Exploring the multi-targeted mechanism of Saikosaponin A in prostate cancer treatment: a network pharmacology and molecular docking approach by Genbao Zhu, Genbao Zhu, Genbao Zhu, Zhiming Jiang, Niuping Zhu, Niuping Zhu, Donghui Wang, Donghui Wang, Tianpeng Guo, Tianpeng Guo, Yiqing Meng, Yiqing Meng, Yi Zhu, Yi Zhu, Kemeng Tan, Mengxue Hu, Heng Tang, Xuannian Wang, Xuannian Wang

“…Lastly, in vitro experiments were performed for validation.ResultsA least of four key targets, namely BCL2 apoptosis regulator (BCL2), estrogen receptor 1 (ESR1), hypoxia-inducible factor 1 subunit alpha (HIF1A), and signal transducer and activator of transcription 3 (STAT3) were identified in this study, and molecular docking analyses revealed that SSA stably binds to these targets. …”
Get full text

Mechanism of Threshold Voltage Instability in Double Gate α-IGZO Nanosheet TFT Under Bias and Temperature Stress by Muhammad Aslam, Shu-Wei Chang, Yi-Ho Chen, Yao-Jen Lee, Yiming Li, Wen-Hsi Lee

“…Given the demand for CMOS-compatible, ultra-scaled, reliable, and high-performing devices, we fabricate and analyze scaled-channel a-IGZO-TFTs with an optimal double-gate structure, a thin nanosheet-based channel, and an effective high- <inline-formula> <tex-math notation="LaTeX">$\kappa$ </tex-math></inline-formula> dielectric namely HfO2. The reliably reported double gate IGZO nanosheet TFTs (DG-IGZO-NS-TFTs) are tested under positive and negative bias stress at variant temperatures, and the resulting modulations are analyzed critically. …”
Get full text

PortNet: Achieving lightweight architecture and high accuracy in lung cancer cell classification by Kaikai Zhao, Youjiao Si, Liangchao Sun, Xiangjiao Meng

“…Method: This paper introduces a model named PortNet, designed to significantly reduce the model's parameter size and achieve lightweight characteristics without compromising classification accuracy. …”
Get full text

Genome-wide identification, characterization, and expression analysis of BZR transcription factor family in Gerbera hybrida by Qishan Luo, Gan Huang, Xiaohui Lin, Xiaojing Wang, Yaqin Wang

“…The identified BZR genes, named GhBEH1-7 (GhBEH1, GhBEH2, GhBEH3, GhBEH4, GhBEH5, GhBEH6, GhBEH7), are distributed across chromosomes 3, 5, 10, 11, 12, 14 and 15. …”
Get full text

Repetition of Prediabetes Enhances the Risk of Developing Diabetes by Yoshihiro Numata, Toshihide Ohya, Yasuhiko Nitta, Yumiko Yoshinaka, Azusa Shogakiuchi, Akihiro Toyota

“…Among them, we focused the individuals who fulfilled the criteria for prediabetes in both FPG and HbA1c, and this group was named as PD3. Similarly, all subjects were categorized into 4 groups by the frequency of the status of PD3 during three years. …”
Get full text

Computational and experimental exploration of morpholine pendent 2-hydrazineyl thiazole: Insights from DFT, ADME profiling, antifungal efficacy and molecular docking analyses by Vishnu A. Adole, I.Antony Danish, J.Jebasingh Kores, J.Winfred Jebaraj, S. Janani, Suresh K. Ghotekar, Rakesh D. Amrutkar

“…Significant interactions between the donor and acceptor, namely involving LP(3)N25 → σ*C24-C26, were confirmed by second-order perturbation energies, yielding a stabilization energy of 12.54 kcal/mol. …”
Get full text

