Cell Connections by Tunneling Nanotubes: Effects of Mitochondrial Trafficking on Target Cell Metabolism, Homeostasis, and Response to Therapy by Marie-Luce Vignais, Andrés Caicedo, Jean-Marc Brondello, Christian Jorgensen

“…Intercellular communications play a major role in tissue homeostasis and responses to external cues. Novel structures for this communication have recently been described. …”
Get full text

Fragment-based screening maps inhibitor interactions in the ATP-binding site of checkpoint kinase 2. by M Cris Silva-Santisteban, Isaac M Westwood, Kathy Boxall, Nathan Brown, Sam Peacock, Craig McAndrew, Elaine Barrie, Meirion Richards, Amin Mirza, Antony W Oliver, Rosemary Burke, Swen Hoelder, Keith Jones, G Wynne Aherne, Julian Blagg, Ian Collins, Michelle D Garrett, Rob L M van Montfort

“…Furthermore, the CHK2 crystal structures with a quinoxaline-based fragment and its follow-up compound highlight a hydrophobic area above the hinge region not previously explored in rational CHK2 inhibitor design, but which might be exploited to enhance both potency and selectivity of CHK2 inhibitors.…”
Get full text

Pathogenicity and virulence of Chlamydia trachomatis: Insights into host interactions, immune evasion, and intracellular survival by Alix McCullough, Steven Huang, Mary M. Weber

“…We delve into its interactions with host cytoskeletal structures, immune signaling pathways, and intracellular trafficking systems, as well as its strategies for immune evasion and persistence. …”
Get full text

Role of Extracellular microRNAs in Sepsis-Induced Acute Lung Injury by Chenlu Xiong, Xuan Huang, Shibiao Chen, Yong Li

“…Extracellular vesicles (EVs) are a heterogeneous population of spherical membrane structures released by almost all types of cells, containing various cellular components. …”
Get full text

Dendritic targeting in the leg neuropil of Drosophila: the role of midline signalling molecules in generating a myotopic map. by David J Brierley, Eric Blanc, O Venkateswara Reddy, K Vijayraghavan, Darren W Williams

“…Neural maps are emergent, highly ordered structures that are essential for organizing and presenting synaptic information. …”
Get full text

Evaluation of lipid peroxidation, lipid profile and antioxidant status in patients with non-insulin dependent diabetes mellitus in Najaf / Iraq. by Abdulhussain J. M. Shamsa

“…Lipid peroxidation of cellular structures, a consequence of increased oxygen free radicals, is thought to play an important role in atherosclerosis and microvascular complications of diabetes mellitus. …”
Get full text

Enteropathogenic Escherichia coli induces Entamoeba histolytica superdiffusion movement on fibronectin by reducing traction forces. by Yuanning Guo, Jun Ye, Ariel Shemesh, Anas Odeh, Meirav Trebicz-Geffen, Haguy Wolfenson, Serge Ankri

“…This increased motility is accompanied by a reduction in F-actin-dependent traction forces and podosome-like structures on fibronectin-coated substrates, but with increased F-actin localization in the upper part of the cytoplasm. …”
Get full text

Bibliometric Analysis of The Last 40 Years of Chest Journal by Pınar Yıldız Gülhan, Mehmet Nurullah Kurutkan

“…According to the Co-Occurrence network map analysis, Chest journal's publications consist of clusters of cellular structures, thoracic oncology, chest infection, pulmonary and cardiovascular, sleep and pulmonary function test, and obstructive lung diseases. …”
Get full text

DNA electrophoretic migration patterns change after exposure of Jurkat cells to a single intense nanosecond electric pulse. by Stefania Romeo, Luigi Zeni, Maurizio Sarti, Anna Sannino, Maria Rosaria Scarfì, P Thomas Vernier, Olga Zeni

“…Intense nanosecond pulsed electric fields (nsPEFs) interact with cellular membranes and intracellular structures. Investigating how cells respond to nanosecond pulses is essential for a) development of biomedical applications of nsPEFs, including cancer therapy, and b) better understanding of the mechanisms underlying such bioelectrical effects. …”
Get full text

