Structural basis for substrate recognition mechanism of human SLC26A7 by Xiaorong Li, Xiaoxu Yang, Xiaoli Lu, Bingqian Lin, Yuanyuan Zhang, Bangdong Huang, Yutong Zhou, Jing Huang, Kun Wu, Qiang Zhou, Ximin Chi

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Structural mechanisms for centrosomal recruitment and organization of the microtubule nucleator γ-TuRC by Qi Gao, Florian W. Hofer, Sebastian Filbeck, Bram J. A. Vermeulen, Martin Würtz, Annett Neuner, Charlotte Kaplan, Maja Zezlina, Cornelia Sala, Hyesu Shin, Oliver J. Gruss, Elmar Schiebel, Stefan Pfeffer

“…This study provides a unique view on γ-TuRC structure and molecular organization at centrosomes and identifies an important cellular function of centriole-lumenal γ-TuRCs.…”
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Aridity-induced structural and functional adaptations in Solanum surattense across dryland ecosystems by Sadaf Rafiq, Ummar Iqbal, Sana Abid, Muhammad Sharif, Abdul Wahab, Muhammad Kaleem, Musarat Mansha, Ansar Mehmood, Shankarappa Sridhara, Eman A. Mahmoud, Khalid F. Almutairi, Hosam O. Elansary, Khawaja Shafique Ahmad

“…Abstract Aridity is a key environmental filter that governs plant community structure by constraining species diversity, distribution, and adaptive capacity, particularly within arid and semi-arid ecosystems. …”
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Structural and mechanistic bases for resistance of the M66I capsid variant to lenacapavir by Lorenzo Briganti, Arun S. Annamalai, Stephanie M. Bester, Guochao Wei, Jonathan R. Andino-Moncada, Satya P. Singh, Alex B. Kleinpeter, Meghna Tripathi, Binh Nguyen, Rajalingam Radhakrishnan, Parmit K. Singh, Juliet Greenwood, Lauren I. Schope, Reed Haney, Szu-Wei Huang, Eric O. Freed, Alan N. Engelman, Ashwanth C. Francis, Mamuka Kvaratskhelia

“…Here we investigated structural and mechanistic bases for how the M66I change affects LEN binding to CA and viral replication. …”
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Cataract‐Causing Mutant R188C of βB2 Crystallin With Low Structural Stability is Sensitive to Environmental Stresses and Prone to Aggregates Formation by Yibo Yu, Silong Chen, Ying Zhang, Hang Song, Jiarui Guo, Chengpeng Wu, Wei Wu, Jingjie Xu, Xiaoyu Cheng, Chenqi Luo, Jing Guo, Yip Chee Chew, Ke Yao, Xiangjun Chen, Lidan Hu

“…We examined the effects of the R188C mutation on βB2‐crystallin's structural stability and resistance to environmental stressors using purified proteins and cellular models. …”
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Structure-guided engineering of snake toxins for selective modulation of adrenergic and muscarinic receptors by Yixuan Zhong, Huihui Tao, Yu Zhang, Binbin He, Haizhan Jiao, Dandan Wang, Maikun Teng, Hongli Hu, Qiong Guo, Yuyong Tao

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Structure and identification of the native PLP synthase complex from Methanosarcina acetivorans lysate by Angela Agnew, Ethan Humm, Kang Zhou, Robert P. Gunsalus, Z. Hong Zhou

“…In addition to being the first reconstruction of the PdxS enzyme from a heterogeneous cellular sample, our results reveal a departure from previously published archaeal PdxS crystal structures, lacking the 37-amino-acid insertion present in these prior cases. …”
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Cell structure-impact property relationship of polypropylene/thermoplastic elastomer blend foams by A. Heidari, M. Fasihi

“…The purpose of the present study was to investigate the effect of cellular structure on the impact strength of polypropylene/polyolefin elastomers blend foams produced by the continuous extrusion process. …”
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Sound-absorbing aerated concrete based on China fly ash by Wenxu Xiao

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Hox Targets and Cellular Functions by Ernesto Sánchez-Herrero

“…Hox genes determine structures though the regulation of targets implementing cellular functions and by coordinating cell behavior. …”
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P06 | MICROGRAVITY-INDUCED CHANGES IN CYTOSKELETON STRUCTURE OF TCAM-2 CELLS

