Growth Cones: Structural, Molecular and Functional Relevance to Neuronal Migration, Regeneration and Reproductive Function by Mona Sharma, Anmol Garg, Tanya Gupta

“…During axonal growth and synaptogenesis, the developing axons exhibit a highly dynamic region at their leading edges, aptly described as the “growth cone.” These structures serve as the guiding force for extending axons by transducing attractive and repulsive cues into cellular signals that modulate the internal cytoskeletal environment, thereby directing axonal growth toward or away from stimuli within the surrounding neural circuitry. …”
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Glyoxal is a superior fixative to formaldehyde in promoting antigenicity and structural integrity in murine cardiac tissues by Allen C.T. Teng, Dev Mehangrey, Ava Vandenbelt, Karl Vearncombe, Justin D. Callahan, Priya Mistry, Wenping Li, Cristine J. Reitz, Omar Hamed, Madison Roche, Uros Kuzmanov, Jason E. Fish, Slava Epelman, Anthony O. Gramolini

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Amino acid-based structural improvement of CaMKAR, a CaMKII activity biosensor by Alex Severino, Oscar Reyes Gaido, Elizabeth Luczak

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Structural and functional characterization of the cardiac mitochondria-associated reticular membranes in the ob/ob mouse model by Hala Guedouari, Maya Dia, Juliette Geoffray, Camille Brun, Florentin Moulin, Lucas Givre, Lucid Belmudes, Christelle Leon, Stephanie Chanon, Jingwei Ji-Cao, Christophe Chouabe, Sylvie Ducreux, Claire Crola Da Silva, Ludovic Gomez, Yohann Couté, Helene Thibault, Jennifer Rieusset, Melanie Paillard

“…MAM proteome analyses showed mainly increased processes in ob/ob hearts: cellular response to stress, lipid metabolism, ion transport and membrane organization. …”
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Advances in KEAP1-based PROTACs as emerging therapeutic modalities: Structural basis and progress by Jing Chen, Disheng Feng, Rui Zhu, Hua Li, Lixia Chen

“…This regulatory mechanism maintains cellular redox homeostasis by preventing NRF2 overactivation. …”
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New structural scaffolds to enhance the metabolic stability of arginine-derived PAD4 inhibitors by Yijiang Jia, Sina Bahraminejad, Chenyao Jiang, Ayijiang Taledaohan, Dejian Ma, Jianxiong Jiang, Yuji Wang, Jiawang Liu

“…On the basis of the structure of a well-known PAD4 inhibitor BB-Cl-amidine (3), we designed two metabolically stable scaffolds, providing two arginine-derived PAD4 inhibitors (7 and 8). …”
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Preparation, Structural Characterization and Antioxidant Activity of Carboxylated Chitosan-Pectin-based Silver Nanoparticles by Yongjin SUN, Hongjie WANG, Jing HUANG, Yunlong ZHAO, Huiying LIAO, Shuyun LIANG, Jinyuan CAI, Xia LI

“…Face-centered cubic crystalline structures were identified in both types through XRD analysis, where CP-AgNPs exhibited enhanced colloidal stability compared to P-AgNPs as evidenced by Zeta potential measurements. …”
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Structural insights into prolactin-releasing peptide receptor signaling and G-protein coupling selectivity by Zhangsong Wu, Chen Qiu, Yiming Liu, Xiaoyi Yan, Qiaohui Li, Shirui Jiang, Jun Xu, Xin Pan, Fang Ye, Zhiyi Zhang, Peiruo Ning, Binghao Zhang, Lezhi Xu, Bangning Cheng, Xufu Xiang, Chungen Qian, Yang Du, Geng Chen

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Hypoxia‐Driven Neurovascular Impairment Underlies Structural‐Functional Dissociation in Diabetic Sudomotor Dysfunction by Xu Guo, Chao Zhang, Yuzhen Wang, Zhao Li, Yaxin Tan, Dongzhen Zhu, Wei Song, Yi Kong, Jinpeng Du, Yuyan Huang, Liting Liang, Jianjun Li, Mengde Zhang, Linhao Hou, Qinhua Liu, Feng Tian, Bingyang Yu, Yue Kong, Zhenyu Zhou, Xiaobing Fu, Sha Huang