Image-based analysis of living mammalian cells using label-free 3D refractive index maps reveals new organelle dynamics and dry mass flux. by Patrick A Sandoz, Christopher Tremblay, F Gisou van der Goot, Mathieu Frechin

“…We could observe the shape and dry mass dynamics of LDs, endocytic structures, and entire cells' division that have so far, to the best of our knowledge, been out of reach. …”
Get full text

Shared biophysical mechanisms determine early biofilm architecture development across different bacterial species. by Hannah Jeckel, Francisco Díaz-Pascual, Dominic J Skinner, Boya Song, Eva Jiménez-Siebert, Kerstin Strenger, Eric Jelli, Sanika Vaidya, Jörn Dunkel, Knut Drescher

“…Bacterial biofilms are among the most abundant multicellular structures on Earth and play essential roles in a wide range of ecological, medical, and industrial processes. …”
Get full text

Model of Biomineralization of Ferrum Compounds by Gallionella Cells Immobilized on Contact Loading of Bioreactor by Oleksandr Kvartenko, Iryna Gryuk, Larysa Sablii

“…The totality of presented processes results in speeding up the fermentative oxidation of Fe2+ on the surface of a cell with the final formation of matrix structures of biominerals and the increased efficiency of bioreactors operation.…”
Get full text

The role of response elements organization in transcription factor selectivity: the IFN-β enhanceosome example. by Yongping Pan, Ruth Nussinov

“…The IFN-β enhanceosome provides a good model system: it is small; its components' crystal structures are available; and there are biochemical and cellular data. …”
Get full text

Impact of the small bowel impassability on expression of the hypoxia-induced factor-1α by D. A. Kluiko

“…In experimental ileus, complete or partial one, partial pressure and velocity of the oxygen mass-transduction in peritoneum were statistically significantly lower, than such in a control, indicating on inhibition of cellular structures, utilizing the oxygen, what promotes the adhesive disease occurrence. …”
Get full text

Thyroid-Like Low-Grade Nasopharyngeal Papillary Adenocarcinoma with Biphasic Histology by Rusella Mirza, Nestor Dela Cruz, Guillermo A. Herrera

“…Microscopically, it was composed of papillary structures admixed with a few solid areas of spindle cells. …”
Get full text

Impact of partial enzymatic hydrolysis on the transport and uptake of SPI nanoparticles post-digestion by Ling Chen, Yuan Lv, Xiaoyong Wang, Maoshen Chen, Hui Zhang

“…Despite extensive research on protein-based nanoparticles for nutrient delivery, the structural features that govern bile salt interactions and subsequently enhance intestinal absorption and metabolic transformation remain insufficiently clarified. …”
Get full text

A unique modification of the eukaryotic initiation factor 5A shows the presence of the complete hypusine pathway in Leishmania donovani. by Bhavna Chawla, Ravi Ranjan Kumar, Nidhi Tyagi, Gowri Subramanian, N Srinivasan, Myung Hee Park, Rentala Madhubala

“…We present here the molecular and structural basis of the function of DOHH from the protozoan parasite, Leishmania donovani, which causes visceral leishmaniasis. …”
Get full text

Interrogation of the protein-protein interactions between human BRCA2 BRC repeats and RAD51 reveals atomistic determinants of affinity. by Daniel J Cole, Eeson Rajendra, Meredith Roberts-Thomson, Bryn Hardwick, Grahame J McKenzie, Mike C Payne, Ashok R Venkitaraman, Chris-Kriton Skylaris

“…A previously published crystal structure reports the structural basis of the interaction between human BRC4 and the catalytic core domain of RAD51. …”
Get full text

Osteoarthritis and age. Role of aging in the etiology and pathogenesis of the disease by L. V. Luchikhina, O. I. Mendel, V. Mendel, G. N. Golukhov

“…It describes the processes underlying aging and OA at the molecular and cellular level, with emphasis on the role of chronic nonspecific inflammation. …”
Get full text

Mitochondrial Dysfunction in Congenital Heart Disease by Julie Pires Da Silva, Mariana Casa de Vito, Carissa Miyano, Carmen C. Sucharov

“…Mitochondria play a crucial role in multiple cellular processes such as energy metabolism, generation of reactive oxygen species, excitation–contraction coupling, cell survival and death. …”
Get full text