Efficacy of Novel Noncontrast Cardiac Magnetic Resonance Methods in Indicating Fibrosis in Hypertrophic Cardiomyopathy by Maedeh Sharifian, Nahid Rezaeian, Sanaz Asadian, Ali Mohammadzadeh, Ali Nahardani, Kianosh Kasani, Yaser Toloueitabar, Ali Mohammad Farahmand, Leila Hosseini

“…We evaluated the efficacy of 2 novel contrast-free CMR methods, namely, diffusion-weighted imaging (DWI) and feature-tracking (FT) method, in detecting myocardial fibrosis. …”
Get full text

Harnessing national data systems to understand circumstances surrounding veteran suicide: linking Department of Veterans Affairs and National Violent Death Reporting System Data by Claire A. Hoffmire, Alexandra L. Schneider, Laurel A. Gaeddert, Joseph Logan, Julie A. Kittel, Ryan Holliday, Lindsey L. Monteith

“…Three linkage stages: (1) exact (matched on: age, sex, death date, underlying cause of death, day of month of birth, first initial of last name); (2) probable (all but one variable matched); (3) possible (all but 2 variables matched). …”
Get full text

Determination of Pharmaceutical Residues by UPLC-MS/MS Method: Validation and Application on Surface Water and Hospital Wastewater by Bui Van Hoi, Cam-Tu Vu, Lan-Anh Phung-Thi, Thao Thi Nguyen, Phuong Thanh Nguyen, Huong Mai, Phuong-Thu Le, Thanh-Hien Nguyen, Dao Thanh Duong, Hue Nguyen Thi, Dung Le-Van, Dinh Binh Chu

“…In this study, an analytical method for the simultaneous determination of 7 major pharmaceutical residues in Vietnam, namely, carbamazepine, ciprofloxacin, ofloxacin, ketoprofen, paracetamol, sulfamethoxazole, and trimethoprim, in surface water and hospital wastewater has been developed. …”
Get full text

Use of Multimodal Artificial Intelligence in Surgical Instrument Recognition by Syed Ali Haider, Olivia A. Ho, Sahar Borna, Cesar A. Gomez-Cabello, Sophia M. Pressman, Dave Cole, Ajai Sehgal, Bradley C. Leibovich, Antonio Jorge Forte

“…For precise subtype identification of instrument names (like “Mayo scissors” or “Kelly forceps”), all models had low accuracy, with SID 2.0 having an accuracy of 39.1%, followed by ChatGPT-4o (33.69%). …”
Get full text

Differential Production of Midkine and Pleiotrophin by Innate APCs upon Stimulation through Nucleic Acid-Sensing TLRs by Elias A. Said, Sumaya Al-Dughaishi, Wadha Al-Hatmi, Iman Al-Reesi, Mohammed S. Al-Balushi, Atika Al-Bimani, Juma Z. Al-Busaidi, Marwa Al-Riyami, Murtadha Al-Khabori, Salam Al-Kindi, Francesco A. Procopio, Shadia Al-Sinawi, Aliyaa Al-Ansari, Crystal Y. Koh, Khalid Al-Naamani, Ali A. Al-Jabri

“…We investigated whether NAS TLRs can induce MK and PTN production by human iAPCs, namely monocytes, macrophages, MDDCs, myeloid dendritic cells (mDCs), and pDCs. …”
Get full text

Soil porosity as a key factor of soil aggregate stability: insights from restricted grazing by Yi Yang, Yi Yang, Yi Yang, Zhongju Meng, Zhongju Meng, Zhongju Meng, Haonian Li, Haonian Li, Haonian Li, Yue Gao, Yue Gao, Yue Gao, Tianyang Li, Tianyang Li, Tianyang Li, Lei Qin

“…This study examined the effects of two different grazing management strategies, namely, restricted grazing and free grazing (CK), on soil structure indicators in the desert steppe. …”
Get full text

Anatomic Variations Important for Dental Implantation in the Mandible—A Systematic Review by Zlata Rajkovic Pavlovic, Milos Stepovic, Marija Bubalo, Ivana Zivanovic Macuzic, Maja Vulovic, Nevena Folic, Jovana Milosavljevic, Valentina Opancina, Dobrivoje Stojadinovic

