Distinct regulation of Tau Monomer and aggregate uptake and intracellular accumulation in human neurons by Amir T. Marvian, Tabea Strauss, Qilin Tang, Benjamin J. Tuck, Sophie Keeling, Daniel Rüdiger, Negar Mirzazadeh Dizaji, Hossein Mohammad-Beigi, Brigitte Nuscher, Pijush Chakraborty, Duncan S. Sutherland, William A. McEwan, Thomas Köglsperger, Stefan Zahler, Markus Zweckstetter, Stefan F. Lichtenthaler, Wolfgang Wurst, Sigrid Schwarz, Günter Höglinger

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PRRSV GP4 subunit vaccine combined with adenovirus heterologous prime-boost immunization strategy induced a significant immune response in mice by Honghuan Li, Wenxiang Zhang, Wenxing Wang, Yanjie Qiao, Mingguo Xu, Ziwei Liu, Xiaoxiao Gu, Aodi Wu, Zhongchen Ma, Chuangfu Chen, Wei Zhang

“…Results In this study, predictive analysis of PRRSV GP4 antigen structures in two expressed modes, and the results showed good antigenicity. …”
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Antioxidants to Defend Healthy and Youthful Skin—Current Trends and Future Directions in Cosmetology by Anna Budzianowska, Katarzyna Banaś, Jaromir Budzianowski, Małgorzata Kikowska

“…Oxidative stress, primarily driven by an imbalance between reactive oxygen species (ROS) production and the skin’s defense mechanisms, accelerates aging processes, damages cellular structures, and compromises skin integrity. …”
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GLUT4 traffic through an ESCRT-III-dependent sorting compartment in adipocytes. by Françoise Koumanov, Vinit J Pereira, Paul R Whitley, Geoffrey D Holman

“…Introduction of the dominant negative inhibitory constructs of the ESCRT-III components CHMP3 (CHMP3(1-179)) and Vps4 (GFP-Vps4(E235Q)) into rat adipocytes leads to the accumulation of GLUT4 in large, coalesced and extended vesicles structures that co-localise with the inhibitory constructs over large parts of the extended structure. …”
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Differential lipid dependence of the function of bacterial sodium channels. by Nazzareno D'Avanzo, Emily C McCusker, Andrew M Powl, Andrew J Miles, Colin G Nichols, B A Wallace

“…The lipid bilayer is important for maintaining the integrity of cellular compartments and plays a vital role in providing the hydrophobic and charged interactions necessary for membrane protein structure, conformational flexibility and function. …”
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Circular RNA: functions, applications and prospects by Minghon Lu

“…With vigorous research being carried out regarding their still unclear diversified roles and precise molecular structure, circRNAs are bound to become the new revolutionary perspective on cellular regulation, protein signalling and disease pathogenesis.…”
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Omsk Hemorrhagic Fever Virus: A Comprehensive Review from Epidemiology to Diagnosis and Treatment by Erica Diani, Riccardo Cecchetto, Emil Tonon, Marco Mantoan, Virginia Lotti, Anna Lagni, Asia Palmisano, Pier Paolo Piccaluga, Davide Gibellini

“…OHFV is a flavivirus and shares structural and morphological features with tick-borne encephalitis (TBE) complex viruses. …”
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Genome-Wide Analysis of Gene and Protein Expression of Dysplastic Naevus Cells by Linda Gao, Frans A. van Nieuwpoort, Jacoba J. Out-Luiting, Paul J. Hensbergen, Femke A. de Snoo, Wilma Bergman, Remco van Doorn, Nelleke A. Gruis

“…Additionally, melanocytes in dysplastic naevi show structural mitochondrial and melanosomal alterations and have elevated reactive oxygen species (ROS) levels. …”
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Expression and Localization of hspa5 in Response to Thermal Stress in the Spotted Sea Bass (Lateolabrax maculatus) by Xiaoqiang LIU, Chunhui FENG, Haishen WEN, Yun LI, Tianyu JIANG, Xin QI

“…Structural modeling indicated that the secondary structure of HSPA5 was predominantly composed of α-helices, accompanied by some irregular coiling.To investigate the response mechanism of hspa5 in L. maculatus under high-temperature stress, we analyzed its expression in liver tissue using real-time quantitative polymerase chain reaction (qPCR) under a 30 ℃ heat stress condition. …”
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Engineering Lipid–Polymer Nanoparticles for siRNA Delivery to Cancer Cells by Arthur Manda, Abdulelah Alhazza, Hasan Uludağ, Hamidreza Montazeri Aliabadi

