cristina Vălean, Emanoil Linul, Dipen Kumar Rajak

“…The study showed that the compressive behavior of the examined parts is similar to cellular materials (e.g., foams) and varies based on the IP, exhibiting brittle, quasi-brittle, or ductile fracture modes. …”
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Investigation of cell development and tissue structure network based on natural Language processing of scRNA-seq data by Suwen Wei, Yuer Lu, Peng Wang, Qichao Li, Jianwei Shuai, Qi Zhao, Hai Lin, Yuming Peng

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Structure-based design, synthesis and crystallization of 2-arylquinazolines as lipid pocket ligands of p38α MAPK. by Mike Bührmann, Bianca M Wiedemann, Matthias P Müller, Julia Hardick, Maria Ecke, Daniel Rauh

“…Here, we present the structure-based design and synthesis of a focused library of 2-arylquinazoline derivatives to target the lipophilic C-terminal binding pocket in p38α MAPK, for which a clear biological function has yet to be identified. …”
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Glycosyl Mobile Radical Structures of Folic Acid Receptors Impact the Internalization of Functionalized Folate Amphiphilic Alternating Copolymer in Cancer Cells by Emilyn B. Aucoin, Elizabeth Skapinker, Abdulrahman M. Yaish, Yunfan Li, Haley L. Kombargi, Daniel Jeyaraj, Pankaj Garg, Nicole Mendonza, Cecile Malardier-Jugroot, Myron R. Szewczuk

“…These glycosylation sites have been reported to be crucial for the receptor’s structural integrity and its ability to bind and internalize FA. …”
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Mountable lattice metamaterials with In-situ reprogrammable stiffness by Nan Yang, Daiyao Lin, Huaxian Wei, Miao Zhao

“…Additionally, we construct a cellular structure with [Formula: see text] units that achieves [Formula: see text] reprogrammable stiffnesses states by discretely changing the [Formula: see text], offering theoretically infinite possibilities. …”
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Structure of the Mg-chelatase cofactor GUN4 reveals a novel hand-shaped fold for porphyrin binding. by Mark A Verdecia, Robert M Larkin, Jean-Luc Ferrer, Roland Riek, Joanne Chory, Joseph P Noel

“…GUN4 may also play a role in both photoprotection and the cellular shuttling of tetrapyrroles. Here we report a 1.78-A resolution crystal structure of Synechocystis GUN4, in which the porphyrin-binding domain adopts a unique three dimensional fold with a "cupped hand" shape. …”
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Agonistic anti-NKG2D antibody structure reveals unique stoichiometry and epitope compared to natural ligands by Daniel Fallon, Ching-Shin Huang, Jingya Ma, Christopher Morgan, Zhaohui Sunny Zhou

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Antifungal mechanism of carvacrol and osthole can disrupt cell structure integrity and interfere with energy metabolism in Neopestalotiopsis ellipsospora by Huifang Liu, Jianmei Yao, Rongxiu Yin, Chiyu Ma, Lulu Li, Wen Yang, Zhiwei Lei

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The Centriole Stability Assay: A Method to Investigate Mechanisms Involved in the Maintenance of the Centrosome Structure in Drosophila Cultured Cells by Mariana Lince-Faria, Ana Ferreira-Silva, Ana Pimenta-Marques

“…This study presents a protocol that decouples centrosome biogenesis from maintenance, allowing the study of critical factors and pathways involved in the maintenance of the integrity of these important cellular structures.…”
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Soft X-ray tomography reveals variations in B. subtilis biofilm structure upon tasA deletion by Anthoula Chatzimpinou, Anne Diehl, A. Tobias Harhoff, Kristina Driller, Bieke Vanslembrouck, Jian-Hua Chen, Kristaps Kairišs, Valentina Loconte, Mark A. Le Gros, Carolyn Larabell, Kürşad Turgay, Hartmut Oschkinat, Venera Weinhardt