“…<b>Conclusions</b>: The distances of the named anatomic landmarks to the surrounding bone structures that are used as a guide during planning are of huge importance, so proper and detailed measurements must be executed by experienced professionals using CBCT. …”
Get full text

Effect of ISPAD Anaerobic Digestion on Ammonia Volatilization from Soil Applied Swine Manure by Susan King, Michael Schwalb, David Giard, Joann Whalen, Suzelle Barrington

“…The objective of this study was therefore to measure NH3 volatilization from both ISPAD and open tank swine manures when applied to 5 different soils, namely, washed sand, a Ste Rosalie clay, an Upland sandy loam, a St Bernard loam, and an Ormstown loam. …”
Get full text

Assessment of Nutritional Status in Patients with Head and Neck Cancer Before Radiotherapy: A Single-center, Cross-sectional Study by Susetyowati SUSETYOWATI, Fuadiyah Nila KURNIASARI, Amalia Sarah SHOLIKHATI, Mardiah HARDIANTI, Ericko EKAPUTRA

“…The aim of this research was to assess nutritional status by comparing several parameters, namely anthropometry, biochemistry, physical condition, and inflammatory parameters, with Patient Generated-Subjective Global Assessment (PG-SGA) as the gold standard. …”
Get full text

Research on the Performance of a Liquid–Solid Triboelectric Nanogenerator Prototype Based on Multiphase Liquid by Wei Wang, Jin Yan, Xianzhang Wang, Hongchen Pang, Chengqi Sun, Yin Sun, Lijun Wang, Dapeng Zhang

“…This paper outlines the limitations of the ML-TENG, named PRO, and suggests avenues for future improvement. …”
Get full text

Gross and Histopathology of Goats Feeding on Opuntia stricta in Laikipia County, Kenya by Jackson M. Ncebere, Paul G. Mbuthia, Robert M. Waruiru, Peter K. Gathumbi

“…Various plant species such as Opuntia stricta have developed defensive measures, namely, spines, thorns, and other sharp pointed structures to protect themselves from herbivores and other animals feeding on them. …”
Get full text

Black Carbon Exposure Characteristics in Diesel Engine Vehicle-related Jobs by Sangjun Choi, Ju-Hyun Park, Won Kim, Seung Won Kim, Kyong-Hui Lee, Taejin Chung, Jihoon Park, Seung-Hun Ryu, Jungah Shin, Dong-Hee Koh, Dong-Uk Park

“…Abstract We aimed to characterize the black carbon (BC) exposure from eight types of jobs involving diesel engine vehicles—namely, machinery operation, forklift operation, automobile assembly, garbage collection, garbage truck driving, delivery, toll operation, and crane operation—across seven industries. …”
Get full text

Effect of Prehospital Epinephrine on Outcomes of Out-of-Hospital Cardiac Arrest: A Bayesian Network Approach by Joonghee Kim, Yu Jin Kim, Sangsoo Han, Han Joo Choi, Hyungjun Moon, Giwoon Kim

“…We analyzed a prospective regional registry of OHCA where a prehospital advanced life support (ALS) protocol named “Smart ALS (SALS)” was gradually implemented from July 2015 to December 2016. …”
Get full text

Oocyte transcriptomes and follicular fluid proteomics of ovine atretic follicles reveal the underlying mechanisms of oocyte degeneration by Yukun Song, Erhan Hai, Nan Zhang, Yu Zhang, Junlan Wang, Xitong Han, Jiaxin Zhang

“…Moreover, we identified atresia-specific genes, namely FTH1, TF, and ACSL4, which may participate in regulation of oocyte ferroptosis in atretic follicles through a series of mechanisms including ferritinophagy, ferritin transport, and lipid metabolism. …”
Get full text