Steatohepatitis-induced vascular niche alterations promote melanoma metastasis by Johannes Hoffmann, Julia Schüler, Bianca Dietsch, Sina Wietje Kürschner-Zacharias, Carsten Sticht, Felix A. Trogisch, Maren Schreitmüller, Tinja Baljkas, Kai Schledzewski, Manuel Reinhart, Sebastian A. Wohlfeil, Manuel Winkler, Christian David Schmid, Joerg Heineke, Cyrill Géraud, Sergij Goerdt, Philipp-Sebastian Reiners-Koch, Victor Olsavszky

“…Conclusion We discovered that the hepatic vascular niche acts as a delicate sensor to even short-term nutritional alterations during the development of MASLD/MASH. The dynamic adaptations to the metabolic challenges of developing MASLD/MASH caused an early shift from the normal hepatic vascular niche to a pre-metastatic vascular niche that promoted hepatic melanoma metastasis in the context of cell-autonomous and acquired melanoma cell features. …”
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Global digital elevation model (GDEM) product generation by correcting ASTER GDEM elevation with ICESat-2 altimeter data by B. Li, B. Li, B. Li, B. Li, H. Xie, H. Xie, S. Liu, Z. Ye, Z. Hong, Q. Weng, Q. Weng, Q. Weng, Y. Sun, Q. Xu, X. Tong

“…IC2-GDEM facilitates seamless integration with these historical datasets, which is essential for longitudinal studies examining long-term environmental change, land use dynamics, and climate impacts. Meanwhile, IC2-GDEM can serve as a new complementary data source for existing DEMs (such as Copernicus DEM) mainly sourced from synthetic aperture radar (SAR) observation. …”
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Hypercysteinemia, A Potential Risk Factor for Central Obesity and Related Disorders in Azores, Portugal by Ana Lima, Rita Ferin, Mafalda Bourbon, José Baptista, M. Leonor Pavão

“…Lisbon subjects (18% vs. 4%, P=0.001), namely, in male gender. Moreover, plasma Cys levels predicted waist circumference (β coefficient = 0.102, P=0.032) and concomitant central obesity and were also associated with insulin resistance. …”
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Inhibition of Endothelial Cell Tube Formation by Anti-Vascular Endothelial Growth Factor/Anti-Angiopoietin-2 RNA Nanoparticles by Cheng Zhong, Zhanquan Shi, Chia-Yang Liu, Daniel W. Binzel, Kai Jin, Xin Li, Peixuan Guo, S. Kevin Li

“…<b>Methods</b>: Three groups of RNA nanoparticles were evaluated, namely, pRNA-3WJ series, RNA square series (polygon-type RNA nanoparticles), and 8WJ series (multiple-way junction RNA nanoparticles), which were conjugated with a single anti-VEGF, the combination of one anti-VEGF and one anti-Ang2, or multiple anti-VEGF aptamers. …”
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Efficacy of Chinese Herbal Medicine in the Treatment of Moderate-Severe Painful Diabetic Peripheral Neuropathy: A Retrospective Study by Yujiao Zheng, Fan Yang, Lin Han, Xiaowen Gou, Fengmei Lian, Wenke Liu, Linhua Zhao, Bing Pang, Xiyan Zhao, Xiaolin Tong

“…The amelioration of 3 common symptoms, namely, limb pain, limb numbness, and insomnia, was evident, and the major response of common symptoms at month 6 including limb pain, insomnia, and limb coldness was significantly increased compared with the results at month 3 (P<0.05). …”
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Transformer-based travel time estimation method for plateau and mountainous environments by Guangjun Qu, Kefa Zhou, Rui Wang, Dong Li, Yingpeng Lu, Zhihong Lv, Dequan Zhao, Aijun Zhang, Qing Zhang

“…When evaluated alongside the five models that are most commonly utilized in urban settings, the mean absolute percentage error (MAPE) of our model exhibited a 14.89% improvement in plateau environments and a 12.20% improvement in mountainous environments in comparison with the most effective model, namely MetaTTE-GRU. These findings substantiate the assertion that the proposed model is an effective means of estimating travel times in complex environments, and that it exhibits superior accuracy compared to existing LSTM-based estimation models.…”
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Sustainability by extraction of bioactive compounds from onion seeds by Mestour, Selma, Meniai, Abdeslam-Hassen, Melloul, Sarra, Louaer, Mehdi