“…This study addresses this gap by demonstrating that despite structural integrity, sweat glands (SGs) in diabetic individuals with DFUs, and a murine model of diabetic neuropathy (DN), exhibit functional impairments, as confirmed by histological and functional assays. …”
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Analysis of complex chromosomal structural variants through optical genome mapping integrated with karyotyping by Xiaoxi Zhu, Huiling Zheng, Xue Wan, Hang Duan, Ying Qi, Weijia Tang, Fan Yang, Fan Yang, Limei Yu, Limei Yu

“…Background and ObjectiveParental chromosomal structural variations (SVs) represent a primary genetic factor contributing to recurrent spontaneous abortion (RSA). …”
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Structural Insights into Bortezomib-Induced Activation of the Caseinolytic Chaperone-Protease System in Mycobacterium tuberculosis by Biao Zhou, Yamin Gao, Heyu Zhao, Banghui Liu, Han Zhang, Cuiting Fang, Hang Yuan, Jingjing Wang, Zimu Li, Yi Zhao, Xiaodong Huang, Xiyue Wang, A. Sofia. F. Oliveira, James Spencer, Adrian J. Mulholland, Steven G. Burston, Jinxing Hu, Ning Su, Xinwen Chen, Jun He, Tianyu Zhang, Xiaoli Xiong

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Modelling cell shape in 3D structured environments: A quantitative comparison with experiments. by Rabea Link, Mona Jaggy, Martin Bastmeyer, Ulrich S Schwarz

“…Cell shape plays a fundamental role in many biological processes, including adhesion, migration, division and development, but it is not clear which shape model best predicts three-dimensional cell shape in structured environments. Here, we compare different modelling approaches with experimental data. …”
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The ALX4 dimer structure provides insight into how disease alleles impact function by Brittany Cain, Zhenyu Yuan, Evelyn Thoman, Rhett A. Kovall, Brian Gebelein

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Causal signals between codon bias, mRNA structure, and the efficiency of translation and elongation by Cristina Pop, Silvi Rouskin, Nicholas T Ingolia, Lu Han, Eric M Phizicky, Jonathan S Weissman, Daphne Koller

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Cell Structure of the Preoral Mycangia of <i>Xyleborus</i> (Coleoptera: Curculiondiae) Ambrosia Beetles by Ross A. Joseph, Esther Tirmizi, Abolfazl Masoudi, Nemat O. Keyhani

“…However, information concerning the cellular structure and function of <i>Xyleborus</i> mycangia remains limited. …”
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Modeling soil as a living system: Feedback between microbial activity and spatial structure by Riz Fernando Noronha, Kim Sneppen, Kunihiko Kaneko

“…Soil is a complex, dynamic material with physical properties that depend on its biological content. We propose a cellular automaton model for self-organizing soil structure, where soil aggregates serve as food for microbial species. …”
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The Effect of Iron Deficiency on Cardiac Function and Structure in Heart Failure with Reduced Ejection Fraction by Pieter Martens

“…The IRON-CRT trials show that ferric carboxymaltose is capable of improving cardiac structure and cardiac performance. This article discusses the effect of iron deficiency on cardiac function and structure and how it can be alleviated.…”
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Computational Approach in Formulating Mechanical Characteristics of 3D Star Honeycomb Auxetic Structure by Mozafar Shokri Rad, Zaini Ahmad, Amran Alias

“…The primary outcome of the study is a design guideline for the use of 3D star honeycomb auxetic cellular structure in structural applications.…”
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Cryo-EM structure of single-layered nucleoprotein-RNA complex from Marburg virus by Luca Zinzula, Florian Beck, Marianna Camasta, Stefan Bohn, Chuan Liu, Dustin Morado, Andreas Bracher, Juergen M. Plitzko, Wolfgang Baumeister

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Allosteric conformational change cascade in cytoplasmic dynein revealed by structure-based molecular simulations. by Shintaroh Kubo, Wenfei Li, Shoji Takada

“…Dynein hydrolyzes ATP in a ring-like structure, containing 6 AAA+ (ATPases associated with diverse cellular activities) modules, which is ~15 nm away from the MT binding domain (MTBD). …”
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