“…In contrast, the ΔtasA genetic knock-out showed a loss of cellular orientation and changes in the extracellular matrix. …”
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Analysis of bacterial community structure in different types of Daqu based on third-generation sequencing and pure culture techniques by WANG Wenhang, CAI Wenchao, YU Peirong, CHEN Wei, SHAN Chunhui, GUO Zhuang, WANG Yurong

“…To investigate the differences in bacterial community structure between high- and medium-high-temperature Daqu, the bacterial community structure of the two types of Daqu was analyzed by third-generation sequencing technology, the correlation between bacterial community and gene functions of bacterial community were analyzed, and the strains were isolated and identified by microbial pure culture and molecular biology techniques. …”
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Response of Soil Microbial Diversity, Community Structure, and Functional Potential to Primary Forest Conversion in Northwestern Hunan Province by XIAO Huacui, SHENG Hao, SU Guohui, ZHOU Ping

“…[Objective] To explore the impact of primary forest conversion on soil microbial community diversity, structure and functions, in order to provide a theoretical reference for soil health preservation. …”
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Evenly Distributed Microporous Structure and E7 Peptide Functionalization Synergistically Accelerate Osteogenesis and Angiogenesis in Engineered Periosteum by Qihong Li, Chen Li, Jun Yan, Chunli Zhang, Yu Jiang, Xiantong Hu, Liwei Han, Li Li, Peng Wang, Lingzhou Zhao, Yantao Zhao

“…The E7 peptide (EPLQLKM), which exhibits a specific affinity for mesenchymal stem cells (MSCs), is beneficial for modulating cellular functions. In this study, a unique microporous structured carboxymethyl chitosan/sodium alginate membrane with a proper mass ratio is developed by the addition of Poloxam 407 （P407）, which is then functionalized with the E7 affinitive peptide. …”
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Myofiber structure, sarcoplasmic reticulum Ca2+ handling, and contractile function after muscle‐damaging exercise in humans by V. Handegard, P. K. Lunde, M. Frisk, O. Seynnes, N. Ørtenblad, W. E. Louch, G. Paulsen, T. Raastad

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Distinct cellular states determine calcium signaling response by Jason Yao, Anna Pilko, Roy Wollman

“…It is unknown whether cell‐to‐cell variability rises from biochemical stochastic fluctuations or distinct cellular states. Here, we utilize calcium response to adenosine trisphosphate as a model for investigating the structure of heterogeneity within a population of cells and analyze whether distinct cellular response states coexist. …”
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Sorting of complex sphingolipids within the cellular endomembrane systems by Victor O. Svistunov, Kigumbi J. Ehrmann, Wayne I. Lencer, Wayne I. Lencer, Wayne I. Lencer, S. S. Schmieder, S. S. Schmieder

“…Cells contain a plethora of structurally diverse lipid species, which are unevenly distributed across the different cellular membrane compartments. …”
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Matrix-product unitaries: Beyond quantum cellular automata by Georgios Styliaris, Rahul Trivedi, David Perez-Garcia, J. Ignacio Cirac

“…In particular, we study the structure of a subclass with a direct-sum form which maximally violates the QCA property. …”
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Unraveling Novel Subsets of Lymphocytes Involved in Sac Expansion in the Tertiary Lymphoid Structure Within an Abdominal Aortic Aneurysm by Itaru Hosaka, Ippei Ikegami, Takuma Mikami, Tatsuya Sato, Toshifumi Ogawa, Kei Mukawa, Marenao Tanaka, Keisuke Endo, Yukinori Akiyama, Akihito Ohkawa, Junji Nakazawa, Tsuyoshi Shibata, Tomohiro Nakajima, Yutaka Iba, Chikara Shiiku, Satoshi Sumino, Ryuji Koshima, Kenichi Takano, Shingo Ichimiya, Nobuyoshi Kawaharada, Masato Furuhashi

“…A tertiary lymphoid structure (TLS) within vascular lesions has recently been focused on for its role in modulation of inflammation in local tissues. …”
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