“…About ten components were identified in the extracts, but with four major ones, namely 9,12-octadecadienoic acid, methyl ester, 9,12-octadecadienoic acid (Z,Z)-, methyl ester, 9-octadecadienoic acid (Z)-, methyl ester and hexadecanoic acid, methyl ester, present with significant percentages, depending on the operating parameters values. …”
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Typical and atypical metabolic characteristics of three iridaceae isoflavone components: in vitro and in silico studies by Jifeng Gu, Jifeng Gu, Huishan Zhang, Mei Wang, Yuyang Zhou, Yuyang Zhou, Zhipeng Deng, Rong Shi

“…BackgroundBelamcanda chinensis (L.) DC (Chinese name Shegan) has been widely used because of its pharmacological activity and remarkable therapeutic effects in sore throat. …”
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Cytotoxic Constituents from the Rhizomes of Curcuma zedoaria by Omer Abdalla Ahmed Hamdi, Syarifah Nur Syed Abdul Rahman, Khalijah Awang, Norhanom Abdul Wahab, Chung Yeng Looi, Noel Francis Thomas, Sri Nurestri Abd Malek

“…Investigation on the chemical components in the hexane and dichloromethane fractions gave 19 compounds, namely, labda-8(17),12 diene-15,16 dial (1), dehydrocurdione (2), curcumenone (3), comosone II (4), curcumenol (5), procurcumenol (6), germacrone (7), zerumbone epoxide (8), zederone (9), 9-isopropylidene-2,6-dimethyl-11-oxatricyclo[6.2.1.01,5]undec-6-en-8-ol (10), furanodiene (11), germacrone-4,5-epoxide (12), calcaratarin A (13), isoprocurcumenol (14), germacrone-1,10-epoxide (15), zerumin A (16), curcumanolide A (17), curcuzedoalide (18), and gweicurculactone (19). …”
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Mechanical Behavior of Ion-Exchanged Alkali Aluminosilicate Glass Ceramics by Bruno M. F. Nunes, André Dinis, Jorge C. Fernandes, Rui M. Almeida, Luís F. Santos

“…Several processes can be used to maximize the mechanical strength of glasses, namely thermal or chemical treatments. Glass ceramics, obtained through controlled crystallization, can enhance the mechanical properties of these materials and, as long as the crystals remain small enough, transparent glass ceramics can be obtained. …”
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Person-centered support for patients with a pituitary tumor following surgery by Sofie Jakobsson, Oskar Ragnarsson, Tobias Hallén, David Krabbe, Ann-Charlotte Olofsson, Daniel S Olsson, Penelope Trimpou, Thomas Skoglund, Gudmundur Johannsson

“…Design and methods: This study is a prospective, single-center study using a quasi-experimental design to evaluate the effect of a 12-month person-centered practice by means of a name-given nurse care manager, an interdisciplinary team and peer support against usual care. …”
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The use of kinematic photogrammetry and LiDAR for reconstruction of a unique object with extreme topography: a case study of Dutchman’s Cap, Baltic seacoast, Lithuania by Birutė Ruzgienė, Lina Kuklienė, Indrius Kuklys, Dainora Jankauskienė, Dainora Jankauskienė, Sérgio Lousada, Sérgio Lousada, Sérgio Lousada, Sérgio Lousada, Sérgio Lousada

“…The paper deals with the use of kinematic remote sensing technique for the study of surface with extreme topography as is a near-vertical cliff named Olandian hat situated in the Seaside regional park on the Baltic sea coast of Lithuania. …”
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Trophic transfer of arsenic in the food chain from selected crops grown in long-term wastewater contaminated soil by Mudasra Munir, Kafeel Ahmad, Zafar Iqbal Khan, Shahzad Akhtar, Muhammad Nadeem, Asma Ashfaq, Mohammad Faisal, Abdulrahman A. Alatar, Hafiza Mamona Nazir, Ifra Saleem Malik

“…All the soil and vegetable samples contaminated with different water sources were collected from three districts, namely, Jhang, Faisalabad and Toba Tek Singh. All samples were digested via the wet digestion method. …”
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Radiation-induced rescue effect on human breast carcinoma cells is regulated by macrophages by Spoorthy Pathikonda, Li Tian, Clement Manohar Arava, Shuk Han Cheng, Yun Wah Lam

