Intratumoral pan-ErbB targeted CAR-T for head and neck squamous cell carcinoma: interim analysis of the T4 immunotherapy study by Fiona Reid, Sophie Papa, John Maher, Jean-Pierre Jeannon, James Spicer, Victoria Gibson, Selvam Thavaraj, Michael Metoudi, Christopher Fisher, Nicholas Beckley-Hoelscher, Andrew Hope, Maria Elstad, Antonella Adami, Richard Beatson, Molly Sarah George, Daniela Achkova, Evangelia Williams, Sefina Arif, Abdel Douri, Marc Delord, Mike Lyne, Dharshene Shivapatham, Sakina Gooljar, Arindam Mitra, Linda Gomm, Cienne Morton, Rhonda Henley-Smith, Alice Santambrogio, Cynthia Andoniadou, Sarah Allen, Gary J R Cook, Ana C Parente-Pereira, David M Davies, Farzin Farzaneh, Anna Schurich, Teresa Guerrero-Urbano

“…To target upregulated ErbB dimer expression in this cancer, we developed an autologous CD28-based chimeric antigen receptor T-cell (CAR-T) approach named T4 immunotherapy. Patient-derived T-cells are engineered by retroviral transduction to coexpress a panErbB-specific CAR called T1E28ζ and an IL-4-responsive chimeric cytokine receptor, 4αβ, which allows IL-4-mediated enrichment of transduced cells during manufacture. …”
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O debate entre cosmopolitismo, patriotismo e nacionalismo: uma introdução geral ao tema by Mariane Gehlen Perin

“…Cosmopolitanism, with its origin in Ancient Greece with Diogenes of Sinope, was preserved within the stoic doctrine and got mixed in the course of history with other familiar currents, namely universalism and internationalism. Such tendency survives today through trends more in tune with remote cosmopolitanism or even other more distant trends. …”
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Overview: quasi-Lagrangian observations of Arctic air mass transformations – introduction and initial results of the HALO–(𝒜 𝒞)³ aircraft campaign by M. Wendisch, S. Crewell, A. Ehrlich, A. Herber, B. Kirbus, C. Lüpkes, M. Mech, S. J. Abel, E. F. Akansu, F. Ament, C. Aubry, C. Aubry, S. Becker, S. Borrmann, S. Borrmann, H. Bozem, M. Brückner, H.-C. Clemen, S. Dahlke, G. Dekoutsidis, J. Delanoë, E. De La Torre Castro, E. De La Torre Castro, E. De La Torre Castro, H. Dorff, R. Dupuy, O. Eppers, F. Ewald, G. George, G. George, I. V. Gorodetskaya, S. Grawe, S. Groß, J. Hartmann, S. Henning, L. Hirsch, E. Jäkel, P. Joppe, P. Joppe, O. Jourdan, Z. Jurányi, M. Karalis, M. Kellermann, M. Klingebiel, M. Lonardi, M. Lonardi, J. Lucke, J. Lucke, A. E. Luebke, M. Maahn, N. Maherndl, M. Maturilli, B. Mayer, J. Mayer, S. Mertes, J. Michaelis, J. Michaelis, M. Michalkov, G. Mioche, M. Moser, M. Moser, H. Müller, R. Neggers, D. Ori, D. Paul, F. M. Paulus, C. Pilz, F. Pithan, M. Pöhlker, M. Pöhlker, V. Pörtge, M. Ringel, N. Risse, G. C. Roberts, S. Rosenburg, J. Röttenbacher, J. Rückert, M. Schäfer, J. Schaefer, V. Schemann, I. Schirmacher, J. Schmidt, S. Schmidt, J. Schneider, S. Schnitt, A. Schwarz, H. Siebert, H. Sodemann, H. Sodemann, T. Sperzel, T. Sperzel, G. Spreen, B. Stevens, F. Stratmann, G. Svensson, C. Tatzelt, T. Tuch, T. Vihma, C. Voigt, C. Voigt, L. Volkmer, A. Walbröl, A. Weber, B. Wehner, B. Wetzel, M. Wirth, T. Zinner

“…The campaign focused on one specific challenge posed by the models, namely the reasonable representation of transformations of air masses during their meridional transport into and out of the Arctic via northward moist- and warm-air intrusions (WAIs) and southward marine cold-air outbreaks (CAOs). …”
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Efficacy and safety of SHR8554 on postoperative pain in subjects with moderate to severe acute pain following orthopedic surgery: A multicenter, randomized, double-blind, dose-expl... by Yanhua Zhao, Zhisheng Lu, Xuesong Song, Haihui Xie, Xungang Xiao, Guonian Wang, Qi Zhou, Qingmei Zhang, Liang Liu, Zhijian Lan, Ning Bai, Haiyan Wang, Zhihao Pan, Liang Dong, Xianzhong Lin, Gang Chen, Qinghui Wang, Jiangtao Dong, Jia Deng, Yongshan Nan, Jiaqiang Zhang, Xiaohua Zhou, Yanjuan Huang, Yongquan Chen, Huanzhong He, Ye Yang, Dengpan Yao, Jintai Jia, Shuan Jin, Yafeng Zhang, Zhonghui Luo, Jiangang Li, Linzhong Zhang, Fang Wang, Juehua Jing, Jiang Zhu, Lin Li, Guangda Wang, Huajing Guo, Qiang Wang, Diansan Su, Weifeng Yu, Xiyao Gu