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Neurological impact of HIV/AIDS and substance use alters brain function and structure by James Haorah, Samikkannu Malaroviyam, Hemavathi Iyappan, Thangavel Samikkannu

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β-hairpin-mediated formation of structurally distinct multimers of neurotoxic prion peptides. by Andrew C Gill

“…These simulations provide an important new atomic-level model for the formation of oligomers and fibrils of the prion protein and suggest that stabilization of β-hairpin structure may enhance cellular toxicity by altering the balance between oligomeric and fibrillar protein assemblies.…”
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CHD1L in cancer and beyond: structure, oncogenic functions, and therapeutic potential by Sophia Clune, Paul Awolade, Hector Esquer, Qiong Zhou, Daniel V. LaBarbera

“…This review covers CHD1L’s structure, oncogenic functions, and developmental origins, and highlights emerging therapeutic strategies that target CHD1L as a druggable vulnerability in cancer.…”
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Staphylococcus aureus cell wall structure and dynamics during host-pathogen interaction. by Joshua A F Sutton, Oliver T Carnell, Lucia Lafage, Joe Gray, Jacob Biboy, Josie F Gibson, Eric J G Pollitt, Simone C Tazoll, William Turnbull, Natalia H Hajdamowicz, Bartłomiej Salamaga, Grace R Pidwill, Alison M Condliffe, Stephen A Renshaw, Waldemar Vollmer, Simon J Foster

“…Peptidoglycan is the major structural component of the Staphylococcus aureus cell wall, in which it maintains cellular integrity, is the interface with the host, and its synthesis is targeted by some of the most crucial antibiotics developed. …”
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Experimental-Morphological Study of Several Types of Fibrillar Structured Drainages for Glaucoma Surgery by N. S. Khodjaev, M. N. Kolomeytsev, A. V. Sidorova, V. V. Molchanov, N. G. Sedush, T. H. Tenchurin

“…Histological examination showed that the fibrous structure of drainage was practically not determined, an abundance of cellular elements was observed throughout the drainage: macrophages and multinucleate giants predominated, fibroblasts, fibroblasts, lymphocytes, and newly formed connective tissue fibers between the drainage fibers were present. …”
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Cryo-TEM structure of β-glucocerebrosidase in complex with its transporter LIMP-2 by Jan Philipp Dobert, Jan-Hannes Schäfer, Thomas Dal Maso, Priyadarshini Ravindran, Dustin J. E. Huard, Eileen Socher, Lisa A. Schildmeyer, Raquel L. Lieberman, Wim Versées, Arne Moeller, Friederike Zunke, Philipp Arnold

“…Abstract Targeting proteins to their final cellular destination requires transport mechanisms and nearly all lysosomal enzymes reach the lysosome via the mannose-6-phosphate receptor pathway. …”
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Mapping knowledge structure and research of the biologic treatment of asthma: A bibliometric study by Jiamin Sun, Shiyao Bai, Jieyu Zhao, Danling Li, Xueqing Ma, Lin Ma, Xinming Su

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Structure and kinetic investigation of Streptococcus pyogenes family GH38 alpha-mannosidase. by Michael D L Suits, Yanping Zhu, Edward J Taylor, Julia Walton, David L Zechel, Harry J Gilbert, Gideon J Davies

“…<h4>Methodology/principal findings</h4>Here we show that the Streptococcus pyogenes (M1 GAS SF370) GH38 enzyme (Spy1604; hereafter SpGH38) is an alpha-mannosidase with specificity for alpha-1,3 mannosidic linkages. The 3D X-ray structure of SpGH38, obtained in native form at 1.9 A resolution and in complex with the inhibitor swainsonine (K(i) 18 microM) at 2.6 A, reveals a canonical GH38 five-domain structure in which the catalytic "-1" subsite shows high similarity with the Drosophila enzyme, including the catalytic Zn(2+) ion. …”
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Cryo-ET of actin cytoskeleton and membrane structure in lamellipodia formation using optogenetics by Hironori Inaba, Tsuyoshi Imasaki, Kazuhiro Aoyama, Shogo Yoshihara, Hiroko Takazaki, Takayuki Kato, Hidemasa Goto, Kaoru Mitsuoka, Ryo Nitta, Takao Nakata

“…Here, we combined optogenetics with cryo-electron tomography (cryo-ET) to visualize the actin cytoskeleton and membrane structures during lamellipodia formation with temporal precision. …”
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