“…This protective effect could be further enhanced by the prior treatment of bystander cells with factors from UV-irradiated cells. We named the former effect “basal RIRE” and the latter “active RIRE” which were cell type-dependent. …”
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Non‐Invasive Tumor‐Naïve Minimal Residual Disease Detection of Liver Cancer by Incorporating Circulating Tumor DNA Features and Alpha‐Fetoprotein: A Prospective Study by Qingqi Ren, Shiyong Li, Guolin Zhong, Yunfei Li, Dao‐Ling Huang, Liangliang Zhang, Yumin Feng, Guanghui Long, Mao Mao

“…In this study, we expanded upon our previously developed multi‐omics assay, initially designed for liver cancer early detection by calculating a cancer signal score (PHCC), to determine the MRD status (named SeekInCure). This process integrated protein tumor marker alpha‐fetoprotein (AFP) and cancer genomic hallmarks, copy number aberration (CNA) and fragment size (FS). …”
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The role of pro-environmental behavior in the development of sustainable tourism by N. Zulvianti, H. Akmal, M.R. Putra

“…This research aims to show three direct effects: first, the effect of satisfaction and electronic word of mouth on the sustainability of tourism; second, the effect of satisfaction on electronic word of mouth; and third, three moderating effects of pro-environmental behavior, namely, moderating the influence of tourist satisfaction on tourism sustainability, moderating the influence of electronic word of mouth on tourism sustainability, and moderating the influence of satisfaction with electronic word of mouth.METHODS: This study is a quantitative study involving 420 tourists as respondents who visited West Sumatra from January to April 2023. …”
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A novel agricultural drought index based on multi-source remote sensing data and interpretable machine learning by Hao Chen, Ni Yang, Xuanhua Song, Chunhua Lu, Menglan Lu, Tan Chen, Shulin Deng

“…Here, we used solar-induced chlorophyll fluorescence, water balance, soil moisture, and land surface temperature to develop a new integrated remote sensing drought index, namely interpretable machine learning drought index (IMLDI), based on the Bayesian optimized tree-based Light Gradient Boosting Machine and SHapley Additive exPlainations. …”
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Prospective cohort study of the evaluation of patient benefit from the redevelopment of a complete national forensic mental health service: the Dundrum Forensic Redevelopment Evalu... by Harry G Kennedy, Mary Davoren, Ken O’Reilly, Damian Mohan

“…Patients will be rated for physical health, mental health, offending behaviours and other recovery measures relevant to the forensic hospital setting at admission to the hospital and 6 monthly thereafter.Lagged causal model analysis will be used to assess the existence and significance of potential directed relationships between the baseline measures of symptomatology of schizophrenia and violence risk and final outcome namely length of stay. Time intervals including length of stay will be measured by median and 95% CI using Kaplan-Meier and Cox regression analyses and survival analyses. …”
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EXPERIENCE OF USING PLANET EARTH OBSERVATION DATA IN RETRAINING COURSES FOR EDUCATORS IN THE JUNIOR ACADEMY OF SCIENCES OF UKRAINE by Stanislav O. Dovgyi, Svitlana M. Babiichuk, Olha V. Tomchenko

“…Increased number of GIS and Remote Sensing after-school clubs in the territorial branches of the Junior Academy of Sciences (from 1 in Kyiv as of 2019 to 9 in the regions as of 2022, namely in Poltava, Sumy, Volyn, Kyiv, Kirovohrad, Zakarpattia, Lviv, Kharkiv and Chernivtsi) is indicative of the course’s effectiveness. …”
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Assessment of patient preferences for assisted reproductive technology in China: a discrete choice experiment by Lingli Zhang, Xin Li, Jiali Chen, Yanyan Liu, Yanjun Sun, Yuwen Bao, Xiaodan Qian, Kexing Fang, Bin Wan, Haixia Ding

“…The latent class model revealed two distinct classes named ‘outcome driven’ and ‘cost driven’. Preferences varied according to their age, monthly household income and location.Conclusions This study investigated the preferences of infertile patients when seeking medical assistance for infertility. …”
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