“…Trial Registration: Trial Name: Study on the Efficacy and Safety of SHR8554 Injection for Postoperative Analgesia in Orthopedics: Multicenter, Randomized, Double Blind, Dose Exploration, Placebo/Positive Control, Phase II/III Clinical Trial Registered on: chinadrugtrials.org.cn Identifier: CTR20220639.…”
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Genome-wide association study identifies candidate genes affecting body conformation traits of Zhongwei goat by Mingxuan Han, Xinbo Wang, Haidong Du, Yanlong Cao, Zhanqiang Zhao, Shuran Niu, Xuxu Bao, Youjun Rong, Xiaofang Ao, Furong Guo, Qincheng Xia, Fangzheng Shang, Ruijun Wang, Yanjun Zhang

“…In this study, we used the MGISEQ-T7 platform to re-sequence 240 Zhongwei goats (133 male; 107 female) belonging to 5 metrics of growth traits at different growth stages (40 days and 6 months, here in after referred to as 40d and 6 m), namely, Body Weight (BW), Body Height (BH), Body Length (BL), Chest Circumference (CC), Tube Circumference (TC) were examined. …”
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Performance Evaluation of Dual-Drive Mach-Zehnder Modulator and Optomechanical Crystal Cavity Comb Generation for All-Optical Band Conversion in 5G-Advanced Cellular Systems by Vicente Fito, Raul Ortiz, Maria Morant, Laura Mercade, Alejandro Martinez, Roberto Llorente

“…Multiband operation is a key aspect of emerging 5G-Advanced cellular systems, also named 5.5G, which target seamless provision of multi-gigabit per second connectivity employing sub-6 GHz and mm-wave overlapping coverage. …”
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Diagnosis and Treatment of Irritable Bowel Syndrome: Clinical Recommendations of the Russian Gastroenterological Association and Association of Coloproctologists of Russia by V. T. Ivashkin, I. V. Maev, Yu. A. Shelygin, E. K. Baranskaya, S. S. Belous, E. A. Belousova, A. G. Beniashvili, S. V. Vasilyev, A. V. Veselov, E. G. Grigoryev, N. V. Kostenko, V. N. Kashnikov, V. F. Kulikovskiy, I. D. Loranskaya, O. S. Lyashenko, E. A. Poluektova, V. G. Rumyantsev, V. M. Timerbulatov, O. Yu. Fomenko, D. A. Khubezov, E. Yu. Chashkova, G. I. Chibisov, M. V. Shapina, A. A. Sheptulin, O. S. Shifrin, A. S. Trukhmanov, O. P. Alekseeva, S. A. Alekseenko, A. Yu. Baranovsky, O. Yu. Zolnikova, N. V. Korochanskaya, S. N. Mammayev, I. B. Khlynov, V. V. Tsukanov

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Att lära om naturen från naturen och i naturen by Sara Planting-Bergloo, Emma Rova, Charlotte Lennartsdotter, Per Rohlin, Maria Andrée

“…For example, students need to be able to identify and name species, master a variety of methods to actually implement tasks in the field, know how work should be documented and to draw conclusions based on both measurable results and on more general ecological relationships. …”
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PENGEMBANGAN INSTRUMEN PENILAIAN HASIL BELAJAR FISIKA BERORIENTASI HOTS (Higher Order Thinking Skills) PADA MATERI ELASTISITAS DAN HUKUM HOOKE by Dona Desilva, Indra Sakti, Rosane Medriati

“…This research was a level 1 R & D which was adapted into eight stages, namely potential problems, literature studies and information gathering, product design, validated design, tested design, first product, validated product and tested product. …”
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BIJAKAWEB: Platform Berbasis Web Untuk Deteksi Hate Speech Pada Komentar Berita Bahasa Indonesia by Moh. Firdaus, Permata Nur Miftahur Rizki

“…The model with the best accuracy was implemented on a web platform named BijakaWeb (Web Bijak Dalam Berkomentar) using Django fullstack framework. …”
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The report of Chief of the General Staff of USSR marshal Alexander Jegorov about his visit in Lithuania, Latvia, and Estonia on 15th-26th of February, 1937 by Zenonas Butkus, Magnus llmjarv

