Geometrical constraint change determines organized collective migration of follower cells by Mitsuru Sentoku, Masaharu Endo, Miki Takei, Wataru Hanamoto, Kenji Yasuda

“…In a single-cell-wide T-shaped branching structure, rear cells selected alternate pathways, avoiding direct alignment with preceding cells. …”
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Engineering dimer mutants of human geranylgeranyl pyrophosphate synthase. by Sean J Ezekiel, Mackenzie Searle, Jaeok Park

“…However, the enzyme's native hexameric quaternary structure presents challenges for crystallographic studies. …”
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Single-cell transcriptomics analysis reveals that the tumor-infiltrating B cells determine the indolent fate of papillary thyroid carcinoma by Chunmei Li, Pei Wang, Zhizhong Dong, Weihan Cao, Yanjun Su, Jianming Zhang, Shuyan Zhao, Zhiyuan Wang, Zi Lei, Li Shi, Ruochuan Cheng, Wen Liu

“…Methods We used single-cell RNA sequencing (scRNA-seq) to analyze cellular differences in 10 early-stage PTC tumors. …”
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The Potential Role of the Microbiome in the Pathogenesis of Nasal Tumors: A Comprehensive Review by Antonella Loperfido, Davide Rizzo, Bruno Fionda, Luca Mureddu, Andrea Tondo, Luca Tagliaferri, Gianluca Bellocchi, Giovanni Delogu, Francesco Bussu

“…Cancers of the nose, and especially the nose vestibule, represent a significant challenge for clinicians due to their rarity, the intricate nature of surrounding vital structures, the nonspecific early symptoms, and the etiological factors that are not completely understood. …”
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TRPM channels in human cancers: regulatory mechanism and therapeutic prospects by Qinfeng Liu, Mengyu Hu, Shi Li, Xin Zhang, Rui Zhang, Hao Lyu, Shuai Xiao, Dong Guo, Xing-Zhen Chen, Jingfeng Tang, Cefan Zhou

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Isoform switching facilitates period control in the Neurospora crassa circadian clock by Ozgur E Akman, James C W Locke, Sanyi Tang, Isabelle Carré, Andrew J Millar, David A Rand

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Intraoperative Confocal Laser Endomicroscopy Detects Prostate Cancer at the Single-Cell Level with High Specificity and in Real Time: A Preclinical Proof of Concept by Ann-Christin Eder, Jessica Matthias, Francois Lacombe, Lisa-Charlotte Domogalla, Antoine Jacques, Nils Steinacker, Gaetan Christien, Elodie Martin, Aline Criton, Matthias Eder

“…<b>Conclusions:</b> This preclinical proof of concept demonstrates the potential of intraoperative PSMA-specific NIR-pCLE imaging to visualize tissue structures in real time at cellular resolution. Clinical implementation could provide surgeons with valuable additional information, potentially advancing PCa patient care through improved surgical precision.…”
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Rule-based cell systems model of aging using feedback loop motifs mediated by stress responses. by Andres Kriete, William J Bosl, Glenn Booker

“…We evolve an integrated generic cell network to represent the connectivity of key cellular mechanisms structured into positive and negative feedback loop motifs centrally important for aging. …”
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A telomere-associated molecular landscape reveals immunological, microbial, and therapeutic heterogeneity in colorectal cancer by Yinmeng Zhang, Jiawei Fan, Jiahui Zhao, He Zhu, Yan Xia, Hong Xu

“…Finally, scRNA analysis highlighted profound cellular and functional divergence between TELscore subgroups. …”
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α‐Synuclein Pathology Spreads in a Midbrain–Hindbrain Assembloid Model by Gemma Gomez‐Giro, Daniela Frangenberg, Daniela Vega, Alise Zagare, Kyriaki Barmpa, Paul M. A. Antony, Graham Robertson, Rahman Sabahi‐Kaviani, Kristian Haendler, Nathalie Kruse, Florentia Papastefanaki, Rebecca Matsas, Malte Spielmann, Regina Luttge, Jens C. Schwamborn

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Electrical Stimulation of Oral Tissue-Derived Stem Cells: Unlocking New Potential for Dental and Periodontal Regeneration by Rúben S. Pires, Mafalda S. Santos, Filipe Miguel, Cláudia L. da Silva, João Carlos Silva