“…We hypothesized that specially designed low-molecular-weight PEIs can partially or completely replace the ionizable lipids for more accommodating vehicles due to the structural flexibility offered by polymers, which could lead to safer and more efficient nucleic acid delivery. …”
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Precision design of dextran-permeated agarose hydrogels matching adipose stem cell adhesion timescales by Nicole Guazzelli, Ludovica Cacopardo, Arti Ahluwalia

“…Tailoring time-dependent materials to elicit specific cellular responses is, however, a challenge because of the intricate relationship between the substrate relaxation time (τrel) and the cell sensing time-window which depends on the time required for the formation of focal adhesions (τb) and the duration of their lifetime (τL). …”
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Virus-like Particles Produced in Plants: A Promising Platform for Recombinant Vaccine Development by Eugenia S. Mardanova, Egor A. Vasyagin, Nikolai V. Ravin

“…The capsid proteins of many viruses are capable of spontaneous self-assembly into virus-like particles (VLPs), which do not contain the viral genome and are therefore not infectious. VLPs are structurally similar to their parent viruses and are therefore effectively recognized by the immune system and can induce strong humoral and cellular immune responses. …”
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P51 | DECELLULARIZATION OF HUMAN LUNG SCAFFOLD FOR TUMOR MICROENVIRONMENT MODELLING STUDY

“…An effective decellularization process must remove all cellular material while preserving the ECM’s structure and composition2. …”
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Connecting macroscopic observables and microscopic assembly events in amyloid formation using coarse grained simulations. by Noah S Bieler, Tuomas P J Knowles, Daan Frenkel, Robert Vácha

“…The pre-fibrillar stages of amyloid formation have been implicated in cellular toxicity, but have proved to be challenging to study directly in experiments and simulations. …”
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Dynamic rotation of the protruding domain enhances the infectivity of norovirus. by Chihong Song, Reiko Takai-Todaka, Motohiro Miki, Kei Haga, Akira Fujimoto, Ryoka Ishiyama, Kazuki Oikawa, Masaru Yokoyama, Naoyuki Miyazaki, Kenji Iwasaki, Kosuke Murakami, Kazuhiko Katayama, Kazuyoshi Murata

“…Norovirus is the major cause of epidemic nonbacterial gastroenteritis worldwide. Lack of structural information on infection and replication mechanisms hampers the development of effective vaccines and remedies. …”
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Title not available by Thetiot, Melina, Cossart, Pascale, Bally-Cuif, Laure

“…Current challenges and future directions have also been discussed alongside with the ethical implications of generating functional structures from human cells in vitro.…”
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Genomic and Epigenomic Plasticity in the Hypoxic Environment by Emanuele Cricchi, Alessio Bertozzo, Martina Minisini, Claudio Brancolini

“…In this review, we will discuss the complex genomic and epigenomic structures that are modulated by oxygen and control the activity of cis-regulatory elements and the adaptations to variations in O₂ availability.…”
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Respiratory microphysiological system in respiratory research: recent advances and future prospects by Jiaxiang Yin, Zirong Bi, Tiankai Dai, Xiaoyue Zhu, Tao Xu, Huisheng Liu

“…Abstract Respiratory diseases encompass a broad range of conditions that affect the airways, alveolus, and other structures involved in breathing. With respiratory viruses emerging and spreading rapidly, and factors like air pollution, smoking, occupational hazards, and genetics as major risk contributors, respiratory diseases have emerged as a primary cause of illness and mortality around the globe. …”
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Inhibition of human-HPV hybrid ecDNA enhancers reduces oncogene expression and tumor growth in oropharyngeal cancer by Takuya Nakagawa, Jens Luebeck, Kaiyuan Zhu, Joshua T. Lange, Roman Sasik, Chad Phillips, Sayed Sadat, Sara Javadzadeh, Qian Yang, Abdula Monther, Santiago Fassardi, Allen Wang, Kersi Pestonjamasp, Brin Rosenthal, Kathleen M. Fisch, Paul Mischel, Vineet Bafna, Joseph A. Califano

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PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY AS A COMPLICATION OF RITUXIMAB THERAPY FOR RHEUMATOID ARTHRITIS (A CASE REPORT) by I. B. Bashkova, I. V. Madyanov, M. S. Shostak, T. V. Prokopyeva

“…The disease is caused by activation of opportunistic viral (JC-virus) infection in the presence of weakened cellular immunity, which leads to massive demyelination of brain structures. …”
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