“…It raises doubts about the statement that has been and is still widely used in the works devoted to history, namely, that parceling out of the Baltic states in 1939 and their occupation in 1940 have been the actions provoked by the intricacies in the international situation and may not be directly associated with the preceding Soviet policy, which in general failed to be conceptual and well-planned and that at that time they received the given states not as a result of "their Baltic policy" but directly from "the hands of Berlin." …”
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EVALUASI ELEMEN TEKNIS RUANG BERSAMA RUSUNAWA MAHASISWA SEBAGAI HUNIAN SEHAT DI MASA PANDEMI COVID-19 by Citra Amalia Amal, Andi Annisa Amalia, Siti Fuadillah A. Amin, Rifaldi Rifaldi

“…The research location is in two student flats in Makassar City, namely Rusunawa Hasanuddin University, and the Rusunawa Muslim University of Indonesia. …”
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Hubungan Electronic Customer Relationship Management (E-Crm) Terhadap Loyalitas Pasien Di Rumah Sakit: Tinjauan Pustaka by Sabrina Aulia Rahma, Holipah Holipah, Harun Al Rasyid, Fida Rahmayanti

“…E-CRM is a Customer Relationship Management (CRM) that is made electronically using a web browser, internet and other electronic media such as call centers, email, and personalization which is one way to approach patients with one of the goals, namely increasing patient loyalty. This study aims to examine the relationship of e-CRM to patient loyalty in hospitals. …”
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Occurrence of Alternaria Toxins, Ochratoxin A and Aflatoxins B1 in Green Arabic Coffee (Coffea arabica) in Saudi Arabia: Risk Assessment on HepG-2 Cell Line and Male Albino Rats by Ahmed Hashim Almusallam, Ahmed Mahmoud Ismail

“…HPLC analysis revealed the detection of four Alternaria toxins (ALT-Ts) namely Altenuene (ALT), Tenuazonic acid (TA), Alternariol (AOH), and Altenuisol being AOH reported as the frequently detected mycotoxin in 18 coffee beans samples representing 75 % with quantity ranged 0.98 to 8.97 μg/g. …”
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Identification of the Granule-Bound Starch Synthase (GBSS) Genes Involved in Amylose Biosynthesis in Tartary Buckwheat (<i>Fagopyrum tataricum</i> (L.) Gaertn.) by Juan Huang, Fei Liu, Jieqiong Zhang, Bin Tang, Jiao Deng, Taoxiong Shi, Liwei Zhu, Hongyou Li, Qingfu Chen

“…Based on the genome data of Tartary buckwheat, five <i>FtGBSS</i> genes, namely <i>FtGBSS-1</i> to <i>FtGBSS-5</i>, were identified on three chromosomes, exhibiting about 1800 bp lengths in their CDSs and numerous exons and introns in gene structures. …”
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Une inscription méconnue de Cos/Cosa dans la cité des Cadurques by Sabine Armani

“…It is also unknown whether this conveyance had a name, as is sometimes the case (AE 1989, 521 = 1991, 1222). …”
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Penerapan Covid Shooter Berbasis Android sebagai Game Edukasi Pencegahan Covid-19 pada Anak Usia Dini by Rocky Ardiansyah Yudistira Putra, Unzilla Savika Putri, Ginanjar Setyo Permadi, Dodik Arwin Dermawan

“…Before the application of the game is carried out, first a game is made about the dangers of covid-19. This game name is Covid Shooter which tells the adventures of a virus specialist doctor with a mission to eradicate covid-19. …”
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Implementasi Metode Naive Bayes untuk Mendeteksi Stres Siswa Berdasarkan Tweet pada Sistem Monitoring Stres by Diva Fardiana Risa, Fajar Pradana, Fitra Abdurrachman Bachtiar

“…Therefore, this research will build a feature to detect stress levels via tweet on a twitter account using the Naïve Bayes method which will be able to classify students' stress levels based on student tweets into three classes, namely light stress, moderate stress and severe stress classes. …”
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UGCG promotes chemoresistance and breast cancer progression via NF-κB and Wnt/β-catenin pathway activation by Li Long, Lei Wang, Yiran Liang, Fangzhou Ye, Yuhan Jin, Dan Luo, Xiaoyan Li, Yajie Wang, Yaming Li, Dianwen Han, Bing Chen, Wenjing Zhao, Lijuan Wang, Qifeng Yang

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Knowledge Distillation in Object Detection for Resource-Constrained Edge Computing by Arief Setyanto, Theopilus Bayu Sasongko, Muhammad Ainul Fikri, Dhani Ariatmanto, I. Made Artha Agastya, Rakandhiya Daanii Rachmanto, Affan Ardana, In Kee Kim

“…We consider both accuracy drop and model size to choose either MobileNetV2 or RepViT model to replace CSPDarknet53 in the modified YOLOv4 named M-YOLO-CRD and RV-YOLO-CRD. Our evaluation results demonstrate that RV-YOLO-CRD reduces 30% of model size and achieves better mean average precision (mAP) than M-YOLO-CRD. …”
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