“…The tooth and its supporting periodontium are essential structures of the oral cavity, frequently compromised by conditions such as dental defects, aries, and periodontal diseases, which, if poorly treated, often lead to tooth loss. …”
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Screening of G-quadruplex DNA ligands by fluorescence detection of peptide displacement by Valentina Arciuolo, Simona Marzano, Rossella Buono, Nicola Grasso, Anna Di Porzio, Antonio Randazzo, Bruno Pagano, Jussara Amato

“…G-quadruplexes (G4s) are noncanonical DNA/RNA structures involved in key cellular processes, and their interactions with proteins are emerging as therapeutic targets. …”
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Network spreading and local biological vulnerability in amyotrophic lateral sclerosis by Asa Farahani, Justine Y. Hansen, Vincent Bazinet, Golia Shafiei, D. Louis Collins, Mahsa Dadar, Sanjay Kalra, Alain Dagher, Bratislav Misic

“…Here, we investigate how network structure and local biological features shape the spatial patterning of atrophy in ALS. …”
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Salt, Aldosterone, and Parathyroid Hormone: What Is the Relevance for Organ Damage? by Cristiana Catena, Gian Luca Colussi, Gabriele Brosolo, Nicole Bertin, Marileda Novello, Andrea Palomba, Leonardo A. Sechi

“…Structured interventions on lifestyle have been suggested as a cost-effective strategy for prevention of cardiovascular disease. …”
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Modifying the Glycocalyx of Melanoma Cells via Metabolic Glycoengineering Using <i>N</i>-Acetyl-<span style="font-variant: small-caps">d</span>-glucosamine Analogues by David Harris, Marcel Groß, Sebastian Staebler, Regina Ebert, Jürgen Seibel, Anja Katrin Boßerhoff

“…Tumor cells are decorated with aberrant glycan structures on cell surfaces. It is well known that the glycocalyx serves as a main cellular regulator, although its role in cancer is still not completely understood. …”
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A Refined Approach to Isolate Interneurons for High-Validity Epigenetic Studies in Human Brain Tissue by Ariel Cariaga-Martínez, Kilian Jesús Gutierrez, Ignacio Regidor, Marta Del Álamo, Jerónimo Saiz-Ruiz, Raúl Alelú-Paz

“…We isolate permeabilized cell-like structures suitable for downstream epigenetic analysis. …”
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Sonosynthesis and artificial intelligence-enhanced characterization of PEGylated Camellia sinensis-encapsulated zinc oxide nanoparticles: cytotoxicity capacity against cervical can... by Anıl Asmaz, Fulya Ustun-Alkan, Ismail Bergutay Kalaycilar, Tarik Kucukdeniz, Fatih Özbaş, Selcan Karakuş

“…Moreover, advanced computer vision and texture analysis have provided intricate details regarding the surfaces of CL/ZnO NPs, revealing crucial morphological features and distribution patterns that are essential for understanding their interactions with cellular structures. Statistical evaluation revealed a pronounced cytotoxic effect of CL/ZnO NPs on HeLa cells, with IC50 values of 13.708 µg mL−1 at 48 hours, compared to >100 µg mL−1 for L929 cells, indicating selective anti-cancer activity of NPs with minimal impact on fibroblast cells. …”
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Unravelling the Significance of Extracellular Vesicle‐Associated DNA in Cancer Biology and Its Potential Clinical Applications by Jamal Ghanam, Kristína Lichá, Venkatesh Kumar Chetty, Ommolbanin Asad Pour, Dirk Reinhardt, Barbora Tamášová, Peter Hoyer, Jan Lötvall, Basant Kumar Thakur

“…EV‐DNA is actively released by both normal and malignant cells and consists of diverse fragments with varying structures. Because EV‐DNA spans the entire genome of cells from which it originates, it continues to be attractive as a biomarker for cancer diagnosis and monitoring. …”
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Direct laser writing of electronically conductive microstructures within soft hydrogel substrates by Lorenzo Lucherini, Veronica Navello, Outman Akouissi, Stéphanie P. Lacour, Esther Amstad

“…Using two-photon direct laser writing, we demonstrate the ability to pattern encapsulated conductive structures at the surface or within the bulk of the hydrogels. …”
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Peritoneal Response to Abdominal Surgery: The Role of Equine Abdominal Adhesions and Current Prophylactic Strategies by Juliana de Moura Alonso, Ana Liz Garcia Alves, Marcos Jun Watanabe, Celso Antonio Rodrigues, Carlos Alberto Hussni

“…Adhesions are highly cellular, vascularized, dynamic structures that are influenced by complex signaling mechanisms. …”
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